JPWO2022094473A5 - - Google Patents

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Publication number
JPWO2022094473A5
JPWO2022094473A5 JP2023551948A JP2023551948A JPWO2022094473A5 JP WO2022094473 A5 JPWO2022094473 A5 JP WO2022094473A5 JP 2023551948 A JP2023551948 A JP 2023551948A JP 2023551948 A JP2023551948 A JP 2023551948A JP WO2022094473 A5 JPWO2022094473 A5 JP WO2022094473A5
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JP
Japan
Prior art keywords
polypeptide
modified
item
seq
amino acid
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023551948A
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English (en)
Japanese (ja)
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JP2023550545A5 (https=
JP2023550545A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/057741 external-priority patent/WO2022094473A1/en
Publication of JP2023550545A publication Critical patent/JP2023550545A/ja
Publication of JP2023550545A5 publication Critical patent/JP2023550545A5/ja
Publication of JPWO2022094473A5 publication Critical patent/JPWO2022094473A5/ja
Pending legal-status Critical Current

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JP2023551948A 2020-11-02 2021-11-02 インターロイキン-18バリアントおよび使用の方法 Pending JP2023550545A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063108794P 2020-11-02 2020-11-02
US63/108,794 2020-11-02
PCT/US2021/057741 WO2022094473A1 (en) 2020-11-02 2021-11-02 Interleukin-18 variants and methods of use

Publications (3)

Publication Number Publication Date
JP2023550545A JP2023550545A (ja) 2023-12-01
JP2023550545A5 JP2023550545A5 (https=) 2024-11-12
JPWO2022094473A5 true JPWO2022094473A5 (https=) 2024-11-12

Family

ID=81384408

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023551948A Pending JP2023550545A (ja) 2020-11-02 2021-11-02 インターロイキン-18バリアントおよび使用の方法

Country Status (14)

Country Link
US (3) US11850276B2 (https=)
EP (1) EP4236990A4 (https=)
JP (1) JP2023550545A (https=)
KR (1) KR20230117120A (https=)
CN (1) CN116723851A (https=)
AR (1) AR123978A1 (https=)
AU (2) AU2021371040C1 (https=)
CA (1) CA3197145A1 (https=)
GB (1) GB2617483B (https=)
IL (1) IL302517A (https=)
MX (1) MX2023005068A (https=)
NZ (1) NZ800435A (https=)
TW (1) TW202233657A (https=)
WO (1) WO2022094473A1 (https=)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111315395A (zh) 2017-09-06 2020-06-19 耶鲁大学 白细胞介素-18变体和使用方法
US20230146665A1 (en) 2021-07-27 2023-05-11 Xencor, Inc. Il-18-fc fusion proteins
WO2023147488A1 (en) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Cytokine associated tumor infiltrating lymphocytes compositions and methods
JP2025508823A (ja) 2022-02-23 2025-04-10 ブライト ピーク セラピューティクス エージー 免疫抗原特異的il-18免疫サイトカイン及びその使用
WO2024044780A1 (en) * 2022-08-26 2024-02-29 Sutro Biopharma, Inc. Interleukin-18 variants and uses thereof
JP2025529313A (ja) * 2022-09-06 2025-09-04 ティージェイ バイオファーマ (シャンハイ) カンパニー, リミテッド Il-18バリアントポリペプチド
US20240166705A1 (en) 2022-11-07 2024-05-23 Xencor, Inc. Il18-fc fusion proteins
WO2024118836A1 (en) 2022-11-30 2024-06-06 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes with shortened rep step
WO2024158838A2 (en) * 2023-01-24 2024-08-02 Simcha IL-18, Inc. Methods and compositions for combination therapy
WO2024259270A2 (en) * 2023-06-16 2024-12-19 Simcha IL-18, Inc. Administration of engineered interleukin-18 therapeutics
AU2024296516A1 (en) 2023-07-13 2026-01-22 Iovance Biotherapeutics, Inc. Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes
US20250188166A1 (en) 2023-08-23 2025-06-12 Bright Peak Therapeutics Ag Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025085447A1 (en) 2023-10-17 2025-04-24 Xencor, Inc. Pd-1 targeted il18-fc fusion proteins
US20250179137A1 (en) 2023-12-05 2025-06-05 Regeneron Pharmaceuticals, Inc. Il18 receptor agonists and methods of use thereof
CN120189493A (zh) * 2023-12-22 2025-06-24 广州威溶特医药科技有限公司 Dr-18和m1病毒在制备抗肿瘤药物中的应用
US12134635B1 (en) 2023-12-29 2024-11-05 Sonnet BioTherapeutics, Inc. Interleukin 18 (IL-18) variants and fusion proteins comprising same
WO2025151273A1 (en) * 2024-01-08 2025-07-17 Adimab, Llc Il-18 polypeptides and uses thereof
WO2025242835A1 (en) 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer
WO2026006784A1 (en) 2024-06-28 2026-01-02 Iovance Biotherapeutics, Inc. Methods of making tumor reactive peripheral blood lymphocytes (trpbl)

Family Cites Families (17)

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Publication number Priority date Publication date Assignee Title
US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
EP0816499A3 (en) 1996-06-27 1999-10-27 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma
JP2007143555A (ja) * 1996-11-29 2007-06-14 Hayashibara Biochem Lab Inc ポリペプチド
JP4024366B2 (ja) 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド
JP3955352B2 (ja) 1997-02-25 2007-08-08 株式会社林原生物化学研究所 破骨細胞形成阻害剤
TWI227136B (en) 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
AU7516601A (en) 2000-06-02 2001-12-17 Susan B Dillon Methods of treating viral diseases with il-18 and il-18 combinations
ATE315647T1 (de) 2001-03-08 2006-02-15 Ares Trading Sa Interleukin -18 mutantenproteine, deren herstellung und verwendung
US6800479B2 (en) 2001-12-11 2004-10-05 Samyang Genex Corporation Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them
ATE459647T1 (de) * 2003-04-15 2010-03-15 Glaxosmithkline Llc Humane il-18 substitutionsmutanten und deren konjugate
WO2005075648A1 (en) * 2004-01-28 2005-08-18 Gifu University Interleukin-18 mutant proteins
JP5916622B2 (ja) * 2010-01-04 2016-05-11 マピ ファーマ リミテッド グラチラマーまたはその薬理学的に許容される塩を含むデポーシステム
WO2017102010A1 (en) 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
CN111315395A (zh) * 2017-09-06 2020-06-19 耶鲁大学 白细胞介素-18变体和使用方法
JP2020143000A (ja) * 2019-03-04 2020-09-10 大陽日酸株式会社 融合タンパク質及びその製造方法、目的タンパク質の製造方法
US12029778B2 (en) * 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use
WO2022038417A2 (en) * 2020-08-19 2022-02-24 Bright Peak Therapeutics Ag Modified il-18 polypeptides and uses thereof

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