KR100243514B1 - 피롤로아제핀 유도체 - Google Patents

피롤로아제핀 유도체 Download PDF

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Publication number
KR100243514B1
KR100243514B1 KR1019930701044A KR930701044A KR100243514B1 KR 100243514 B1 KR100243514 B1 KR 100243514B1 KR 1019930701044 A KR1019930701044 A KR 1019930701044A KR 930701044 A KR930701044 A KR 930701044A KR 100243514 B1 KR100243514 B1 KR 100243514B1
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KR
South Korea
Prior art keywords
group
compound
formula
defined above
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019930701044A
Other languages
English (en)
Korean (ko)
Other versions
KR930702354A (ko
Inventor
아키라 미즈노
히데츠우라 초
미키코 미야
도시오 다츠오카
다카후미 이시하라
Original Assignee
도리이 신이치로
산토리 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 도리이 신이치로, 산토리 가부시키가이샤 filed Critical 도리이 신이치로
Publication of KR930702354A publication Critical patent/KR930702354A/ko
Application granted granted Critical
Publication of KR100243514B1 publication Critical patent/KR100243514B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
KR1019930701044A 1991-08-07 1992-08-06 피롤로아제핀 유도체 Expired - Fee Related KR100243514B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP221191/1991 1991-08-07
JP91-221191 1991-08-07
JP22119191 1991-08-07
PCT/JP1992/001008 WO1993003031A1 (fr) 1991-08-07 1992-08-06 Derive de pyrroloazepine

Publications (2)

Publication Number Publication Date
KR930702354A KR930702354A (ko) 1993-09-08
KR100243514B1 true KR100243514B1 (ko) 2000-03-02

Family

ID=16762903

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930701044A Expired - Fee Related KR100243514B1 (ko) 1991-08-07 1992-08-06 피롤로아제핀 유도체

Country Status (10)

Country Link
US (1) US5397780A (enExample)
EP (1) EP0551527B8 (enExample)
JP (1) JP3242652B2 (enExample)
KR (1) KR100243514B1 (enExample)
AT (1) ATE236162T1 (enExample)
AU (1) AU655841B2 (enExample)
CA (1) CA2093631C (enExample)
DE (1) DE69232980T2 (enExample)
ES (1) ES2196001T3 (enExample)
WO (1) WO1993003031A1 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69620745T2 (de) * 1995-12-01 2002-10-31 Suntory Limited, Osaka Pyrroloazepin-derivate
JPH10251258A (ja) * 1997-03-14 1998-09-22 Suntory Ltd ピロロアゼピン系化合物
JPH11193289A (ja) 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド誘導体
JPH11193290A (ja) * 1997-12-26 1999-07-21 Suntory Ltd ピロールスルホンアミド系化合物
US10556013B2 (en) 2017-06-20 2020-02-11 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
EP4497474A3 (en) 2018-10-17 2025-04-23 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3563979A (en) * 1966-10-21 1971-02-16 Upjohn Co 1,2,3,4,5,6 - hexahydroazepino(4,3 - b)indoles and 1,2,3,4,5,6-hexahydroazepino(3,2-b)indoles
US3573323A (en) * 1969-02-28 1971-03-30 Upjohn Co 1,2,3,4,5,10-hexahydroazepino(2,3-b)indoles
US3573324A (en) * 1969-02-28 1971-03-30 Upjohn Co 2,3,4,5,10,10a-hexahydroazepino(2,3-b)indoles
JPS62161786A (ja) * 1986-01-08 1987-07-17 Mitsubishi Chem Ind Ltd ピロ−ル化合物
US4729996A (en) * 1986-05-29 1988-03-08 Harbor Branch Oceanographic Institution, Inc. Antitumor compositions and their methods of use
DE3903368A1 (de) * 1989-02-04 1990-08-09 Basf Ag Verfahren zur herstellung von kondensierten cyclischen amidinen
JP3198117B2 (ja) * 1990-02-07 2001-08-13 サントリー株式会社 ピロロアゼピン誘導体

Also Published As

Publication number Publication date
ATE236162T1 (de) 2003-04-15
EP0551527A4 (enExample) 1994-08-31
CA2093631A1 (en) 1993-02-08
CA2093631C (en) 2003-09-23
DE69232980D1 (de) 2003-05-08
AU655841B2 (en) 1995-01-12
EP0551527B8 (en) 2003-08-13
WO1993003031A1 (fr) 1993-02-18
AU2403192A (en) 1993-03-02
JP3242652B2 (ja) 2001-12-25
KR930702354A (ko) 1993-09-08
US5397780A (en) 1995-03-14
EP0551527B1 (en) 2003-04-02
ES2196001T3 (es) 2003-12-16
EP0551527A1 (en) 1993-07-21
DE69232980T2 (de) 2004-02-05

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