JPWO2022094473A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022094473A5 JPWO2022094473A5 JP2023551948A JP2023551948A JPWO2022094473A5 JP WO2022094473 A5 JPWO2022094473 A5 JP WO2022094473A5 JP 2023551948 A JP2023551948 A JP 2023551948A JP 2023551948 A JP2023551948 A JP 2023551948A JP WO2022094473 A5 JPWO2022094473 A5 JP WO2022094473A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- modified
- item
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000003810 Interleukin-18 Human genes 0.000 claims description 126
- 108090000171 Interleukin-18 Proteins 0.000 claims description 126
- 230000035772 mutation Effects 0.000 claims description 42
- 206010028980 Neoplasm Diseases 0.000 claims description 36
- 210000004027 cell Anatomy 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 35
- 201000011510 cancer Diseases 0.000 claims description 26
- 150000001413 amino acids Chemical class 0.000 claims description 18
- 102000002669 Small Ubiquitin-Related Modifier Proteins Human genes 0.000 claims description 17
- 108010043401 Small Ubiquitin-Related Modifier Proteins Proteins 0.000 claims description 17
- 102000039446 nucleic acids Human genes 0.000 claims description 17
- 108020004707 nucleic acids Proteins 0.000 claims description 17
- 150000007523 nucleic acids Chemical class 0.000 claims description 17
- 229920001184 polypeptide Polymers 0.000 claims description 15
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 13
- 102000044166 interleukin-18 binding protein Human genes 0.000 claims description 13
- 108010070145 interleukin-18 binding protein Proteins 0.000 claims description 13
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 12
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 12
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 12
- 102000004557 Interleukin-18 Receptors Human genes 0.000 claims description 12
- 108010017537 Interleukin-18 Receptors Proteins 0.000 claims description 12
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 12
- 210000000822 natural killer cell Anatomy 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 102220470467 Adenosine 5'-monophosphoramidase HINT2_C38S_mutation Human genes 0.000 claims description 10
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 claims description 10
- 102220214526 rs1060502912 Human genes 0.000 claims description 9
- 101000708016 Caenorhabditis elegans Sentrin-specific protease Proteins 0.000 claims description 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 8
- 102220477448 YY1-associated factor 2_S105D_mutation Human genes 0.000 claims description 8
- 235000001014 amino acid Nutrition 0.000 claims description 8
- 230000001580 bacterial effect Effects 0.000 claims description 8
- 102220517454 DDIT3 upstream open reading frame protein_C68Y_mutation Human genes 0.000 claims description 7
- 108020001507 fusion proteins Proteins 0.000 claims description 7
- 102000037865 fusion proteins Human genes 0.000 claims description 7
- 102220283780 rs1555750712 Human genes 0.000 claims description 7
- 102220576078 HLA class I histocompatibility antigen, B alpha chain_Q56L_mutation Human genes 0.000 claims description 5
- 102220602509 Small integral membrane protein 1_M51K_mutation Human genes 0.000 claims description 5
- 102220417886 c.169C>G Human genes 0.000 claims description 5
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 5
- 208000030159 metabolic disease Diseases 0.000 claims description 5
- 239000002773 nucleotide Substances 0.000 claims description 5
- 125000003729 nucleotide group Chemical group 0.000 claims description 5
- 102220420324 rs773113395 Human genes 0.000 claims description 5
- 102220505238 5-hydroxytryptamine receptor 1B_P57K_mutation Human genes 0.000 claims description 4
- 102220575517 Glutamate receptor ionotropic, NMDA 2A_Q56A_mutation Human genes 0.000 claims description 4
- 102220506215 Lysophospholipid acyltransferase 5_M51R_mutation Human genes 0.000 claims description 4
- 102220489345 Melanoma-associated antigen 1_K53G_mutation Human genes 0.000 claims description 4
- 208000032818 Microsatellite Instability Diseases 0.000 claims description 4
- 102220496972 Platelet-activating factor acetylhydrolase 2, cytoplasmic_K53T_mutation Human genes 0.000 claims description 4
- 102220402269 c.152T>C Human genes 0.000 claims description 4
- 244000309459 oncolytic virus Species 0.000 claims description 4
- 102220226169 rs1064793657 Human genes 0.000 claims description 4
- 102200149714 rs113604459 Human genes 0.000 claims description 4
- 102220342210 rs1555392885 Human genes 0.000 claims description 4
- 102200037006 rs1731017 Human genes 0.000 claims description 4
- 102200067664 rs397507595 Human genes 0.000 claims description 4
- 208000035473 Communicable disease Diseases 0.000 claims description 3
- 102000043129 MHC class I family Human genes 0.000 claims description 3
- 108091054437 MHC class I family Proteins 0.000 claims description 3
- 108091005804 Peptidases Proteins 0.000 claims description 3
- 239000004365 Protease Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims 4
- 102000043959 human IL18 Human genes 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 102220171385 rs143973840 Human genes 0.000 claims 1
- -1 multimer Substances 0.000 description 21
- 239000003795 chemical substances by application Substances 0.000 description 18
- 102100038078 CD276 antigen Human genes 0.000 description 9
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 description 9
- 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 9
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 9
- 102100040678 Programmed cell death protein 1 Human genes 0.000 description 9
- 235000018102 proteins Nutrition 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 108010074708 B7-H1 Antigen Proteins 0.000 description 6
- 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 6
- 101000884279 Homo sapiens CD276 antigen Proteins 0.000 description 6
- 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 6
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 description 6
- 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 6
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 description 6
- 101000611936 Homo sapiens Programmed cell death protein 1 Proteins 0.000 description 6
- 101000633784 Homo sapiens SLAM family member 7 Proteins 0.000 description 6
- 102100032913 Leukocyte surface antigen CD47 Human genes 0.000 description 6
- 102100029198 SLAM family member 7 Human genes 0.000 description 6
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 description 6
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 description 6
- 102100038929 V-set domain-containing T-cell activation inhibitor 1 Human genes 0.000 description 6
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 6
- 239000000427 antigen Substances 0.000 description 6
- 108091007433 antigens Proteins 0.000 description 6
- 102000036639 antigens Human genes 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 230000003571 opsonizing effect Effects 0.000 description 6
- 102000003298 tumor necrosis factor receptor Human genes 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 102100037435 Antiviral innate immune response receptor RIG-I Human genes 0.000 description 4
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 239000006172 buffering agent Substances 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 229940044680 immune agonist Drugs 0.000 description 4
- 239000012651 immune agonist Substances 0.000 description 4
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- 230000011664 signaling Effects 0.000 description 4
- FFILOTSTFMXQJC-QCFYAKGBSA-N (2r,4r,5s,6s)-2-[3-[(2s,3s,4r,6s)-6-[(2s,3r,4r,5s,6r)-5-[(2s,3r,4r,5r,6r)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2r,3s,4r,5r,6r)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(e)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 description 3
- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 description 3
- 102100030310 5,6-dihydroxyindole-2-carboxylic acid oxidase Human genes 0.000 description 3
- 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 3
- 102100026423 Adhesion G protein-coupled receptor E5 Human genes 0.000 description 3
- 101100067974 Arabidopsis thaliana POP2 gene Proteins 0.000 description 3
- 102000003984 Aryl Hydrocarbon Receptors Human genes 0.000 description 3
- 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 description 3
- 102100029822 B- and T-lymphocyte attenuator Human genes 0.000 description 3
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 description 3
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 description 3
- 102100038080 B-cell receptor CD22 Human genes 0.000 description 3
- 102100024222 B-lymphocyte antigen CD19 Human genes 0.000 description 3
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 description 3
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 description 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 3
- 239000002126 C01EB10 - Adenosine Substances 0.000 description 3
- 102100024217 CAMPATH-1 antigen Human genes 0.000 description 3
- 102100032976 CCR4-NOT transcription complex subunit 6 Human genes 0.000 description 3
- 102100024263 CD160 antigen Human genes 0.000 description 3
- 102100038077 CD226 antigen Human genes 0.000 description 3
- 102100027207 CD27 antigen Human genes 0.000 description 3
- 101710185679 CD276 antigen Proteins 0.000 description 3
- 101150013553 CD40 gene Proteins 0.000 description 3
- 102100032912 CD44 antigen Human genes 0.000 description 3
- 102100036008 CD48 antigen Human genes 0.000 description 3
- 108010065524 CD52 Antigen Proteins 0.000 description 3
- 108010062802 CD66 antigens Proteins 0.000 description 3
- 102100025221 CD70 antigen Human genes 0.000 description 3
- 108060001253 CD99 Proteins 0.000 description 3
- 102000024905 CD99 Human genes 0.000 description 3
- 108010021064 CTLA-4 Antigen Proteins 0.000 description 3
- 229940045513 CTLA4 antagonist Drugs 0.000 description 3
- 102100024533 Carcinoembryonic antigen-related cell adhesion molecule 1 Human genes 0.000 description 3
- 102100036466 Delta-like protein 3 Human genes 0.000 description 3
- 102100033553 Delta-like protein 4 Human genes 0.000 description 3
- 102000001301 EGF receptor Human genes 0.000 description 3
- 102000012804 EPCAM Human genes 0.000 description 3
- 101150084967 EPCAM gene Proteins 0.000 description 3
- 102100037241 Endoglin Human genes 0.000 description 3
- 108010036395 Endoglin Proteins 0.000 description 3
- 102100032031 Epidermal growth factor-like protein 7 Human genes 0.000 description 3
- 102100031940 Epithelial cell adhesion molecule Human genes 0.000 description 3
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 3
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 3
- 102100037362 Fibronectin Human genes 0.000 description 3
- 108010067306 Fibronectins Proteins 0.000 description 3
- 102100035139 Folate receptor alpha Human genes 0.000 description 3
- 101710088083 Glomulin Proteins 0.000 description 3
- 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 3
- 102000010956 Glypican Human genes 0.000 description 3
- 108050001154 Glypican Proteins 0.000 description 3
- 108050007237 Glypican-3 Proteins 0.000 description 3
- 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 3
- 108010007707 Hepatitis A Virus Cellular Receptor 2 Proteins 0.000 description 3
- 102100022623 Hepatocyte growth factor receptor Human genes 0.000 description 3
- 101000773083 Homo sapiens 5,6-dihydroxyindole-2-carboxylic acid oxidase Proteins 0.000 description 3
- 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 3
- 101000718243 Homo sapiens Adhesion G protein-coupled receptor E5 Proteins 0.000 description 3
- 101000834898 Homo sapiens Alpha-synuclein Proteins 0.000 description 3
- 101000864344 Homo sapiens B- and T-lymphocyte attenuator Proteins 0.000 description 3
- 101000884305 Homo sapiens B-cell receptor CD22 Proteins 0.000 description 3
- 101000980825 Homo sapiens B-lymphocyte antigen CD19 Proteins 0.000 description 3
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 description 3
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 3
- 101000761938 Homo sapiens CD160 antigen Proteins 0.000 description 3
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 3
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 3
- 101000716130 Homo sapiens CD48 antigen Proteins 0.000 description 3
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 3
- 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 description 3
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 description 3
- 101000872077 Homo sapiens Delta-like protein 4 Proteins 0.000 description 3
- 101100118549 Homo sapiens EGFR gene Proteins 0.000 description 3
- 101000921195 Homo sapiens Epidermal growth factor-like protein 7 Proteins 0.000 description 3
- 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 description 3
- 101001023230 Homo sapiens Folate receptor alpha Proteins 0.000 description 3
- 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 3
- 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 3
- 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 description 3
- 101001037256 Homo sapiens Indoleamine 2,3-dioxygenase 1 Proteins 0.000 description 3
- 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 description 3
- 101000959794 Homo sapiens Interferon alpha-2 Proteins 0.000 description 3
- 101001054334 Homo sapiens Interferon beta Proteins 0.000 description 3
- 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 3
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 description 3
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 3
- 101000998120 Homo sapiens Interleukin-3 receptor subunit alpha Proteins 0.000 description 3
- 101001018097 Homo sapiens L-selectin Proteins 0.000 description 3
- 101001039113 Homo sapiens Leucine-rich repeat-containing protein 15 Proteins 0.000 description 3
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 description 3
- 101000984189 Homo sapiens Leukocyte immunoglobulin-like receptor subfamily B member 2 Proteins 0.000 description 3
- 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 3
- 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 3
- 101001008874 Homo sapiens Mast/stem cell growth factor receptor Kit Proteins 0.000 description 3
- 101000628547 Homo sapiens Metalloreductase STEAP1 Proteins 0.000 description 3
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 description 3
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 description 3
- 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 3
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 3
- 101001084266 Homo sapiens Parathyroid hormone 2 receptor Proteins 0.000 description 3
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 description 3
- 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 description 3
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 3
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 3
- 101000835984 Homo sapiens SLIT and NTRK-like protein 6 Proteins 0.000 description 3
- 101000884271 Homo sapiens Signal transducer CD24 Proteins 0.000 description 3
- 101000652359 Homo sapiens Spermatogenesis-associated protein 2 Proteins 0.000 description 3
- 101000874179 Homo sapiens Syndecan-1 Proteins 0.000 description 3
- 101000831007 Homo sapiens T-cell immunoreceptor with Ig and ITIM domains Proteins 0.000 description 3
- 101000596234 Homo sapiens T-cell surface protein tactile Proteins 0.000 description 3
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 3
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 description 3
- 101000831567 Homo sapiens Toll-like receptor 2 Proteins 0.000 description 3
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 description 3
- 101000669460 Homo sapiens Toll-like receptor 5 Proteins 0.000 description 3
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 description 3
- 101000904724 Homo sapiens Transmembrane glycoprotein NMB Proteins 0.000 description 3
- 101000795117 Homo sapiens Triggering receptor expressed on myeloid cells 2 Proteins 0.000 description 3
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 description 3
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 101000851376 Homo sapiens Tumor necrosis factor receptor superfamily member 8 Proteins 0.000 description 3
- 101000807561 Homo sapiens Tyrosine-protein kinase receptor UFO Proteins 0.000 description 3
- 101000955999 Homo sapiens V-set domain-containing T-cell activation inhibitor 1 Proteins 0.000 description 3
- 101000666896 Homo sapiens V-type immunoglobulin domain-containing suppressor of T-cell activation Proteins 0.000 description 3
- 108060003951 Immunoglobulin Proteins 0.000 description 3
- 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 description 3
- 102100022337 Integrin alpha-V Human genes 0.000 description 3
- 102100040018 Interferon alpha-2 Human genes 0.000 description 3
- 102100026720 Interferon beta Human genes 0.000 description 3
- 102100037850 Interferon gamma Human genes 0.000 description 3
- 108090000174 Interleukin-10 Proteins 0.000 description 3
- 108010065805 Interleukin-12 Proteins 0.000 description 3
- 108090000172 Interleukin-15 Proteins 0.000 description 3
- 108010002350 Interleukin-2 Proteins 0.000 description 3
- 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 3
- 108010065637 Interleukin-23 Proteins 0.000 description 3
- 108010066979 Interleukin-27 Proteins 0.000 description 3
- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 description 3
- 108010067003 Interleukin-33 Proteins 0.000 description 3
- 108010002586 Interleukin-7 Proteins 0.000 description 3
- 108020003285 Isocitrate lyase Proteins 0.000 description 3
- 102000002698 KIR Receptors Human genes 0.000 description 3
- 108010043610 KIR Receptors Proteins 0.000 description 3
- 102220565496 Killer cell immunoglobulin-like receptor 2DL3_Q56E_mutation Human genes 0.000 description 3
- 102100033467 L-selectin Human genes 0.000 description 3
- 102000017578 LAG3 Human genes 0.000 description 3
- 102100040645 Leucine-rich repeat-containing protein 15 Human genes 0.000 description 3
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 description 3
- 102100025583 Leukocyte immunoglobulin-like receptor subfamily B member 2 Human genes 0.000 description 3
- 102100030301 MHC class I polypeptide-related sequence A Human genes 0.000 description 3
- 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 3
- 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 description 3
- 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 3
- 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 3
- 108010061593 Member 14 Tumor Necrosis Factor Receptors Proteins 0.000 description 3
- 102000003735 Mesothelin Human genes 0.000 description 3
- 108090000015 Mesothelin Proteins 0.000 description 3
- 102100026712 Metalloreductase STEAP1 Human genes 0.000 description 3
- 102100034256 Mucin-1 Human genes 0.000 description 3
- 102100023123 Mucin-16 Human genes 0.000 description 3
- 108010063954 Mucins Proteins 0.000 description 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 description 3
- 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 3
- 102100035486 Nectin-4 Human genes 0.000 description 3
- 101710043865 Nectin-4 Proteins 0.000 description 3
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 3
- 108090000772 Neuropilin-1 Proteins 0.000 description 3
- 102000001756 Notch2 Receptor Human genes 0.000 description 3
- 108010029751 Notch2 Receptor Proteins 0.000 description 3
- 102000001760 Notch3 Receptor Human genes 0.000 description 3
- 108010029756 Notch3 Receptor Proteins 0.000 description 3
- 102100030869 Parathyroid hormone 2 receptor Human genes 0.000 description 3
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 3
- 102100029740 Poliovirus receptor Human genes 0.000 description 3
- 101710089372 Programmed cell death protein 1 Proteins 0.000 description 3
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 3
- 102100023068 Protein kinase C-binding protein NELL1 Human genes 0.000 description 3
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 3
- 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 3
- 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 3
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 3
- 101150036449 SIRPA gene Proteins 0.000 description 3
- 102100025504 SLIT and NTRK-like protein 6 Human genes 0.000 description 3
- 101100123851 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) HER1 gene Proteins 0.000 description 3
- 102100038081 Signal transducer CD24 Human genes 0.000 description 3
- 102100035721 Syndecan-1 Human genes 0.000 description 3
- 102100024834 T-cell immunoreceptor with Ig and ITIM domains Human genes 0.000 description 3
- 102100035268 T-cell surface protein tactile Human genes 0.000 description 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 3
- 102100027222 T-lymphocyte activation antigen CD80 Human genes 0.000 description 3
- 101150057140 TACSTD1 gene Proteins 0.000 description 3
- 102000016946 TWEAK Receptor Human genes 0.000 description 3
- 108010014401 TWEAK Receptor Proteins 0.000 description 3
- 108010060818 Toll-Like Receptor 9 Proteins 0.000 description 3
- 102000002689 Toll-like receptor Human genes 0.000 description 3
- 108020000411 Toll-like receptor Proteins 0.000 description 3
- 102100024333 Toll-like receptor 2 Human genes 0.000 description 3
- 102100039360 Toll-like receptor 4 Human genes 0.000 description 3
- 102100039357 Toll-like receptor 5 Human genes 0.000 description 3
- 102100039390 Toll-like receptor 7 Human genes 0.000 description 3
- 102100033117 Toll-like receptor 9 Human genes 0.000 description 3
- 102100023935 Transmembrane glycoprotein NMB Human genes 0.000 description 3
- 102100029678 Triggering receptor expressed on myeloid cells 2 Human genes 0.000 description 3
- 102100040247 Tumor necrosis factor Human genes 0.000 description 3
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 description 3
- 101710181056 Tumor necrosis factor ligand superfamily member 13B Proteins 0.000 description 3
- 108090000138 Tumor necrosis factor ligand superfamily member 15 Proteins 0.000 description 3
- 102100024587 Tumor necrosis factor ligand superfamily member 15 Human genes 0.000 description 3
- 102100028785 Tumor necrosis factor receptor superfamily member 14 Human genes 0.000 description 3
- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 description 3
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 description 3
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 3
- 102100036857 Tumor necrosis factor receptor superfamily member 8 Human genes 0.000 description 3
- 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 description 3
- 108010079206 V-Set Domain-Containing T-Cell Activation Inhibitor 1 Proteins 0.000 description 3
- 102100038282 V-type immunoglobulin domain-containing suppressor of T-cell activation Human genes 0.000 description 3
- 108010065472 Vimentin Proteins 0.000 description 3
- 102000013127 Vimentin Human genes 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 229960005305 adenosine Drugs 0.000 description 3
- MXKCYTKUIDTFLY-ZNNSSXPHSA-N alpha-L-Fucp-(1->2)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-beta-D-GlcpNAc-(1->3)-D-Galp Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](O[C@H]2[C@@H]([C@@H](NC(C)=O)[C@H](O[C@H]3[C@H]([C@@H](CO)OC(O)[C@@H]3O)O)O[C@@H]2CO)O[C@H]2[C@H]([C@H](O)[C@H](O)[C@H](C)O2)O)O[C@H](CO)[C@H](O)[C@@H]1O MXKCYTKUIDTFLY-ZNNSSXPHSA-N 0.000 description 3
- 239000012472 biological sample Substances 0.000 description 3
- 239000002738 chelating agent Substances 0.000 description 3
- 229940127276 delta-like ligand 3 Drugs 0.000 description 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 3
- IJJVMEJXYNJXOJ-UHFFFAOYSA-N fluquinconazole Chemical compound C=1C=C(Cl)C=C(Cl)C=1N1C(=O)C2=CC(F)=CC=C2N=C1N1C=NC=N1 IJJVMEJXYNJXOJ-UHFFFAOYSA-N 0.000 description 3
- 102000018358 immunoglobulin Human genes 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 102000006495 integrins Human genes 0.000 description 3
- 108010044426 integrins Proteins 0.000 description 3
- 108010074108 interleukin-21 Proteins 0.000 description 3
- 239000010445 mica Substances 0.000 description 3
- 229910052618 mica group Inorganic materials 0.000 description 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 108010048507 poliovirus receptor Proteins 0.000 description 3
- 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 3
- 101150047061 tag-72 gene Proteins 0.000 description 3
- 210000005048 vimentin Anatomy 0.000 description 3
- 101710127675 Antiviral innate immune response receptor RIG-I Proteins 0.000 description 2
- 108091007741 Chimeric antigen receptor T cells Proteins 0.000 description 2
- 102100031256 Cyclic GMP-AMP synthase Human genes 0.000 description 2
- 101710118064 Cyclic GMP-AMP synthase Proteins 0.000 description 2
- 101000952099 Homo sapiens Antiviral innate immune response receptor RIG-I Proteins 0.000 description 2
- 101000684503 Homo sapiens Sentrin-specific protease 3 Proteins 0.000 description 2
- 108010034143 Inflammasomes Proteins 0.000 description 2
- 102220557454 Mitochondrial 2-oxoglutarate/malate carrier protein_C68V_mutation Human genes 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 102100023645 Sentrin-specific protease 3 Human genes 0.000 description 2
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000001597 immobilized metal affinity chromatography Methods 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 238000012433 multimodal chromatography Methods 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 101000611183 Homo sapiens Tumor necrosis factor Proteins 0.000 description 1
- 102000000589 Interleukin-1 Human genes 0.000 description 1
- 108010002352 Interleukin-1 Proteins 0.000 description 1
- FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 229930195722 L-methionine Natural products 0.000 description 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229960004452 methionine Drugs 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229940068968 polysorbate 80 Drugs 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 102200145343 rs104894404 Human genes 0.000 description 1
- 102220234446 rs1064795967 Human genes 0.000 description 1
- 102200079914 rs193302884 Human genes 0.000 description 1
- 102220275444 rs760297349 Human genes 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- 239000007929 subcutaneous injection Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
- 239000013603 viral vector Substances 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063108794P | 2020-11-02 | 2020-11-02 | |
| US63/108,794 | 2020-11-02 | ||
| PCT/US2021/057741 WO2022094473A1 (en) | 2020-11-02 | 2021-11-02 | Interleukin-18 variants and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023550545A JP2023550545A (ja) | 2023-12-01 |
| JP2023550545A5 JP2023550545A5 (https=) | 2024-11-12 |
| JPWO2022094473A5 true JPWO2022094473A5 (https=) | 2024-11-12 |
Family
ID=81384408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023551948A Pending JP2023550545A (ja) | 2020-11-02 | 2021-11-02 | インターロイキン-18バリアントおよび使用の方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11850276B2 (https=) |
| EP (1) | EP4236990A4 (https=) |
| JP (1) | JP2023550545A (https=) |
| KR (1) | KR20230117120A (https=) |
| CN (1) | CN116723851A (https=) |
| AR (1) | AR123978A1 (https=) |
| AU (2) | AU2021371040C1 (https=) |
| CA (1) | CA3197145A1 (https=) |
| GB (1) | GB2617483B (https=) |
| IL (1) | IL302517A (https=) |
| MX (1) | MX2023005068A (https=) |
| NZ (1) | NZ800435A (https=) |
| TW (1) | TW202233657A (https=) |
| WO (1) | WO2022094473A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111315395A (zh) | 2017-09-06 | 2020-06-19 | 耶鲁大学 | 白细胞介素-18变体和使用方法 |
| US20230146665A1 (en) | 2021-07-27 | 2023-05-11 | Xencor, Inc. | Il-18-fc fusion proteins |
| WO2023147488A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| JP2025508823A (ja) | 2022-02-23 | 2025-04-10 | ブライト ピーク セラピューティクス エージー | 免疫抗原特異的il-18免疫サイトカイン及びその使用 |
| WO2024044780A1 (en) * | 2022-08-26 | 2024-02-29 | Sutro Biopharma, Inc. | Interleukin-18 variants and uses thereof |
| JP2025529313A (ja) * | 2022-09-06 | 2025-09-04 | ティージェイ バイオファーマ (シャンハイ) カンパニー, リミテッド | Il-18バリアントポリペプチド |
| US20240166705A1 (en) | 2022-11-07 | 2024-05-23 | Xencor, Inc. | Il18-fc fusion proteins |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| WO2024158838A2 (en) * | 2023-01-24 | 2024-08-02 | Simcha IL-18, Inc. | Methods and compositions for combination therapy |
| WO2024259270A2 (en) * | 2023-06-16 | 2024-12-19 | Simcha IL-18, Inc. | Administration of engineered interleukin-18 therapeutics |
| AU2024296516A1 (en) | 2023-07-13 | 2026-01-22 | Iovance Biotherapeutics, Inc. | Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes |
| US20250188166A1 (en) | 2023-08-23 | 2025-06-12 | Bright Peak Therapeutics Ag | Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025085447A1 (en) | 2023-10-17 | 2025-04-24 | Xencor, Inc. | Pd-1 targeted il18-fc fusion proteins |
| US20250179137A1 (en) | 2023-12-05 | 2025-06-05 | Regeneron Pharmaceuticals, Inc. | Il18 receptor agonists and methods of use thereof |
| CN120189493A (zh) * | 2023-12-22 | 2025-06-24 | 广州威溶特医药科技有限公司 | Dr-18和m1病毒在制备抗肿瘤药物中的应用 |
| US12134635B1 (en) | 2023-12-29 | 2024-11-05 | Sonnet BioTherapeutics, Inc. | Interleukin 18 (IL-18) variants and fusion proteins comprising same |
| WO2025151273A1 (en) * | 2024-01-08 | 2025-07-17 | Adimab, Llc | Il-18 polypeptides and uses thereof |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2026006784A1 (en) | 2024-06-28 | 2026-01-02 | Iovance Biotherapeutics, Inc. | Methods of making tumor reactive peripheral blood lymphocytes (trpbl) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| EP0816499A3 (en) | 1996-06-27 | 1999-10-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma |
| JP2007143555A (ja) * | 1996-11-29 | 2007-06-14 | Hayashibara Biochem Lab Inc | ポリペプチド |
| JP4024366B2 (ja) | 1996-11-29 | 2007-12-19 | 株式会社林原生物化学研究所 | ポリペプチド |
| JP3955352B2 (ja) | 1997-02-25 | 2007-08-08 | 株式会社林原生物化学研究所 | 破骨細胞形成阻害剤 |
| TWI227136B (en) | 1998-05-21 | 2005-02-01 | Smithkline Beecham Corp | Novel pharmaceutical composition for the prevention and/or treatment of cancer |
| AU7516601A (en) | 2000-06-02 | 2001-12-17 | Susan B Dillon | Methods of treating viral diseases with il-18 and il-18 combinations |
| ATE315647T1 (de) | 2001-03-08 | 2006-02-15 | Ares Trading Sa | Interleukin -18 mutantenproteine, deren herstellung und verwendung |
| US6800479B2 (en) | 2001-12-11 | 2004-10-05 | Samyang Genex Corporation | Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them |
| ATE459647T1 (de) * | 2003-04-15 | 2010-03-15 | Glaxosmithkline Llc | Humane il-18 substitutionsmutanten und deren konjugate |
| WO2005075648A1 (en) * | 2004-01-28 | 2005-08-18 | Gifu University | Interleukin-18 mutant proteins |
| JP5916622B2 (ja) * | 2010-01-04 | 2016-05-11 | マピ ファーマ リミテッド | グラチラマーまたはその薬理学的に許容される塩を含むデポーシステム |
| WO2017102010A1 (en) | 2015-12-17 | 2017-06-22 | Biontech Rna Pharmaceuticals Gmbh | Novel cytokine fusion proteins |
| CN111315395A (zh) * | 2017-09-06 | 2020-06-19 | 耶鲁大学 | 白细胞介素-18变体和使用方法 |
| JP2020143000A (ja) * | 2019-03-04 | 2020-09-10 | 大陽日酸株式会社 | 融合タンパク質及びその製造方法、目的タンパク質の製造方法 |
| US12029778B2 (en) * | 2019-05-13 | 2024-07-09 | Yale University | Interleukin-18 mimics and methods of use |
| WO2022038417A2 (en) * | 2020-08-19 | 2022-02-24 | Bright Peak Therapeutics Ag | Modified il-18 polypeptides and uses thereof |
-
2021
- 2021-11-02 TW TW110140842A patent/TW202233657A/zh unknown
- 2021-11-02 KR KR1020237018440A patent/KR20230117120A/ko active Pending
- 2021-11-02 CN CN202180089105.7A patent/CN116723851A/zh active Pending
- 2021-11-02 GB GB2308183.9A patent/GB2617483B/en active Active
- 2021-11-02 AU AU2021371040A patent/AU2021371040C1/en active Active
- 2021-11-02 AR ARP210103038A patent/AR123978A1/es unknown
- 2021-11-02 IL IL302517A patent/IL302517A/en unknown
- 2021-11-02 MX MX2023005068A patent/MX2023005068A/es unknown
- 2021-11-02 NZ NZ800435A patent/NZ800435A/en unknown
- 2021-11-02 JP JP2023551948A patent/JP2023550545A/ja active Pending
- 2021-11-02 CA CA3197145A patent/CA3197145A1/en active Pending
- 2021-11-02 WO PCT/US2021/057741 patent/WO2022094473A1/en not_active Ceased
- 2021-11-02 EP EP21887776.9A patent/EP4236990A4/en active Pending
-
2022
- 2022-12-01 US US18/060,816 patent/US11850276B2/en active Active
-
2023
- 2023-11-03 US US18/501,206 patent/US12582701B2/en active Active
- 2023-11-03 US US18/501,210 patent/US12564621B2/en active Active
-
2025
- 2025-05-12 AU AU2025203386A patent/AU2025203386A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB2617483A (en) | Interleukin-18 variants and methods of use | |
| JPWO2022094473A5 (https=) | ||
| JP7622193B2 (ja) | 免疫応答を調節するための方法 | |
| TWI800506B (zh) | 免疫結合物 | |
| CN110785435B (zh) | 与il-12和il-18的基于il-15的融合物 | |
| JP2020533301A5 (https=) | ||
| CN105017429B (zh) | 多聚体il-15可溶性融合分子与其制造与使用方法 | |
| US20210024631A1 (en) | Bi-functional proteins and construction thereof | |
| JP2022536898A (ja) | 新規il-15プロドラッグおよびその使用方法 | |
| JP2024177464A (ja) | サイトカイン融合タンパク質 | |
| CA3197935A1 (en) | Interleukin-2-fc fusion proteins and methods of use | |
| CN112654636A (zh) | 可活化白介素12多肽及其使用方法 | |
| JP2020512814A (ja) | 免疫抱合体 | |
| JP2021520829A (ja) | IL−15/IL−15RA Fc融合タンパク質およびTIM−3抗原結合ドメインを含む、TIM−3標的化ヘテロ二量体融合タンパク質 | |
| CN113811549A (zh) | 非靶向和靶向性il-10 fc融合蛋白 | |
| JP2019533449A (ja) | 多量体il−15に基づく分子 | |
| CN111094341A (zh) | 在可变域和恒定域之间的肘区中具有功能域的抗体 | |
| CN112074267A (zh) | 成纤维细胞结合剂及其用途 | |
| WO2011076781A1 (en) | Tetravalent cd47-antibody constant region fusion protein for use in therapy | |
| JP7642857B2 (ja) | 二重特異性多機能性融合ポリペプチド | |
| CN114502188B (zh) | 人工免疫监视嵌合抗原受体及其表达细胞 | |
| CN116801897A (zh) | 包含嗜乳脂蛋白的同二聚体和异二聚体蛋白 | |
| CN114080397A (zh) | Il-7-fc融合蛋白 | |
| CN118019849A (zh) | Il-2变体及其融合蛋白 | |
| JP2022538894A (ja) | 組換えヒトシアリダーゼ、シアリダーゼ融合タンパク質およびその使用方法 |