AU2021371040C1 - Interleukin-18 variants and methods of use - Google Patents

Interleukin-18 variants and methods of use Download PDF

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Publication number
AU2021371040C1
AU2021371040C1 AU2021371040A AU2021371040A AU2021371040C1 AU 2021371040 C1 AU2021371040 C1 AU 2021371040C1 AU 2021371040 A AU2021371040 A AU 2021371040A AU 2021371040 A AU2021371040 A AU 2021371040A AU 2021371040 C1 AU2021371040 C1 AU 2021371040C1
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Australia
Prior art keywords
polypeptide
seq
variant
stabilized
cases
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AU2021371040A
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English (en)
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AU2021371040B2 (en
AU2021371040A1 (en
Inventor
Tom Boone
Aaron RING
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Simcha Il 18 Inc
Yale University
Original Assignee
Simcha Il 18 Inc
Yale University
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Application filed by Simcha Il 18 Inc, Yale University filed Critical Simcha Il 18 Inc
Publication of AU2021371040A1 publication Critical patent/AU2021371040A1/en
Publication of AU2021371040B2 publication Critical patent/AU2021371040B2/en
Priority to AU2025203386A priority Critical patent/AU2025203386A1/en
Application granted granted Critical
Publication of AU2021371040C1 publication Critical patent/AU2021371040C1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AU2021371040A 2020-11-02 2021-11-02 Interleukin-18 variants and methods of use Active AU2021371040C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2025203386A AU2025203386A1 (en) 2020-11-02 2025-05-12 Interleukin-18 variants and methods of use

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063108794P 2020-11-02 2020-11-02
US63/108,794 2020-11-02
PCT/US2021/057741 WO2022094473A1 (en) 2020-11-02 2021-11-02 Interleukin-18 variants and methods of use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025203386A Division AU2025203386A1 (en) 2020-11-02 2025-05-12 Interleukin-18 variants and methods of use

Publications (3)

Publication Number Publication Date
AU2021371040A1 AU2021371040A1 (en) 2023-06-22
AU2021371040B2 AU2021371040B2 (en) 2025-02-13
AU2021371040C1 true AU2021371040C1 (en) 2025-05-29

Family

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Family Applications (2)

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AU2021371040A Active AU2021371040C1 (en) 2020-11-02 2021-11-02 Interleukin-18 variants and methods of use
AU2025203386A Pending AU2025203386A1 (en) 2020-11-02 2025-05-12 Interleukin-18 variants and methods of use

Family Applications After (1)

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AU2025203386A Pending AU2025203386A1 (en) 2020-11-02 2025-05-12 Interleukin-18 variants and methods of use

Country Status (14)

Country Link
US (3) US11850276B2 (https=)
EP (1) EP4236990A4 (https=)
JP (1) JP2023550545A (https=)
KR (1) KR20230117120A (https=)
CN (1) CN116723851A (https=)
AR (1) AR123978A1 (https=)
AU (2) AU2021371040C1 (https=)
CA (1) CA3197145A1 (https=)
GB (1) GB2617483B (https=)
IL (1) IL302517A (https=)
MX (1) MX2023005068A (https=)
NZ (1) NZ800435A (https=)
TW (1) TW202233657A (https=)
WO (1) WO2022094473A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111315395A (zh) 2017-09-06 2020-06-19 耶鲁大学 白细胞介素-18变体和使用方法
US20230146665A1 (en) 2021-07-27 2023-05-11 Xencor, Inc. Il-18-fc fusion proteins
WO2023147488A1 (en) 2022-01-28 2023-08-03 Iovance Biotherapeutics, Inc. Cytokine associated tumor infiltrating lymphocytes compositions and methods
JP2025508823A (ja) 2022-02-23 2025-04-10 ブライト ピーク セラピューティクス エージー 免疫抗原特異的ｉｌ－１８免疫サイトカイン及びその使用
WO2024044780A1 (en) * 2022-08-26 2024-02-29 Sutro Biopharma, Inc. Interleukin-18 variants and uses thereof
JP2025529313A (ja) * 2022-09-06 2025-09-04 ティージェイ バイオファーマ （シャンハイ） カンパニー， リミテッド Ｉｌ－１８バリアントポリペプチド
US20240166705A1 (en) 2022-11-07 2024-05-23 Xencor, Inc. Il18-fc fusion proteins
WO2024118836A1 (en) 2022-11-30 2024-06-06 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes with shortened rep step
WO2024158838A2 (en) * 2023-01-24 2024-08-02 Simcha IL-18, Inc. Methods and compositions for combination therapy
WO2024259270A2 (en) * 2023-06-16 2024-12-19 Simcha IL-18, Inc. Administration of engineered interleukin-18 therapeutics
AU2024296516A1 (en) 2023-07-13 2026-01-22 Iovance Biotherapeutics, Inc. Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes
US20250188166A1 (en) 2023-08-23 2025-06-12 Bright Peak Therapeutics Ag Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof
WO2025041101A1 (en) 2023-08-23 2025-02-27 Bright Peak Therapeutics Ag Activatable il-18 immunocytokines and uses thereof
WO2025085447A1 (en) 2023-10-17 2025-04-24 Xencor, Inc. Pd-1 targeted il18-fc fusion proteins
US20250179137A1 (en) 2023-12-05 2025-06-05 Regeneron Pharmaceuticals, Inc. Il18 receptor agonists and methods of use thereof
CN120189493A (zh) * 2023-12-22 2025-06-24 广州威溶特医药科技有限公司 Dr-18和m1病毒在制备抗肿瘤药物中的应用
US12134635B1 (en) 2023-12-29 2024-11-05 Sonnet BioTherapeutics, Inc. Interleukin 18 (IL-18) variants and fusion proteins comprising same
WO2025151273A1 (en) * 2024-01-08 2025-07-17 Adimab, Llc Il-18 polypeptides and uses thereof
WO2025242835A1 (en) 2024-05-22 2025-11-27 Ose Immunotherapeutics Molecules comprising masking linkers and uses thereof for the treatment of cancer
WO2026006784A1 (en) 2024-06-28 2026-01-02 Iovance Biotherapeutics, Inc. Methods of making tumor reactive peripheral blood lymphocytes (trpbl)

Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2004091517A2 (en) * 2003-04-15 2004-10-28 Smithkline Beecham Corporation Conjugates comprising human il-18 and substitution mutants thereof
US20190070262A1 (en) * 2017-09-06 2019-03-07 Yale University Interleukin-18 variants and methods of use
WO2022038417A2 (en) * 2020-08-19 2022-02-24 Bright Peak Therapeutics Ag Modified il-18 polypeptides and uses thereof

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US6156501A (en) 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
EP0816499A3 (en) 1996-06-27 1999-10-27 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma
JP2007143555A (ja) * 1996-11-29 2007-06-14 Hayashibara Biochem Lab Inc ポリペプチド
JP4024366B2 (ja) 1996-11-29 2007-12-19 株式会社林原生物化学研究所 ポリペプチド
JP3955352B2 (ja) 1997-02-25 2007-08-08 株式会社林原生物化学研究所 破骨細胞形成阻害剤
TWI227136B (en) 1998-05-21 2005-02-01 Smithkline Beecham Corp Novel pharmaceutical composition for the prevention and/or treatment of cancer
AU7516601A (en) 2000-06-02 2001-12-17 Susan B Dillon Methods of treating viral diseases with il-18 and il-18 combinations
ATE315647T1 (de) 2001-03-08 2006-02-15 Ares Trading Sa Interleukin -18 mutantenproteine, deren herstellung und verwendung
US6800479B2 (en) 2001-12-11 2004-10-05 Samyang Genex Corporation Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them
WO2005075648A1 (en) * 2004-01-28 2005-08-18 Gifu University Interleukin-18 mutant proteins
JP5916622B2 (ja) * 2010-01-04 2016-05-11 マピ ファーマ リミテッド グラチラマーまたはその薬理学的に許容される塩を含むデポーシステム
WO2017102010A1 (en) 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
JP2020143000A (ja) * 2019-03-04 2020-09-10 大陽日酸株式会社 融合タンパク質及びその製造方法、目的タンパク質の製造方法
US12029778B2 (en) * 2019-05-13 2024-07-09 Yale University Interleukin-18 mimics and methods of use

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2004091517A2 (en) * 2003-04-15 2004-10-28 Smithkline Beecham Corporation Conjugates comprising human il-18 and substitution mutants thereof
US20190070262A1 (en) * 2017-09-06 2019-03-07 Yale University Interleukin-18 variants and methods of use
WO2022038417A2 (en) * 2020-08-19 2022-02-24 Bright Peak Therapeutics Ag Modified il-18 polypeptides and uses thereof

Non-Patent Citations (1)

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Title
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Also Published As

Publication number Publication date
WO2022094473A1 (en) 2022-05-05
AU2021371040B2 (en) 2025-02-13
IL302517A (en) 2023-07-01
AR123978A1 (es) 2023-02-01
EP4236990A1 (en) 2023-09-06
EP4236990A4 (en) 2025-03-19
TW202233657A (zh) 2022-09-01
AU2025203386A1 (en) 2025-06-05
US12564621B2 (en) 2026-03-03
GB2617483B (en) 2025-03-12
CN116723851A (zh) 2023-09-08
US20230277625A1 (en) 2023-09-07
US20240066100A1 (en) 2024-02-29
NZ800435A (en) 2025-12-19
CA3197145A1 (en) 2022-05-05
JP2023550545A (ja) 2023-12-01
GB2617483A (en) 2023-10-11
AU2021371040A1 (en) 2023-06-22
US11850276B2 (en) 2023-12-26
US20240075104A1 (en) 2024-03-07
GB202308183D0 (en) 2023-07-19
MX2023005068A (es) 2023-07-14
KR20230117120A (ko) 2023-08-07
US12582701B2 (en) 2026-03-24

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