JP2023550545A5 - - Google Patents
Info
- Publication number
- JP2023550545A5 JP2023550545A5 JP2023551948A JP2023551948A JP2023550545A5 JP 2023550545 A5 JP2023550545 A5 JP 2023550545A5 JP 2023551948 A JP2023551948 A JP 2023551948A JP 2023551948 A JP2023551948 A JP 2023551948A JP 2023550545 A5 JP2023550545 A5 JP 2023550545A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- modified
- item
- seq
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063108794P | 2020-11-02 | 2020-11-02 | |
| US63/108,794 | 2020-11-02 | ||
| PCT/US2021/057741 WO2022094473A1 (en) | 2020-11-02 | 2021-11-02 | Interleukin-18 variants and methods of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023550545A JP2023550545A (ja) | 2023-12-01 |
| JP2023550545A5 true JP2023550545A5 (https=) | 2024-11-12 |
Family
ID=81384408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023551948A Pending JP2023550545A (ja) | 2020-11-02 | 2021-11-02 | インターロイキン－１８バリアントおよび使用の方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US11850276B2 (https=) |
| EP (1) | EP4236990A4 (https=) |
| JP (1) | JP2023550545A (https=) |
| KR (1) | KR20230117120A (https=) |
| CN (1) | CN116723851A (https=) |
| AR (1) | AR123978A1 (https=) |
| AU (2) | AU2021371040C1 (https=) |
| CA (1) | CA3197145A1 (https=) |
| GB (1) | GB2617483B (https=) |
| IL (1) | IL302517A (https=) |
| MX (1) | MX2023005068A (https=) |
| NZ (1) | NZ800435A (https=) |
| TW (1) | TW202233657A (https=) |
| WO (1) | WO2022094473A1 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL272635B2 (en) | 2017-09-06 | 2024-02-01 | Univ Yale | Variants of interleukin-18 and methods of use |
| US20230146665A1 (en) | 2021-07-27 | 2023-05-11 | Xencor, Inc. | Il-18-fc fusion proteins |
| EP4469065A1 (en) | 2022-01-28 | 2024-12-04 | Iovance Biotherapeutics, Inc. | Cytokine associated tumor infiltrating lymphocytes compositions and methods |
| AU2023226512A1 (en) | 2022-02-23 | 2024-08-29 | Bright Peak Therapeutics Ag | Immune antigen specific il-18 immunocytokines and uses thereof |
| WO2024044780A1 (en) * | 2022-08-26 | 2024-02-29 | Sutro Biopharma, Inc. | Interleukin-18 variants and uses thereof |
| US20260092093A1 (en) * | 2022-09-06 | 2026-04-02 | TJ Biopharma (Shanghai) Co., Ltd. | Il-18 variant polypeptides |
| WO2024102693A2 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Il-18-fc fusion proteins |
| WO2024118836A1 (en) | 2022-11-30 | 2024-06-06 | Iovance Biotherapeutics, Inc. | Processes for production of tumor infiltrating lymphocytes with shortened rep step |
| AU2024212675A1 (en) * | 2023-01-24 | 2025-07-31 | Simcha IL-18, Inc. | Methods and compositions for combination therapy |
| WO2024259270A2 (en) * | 2023-06-16 | 2024-12-19 | Simcha IL-18, Inc. | Administration of engineered interleukin-18 therapeutics |
| WO2025015318A2 (en) | 2023-07-13 | 2025-01-16 | Iovance Biotherapeutics, Inc. | Cytokine encoding lentiviral vectors and uses thereof for making tumor infiltrating lymphocytes |
| WO2025041101A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Activatable il-18 immunocytokines and uses thereof |
| WO2025041097A1 (en) | 2023-08-23 | 2025-02-27 | Bright Peak Therapeutics Ag | Il-18 polypeptides fused to immune cell antigen specific binding polypeptides and uses thereof |
| WO2025085447A1 (en) | 2023-10-17 | 2025-04-24 | Xencor, Inc. | Pd-1 targeted il18-fc fusion proteins |
| WO2025122614A1 (en) | 2023-12-05 | 2025-06-12 | Regeneron Pharmaceuticals, Inc. | Il18 receptor agonists and methods of use thereof |
| CN120189493A (zh) * | 2023-12-22 | 2025-06-24 | 广州威溶特医药科技有限公司 | Dr-18和m1病毒在制备抗肿瘤药物中的应用 |
| US12134635B1 (en) | 2023-12-29 | 2024-11-05 | Sonnet BioTherapeutics, Inc. | Interleukin 18 (IL-18) variants and fusion proteins comprising same |
| WO2025151273A1 (en) * | 2024-01-08 | 2025-07-17 | Adimab, Llc | Il-18 polypeptides and uses thereof |
| WO2025242835A1 (en) | 2024-05-22 | 2025-11-27 | Ose Immunotherapeutics | Molecules comprising masking linkers and uses thereof for the treatment of cancer |
| WO2026006784A1 (en) | 2024-06-28 | 2026-01-02 | Iovance Biotherapeutics, Inc. | Methods of making tumor reactive peripheral blood lymphocytes (trpbl) |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6156501A (en) | 1993-10-26 | 2000-12-05 | Affymetrix, Inc. | Arrays of modified nucleic acid probes and methods of use |
| EP0816499A3 (en) | 1996-06-27 | 1999-10-27 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Genomic DNA encoding a polypeptide capable of inducing the production of interferon-gamma |
| JP2007143555A (ja) * | 1996-11-29 | 2007-06-14 | Hayashibara Biochem Lab Inc | ポリペプチド |
| JP4024366B2 (ja) | 1996-11-29 | 2007-12-19 | 株式会社林原生物化学研究所 | ポリペプチド |
| JP3955352B2 (ja) * | 1997-02-25 | 2007-08-08 | 株式会社林原生物化学研究所 | 破骨細胞形成阻害剤 |
| TWI227136B (en) | 1998-05-21 | 2005-02-01 | Smithkline Beecham Corp | Novel pharmaceutical composition for the prevention and/or treatment of cancer |
| CN1457258A (zh) | 2000-06-02 | 2003-11-19 | 史密丝克莱恩比彻姆公司 | 用il－18和il－18组合物治疗病毒性疾病的方法 |
| WO2002101049A2 (en) | 2001-03-08 | 2002-12-19 | Ares Trading S.A. | Interleukin-18 mutants, their production and use |
| US6800479B2 (en) | 2001-12-11 | 2004-10-05 | Samyang Genex Corporation | Recombinant adenoviruses expressing interleukin-18 protein and gene therapy using them |
| EP2261244A3 (en) * | 2003-04-15 | 2011-02-23 | Glaxosmithkline LLC | Human il-18 substitution mutants and their conjugates |
| WO2005075648A1 (en) * | 2004-01-28 | 2005-08-18 | Gifu University | Interleukin-18 mutant proteins |
| HUE060304T2 (hu) * | 2010-01-04 | 2023-02-28 | Mapi Pharma Ltd | Glatiramer acetátot tartalmazó depó rendszer |
| WO2017102010A1 (en) | 2015-12-17 | 2017-06-22 | Biontech Rna Pharmaceuticals Gmbh | Novel cytokine fusion proteins |
| IL272635B2 (en) * | 2017-09-06 | 2024-02-01 | Univ Yale | Variants of interleukin-18 and methods of use |
| JP2020143000A (ja) * | 2019-03-04 | 2020-09-10 | 大陽日酸株式会社 | 融合タンパク質及びその製造方法、目的タンパク質の製造方法 |
| US12029778B2 (en) * | 2019-05-13 | 2024-07-09 | Yale University | Interleukin-18 mimics and methods of use |
| CA3189327A1 (en) * | 2020-08-19 | 2022-02-24 | Vijaya Raghavan PATTABIRAMAN | Modified il-18 polypeptides and uses thereof |
-
2021
- 2021-11-02 JP JP2023551948A patent/JP2023550545A/ja active Pending
- 2021-11-02 AR ARP210103038A patent/AR123978A1/es unknown
- 2021-11-02 MX MX2023005068A patent/MX2023005068A/es unknown
- 2021-11-02 AU AU2021371040A patent/AU2021371040C1/en active Active
- 2021-11-02 NZ NZ800435A patent/NZ800435A/en unknown
- 2021-11-02 GB GB2308183.9A patent/GB2617483B/en active Active
- 2021-11-02 CN CN202180089105.7A patent/CN116723851A/zh active Pending
- 2021-11-02 IL IL302517A patent/IL302517A/en unknown
- 2021-11-02 KR KR1020237018440A patent/KR20230117120A/ko active Pending
- 2021-11-02 TW TW110140842A patent/TW202233657A/zh unknown
- 2021-11-02 WO PCT/US2021/057741 patent/WO2022094473A1/en not_active Ceased
- 2021-11-02 EP EP21887776.9A patent/EP4236990A4/en active Pending
- 2021-11-02 CA CA3197145A patent/CA3197145A1/en active Pending
-
2022
- 2022-12-01 US US18/060,816 patent/US11850276B2/en active Active
-
2023
- 2023-11-03 US US18/501,206 patent/US12582701B2/en active Active
- 2023-11-03 US US18/501,210 patent/US12564621B2/en active Active
-
2025
- 2025-05-12 AU AU2025203386A patent/AU2025203386A1/en active Pending
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