JP2020506685A5 - - Google Patents

Download PDF

Info

Publication number
JP2020506685A5
JP2020506685A5 JP2019538439A JP2019538439A JP2020506685A5 JP 2020506685 A5 JP2020506685 A5 JP 2020506685A5 JP 2019538439 A JP2019538439 A JP 2019538439A JP 2019538439 A JP2019538439 A JP 2019538439A JP 2020506685 A5 JP2020506685 A5 JP 2020506685A5
Authority
JP
Japan
Prior art keywords
antibody molecule
amino acid
seq
acid sequence
sulfatase motif
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019538439A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020506685A (ja
JP7303110B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/014224 external-priority patent/WO2018136626A1/en
Publication of JP2020506685A publication Critical patent/JP2020506685A/ja
Publication of JP2020506685A5 publication Critical patent/JP2020506685A5/ja
Priority to JP2023029602A priority Critical patent/JP2023065550A/ja
Application granted granted Critical
Publication of JP7303110B2 publication Critical patent/JP7303110B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019538439A 2017-01-18 2018-01-18 抗体分子-薬物コンジュゲートおよびその使用 Active JP7303110B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023029602A JP2023065550A (ja) 2017-01-18 2023-02-28 抗体分子-薬物コンジュゲートおよびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762447813P 2017-01-18 2017-01-18
US62/447,813 2017-01-18
US201762492641P 2017-05-01 2017-05-01
US62/492,641 2017-05-01
PCT/US2018/014224 WO2018136626A1 (en) 2017-01-18 2018-01-18 Antibody molecule-drug conjugates and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023029602A Division JP2023065550A (ja) 2017-01-18 2023-02-28 抗体分子-薬物コンジュゲートおよびその使用

Publications (3)

Publication Number Publication Date
JP2020506685A JP2020506685A (ja) 2020-03-05
JP2020506685A5 true JP2020506685A5 (https=) 2021-02-25
JP7303110B2 JP7303110B2 (ja) 2023-07-04

Family

ID=61148525

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019538439A Active JP7303110B2 (ja) 2017-01-18 2018-01-18 抗体分子-薬物コンジュゲートおよびその使用
JP2023029602A Withdrawn JP2023065550A (ja) 2017-01-18 2023-02-28 抗体分子-薬物コンジュゲートおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023029602A Withdrawn JP2023065550A (ja) 2017-01-18 2023-02-28 抗体分子-薬物コンジュゲートおよびその使用

Country Status (9)

Country Link
US (1) US11890319B2 (https=)
EP (1) EP3571223B1 (https=)
JP (2) JP7303110B2 (https=)
KR (1) KR102697723B1 (https=)
CN (1) CN110431150A (https=)
AU (1) AU2018209940A1 (https=)
CA (1) CA3049449A1 (https=)
ES (1) ES2994374T3 (https=)
WO (1) WO2018136626A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017083515A2 (en) 2015-11-10 2017-05-18 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
JP7303110B2 (ja) 2017-01-18 2023-07-04 ビステラ, インコーポレイテッド 抗体分子-薬物コンジュゲートおよびその使用
WO2020127369A1 (en) 2018-12-21 2020-06-25 Ose Immunotherapeutics Bifunctional molecule directed against human pd-1
MX2021007274A (es) 2018-12-21 2021-07-15 Ose Immunotherapeutics Molecula bifuncional anti-pd-1/sirpa.
ES2963700T3 (es) 2018-12-21 2024-04-01 Ose Immunotherapeutics Anticuerpo humanizado anti-PD-1 humana
KR20210108978A (ko) 2018-12-21 2021-09-03 오제 이뮈노테라프틱스 이작용성 항-pd-1/il-7 분자
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
WO2020191486A1 (en) 2019-03-27 2020-10-01 National Research Council Of Canada Antigen-binding agents that specifically bind epidermal growth factor receptor variant iii
JP7479135B2 (ja) * 2019-11-12 2024-05-08 デンカ株式会社 抗rsウイルスを認識する抗体、並びに該抗体を用いた免疫測定方法及び免疫測定器具
CA3163608A1 (en) * 2020-01-10 2021-07-15 Romesh R. Subramanian Muscle-targeting complexes and uses thereof
KR20240085798A (ko) 2020-04-03 2024-06-17 비스테라, 인크. 항체 분자-약물 접합체 및 이의 용도
AU2021293287A1 (en) * 2020-06-18 2023-02-16 Nextcure, Inc. Compositions and methods for modulating FLRT3 mediated signal transduction
JP2025524370A (ja) * 2022-06-09 2025-07-30 サンタ アナ バイオ インコーポレイテッド c-Kit及び/またはsiglecを標的とする抗体ならびにその使用
WO2025160291A1 (en) * 2024-01-23 2025-07-31 Lahjavida, Inc. Prodrugs based on tumor targeting near infrared dye-drug conjugates (ddc)

Family Cites Families (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
AU597877B2 (en) 1984-12-26 1990-06-14 Teijin Limited Anti-pseudomonas aeruginosa human monoclonal antibody
IL81370A (en) 1986-02-07 1991-06-30 Genetic Systems Corp Pharmaceutical and diagnostic compositions comprising a plurality of human monoclonal antibodies for the treatment of bacterial diseases,methods for the preparation of the compositions and antibodies and kits containing said compositions
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
JP3101690B2 (ja) 1987-03-18 2000-10-23 エス・ビィ・2・インコーポレイテッド 変性抗体の、または変性抗体に関する改良
WO1988008135A1 (en) 1987-04-10 1988-10-20 Xoma Corporation Human monoclonal antibodies binding determinants of gram negative bacteria
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
WO1990003186A1 (en) 1988-09-19 1990-04-05 Cetus Corporation Gram-negative bacterial endotoxin blocking monoclonal antibodies
US5221732A (en) 1988-12-06 1993-06-22 The United States Of America As Represented By The Department Of Health And Human Services Antimicrobial magainin modified peptides
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
JPH04211393A (ja) * 1990-02-08 1992-08-03 Sumitomo Pharmaceut Co Ltd ヒトモノクローナル抗体及びそれを有効成分とする緑膿菌感染症治療剤
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
CA2042448A1 (en) 1990-06-05 1991-12-06 Jonathan P. Duvick Antimicrobial peptides and plant disease resistance based thereon
US5447914A (en) 1990-06-21 1995-09-05 Emory University Antimicrobial peptides
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
CA2095633C (en) 1990-12-03 2003-02-04 Lisa J. Garrard Enrichment method for variant proteins with altered binding properties
AU648140B2 (en) 1991-02-01 1994-04-14 Virtual Drug Development, Inc. Reverse antimicrobial peptides and antimicrobial compositions
EP1820858B1 (en) 1991-03-01 2009-08-12 Dyax Corporation Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
GB9105292D0 (en) 1991-03-13 1991-04-24 Sandoz Ltd Improvements in or relating to organic compounds
ATE414768T1 (de) 1991-04-10 2008-12-15 Scripps Research Inst Bibliotheken heterodimerer rezeptoren mittels phagemiden
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
DK1621554T4 (da) 1992-08-21 2012-12-17 Univ Bruxelles Immunoglobuliner blottet for lette kæder
US5607914A (en) 1993-01-13 1997-03-04 Pioneer Hi-Bred International, Inc. Synthetic antimicrobial peptides
US5459235A (en) 1993-03-19 1995-10-17 The Regents Of The University Of California Antimicrobial peptides antibodies and nucleic acid molecules from bovine neutrophils
US5550109A (en) 1994-05-24 1996-08-27 Magainin Pharmaceuticals Inc. Inducible defensin peptide from mammalian epithelia
US6184344B1 (en) 1995-05-04 2001-02-06 The Scripps Research Institute Synthesis of proteins by native chemical ligation
US6057291A (en) 1995-06-02 2000-05-02 University Of British Columbia Antimicrobial cationic peptides
US5734015A (en) 1995-06-19 1998-03-31 Magainin Pharmaceuticals Inc. Family of linear antimicrobial peptides from hagfish intestine
DE69637731D1 (de) 1995-08-23 2008-12-11 Univ British Columbia Antimikrobielle kationische peptide und methoden zu ihrer identifizierung
US6605698B1 (en) 1995-12-13 2003-08-12 Syngenta Limited Antifungal peptides and composition thereof
US5714577A (en) 1996-01-26 1998-02-03 University Of Pittsburgh Antimicrobial peptides
US5994308A (en) 1996-02-28 1999-11-30 Board Of Trustees Of Southern Illinois University Broad spectrum antimicrobial peptides containing a tryptophan triplet and methods of use
US5773696A (en) 1996-03-29 1998-06-30 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
US5856127A (en) 1996-07-26 1999-01-05 The Research Foundation Of State University Of New York Antimicrobial peptides
WO1998007833A1 (en) 1996-08-22 1998-02-26 The Trustees Of The University Of Pennsylvania Compositions and methods for use of defensin
US6121436A (en) 1996-12-13 2000-09-19 Monsanto Company Antifungal polypeptide and methods for controlling plant pathogenic fungi
US6307018B1 (en) 1996-12-24 2001-10-23 The Scripps Research Institute General chemical ligation
US5998374A (en) 1997-02-28 1999-12-07 The Regents Of University Of California Clavaspirins
NL1006164C2 (nl) 1997-05-29 1998-12-01 Univ Leiden Antimicrobiële peptiden.
FR2766191B1 (fr) 1997-07-21 2000-11-10 Ifremer Peptides anti-microbiens de crustaces
EP0988314B1 (en) 1997-07-31 2006-07-19 Philip Richard Abraham Synthetic peptides with antimicrobial and endotoxin neutralizing properties for management of the sepsis syndrome
US6576755B1 (en) 1997-09-10 2003-06-10 Zymogenetics, Inc. Beta-defensins
WO1999015548A2 (en) 1997-09-25 1999-04-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Isolated and recombinant antimicrobial peptides thrombocidin-1 (tc-1) and thrombocidin-2 (tc-2) or variants thereof
NL1008139C2 (nl) 1998-01-27 1999-07-28 Stichting Tech Wetenschapp Antimicrobiële peptiden.
CA2320429C (en) 1998-02-18 2011-04-19 Harbor-Ucla Research And Education Institute Antimicrobial peptides and derived metapeptides
US6476189B1 (en) 1998-08-12 2002-11-05 National Institute Of Agrobiological Sciences Antibacterial peptides and antibacterial agents containing such peptides as an effective ingredient
US6288212B1 (en) 1998-08-28 2001-09-11 The University Of British Columbia Anti-endotoxic, antimicrobial cationic peptides and methods of use therefor
CN1325405A (zh) 1998-08-31 2001-12-05 格莱风科学公司 膜多肽的脂基质协助的化学结合和合成
US20040052814A1 (en) 1998-09-28 2004-03-18 Wenyuan Shi Fusion proteins for targeted delivery of antimicrobial peptides
US6107460A (en) 1999-03-01 2000-08-22 The Board Of Regents Of The University Of Oklahoma Antimicrobial peptides and methods of use thereof
US7244710B2 (en) 2002-05-21 2007-07-17 Zengen, Inc. Treatment of ophthalmic infections using antimicrobial peptides
JP2003523315A (ja) 1999-04-23 2003-08-05 セント・ジュード・メディカル・インコーポレーテッド 抗菌剤と接合した抗体またはリガンドを含む抗菌性接合体
EP1179012B2 (en) 1999-05-17 2009-07-15 ConjuChem Biotechnologies Inc. Long lasting fusion peptide inhibitors of viral infection
FR2796072B1 (fr) 1999-07-08 2003-09-19 Centre Nat Rech Scient Peptides anti-microbiens de mollusques
US7071293B1 (en) 1999-08-18 2006-07-04 The University Of Iowa Research Foundation Alpha helical peptides with broad spectrum antimicrobial activity that are insensitive to salt
US20030143234A1 (en) 1999-08-20 2003-07-31 Wenyuan Shi Anti-microbial targeting chimeric pharmaceutical
EP1101771A1 (en) 1999-11-15 2001-05-23 Korea Kumho Petrochemical Co. Ltd. Pathogen-induced genes from Capsicum annuum
US6573361B1 (en) 1999-12-06 2003-06-03 Monsanto Technology Llc Antifungal proteins and methods for their use
MXPA02006028A (es) 1999-12-15 2004-08-23 Cubist Pharm Inc Lipopeptidos novedosos como agentes antibacterianos.
EP1130091A3 (en) 2000-03-01 2001-11-14 Message Pharmaceuticals, Inc. Bacterial RNaseP Proteins and their use in identifying antibacterial compounds
AU2001281463A1 (en) 2000-03-16 2001-09-24 The Regents Of The University Of California Chemoselective ligation
US6337317B1 (en) 2000-06-27 2002-01-08 The University Of British Columbia Antimicrobial peptides and methods of use thereof
US6492328B2 (en) 2000-06-28 2002-12-10 The University Of Iowa Research Foundation Novispirins: antimicrobial peptides
US6727066B2 (en) 2000-07-28 2004-04-27 Incyte Corporation Genes expressed in treated human C3A liver cell cultures
AU2001279073B2 (en) 2000-07-28 2006-08-24 Christopher J. Murphy Transplant media
EP1319025A2 (en) 2000-09-07 2003-06-18 John R. Schreiber Human antibodies against pseudomonas aeruginosa lps derived from transgenic xenomouse
US6875907B2 (en) 2000-09-13 2005-04-05 Pioneer Hi-Bred International, Inc. Antimicrobial peptides and methods of use
GB0026924D0 (en) 2000-11-03 2000-12-20 Univ Cambridge Tech Antibacterial agents
US6835713B2 (en) 2001-02-16 2004-12-28 University Of Pittsburgh Virus derived antimicrobial peptides
US6887847B2 (en) 2001-02-16 2005-05-03 University Of Pittsburgh Virus derived antimicrobial peptides
US7314858B2 (en) 2001-04-18 2008-01-01 The Regents Of The University Of California Retrocyclins: antiviral and antimicrobial peptides
US6872705B2 (en) 2001-07-13 2005-03-29 Allergan, Inc. Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions
WO2003014078A2 (en) 2001-08-08 2003-02-20 The Research Foundation Of The State University Of New York Muc7d1 peptides as antifungal and antibacterial agents
US6743598B2 (en) 2001-08-10 2004-06-01 Mycologics, Inc. Methods for the identification of fungal glucose utilization inhibitors and antifungal agents
US6835536B2 (en) 2001-08-21 2004-12-28 Micrologix Biotech Inc. Antimicrobial cationic peptides and formulations thereof
AU2002336746A1 (en) 2001-09-21 2003-04-01 Message Pharmaceuticals, Inc. Inhibitors of rnase p proteins as antibacterial compounds
US6478825B1 (en) 2001-11-28 2002-11-12 Osteotech, Inc. Implant, method of making same and use of the implant for the treatment of bone defects
CA2515708A1 (en) 2003-02-11 2004-08-26 Transkaryotic Therapies, Inc. Diagnosis and treatment of multiple sulfatase deficiency and other sulfatase deficiencies
US7091185B2 (en) 2003-02-24 2006-08-15 Dow Global Technologies Inc. Periodic antimicrobial peptides
ATE458006T1 (de) 2003-05-14 2010-03-15 Kenta Biotech Ag Humaner monoklonaler antikörper spezifisch für lipopolysacchariden (lps) des serotyps iats o6 von pseudomonas aeruginosa
EP1706425A2 (en) 2003-12-05 2006-10-04 John R. Schreiber Human anti-pseudomonas-aeruginosa antibodies derived from transgenic xenomouse®
JP2005179268A (ja) 2003-12-19 2005-07-07 Gc Corp 口腔用組成物
EP1690875A1 (en) 2005-02-14 2006-08-16 Kenta Biotech AG Human monoclonal antibody specific for lipopolysaccharides (LPS) of the pseudomonas aeruginosa IATS O11 serotype
US7985783B2 (en) 2006-09-21 2011-07-26 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
WO2009120611A2 (en) 2008-03-27 2009-10-01 The Regents Of The University Of California Aldehyde tags, uses thereof in site-specific protein modification
WO2010096394A2 (en) 2009-02-17 2010-08-26 Redwood Biosciences, Inc. Aldehyde-tagged protein-based drug carriers and methods of use
EP2417157A1 (en) 2009-04-09 2012-02-15 Kenta Biotech AG Human monoclonal antibody specific for lipolysaccarides (lps) of serotype lats 01 of pseudomonas aeruginosa
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione
KR20120128686A (ko) 2010-02-18 2012-11-27 심포젠 에이/에스 녹농균의 혈청형 a 지질다당류에 대한 항체
KR101367832B1 (ko) 2010-04-21 2014-02-27 건국대학교 산학협력단 종양 억제 타겟으로서 Hades의 용도
WO2012092175A1 (en) 2010-12-29 2012-07-05 Alper Biotech, Llc Monoclonal antibodies against alpha-actinin-4 antigens, and uses therefor
WO2012097333A2 (en) 2011-01-14 2012-07-19 Redwood Bioscience, Inc. Aldehyde-tagged immunoglobulin polypeptides and method of use thereof
AU2012284097B2 (en) 2011-07-18 2017-08-03 President And Fellows Of Harvard College Engineered microbe-targeting molecules and uses thereof
WO2013024905A1 (en) 2011-08-16 2013-02-21 Meiji Seika Pharma Co., Ltd. Combination drug of antibody against lipopolysaccharide of pseudomonas aeruginosa and antibacterial agent
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
US9556228B2 (en) * 2011-09-22 2017-01-31 Universitaet Leipzig Modified apidaecin derivatives as antibiotic peptides
JP2016503817A (ja) 2012-12-31 2016-02-08 ディヴェロップメント センター フォー バイオテクノロジー アンチグラニュリシン抗体及びその使用方法
CA2925897A1 (en) * 2013-09-30 2015-04-02 Daiichi Sankyo Company, Limited Anti-lps o11 antibody
WO2017083515A2 (en) * 2015-11-10 2017-05-18 Visterra, Inc. Antibody molecule-drug conjugates and uses thereof
US10793632B2 (en) 2016-08-30 2020-10-06 Xencor, Inc. Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors
JP7303110B2 (ja) 2017-01-18 2023-07-04 ビステラ, インコーポレイテッド 抗体分子-薬物コンジュゲートおよびその使用
KR20240085798A (ko) 2020-04-03 2024-06-17 비스테라, 인크. 항체 분자-약물 접합체 및 이의 용도

Similar Documents

Publication Publication Date Title
JP2020506685A5 (https=)
JP6970090B2 (ja) C末端リジンで結合体化された免疫グロブリン
KR101990341B1 (ko) 세포 내재화를 유도하기 위한 cd20-결합 면역독소 및 이의 사용 방법
BR112015023589B1 (pt) Método para a produção de um conjugado de imunoligante/carga útil
JP7514836B2 (ja) トランスグルタミナーゼによるコンジュゲーションのための改変抗体、ならびにそのコンジュゲート、方法および用途
JPWO2018199337A1 (ja) 可溶性タンパク質に対する親和性物質、切断性部分および反応性基を有する化合物またはその塩
JP2018138588A (ja) 新規リンカー、その製造方法およびその応用
JP2020534030A (ja) トランスグルタミナーゼコンジュゲーション方法およびリンカー
JP2019525897A (ja) リジン結合体化免疫グロブリン
JP2000512633A (ja) チオエーテル結合を含む環状ポリペプチドおよびそれらの調製方法
JP2018509394A5 (https=)
WO2007079755A1 (en) Reimmunization and antibody design
JP2024507540A5 (https=)
JP2003522117A (ja) 治療薬の送達のための二機能性分子
US20180028682A1 (en) Maytansine-drug conjugates of her-2 specific binding proteins generated by site specific sortase-enzyme mediated conjugation
EP1015493A1 (en) Novel epithelial tissue targeting agent
KR102861586B1 (ko) 글루타민-함유 경쇄 c-말단 연장부를 포함하는 항체, 그의 접합체, 및 방법 및 용도
WO2014044793A2 (en) Cd22-binding peptides
US11020490B2 (en) Antibody-drug conjugate with a tubulysin analog warhead having a stabilized acetate group in the TUV subunit
EA045916B1 (ru) Антитело, содержащее глутаминсодержащее с-концевое удлинение легкой цепи, его конъюгаты, способы и пути применения
JP2010504313A (ja) ペプチド