JPWO2021247604A5 - - Google Patents
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- JPWO2021247604A5 JPWO2021247604A5 JP2022573633A JP2022573633A JPWO2021247604A5 JP WO2021247604 A5 JPWO2021247604 A5 JP WO2021247604A5 JP 2022573633 A JP2022573633 A JP 2022573633A JP 2022573633 A JP2022573633 A JP 2022573633A JP WO2021247604 A5 JPWO2021247604 A5 JP WO2021247604A5
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- tgf
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063032933P | 2020-06-01 | 2020-06-01 | |
| US63/032,933 | 2020-06-01 | ||
| USPCT/US2020/035598 | 2020-06-01 | ||
| PCT/US2020/035598 WO2021247003A1 (en) | 2020-06-01 | 2020-06-01 | Methods of treating aging-related disorders |
| US202063118536P | 2020-11-25 | 2020-11-25 | |
| US63/118,536 | 2020-11-25 | ||
| PCT/US2021/035285 WO2021247604A1 (en) | 2020-06-01 | 2021-06-01 | Methods of treating aging-related disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023527869A JP2023527869A (ja) | 2023-06-30 |
| JP2023527869A5 JP2023527869A5 (https=) | 2024-06-12 |
| JPWO2021247604A5 true JPWO2021247604A5 (https=) | 2024-06-12 |
Family
ID=76523519
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022573633A Pending JP2023527869A (ja) | 2020-06-01 | 2021-06-01 | 加齢関連障害の治療法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP4157460A1 (https=) |
| JP (1) | JP2023527869A (https=) |
| KR (1) | KR20230031280A (https=) |
| AU (1) | AU2021283199B2 (https=) |
| CA (1) | CA3184756A1 (https=) |
| IL (1) | IL298608A (https=) |
| WO (1) | WO2021247604A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023019215A1 (en) * | 2021-08-11 | 2023-02-16 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases |
| JP2025508939A (ja) * | 2022-03-02 | 2025-04-10 | イミュニティーバイオ インコーポレイテッド | 膵臓癌の治療方法 |
| CN116199787A (zh) * | 2022-08-02 | 2023-06-02 | 四川大学华西医院 | 一种基于uPA的GFD结构域构建的嵌合抗原受体免疫细胞制备及其应用 |
| WO2024211893A2 (en) * | 2023-04-07 | 2024-10-10 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
| KR20260003467A (ko) * | 2024-06-28 | 2026-01-07 | (주)네이처글루텍 | 항산화 및 항노화 펩타이드를 포함하는 조성물 |
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| GB9324807D0 (en) | 1993-12-03 | 1994-01-19 | Cancer Res Campaign Tech | Tumour antibody |
| US6117980A (en) | 1997-02-21 | 2000-09-12 | Genentech, Inc. | Humanized anti-IL-8 monoclonal antibodies |
| JP2001206899A (ja) | 1999-11-18 | 2001-07-31 | Japan Tobacco Inc | TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途 |
| ES2353273T3 (es) | 2000-12-26 | 2011-02-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Anticuerpos anti-cd28. |
| WO2003104425A2 (en) | 2002-06-07 | 2003-12-18 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Novel stable anti-cd22 antibodies |
| JP4463104B2 (ja) | 2002-08-30 | 2010-05-12 | 財団法人化学及血清療法研究所 | ヒト抗ヒトインターロイキン−6抗体及び該抗体フラグメント |
| EP1400534B1 (en) | 2002-09-10 | 2015-10-28 | Affimed GmbH | Human CD3-specific antibody with immunosuppressive properties |
| CN1753912B (zh) | 2002-12-23 | 2011-11-02 | 惠氏公司 | 抗pd-1抗体及其用途 |
| KR20060015482A (ko) | 2003-03-21 | 2006-02-17 | 와이어쓰 | 인터루킨-21/인터루킨-21 수용체의 작용제를 이용한면역장애의 치료 |
| US9005613B2 (en) | 2003-06-16 | 2015-04-14 | Immunomedics, Inc. | Anti-mucin antibodies for early detection and treatment of pancreatic cancer |
| NZ549040A (en) | 2004-02-17 | 2009-07-31 | Schering Corp | Use for interleukin-33 (IL33) and the IL-33 receptor complex |
| ES2375481T3 (es) | 2004-03-30 | 2012-03-01 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Anticuerpos biespecíficos para elegir como diana células que participan en reacciones de tipo alérgico, composiciones y usos de los mismos. |
| CA2763671A1 (en) | 2005-04-26 | 2006-11-02 | Pfizer Inc. | P-cadherin antibodies |
| GB0510790D0 (en) | 2005-05-26 | 2005-06-29 | Syngenta Crop Protection Ag | Anti-CD16 binding molecules |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| WO2009120922A2 (en) | 2008-03-27 | 2009-10-01 | Zymogenetics, Inc. | Compositions and methods for inhibiting pdgfrbeta and vegf-a |
| LT3216803T (lt) | 2008-06-25 | 2020-06-10 | Novartis Ag | Stabilūs ir tirpūs antikūnai, slopinantys vegf |
| NZ603698A (en) | 2008-07-08 | 2014-03-28 | Abbvie Inc | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
| US9273136B2 (en) | 2008-08-04 | 2016-03-01 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Fully human anti-human NKG2D monoclonal antibodies |
| US8298533B2 (en) | 2008-11-07 | 2012-10-30 | Medimmune Limited | Antibodies to IL-1R1 |
| AU2009333580B2 (en) | 2008-12-09 | 2016-07-07 | Genentech, Inc. | Anti-PD-L1 antibodies and their use to enhance T-cell function |
| KR20120060877A (ko) | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| DE102009045006A1 (de) | 2009-09-25 | 2011-04-14 | Technische Universität Dresden | Anti-CD33 Antikörper und ihre Anwendung zum Immunotargeting bei der Behandlung von CD33-assoziierten Erkrankungen |
| AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| WO2011100538A1 (en) | 2010-02-11 | 2011-08-18 | Alexion Pharmaceuticals, Inc. | Therapeutic methods using an ti-cd200 antibodies |
| WO2011127324A2 (en) | 2010-04-08 | 2011-10-13 | JN Biosciences, LLC | Antibodies to cd122 |
| WO2011155607A1 (ja) | 2010-06-11 | 2011-12-15 | 協和発酵キリン株式会社 | 抗tim-3抗体 |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| JP2012034668A (ja) | 2010-08-12 | 2012-02-23 | Tohoku Univ | ヒト型化抗egfr抗体リジン置換可変領域断片及びその利用 |
| GB201103955D0 (en) | 2011-03-09 | 2011-04-20 | Antitope Ltd | Antibodies |
| CN105884900A (zh) | 2011-04-19 | 2016-08-24 | 梅里麦克制药股份有限公司 | 单特异性和双特异性抗igf-1r和抗erbb3抗体 |
| SMT201800269T1 (it) | 2011-04-25 | 2018-07-17 | Daiichi Sankyo Co Ltd | Anticorpo anti-b7-h3 |
| SG10201603962TA (en) | 2011-05-25 | 2016-07-28 | Innate Pharma Sa | Anti-kir antibodies for the treatment of inflammatory disorders |
| US8753640B2 (en) | 2011-05-31 | 2014-06-17 | University Of Washington Through Its Center For Commercialization | MIC-binding antibodies and methods of use thereof |
| WO2012170470A1 (en) | 2011-06-06 | 2012-12-13 | Board Of Regents Of The University Of Nebraska | Compositions and methods for detection and treatment of cancer |
| CN103747803B (zh) | 2011-06-22 | 2016-10-12 | 国家医疗保健研究所 | 抗axl抗体及其用途 |
| AU2012335205A1 (en) | 2011-11-11 | 2014-05-29 | Rinat Neuroscience Corp. | Antibodies specific for Trop-2 and their uses |
| KR101535341B1 (ko) | 2012-07-02 | 2015-07-13 | 한화케미칼 주식회사 | Dll4에 특이적으로 결합하는 신규한 단일클론항체 및 이의 용도 |
| CA2876285A1 (en) | 2012-08-08 | 2014-02-13 | Roche Glycart Ag | Interleukin-10 fusion proteins and uses thereof |
| US20150218280A1 (en) | 2012-08-10 | 2015-08-06 | University Of Southern California | CD20 scFv-ELPs METHODS AND THERAPEUTICS |
| WO2014033130A1 (en) | 2012-08-28 | 2014-03-06 | Institut Curie | Cluster of differentiation 36 (cd36) as a therapeutic target for hiv infection |
| HUE033369T2 (en) | 2012-11-20 | 2017-11-28 | Sanofi Sa | Anti-ceacam5 antibodies and uses thereof |
| WO2014095808A1 (en) | 2012-12-17 | 2014-06-26 | Delenex Therapeutics Ag | Antibodies against il-1 beta |
| TW201446794A (zh) | 2013-02-20 | 2014-12-16 | Novartis Ag | 利用抗-cd123嵌合抗原受體工程化t細胞之初級人類白血病有效靶向 |
| WO2014159531A1 (en) | 2013-03-14 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Monoclonal antibodies targeting epcam for detection of prostate cancer lymph node metastases |
| AU2014268364A1 (en) | 2013-05-24 | 2015-12-10 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| KR102127408B1 (ko) | 2014-01-29 | 2020-06-29 | 삼성전자주식회사 | 항 Her3 scFv 단편 및 이를 포함하는 항 c-Met/항 Her3 이중 특이 항체 |
| EP3099717B1 (en) | 2014-01-31 | 2019-03-27 | Novartis AG | Antibody molecules to tim-3 and uses thereof |
| FR3021970B1 (fr) | 2014-06-06 | 2018-01-26 | Universite Sciences Technologies Lille | Anticorps dirige contre la galectine 9 et inhibiteur de l'activite suppressive des lymphocytes t regulateurs |
| AU2015305754B2 (en) | 2014-08-19 | 2018-10-25 | Merck Sharp & Dohme Llc | Anti-tigit antibodies |
| JP7211703B2 (ja) | 2014-12-22 | 2023-01-24 | ザ ロックフェラー ユニバーシティー | 抗mertkアゴニスト抗体及びその使用 |
| US10744157B2 (en) | 2015-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | Anti-MICA antigen binding fragments, fusion molecules, cells which express and methods of using |
| KR20170138494A (ko) | 2015-04-17 | 2017-12-15 | 엘살리스 비오떼끄 | 항-tyr03 항체 및 이의 용도 |
| KR20240025721A (ko) * | 2015-06-15 | 2024-02-27 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 노화와 연관된 질환을 치료하기 위한 방법 및 조성물 |
| PT3328894T (pt) | 2015-08-06 | 2019-02-13 | Agency Science Tech & Res | Anticorpos de cadeia comum gama/il2rbeta |
| CA2994858C (en) | 2015-09-25 | 2024-01-23 | Genentech, Inc. | Anti-tigit antibodies and methods of use |
| CN108367071B (zh) | 2015-11-13 | 2022-05-13 | 达纳-法伯癌症研究所有限公司 | 用于癌症免疫疗法的nkg2d-ig融合蛋白 |
| MX2018010445A (es) | 2016-03-01 | 2019-10-17 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Anticuerpos especificos del receptor de poliovirus humano (rvp). |
| WO2017189526A1 (en) | 2016-04-25 | 2017-11-02 | Musc Foundation For Research Development | Activated cd26-high immune cells and cd26-negative immune cells and uses thereof |
| MX2019007981A (es) * | 2017-01-03 | 2019-10-15 | Bioatla Llc | Terapeutica de proteinas para el tratamiento de celulas senescentes. |
| GB201708456D0 (en) * | 2017-05-26 | 2017-07-12 | Medical Res Council | Senolytic compounds |
| EP3676289B1 (en) * | 2017-08-28 | 2026-03-04 | Altor BioScience, LLC | Il-15-based fusions to il-7 and il-21 |
| IL312612A (en) * | 2018-07-11 | 2024-07-01 | Rubedo Life Sciences Inc | Senolytic compositions and uses thereof |
| US11401324B2 (en) * | 2018-08-30 | 2022-08-02 | HCW Biologics, Inc. | Single-chain chimeric polypeptides and uses thereof |
| US11518792B2 (en) * | 2018-08-30 | 2022-12-06 | HCW Biologics, Inc. | Multi-chain chimeric polypeptides and uses thereof |
| CA3109361A1 (en) * | 2018-08-30 | 2020-03-05 | HCW Biologics, Inc. | Single-chain and multi-chain chimeric polypeptides and uses thereof |
-
2021
- 2021-06-01 JP JP2022573633A patent/JP2023527869A/ja active Pending
- 2021-06-01 IL IL298608A patent/IL298608A/en unknown
- 2021-06-01 CA CA3184756A patent/CA3184756A1/en active Pending
- 2021-06-01 KR KR1020237000057A patent/KR20230031280A/ko active Pending
- 2021-06-01 EP EP21733685.8A patent/EP4157460A1/en active Pending
- 2021-06-01 WO PCT/US2021/035285 patent/WO2021247604A1/en not_active Ceased
- 2021-06-01 AU AU2021283199A patent/AU2021283199B2/en active Active
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