JPWO2022046922A5 - - Google Patents
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- JPWO2022046922A5 JPWO2022046922A5 JP2023513774A JP2023513774A JPWO2022046922A5 JP WO2022046922 A5 JPWO2022046922 A5 JP WO2022046922A5 JP 2023513774 A JP2023513774 A JP 2023513774A JP 2023513774 A JP2023513774 A JP 2023513774A JP WO2022046922 A5 JPWO2022046922 A5 JP WO2022046922A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 103
- 239000000203 mixture Substances 0.000 claims description 63
- 238000006467 substitution reaction Methods 0.000 claims description 24
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 17
- 230000008685 targeting Effects 0.000 claims description 17
- 206010028980 Neoplasm Diseases 0.000 claims description 16
- 229920001184 polypeptide Polymers 0.000 claims description 14
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 12
- 102000004127 Cytokines Human genes 0.000 claims description 11
- 108090000695 Cytokines Proteins 0.000 claims description 11
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 11
- 239000000427 antigen Substances 0.000 claims description 11
- 102000036639 antigens Human genes 0.000 claims description 11
- 108091007433 antigens Proteins 0.000 claims description 11
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- 108010065805 Interleukin-12 Proteins 0.000 claims description 5
- 102000013462 Interleukin-12 Human genes 0.000 claims description 5
- 102000003812 Interleukin-15 Human genes 0.000 claims description 5
- 108090000172 Interleukin-15 Proteins 0.000 claims description 5
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- 108090000171 Interleukin-18 Proteins 0.000 claims description 5
- 108010002350 Interleukin-2 Proteins 0.000 claims description 5
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- 108010002586 Interleukin-7 Proteins 0.000 claims description 5
- 108010074108 interleukin-21 Proteins 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
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- 108010074328 Interferon-gamma Proteins 0.000 claims description 3
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- 101001068136 Homo sapiens Hepatitis A virus cellular receptor 1 Proteins 0.000 claims description 2
- 101000831286 Homo sapiens Protein timeless homolog Proteins 0.000 claims description 2
- 101000752245 Homo sapiens Rho guanine nucleotide exchange factor 5 Proteins 0.000 claims description 2
- 101000934346 Homo sapiens T-cell surface antigen CD2 Proteins 0.000 claims description 2
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 2
- 101000801234 Homo sapiens Tumor necrosis factor receptor superfamily member 18 Proteins 0.000 claims description 2
- 101000679903 Homo sapiens Tumor necrosis factor receptor superfamily member 25 Proteins 0.000 claims description 2
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- 102000008115 Signaling Lymphocytic Activation Molecule Family Member 1 Human genes 0.000 claims description 2
- 108010074687 Signaling Lymphocytic Activation Molecule Family Member 1 Proteins 0.000 claims description 2
- 102100025237 T-cell surface antigen CD2 Human genes 0.000 claims description 2
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 2
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- 102100033728 Tumor necrosis factor receptor superfamily member 18 Human genes 0.000 claims description 2
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- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims description 2
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- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 10
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 10
- 102000000704 Interleukin-7 Human genes 0.000 claims 4
- 229940117681 interleukin-12 Drugs 0.000 claims 4
- 229940100994 interleukin-7 Drugs 0.000 claims 4
- 102000040430 polynucleotide Human genes 0.000 claims 3
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- 102000008070 Interferon-gamma Human genes 0.000 claims 2
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- 206010006187 Breast cancer Diseases 0.000 claims 1
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- 108060003951 Immunoglobulin Proteins 0.000 description 8
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- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108700012434 CCL3 Proteins 0.000 description 1
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- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 1
- 102100026720 Interferon beta Human genes 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010047761 Interferon-alpha Proteins 0.000 description 1
- 102000006992 Interferon-alpha Human genes 0.000 description 1
- 108090000467 Interferon-beta Proteins 0.000 description 1
- 108090000174 Interleukin-10 Proteins 0.000 description 1
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- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 1
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- OHDXDNUPVVYWOV-UHFFFAOYSA-N n-methyl-1-(2-naphthalen-1-ylsulfanylphenyl)methanamine Chemical compound CNCC1=CC=CC=C1SC1=CC=CC2=CC=CC=C12 OHDXDNUPVVYWOV-UHFFFAOYSA-N 0.000 description 1
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063070782P | 2020-08-26 | 2020-08-26 | |
| US63/070,782 | 2020-08-26 | ||
| PCT/US2021/047574 WO2022046922A2 (en) | 2020-08-26 | 2021-08-25 | Antibody molecules that bind to nkp30 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023539645A JP2023539645A (ja) | 2023-09-15 |
| JPWO2022046922A5 true JPWO2022046922A5 (https=) | 2024-08-30 |
| JP2023539645A5 JP2023539645A5 (https=) | 2024-08-30 |
Family
ID=80353900
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023513774A Pending JP2023539645A (ja) | 2020-08-26 | 2021-08-25 | Ｎｋｐ３０に結合する抗体分子およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20230348593A1 (https=) |
| EP (1) | EP4204096A4 (https=) |
| JP (1) | JP2023539645A (https=) |
| KR (1) | KR20230074144A (https=) |
| CN (1) | CN116917316A (https=) |
| AU (1) | AU2021331076A1 (https=) |
| CA (1) | CA3190766A1 (https=) |
| GB (1) | GB2616128A (https=) |
| WO (1) | WO2022046922A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3737692A4 (en) | 2018-01-09 | 2021-09-29 | Elstar Therapeutics, Inc. | CALRETICULIN AND MODIFIED T-LYMPHOCYTES BINDING CONSTRUCTIONS FOR THE TREATMENT OF DISEASES |
| EP3818083A2 (en) | 2018-07-03 | 2021-05-12 | Elstar Therapeutics, Inc. | Anti-tcr antibody molecules and uses thereof |
| AU2020224681A1 (en) | 2019-02-21 | 2021-09-16 | Marengo Therapeutics, Inc. | Antibody molecules that bind to NKp30 and uses thereof |
| JP7710373B2 (ja) | 2019-02-21 | 2025-07-18 | マレンゴ・セラピューティクス，インコーポレーテッド | Ｔ細胞関連のがん細胞に結合する多機能性分子およびその使用 |
| CN116234829A (zh) | 2020-01-03 | 2023-06-06 | 马伦戈治疗公司 | 抗tcr抗体分子及其用途 |
| CN116003627B (zh) * | 2022-09-16 | 2025-05-13 | 四川大学华西医院 | NKG2D-NKp46细胞接合器分子及其用途 |
| GB202301945D0 (en) | 2023-02-10 | 2023-03-29 | Mount Natalie | Novel immunoconjugates |
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-
2021
- 2021-08-25 AU AU2021331076A patent/AU2021331076A1/en not_active Abandoned
- 2021-08-25 EP EP21862668.7A patent/EP4204096A4/en active Pending
- 2021-08-25 JP JP2023513774A patent/JP2023539645A/ja active Pending
- 2021-08-25 KR KR1020237009894A patent/KR20230074144A/ko active Pending
- 2021-08-25 GB GB2303286.5A patent/GB2616128A/en not_active Withdrawn
- 2021-08-25 CN CN202180073181.9A patent/CN116917316A/zh active Pending
- 2021-08-25 WO PCT/US2021/047574 patent/WO2022046922A2/en not_active Ceased
- 2021-08-25 CA CA3190766A patent/CA3190766A1/en active Pending
-
2023
- 2023-02-22 US US18/172,928 patent/US20230348593A1/en active Pending
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