KR100197306B1 - 면역억제 화합물 - Google Patents

면역억제 화합물 Download PDF

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Publication number
KR100197306B1
KR100197306B1 KR1019920703413A KR920703413A KR100197306B1 KR 100197306 B1 KR100197306 B1 KR 100197306B1 KR 1019920703413 A KR1019920703413 A KR 1019920703413A KR 920703413 A KR920703413 A KR 920703413A KR 100197306 B1 KR100197306 B1 KR 100197306B1
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KR
South Korea
Prior art keywords
straight
alkenyl
hydrogen
alkyl
branched
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019920703413A
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English (en)
Korean (ko)
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KR930701403A (ko
Inventor
엠. 아미스테드 데이빗
에스. 보거 요수아
브이. 메이어스 해롤드
오. 손더스 제프리
디. 텅 로저
Original Assignee
보거 조슈아 에스
버텍스 파마슈티칼스 인코오포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24186237&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100197306(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 보거 조슈아 에스, 버텍스 파마슈티칼스 인코오포레이티드 filed Critical 보거 조슈아 에스
Publication of KR930701403A publication Critical patent/KR930701403A/ko
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Publication of KR100197306B1 publication Critical patent/KR100197306B1/ko
Anticipated expiration legal-status Critical
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
KR1019920703413A 1990-07-02 1991-07-02 면역억제 화합물 Expired - Fee Related KR100197306B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/547,814 US5192773A (en) 1990-07-02 1990-07-02 Immunosuppressive compounds
US07/547,814 1990-07-02
US7/547.814 1990-07-02

Publications (2)

Publication Number Publication Date
KR930701403A KR930701403A (ko) 1993-06-11
KR100197306B1 true KR100197306B1 (ko) 1999-06-15

Family

ID=24186237

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920703413A Expired - Fee Related KR100197306B1 (ko) 1990-07-02 1991-07-02 면역억제 화합물

Country Status (15)

Country Link
US (5) US5192773A (cg-RX-API-DMAC7.html)
EP (1) EP0537269B1 (cg-RX-API-DMAC7.html)
JP (2) JP3095247B2 (cg-RX-API-DMAC7.html)
KR (1) KR100197306B1 (cg-RX-API-DMAC7.html)
AT (1) ATE159247T1 (cg-RX-API-DMAC7.html)
AU (2) AU660623B2 (cg-RX-API-DMAC7.html)
BR (2) BR1100732A (cg-RX-API-DMAC7.html)
CA (1) CA2086428A1 (cg-RX-API-DMAC7.html)
DE (1) DE69127970T2 (cg-RX-API-DMAC7.html)
DK (1) DK0537269T3 (cg-RX-API-DMAC7.html)
ES (1) ES2109269T3 (cg-RX-API-DMAC7.html)
GR (1) GR3025918T3 (cg-RX-API-DMAC7.html)
SG (1) SG49663A1 (cg-RX-API-DMAC7.html)
TW (1) TW215055B (cg-RX-API-DMAC7.html)
WO (1) WO1992000278A1 (cg-RX-API-DMAC7.html)

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HK1004066A1 (en) 1998-11-13
AU660623B2 (en) 1995-07-06
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DE69127970T2 (de) 1998-03-05
AU3309395A (en) 1996-01-11
ES2109269T3 (es) 1998-01-16
GR3025918T3 (en) 1998-04-30
BR1100764A (pt) 2000-02-08
DE69127970D1 (de) 1997-11-20
JPH06501457A (ja) 1994-02-17
US5330993A (en) 1994-07-19
ATE159247T1 (de) 1997-11-15
US5665774A (en) 1997-09-09
EP0537269A1 (en) 1993-04-21
TW215055B (cg-RX-API-DMAC7.html) 1993-10-21
JP3095247B2 (ja) 2000-10-03
AU8285591A (en) 1992-01-23
US5622970A (en) 1997-04-22
CA2086428A1 (en) 1992-01-03
BR1100732A (pt) 2000-06-06
US5516797A (en) 1996-05-14
JP2000143599A (ja) 2000-05-23
US5192773A (en) 1993-03-09
EP0537269B1 (en) 1997-10-15
SG49663A1 (en) 1998-06-15

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