JPWO2022180581A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2022180581A5
JPWO2022180581A5 JP2023551711A JP2023551711A JPWO2022180581A5 JP WO2022180581 A5 JPWO2022180581 A5 JP WO2022180581A5 JP 2023551711 A JP2023551711 A JP 2023551711A JP 2023551711 A JP2023551711 A JP 2023551711A JP WO2022180581 A5 JPWO2022180581 A5 JP WO2022180581A5
Authority
JP
Japan
Prior art keywords
ala
val
cancer
gly
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023551711A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024509099A (ja
JP2024509099A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2022/051660 external-priority patent/WO2022180581A2/en
Publication of JP2024509099A publication Critical patent/JP2024509099A/ja
Publication of JPWO2022180581A5 publication Critical patent/JPWO2022180581A5/ja
Publication of JP2024509099A5 publication Critical patent/JP2024509099A5/ja
Pending legal-status Critical Current

Links

JP2023551711A 2021-02-25 2022-02-25 抗her2抗体‐薬物コンジュゲートおよびその使用 Pending JP2024509099A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163153530P 2021-02-25 2021-02-25
US63/153,530 2021-02-25
PCT/IB2022/051660 WO2022180581A2 (en) 2021-02-25 2022-02-25 Anti-her2 antibody-drug conjugates and uses thereof

Publications (3)

Publication Number Publication Date
JP2024509099A JP2024509099A (ja) 2024-02-29
JPWO2022180581A5 true JPWO2022180581A5 (https=) 2025-02-06
JP2024509099A5 JP2024509099A5 (https=) 2025-02-06

Family

ID=80928968

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023551711A Pending JP2024509099A (ja) 2021-02-25 2022-02-25 抗her2抗体‐薬物コンジュゲートおよびその使用

Country Status (9)

Country Link
US (1) US12521444B2 (https=)
EP (1) EP4297797A2 (https=)
JP (1) JP2024509099A (https=)
KR (1) KR20230154892A (https=)
CN (1) CN117320757A (https=)
AU (1) AU2022228004A1 (https=)
CA (1) CA3208591A1 (https=)
TW (1) TW202302643A (https=)
WO (1) WO2022180581A2 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022010457A (es) 2020-02-25 2022-11-16 Mediboston Ltd Derivados de camptotecina y conjugados de esta.
EP4623936A1 (en) * 2022-11-22 2025-10-01 Keymed Biosciences (Chengdu) Co., Ltd. Fused ring compound, conjugate thereof and use thereof
EP4642490A1 (en) * 2022-12-29 2025-11-05 Beone Medicines I GmbH B7h3 antibody drug conjugates
AU2024253122A1 (en) * 2023-04-07 2025-10-23 Innovent Biologics (Suzhou) Co., Ltd. Antibody-drug conjugates of camptothecin derivatives and uses thereof
WO2025067306A1 (zh) * 2023-09-26 2025-04-03 信达生物制药(苏州)有限公司 靶向her3的抗体-药物偶联物
WO2025067446A1 (zh) * 2023-09-28 2025-04-03 信达生物制药(苏州)有限公司 靶向trop2的抗体-药物偶联物及其制备方法与应用
WO2025131054A1 (en) * 2023-12-22 2025-06-26 Innovent Biologics (Suzhou) Co., Ltd. Antibody drug conjugates targeting to b7-h3 and egfr and the use thereof
WO2025153054A1 (en) * 2024-01-18 2025-07-24 Nona Biosciences (Suzhou) Co., Ltd. Camptothecin analogues, conjugates and methods of use
WO2025195402A1 (zh) * 2024-03-20 2025-09-25 福佑泰生物制药公司 靶向trop2的抗体-药物偶联物治疗癌症的方法

Family Cites Families (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166452A (en) 1976-05-03 1979-09-04 Generales Constantine D J Jr Apparatus for testing human responses to stimuli
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPS6019790A (ja) 1983-07-14 1985-01-31 Yakult Honsha Co Ltd 新規なカンプトテシン誘導体
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
JPS63501765A (ja) 1985-11-01 1988-07-21 インタ−ナショナル、ジェネティック、エンジニアリング インコ−ポレ−テッド 抗体遺伝子のモジュ−ル組立体、それにより産生された抗体及び用途
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5049668A (en) 1989-09-15 1991-09-17 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin analogs
US5004758A (en) 1987-12-01 1991-04-02 Smithkline Beecham Corporation Water soluble camptothecin analogs useful for inhibiting the growth of animal tumor cells
JPH0615547B2 (ja) 1988-01-20 1994-03-02 株式会社ヤクルト本社 新規なカンプトテシン誘導体
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
WO1991004260A2 (en) 1989-09-15 1991-04-04 Research Triangle Institute 10,11-methylenedioxy-20(rs)-camptothecin and 10,11-methylenedioxy-20(s)-camptothecin analogs
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
SG46445A1 (en) 1990-01-26 1998-02-20 Immunomedics Inc Vaccines against cancer and infectious diseases
JP2684104B2 (ja) 1990-02-09 1997-12-03 株式会社ヤクルト本社 新規なカンプトテシン誘導体
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
SK283693B6 (sk) 1990-09-28 2003-12-02 Smithkline Beecham Corporation Spôsob prípravy kamptotecínu alebo jeho farmaceuticky prijateľnej soli
US5162532A (en) 1990-12-20 1992-11-10 North Carolina State University Intermediates and method of making camptothecin and camptothecin analogs
US5658920A (en) 1991-01-16 1997-08-19 Daiichi Pharmaceutical Co., Ltd. Substituted 1H,12H-benz-[DE]pyrano[3',4':6,7] indolizino[1,2-B]quinoline-10,13(9H,15H)-dione compound
EP1400536A1 (en) 1991-06-14 2004-03-24 Genentech Inc. Method for making humanized antibodies
AU665025B2 (en) 1991-09-23 1995-12-14 Cambridge Antibody Technology Limited Production of chimeric antibodies - a combinatorial approach
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
AU2394392A (en) 1991-12-10 1993-07-19 Smithkline Beecham Corporation Treatment of colorectal cancer
DE69333823T2 (de) 1992-03-24 2006-05-04 Cambridge Antibody Technology Ltd., Melbourn Verfahren zur herstellung von gliedern von spezifischen bindungspaaren
ES2149768T3 (es) 1992-03-25 2000-11-16 Immunogen Inc Conjugados de agentes enlazantes de celulas derivados de cc-1065.
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
EP0731842A1 (en) 1993-12-03 1996-09-18 Medical Research Council Recombinant binding proteins and peptides
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
JP4046354B2 (ja) 1996-03-18 2008-02-13 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム 増大した半減期を有する免疫グロブリン様ドメイン
ES2434961T5 (es) 1998-04-20 2018-01-18 Roche Glycart Ag Ingeniería de glicosilación de anticuerpos para mejorar la citotoxicidad celular dependiente del anticuerpo
EP1176195B1 (en) 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
ES2276708T3 (es) 1999-11-24 2007-07-01 Immunogen, Inc. Agentes citotoxicos que comprenden taxanos y su uso terapeutico.
ES2639222T5 (es) 2000-10-06 2023-11-24 Kyowa Kirin Co Ltd Células que producen unas composiciones de anticuerpo
US6855720B2 (en) 2001-03-01 2005-02-15 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6403604B1 (en) 2001-03-01 2002-06-11 California Pacific Medical Center Nitrogen-based camptothecin derivatives
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US6756397B2 (en) 2002-04-05 2004-06-29 Immunogen, Inc. Prodrugs of CC-1065 analogs
CN100522955C (zh) 2002-08-02 2009-08-05 伊缪诺金公司 含有新型强效紫杉烷的细胞毒性剂及其治疗用途
JP2006500364A (ja) 2002-08-16 2006-01-05 イムノージェン インコーポレーテッド 高い反応性と溶解度を有する架橋剤および小分子薬物の標的化送達用コンジュゲートの調製におけるそれらの使用
US8088387B2 (en) 2003-10-10 2012-01-03 Immunogen Inc. Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
US7276497B2 (en) 2003-05-20 2007-10-02 Immunogen Inc. Cytotoxic agents comprising new maytansinoids
CN100406460C (zh) 2003-11-10 2008-07-30 中国科学院上海药物研究所 喜树碱的新衍生物、制备方法和用途
KR20120064120A (ko) 2004-06-01 2012-06-18 제넨테크, 인크. 항체 약물 접합체 및 방법
CN100354279C (zh) 2004-06-04 2007-12-12 中国科学院上海药物研究所 喜树碱的新型结构衍生物、制备方法和用途
EP1817341A2 (en) 2004-11-29 2007-08-15 Seattle Genetics, Inc. Engineered antibodies and immunoconjugates
WO2007095389A2 (en) 2006-02-17 2007-08-23 Novacea, Inc. Treatment of hyperproliferative diseases with camptothecine n-oxide and analogs
KR20200058590A (ko) 2008-04-30 2020-05-27 이뮤노젠 아이엔씨 가교제 및 그 용도
EP2276506A4 (en) 2008-04-30 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
WO2011150386A1 (en) 2010-05-28 2011-12-01 Qualcomm Incorporated Dataset creation for tracking targets with dynamically changing portions
ES2371171B1 (es) 2010-06-08 2012-11-16 Consejo Superior De Investigaciones Científicas (Csic) Derivados de camptotecina como agentes antitumorales.
ES2373172B1 (es) 2010-07-16 2012-12-10 Consejo Superior De Investigaciones Científicas (Csic) Proceso de obtención de derivados solubles en agua de 20 (s) camptotecina como agentes antitumorales.
CN102477042A (zh) 2010-11-26 2012-05-30 复旦大学 10-羟基喜树碱衍生物及其制备方法和用途
US9511150B2 (en) * 2011-07-19 2016-12-06 CellMosaic, Inc. Crosslinking reagents, macromolecules, therapeutic bioconjugates, and synthetic methods thereof
DK2907824T3 (en) 2012-10-11 2018-07-23 Daiichi Sankyo Co Ltd ANTIBODY-drug conjugate
CN103289461B (zh) 2013-07-01 2016-05-04 厦门大学 喜树碱及其衍生物作为防污剂的应用
KR102399277B1 (ko) 2014-04-10 2022-05-18 다이이찌 산쿄 가부시키가이샤 항her3 항체-약물 콘주게이트
JP6612738B2 (ja) * 2014-04-10 2019-11-27 第一三共株式会社 抗her2抗体−薬物コンジュゲート
AU2016214964A1 (en) 2015-02-06 2017-09-07 University Of Technology Sydney Devices, frameworks and methodologies configured to enable automated monitoring and analysis of dwell time
SG10201912173RA (en) * 2016-10-07 2020-02-27 Daiichi Sankyo Co Ltd Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate
CN109106951A (zh) 2017-08-18 2019-01-01 四川百利药业有限责任公司 一种喜树碱-抗体偶联物
US20210163964A1 (en) 2018-04-06 2021-06-03 University Of Florida Research Foundation, Incorporated Engineered streptomyces albus strains
CA3094313A1 (en) 2018-04-06 2019-10-10 Seattle Genetics, Inc. Camptothecin peptide conjugates
TWI851577B (zh) 2018-06-07 2024-08-11 美商思進公司 喜樹鹼結合物
CN109467563B (zh) 2018-06-08 2021-08-03 浙江大学 一种喜树碱衍生物及其在制备抗炎症药物中的应用
JP7561141B2 (ja) * 2019-04-26 2024-10-03 イミュノジェン・インコーポレーテッド カンプトテシン誘導体
MX2022010457A (es) 2020-02-25 2022-11-16 Mediboston Ltd Derivados de camptotecina y conjugados de esta.
IL299001A (en) * 2020-06-19 2023-02-01 Hangzhou Dac Biotech Co Ltd Pairings of a cell-binding molecule with camptocin analogs

Similar Documents

Publication Publication Date Title
JP7644173B2 (ja) 単一分子量ポリサルコシンを含むリガンド-薬物-複合体
JP2019533475A5 (https=)
CN112839683B (zh) 含有标记部-抗人抗体Fab片段复合物的药物组合物
JP2020506971A5 (https=)
JP2010539981A5 (https=)
TW202302643A (zh) 抗her2抗體-藥物結合物及其用途
JPWO2020135201A5 (https=)
JPWO2022180581A5 (https=)
JP2017095457A5 (https=)
JPWO2019195665A5 (https=)
JPWO2021177438A5 (https=)
IL291545B1 (en) Anti-CTLA4 antibodies, antibody fragments, immunoconjugates thereof and uses thereof
JP2020517239A5 (https=)
JPWO2020027100A5 (https=)
JP2024020436A5 (https=)
JPWO2022087243A5 (https=)
CN119325483A (zh) 具有位点特异性修饰的抗体的制备方法
JPWO2022040596A5 (https=)
JPWO2023083381A5 (https=)
JPWO2023143263A5 (https=)
JP7760124B2 (ja) フタロシアニン染料と抗体又はペプチドとのコンジュゲート
JPWO2023051683A5 (https=)
JPWO2023051621A5 (https=)
RU2011108579A (ru) Антитело против удлиненного гликосфинголипида i типа, его производные и применение
JPWO2021139776A5 (https=)