JPWO2021173773A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021173773A5 JPWO2021173773A5 JP2022576332A JP2022576332A JPWO2021173773A5 JP WO2021173773 A5 JPWO2021173773 A5 JP WO2021173773A5 JP 2022576332 A JP2022576332 A JP 2022576332A JP 2022576332 A JP2022576332 A JP 2022576332A JP WO2021173773 A5 JPWO2021173773 A5 JP WO2021173773A5
- Authority
- JP
- Japan
- Prior art keywords
- ala
- och
- val
- independently
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025227067A JP2026041873A (ja) | 2020-02-25 | 2025-12-03 | カンプトテシン誘導体およびそのコンジュゲート |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062981197P | 2020-02-25 | 2020-02-25 | |
| US62/981,197 | 2020-02-25 | ||
| PCT/US2021/019565 WO2021173773A1 (en) | 2020-02-25 | 2021-02-25 | Camptothecin derivatives and conjugates thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025227067A Division JP2026041873A (ja) | 2020-02-25 | 2025-12-03 | カンプトテシン誘導体およびそのコンジュゲート |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023520605A JP2023520605A (ja) | 2023-05-17 |
| JPWO2021173773A5 true JPWO2021173773A5 (https=) | 2024-03-05 |
| JP2023520605A5 JP2023520605A5 (https=) | 2024-03-05 |
Family
ID=74947598
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022576332A Pending JP2023520605A (ja) | 2020-02-25 | 2021-02-25 | カンプトテシン誘導体およびそのコンジュゲート |
| JP2025227067A Pending JP2026041873A (ja) | 2020-02-25 | 2025-12-03 | カンプトテシン誘導体およびそのコンジュゲート |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025227067A Pending JP2026041873A (ja) | 2020-02-25 | 2025-12-03 | カンプトテシン誘導体およびそのコンジュゲート |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US12029736B2 (https=) |
| EP (1) | EP4110402A1 (https=) |
| JP (2) | JP2023520605A (https=) |
| KR (1) | KR20230004453A (https=) |
| CN (1) | CN115551552A (https=) |
| AU (1) | AU2021226341A1 (https=) |
| BR (1) | BR112022017064A2 (https=) |
| CA (1) | CA3168882A1 (https=) |
| MX (1) | MX2022010457A (https=) |
| TW (1) | TW202146055A (https=) |
| WO (1) | WO2021173773A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2022010457A (es) | 2020-02-25 | 2022-11-16 | Mediboston Ltd | Derivados de camptotecina y conjugados de esta. |
| US12521444B2 (en) * | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
| CN116212044A (zh) * | 2021-12-03 | 2023-06-06 | 成都百利多特生物药业有限责任公司 | 抗人Trop2抗体-喜树碱类药物偶联物及其医药用途 |
| AU2023307126A1 (en) * | 2022-07-14 | 2025-02-13 | Medilink Therapeutics (Suzhou) Co., Ltd. | Antibody-drug conjugate, and preparation method therefor and use thereof |
| JP2025524986A (ja) | 2022-07-27 | 2025-08-01 | メディボストン リミテッド | オーリスタチン誘導体およびそのコンジュゲート |
| PE20252282A1 (es) | 2022-10-09 | 2025-09-18 | Lanova Medicines Ltd | Compuestos, composiciones y metodos |
| EP4623936A1 (en) * | 2022-11-22 | 2025-10-01 | Keymed Biosciences (Chengdu) Co., Ltd. | Fused ring compound, conjugate thereof and use thereof |
| WO2024130161A2 (en) * | 2022-12-16 | 2024-06-20 | Bionecure Therapeutics Inc | Novel camptothecin derivatives and conjugates thereof |
| CN119630672B (zh) * | 2023-02-23 | 2026-01-30 | 一线医药（杭州）有限公司 | 喜树碱衍生物及其偶联物以及其制备方法和医药用途 |
| WO2025067306A1 (zh) * | 2023-09-26 | 2025-04-03 | 信达生物制药(苏州)有限公司 | 靶向her3的抗体-药物偶联物 |
| WO2025067446A1 (zh) * | 2023-09-28 | 2025-04-03 | 信达生物制药(苏州)有限公司 | 靶向trop2的抗体-药物偶联物及其制备方法与应用 |
| WO2025103355A1 (zh) * | 2023-11-14 | 2025-05-22 | 信达生物制药(苏州)有限公司 | 抗egfr和her3双特异性抗体-药物偶联物及其用途 |
| WO2025131063A1 (en) * | 2023-12-22 | 2025-06-26 | Fortvita Biologics Inc. | Antibody drug conjugates targeting b7-h3 and trop2 and the use thereof |
| WO2025131054A1 (en) * | 2023-12-22 | 2025-06-26 | Innovent Biologics (Suzhou) Co., Ltd. | Antibody drug conjugates targeting to b7-h3 and egfr and the use thereof |
| WO2025153054A1 (en) * | 2024-01-18 | 2025-07-24 | Nona Biosciences (Suzhou) Co., Ltd. | Camptothecin analogues, conjugates and methods of use |
| WO2025195402A1 (zh) * | 2024-03-20 | 2025-09-25 | 福佑泰生物制药公司 | 靶向trop2的抗体-药物偶联物治疗癌症的方法 |
| WO2025228298A1 (zh) * | 2024-04-28 | 2025-11-06 | 福佑泰生物制药公司 | 靶向TROP2xPD-L1的双特异性抗体药物偶联物及其制备方法与应用 |
| WO2025235686A1 (en) * | 2024-05-07 | 2025-11-13 | Aarvik Therapeutics, Inc. | Fluorocamptothecin compounds, conjugates, and methods thereof |
| WO2026016639A1 (zh) * | 2024-07-19 | 2026-01-22 | 昆山新蕴达生物科技有限公司 | 一种靶向adam-9的抗体-药物偶联物及其制备方法和用途 |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| GB2036891B (en) | 1978-12-05 | 1983-05-05 | Windsor Smith C | Change speed gear |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| JPS63501765A (ja) | 1985-11-01 | 1988-07-21 | インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド | 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途 |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5049668A (en) | 1989-09-15 | 1991-09-17 | Research Triangle Institute | 10,11-methylenedioxy-20(RS)-camptothecin analogs |
| US5004758A (en) * | 1987-12-01 | 1991-04-02 | Smithkline Beecham Corporation | Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells |
| JPH0615547B2 (ja) | 1988-01-20 | 1994-03-02 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| WO1991004260A2 (en) * | 1989-09-15 | 1991-04-04 | Research Triangle Institute | 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| SG46445A1 (en) | 1990-01-26 | 1998-02-20 | Immunomedics Inc | Vaccines against cancer and infectious diseases |
| JP2684104B2 (ja) | 1990-02-09 | 1997-12-03 | 株式会社ヤクルト本社 | 新規なカンプトテシン誘導体 |
| SK283693B6 (sk) | 1990-09-28 | 2003-12-02 | Smithkline Beecham Corporation | Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli |
| US5162532A (en) | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5658920A (en) | 1991-01-16 | 1997-08-19 | Daiichi Pharmaceutical Co., Ltd. | Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound |
| AU2394392A (en) | 1991-12-10 | 1993-07-19 | Smithkline Beecham Corporation | Treatment of colorectal cancer |
| ES2149768T3 (es) | 1992-03-25 | 2000-11-16 | Immunogen Inc | Conjugados de agentes enlazantes de celulas derivados de cc-1065. |
| CA2192725C (en) | 1995-12-28 | 2004-04-20 | Kenji Tsujihara | Camptothecin derivatives |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| ES2276708T3 (es) | 1999-11-24 | 2007-07-01 | Immunogen, Inc. | Agentes citotoxicos que comprenden taxanos y su uso terapeutico. |
| US6403604B1 (en) | 2001-03-01 | 2002-06-11 | California Pacific Medical Center | Nitrogen-based camptothecin derivatives |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6716821B2 (en) | 2001-12-21 | 2004-04-06 | Immunogen Inc. | Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same |
| US6756397B2 (en) | 2002-04-05 | 2004-06-29 | Immunogen, Inc. | Prodrugs of CC-1065 analogs |
| CN100522955C (zh) | 2002-08-02 | 2009-08-05 | 伊缪诺金公司 | 含有新型强效紫杉烷的细胞毒性剂及其治疗用途 |
| JP2006500364A (ja) | 2002-08-16 | 2006-01-05 | イムノージェン インコーポレーテッド | 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用 |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| US7276497B2 (en) | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| CN100406460C (zh) | 2003-11-10 | 2008-07-30 | 中国科学院上海药物研究所 | 喜树碱的新衍生物、制备方法和用途 |
| KR20120064120A (ko) * | 2004-06-01 | 2012-06-18 | 제넨테크, 인크. | 항체 약물 접합체 및 방법 |
| CN100354279C (zh) * | 2004-06-04 | 2007-12-12 | 中国科学院上海药物研究所 | 喜树碱的新型结构衍生物、制备方法和用途 |
| EP1817341A2 (en) | 2004-11-29 | 2007-08-15 | Seattle Genetics, Inc. | Engineered antibodies and immunoconjugates |
| WO2007095389A2 (en) | 2006-02-17 | 2007-08-23 | Novacea, Inc. | Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs |
| KR20200058590A (ko) | 2008-04-30 | 2020-05-27 | 이뮤노젠 아이엔씨 | 가교제 및 그 용도 |
| EP2276506A4 (en) | 2008-04-30 | 2014-05-07 | Immunogen Inc | EFFICIENT CONJUGATES AND HYDROPHILIC BINDER |
| CN102725739A (zh) | 2009-05-18 | 2012-10-10 | 西山修平 | 虚拟单一存储装置上的元信息共享型分布式数据库系统 |
| ES2371171B1 (es) | 2010-06-08 | 2012-11-16 | Consejo Superior De Investigaciones Científicas (Csic) | Derivados de camptotecina como agentes antitumorales. |
| ES2373172B1 (es) | 2010-07-16 | 2012-12-10 | Consejo Superior De Investigaciones Científicas (Csic) | Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales. |
| CN102477042A (zh) | 2010-11-26 | 2012-05-30 | 复旦大学 | 10-羟基喜树碱衍生物及其制备方法和用途 |
| US9511150B2 (en) | 2011-07-19 | 2016-12-06 | CellMosaic, Inc. | Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof |
| DK2907824T3 (en) | 2012-10-11 | 2018-07-23 | Daiichi Sankyo Co Ltd | ANTIBODY-drug conjugate |
| CN103289461B (zh) | 2013-07-01 | 2016-05-04 | 厦门大学 | 喜树碱及其衍生物作为防污剂的应用 |
| JP6612738B2 (ja) | 2014-04-10 | 2019-11-27 | 第一三共株式会社 | 抗ｈｅｒ２抗体−薬物コンジュゲート |
| KR102399277B1 (ko) | 2014-04-10 | 2022-05-18 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
| SG10201912173RA (en) | 2016-10-07 | 2020-02-27 | Daiichi Sankyo Co Ltd | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
| CN109106951A (zh) | 2017-08-18 | 2019-01-01 | 四川百利药业有限责任公司 | 一种喜树碱-抗体偶联物 |
| US20210163964A1 (en) | 2018-04-06 | 2021-06-03 | University Of Florida Research Foundation, Incorporated | Engineered streptomyces albus strains |
| CA3094313A1 (en) * | 2018-04-06 | 2019-10-10 | Seattle Genetics, Inc. | Camptothecin peptide conjugates |
| CN109467563B (zh) | 2018-06-08 | 2021-08-03 | 浙江大学 | 一种喜树碱衍生物及其在制备抗炎症药物中的应用 |
| JP7561141B2 (ja) | 2019-04-26 | 2024-10-03 | イミュノジェン・インコーポレーテッド | カンプトテシン誘導体 |
| MX2022010457A (es) | 2020-02-25 | 2022-11-16 | Mediboston Ltd | Derivados de camptotecina y conjugados de esta. |
| IL299001A (en) | 2020-06-19 | 2023-02-01 | Hangzhou Dac Biotech Co Ltd | Pairings of a cell-binding molecule with camptocin analogs |
| US12521444B2 (en) | 2021-02-25 | 2026-01-13 | Fortvita Biologics Limited | Anti-HER2 antibody-drug conjugates and uses thereof |
-
2021
- 2021-02-25 MX MX2022010457A patent/MX2022010457A/es unknown
- 2021-02-25 US US17/185,012 patent/US12029736B2/en active Active
- 2021-02-25 CA CA3168882A patent/CA3168882A1/en active Pending
- 2021-02-25 TW TW110106742A patent/TW202146055A/zh unknown
- 2021-02-25 AU AU2021226341A patent/AU2021226341A1/en active Pending
- 2021-02-25 KR KR1020227032654A patent/KR20230004453A/ko active Pending
- 2021-02-25 BR BR112022017064A patent/BR112022017064A2/pt not_active Application Discontinuation
- 2021-02-25 CN CN202180020323.5A patent/CN115551552A/zh active Pending
- 2021-02-25 EP EP21712923.8A patent/EP4110402A1/en active Pending
- 2021-02-25 JP JP2022576332A patent/JP2023520605A/ja active Pending
- 2021-02-25 WO PCT/US2021/019565 patent/WO2021173773A1/en not_active Ceased
-
2024
- 2024-05-08 US US18/658,190 patent/US20250000996A1/en active Pending
-
2025
- 2025-12-03 JP JP2025227067A patent/JP2026041873A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2021173773A5 (https=) | ||
| JP3878208B2 (ja) | 芳香族アミド化合物およびそれらのキレート | |
| WO2023131219A1 (en) | Conjugates, compositions and methods of use | |
| JP2020514419A5 (https=) | ||
| JP2021513844A5 (https=) | ||
| JP2020504112A5 (https=) | ||
| RU2003132534A (ru) | Ингибиторы ингибирующего фактора миграции макрофага и способы их идентифицирования | |
| JP2020520926A5 (https=) | ||
| EP2400992A1 (en) | Methods and compositions for protein labelling | |
| JPWO2020252294A5 (https=) | ||
| JP7370520B2 (ja) | 放射性医薬 | |
| JP2020532562A (ja) | 生物学的製剤の粘度を低下させるための化合物 | |
| JPWO2019213005A5 (https=) | ||
| WO2024020536A1 (en) | Hexacyclic topoisomerase inhibitors having cytotoxic activity on cancer cells | |
| WO2024140845A1 (zh) | 一种多臂聚乙二醇-药物偶联物 | |
| EP0087957B1 (en) | Neocarzinostatin complexes, a method for producing the same, and an antitumor agent containing said complexes as an active component | |
| AU2019350536B2 (en) | Sulfomaleimide-based linkers and corresponding conjugates | |
| JPWO2019213445A5 (https=) | ||
| KR100264014B1 (ko) | 백금(iv) 착화합물 및 이를 함유하는 의약 | |
| JP2003506330A (ja) | 放射能標識化ビスホスホネートおよび方法 | |
| JPWO2021081407A5 (https=) | ||
| JPWO2022180581A5 (https=) | ||
| WO1997003993A9 (en) | Process for producing tungsten clusters | |
| JPWO2021190583A5 (https=) | ||
| JP5027144B2 (ja) | 放射性画像診断のための窒化テクネチウム錯体の中間体化合物 |