JPWO2022191283A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022191283A5 JPWO2022191283A5 JP2023505632A JP2023505632A JPWO2022191283A5 JP WO2022191283 A5 JPWO2022191283 A5 JP WO2022191283A5 JP 2023505632 A JP2023505632 A JP 2023505632A JP 2023505632 A JP2023505632 A JP 2023505632A JP WO2022191283 A5 JPWO2022191283 A5 JP WO2022191283A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- residue
- salt
- atom
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 38
- 125000004432 carbon atom Chemical group C* 0.000 claims 35
- 229910052799 carbon Inorganic materials 0.000 claims 24
- 125000004430 oxygen atom Chemical group O* 0.000 claims 17
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004434 sulfur atom Chemical group 0.000 claims 14
- 108060003951 Immunoglobulin Proteins 0.000 claims 12
- 102000018358 immunoglobulin Human genes 0.000 claims 12
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 12
- 125000002947 alkylene group Chemical group 0.000 claims 10
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 150000001540 azides Chemical group 0.000 claims 9
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 6
- 125000003277 amino group Chemical group 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 5
- 239000000126 substance Substances 0.000 claims 5
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 4
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 3
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 3
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 3
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 3
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 2
- 239000004472 Lysine Substances 0.000 claims 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 125000002029 aromatic hydrocarbon group Chemical group 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000001425 triazolyl group Chemical group 0.000 claims 2
- 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 claims 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 claims 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- 125000000729 N-terminal amino-acid group Chemical group 0.000 claims 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- -1 pentafluorophenyloxy group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024217693A JP2025038071A (ja) | 2021-03-11 | 2024-12-12 | 化合物またはその塩、およびそれらにより得られる抗体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021039706 | 2021-03-11 | ||
| JP2021039706 | 2021-03-11 | ||
| PCT/JP2022/010574 WO2022191283A1 (ja) | 2021-03-11 | 2022-03-10 | 化合物またはその塩、およびそれらにより得られる抗体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024217693A Division JP2025038071A (ja) | 2021-03-11 | 2024-12-12 | 化合物またはその塩、およびそれらにより得られる抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022191283A1 JPWO2022191283A1 (https=) | 2022-09-15 |
| JPWO2022191283A5 true JPWO2022191283A5 (https=) | 2024-08-06 |
| JP7605290B2 JP7605290B2 (ja) | 2024-12-24 |
Family
ID=83228078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023505632A Active JP7605290B2 (ja) | 2021-03-11 | 2022-03-10 | 化合物またはその塩、およびそれらにより得られる抗体 |
| JP2024217693A Pending JP2025038071A (ja) | 2021-03-11 | 2024-12-12 | 化合物またはその塩、およびそれらにより得られる抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024217693A Pending JP2025038071A (ja) | 2021-03-11 | 2024-12-12 | 化合物またはその塩、およびそれらにより得られる抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240115719A1 (https=) |
| EP (1) | EP4306535A1 (https=) |
| JP (2) | JP7605290B2 (https=) |
| KR (1) | KR20230154853A (https=) |
| CN (1) | CN116964076A (https=) |
| AU (1) | AU2022234694B2 (https=) |
| CA (1) | CA3212822A1 (https=) |
| WO (1) | WO2022191283A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2020090979A1 (ja) * | 2018-10-31 | 2021-09-24 | 味の素株式会社 | 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩 |
| CA3212822A1 (en) * | 2021-03-11 | 2022-09-15 | Ajinomoto Co., Inc. | Compound or salt thereof, and antibody obtained by using the same |
| CN116947671A (zh) * | 2023-07-26 | 2023-10-27 | 四川轻化工大学 | 一种半刚性含氮的六元芳香羧酸配体及其制备方法 |
| WO2026058917A1 (ja) * | 2024-09-10 | 2026-03-19 | 味の素株式会社 | 抗体親和性物質を含む化合物、修飾抗体およびそれらの塩ならびに抗体誘導体または抗体－機能性物質コンジュゲートの製造方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL106992A (en) | 1988-02-11 | 1994-06-24 | Bristol Myers Squibb Co | Acylhydrazone derivatives of anthracycline and methods for their preparation |
| US5622929A (en) | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| US6214345B1 (en) | 1993-05-14 | 2001-04-10 | Bristol-Myers Squibb Co. | Lysosomal enzyme-cleavable antitumor drug conjugates |
| DK0871490T3 (da) | 1995-12-22 | 2003-07-07 | Bristol Myers Squibb Co | Forgrenede hydrazonlinkere |
| EP1243276A1 (en) | 2001-03-23 | 2002-09-25 | Franciscus Marinus Hendrikus De Groot | Elongated and multiple spacers containing activatible prodrugs |
| DK1545613T3 (da) | 2002-07-31 | 2011-11-14 | Seattle Genetics Inc | Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom |
| WO2004043493A1 (en) | 2002-11-14 | 2004-05-27 | Syntarga B.V. | Prodrugs built as multiple self-elimination-release spacers |
| EP2478912B1 (en) | 2003-11-06 | 2016-08-31 | Seattle Genetics, Inc. | Auristatin conjugates with anti-HER2 or anti-CD22 antibodies and their use in therapy |
| ES3058443T3 (es) | 2015-05-20 | 2026-03-10 | Univ Kagoshima | Modificación específica de anticuerpo con péptido de unión a IgG |
| JP7020403B2 (ja) | 2016-05-02 | 2022-02-16 | 味の素株式会社 | アジド基含有Ｆｃタンパク質 |
| AU2018259856B2 (en) | 2017-04-28 | 2025-05-01 | Ajinomoto Co., Inc. | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof |
| JPWO2019240288A1 (ja) | 2018-06-14 | 2021-07-26 | 味の素株式会社 | 抗体に対する親和性物質、および生体直交性官能基を有する化合物またはその塩 |
| KR102921757B1 (ko) | 2018-06-14 | 2026-02-03 | 아지노모토 가부시키가이샤 | 항체에 대한 친화성 물질, 절단성 부분 및 반응성기를 갖는 화합물 또는 이의 염 |
| WO2020009165A1 (ja) | 2018-07-03 | 2020-01-09 | 味の素株式会社 | 修飾抗体およびその製造方法 |
| JPWO2020090979A1 (ja) | 2018-10-31 | 2021-09-24 | 味の素株式会社 | 抗体に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩 |
| CA3212822A1 (en) * | 2021-03-11 | 2022-09-15 | Ajinomoto Co., Inc. | Compound or salt thereof, and antibody obtained by using the same |
-
2022
- 2022-03-10 CA CA3212822A patent/CA3212822A1/en active Pending
- 2022-03-10 CN CN202280020193.XA patent/CN116964076A/zh active Pending
- 2022-03-10 WO PCT/JP2022/010574 patent/WO2022191283A1/ja not_active Ceased
- 2022-03-10 KR KR1020237030639A patent/KR20230154853A/ko active Pending
- 2022-03-10 EP EP22767237.5A patent/EP4306535A1/en active Pending
- 2022-03-10 JP JP2023505632A patent/JP7605290B2/ja active Active
- 2022-03-10 AU AU2022234694A patent/AU2022234694B2/en active Active
-
2023
- 2023-09-08 US US18/463,903 patent/US20240115719A1/en active Pending
-
2024
- 2024-12-12 JP JP2024217693A patent/JP2025038071A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2022191283A5 (https=) | ||
| JP2023052910A5 (https=) | ||
| JP7417432B2 (ja) | 新規リンカー、その製造方法およびその応用 | |
| AU2018259856B2 (en) | Compound having substance that has affinity for soluble protein, cleavable moiety, and reactive group, or salt thereof | |
| RU2017118326A (ru) | Бициклические пептидные лиганды, специфичные для мт1-ммр | |
| JP2000512633A (ja) | チオエーテル結合を含む環状ポリペプチドおよびそれらの調製方法 | |
| WO2004016274B1 (en) | Novel peptide-conjugated oligomeric compounds | |
| JP2010535714A5 (https=) | ||
| CN112839683B (zh) | 含有标记部-抗人抗体Fab片段复合物的药物组合物 | |
| JP2020502051A5 (https=) | ||
| KR20190126294A (ko) | Ｍｔ１－ｍｍｐ에 대한 결합용 펩티드 리간드 | |
| CA3017926A1 (en) | Methods for synthesizing .alpha.4.beta.7 peptide antagonists | |
| JP2011511778A5 (https=) | ||
| JP2007537989A (ja) | 安定化ペプチド | |
| JP2020506685A5 (https=) | ||
| JPWO2012121057A1 (ja) | 新規な非ペプチド性架橋構造を含む架橋ペプチド、ならびに該架橋ペプチドの合成方法および該方法に用いる新規な有機化合物 | |
| KR970009887B1 (ko) | 심방의 나트륨이뇨성 펩티드의 선형유사체 | |
| AR125263A1 (es) | Nuevo conjugado de análogo de il-2 inmunoestimulante y su método de preparación | |
| JPWO2023234416A5 (https=) | ||
| WO2014010813A1 (ko) | 항체의 Ｆｃ 부위 결합 펩타이드를 이용한 항체 정제용 흡착 칼럼 | |
| EP4676509A2 (en) | Rippled antiparallel cross-beta dimers and related materials, compositions and methods | |
| US20240182517A1 (en) | Silane-containing condensed cyclic dipeptide compound, production method therefor, and method for producing polypeptide compound using same | |
| JPH03504496A (ja) | 水素結合の共有結合置換により安定化されたポリペプチド | |
| JPWO2022154116A5 (https=) | ||
| FI3886914T3 (fi) | Glutamiinin sisältävän kevytketjun c-terminaalisen jatkeen käsittävä vasta-aine, sen konjugaatteja, ja menetelmiä ja käyttöjä |