JPWO2021152147A5 - - Google Patents
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- Publication number
- JPWO2021152147A5 JPWO2021152147A5 JP2022545423A JP2022545423A JPWO2021152147A5 JP WO2021152147 A5 JPWO2021152147 A5 JP WO2021152147A5 JP 2022545423 A JP2022545423 A JP 2022545423A JP 2022545423 A JP2022545423 A JP 2022545423A JP WO2021152147 A5 JPWO2021152147 A5 JP WO2021152147A5
- Authority
- JP
- Japan
- Prior art keywords
- cldna
- dna
- nucleotides
- nucleotide
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003729 nucleotide group Chemical group 0.000 claims 22
- 108020004414 DNA Proteins 0.000 claims 17
- 239000002773 nucleotide Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 5
- 102000053602 DNA Human genes 0.000 claims 3
- 102000016559 DNA Primase Human genes 0.000 claims 3
- 108010092681 DNA Primase Proteins 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 239000013603 viral vector Substances 0.000 claims 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 230000002068 genetic effect Effects 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 229920002851 polycationic polymer Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- NOLHIMIFXOBLFF-KVQBGUIXSA-N (2r,3s,5r)-5-(2,6-diaminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol Chemical compound C12=NC(N)=NC(N)=C2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 NOLHIMIFXOBLFF-KVQBGUIXSA-N 0.000 claims 1
- LUCHPKXVUGJYGU-XLPZGREQSA-N 5-methyl-2'-deoxycytidine Chemical compound O=C1N=C(N)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 LUCHPKXVUGJYGU-XLPZGREQSA-N 0.000 claims 1
- MIWVMNJJKIWXAS-KVQBGUIXSA-N 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-iminopurin-8-one Chemical class C1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(=N)C2=NC1=O MIWVMNJJKIWXAS-KVQBGUIXSA-N 0.000 claims 1
- 108020005031 Concatenated DNA Proteins 0.000 claims 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical class O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 1
- 108091081062 Repeated sequence (DNA) Proteins 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 108091008146 restriction endonucleases Proteins 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025137441A JP2025186257A (ja) | 2020-01-31 | 2025-08-21 | 修飾ヌクレオチドを用いた閉じた直鎖ｄｎａ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20382063 | 2020-01-31 | ||
| EP20382063.4 | 2020-01-31 | ||
| PCT/EP2021/052204 WO2021152147A1 (en) | 2020-01-31 | 2021-01-29 | Closed linear dna with modified nucleotides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025137441A Division JP2025186257A (ja) | 2020-01-31 | 2025-08-21 | 修飾ヌクレオチドを用いた閉じた直鎖ｄｎａ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023511992A JP2023511992A (ja) | 2023-03-23 |
| JP2023511992A5 JP2023511992A5 (https=) | 2024-02-05 |
| JPWO2021152147A5 true JPWO2021152147A5 (https=) | 2024-02-05 |
Family
ID=69713977
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022545423A Pending JP2023511992A (ja) | 2020-01-31 | 2021-01-29 | 修飾ヌクレオチドを用いた閉じた直鎖ｄｎａ |
| JP2025137441A Pending JP2025186257A (ja) | 2020-01-31 | 2025-08-21 | 修飾ヌクレオチドを用いた閉じた直鎖ｄｎａ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025137441A Pending JP2025186257A (ja) | 2020-01-31 | 2025-08-21 | 修飾ヌクレオチドを用いた閉じた直鎖ｄｎａ |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20230323343A1 (https=) |
| EP (1) | EP4097253A1 (https=) |
| JP (2) | JP2023511992A (https=) |
| KR (1) | KR20220133999A (https=) |
| CN (1) | CN115003829A (https=) |
| AU (1) | AU2021213927A1 (https=) |
| CA (1) | CA3164390A1 (https=) |
| WO (1) | WO2021152147A1 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4083227A1 (en) * | 2021-04-29 | 2022-11-02 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases |
| EP4124660A1 (en) * | 2021-07-30 | 2023-02-01 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| EP4388118A4 (en) * | 2021-08-19 | 2025-05-21 | Twist Bioscience Corporation | METHODS AND COMPOSITIONS IN COMPOSITION WITH COVALENTLY CLOSED NUCLEIC ACIDS |
| CN114075595B (zh) * | 2021-11-22 | 2023-11-17 | 上海交通大学 | 甲基化检测组合物、试剂盒及方法 |
| JP2025507359A (ja) * | 2022-02-10 | 2025-03-18 | コード バイオセラピューティクス インコーポレイテッド | 増強されたｄｎａデンドリマー及びその使用方法 |
| JP2025516638A (ja) * | 2022-05-13 | 2025-05-30 | フラッグシップ パイオニアリング イノベーションズ セブン，エルエルシー | 二本鎖ｄｎａ組成物及び関連する方法 |
| CN115976138A (zh) * | 2022-06-02 | 2023-04-18 | 宜明(苏州)细胞生物科技有限公司 | 新型闭合线性双链dna的体外制备技术 |
| WO2024039652A1 (en) | 2022-08-16 | 2024-02-22 | Aldevron, L.L.C. | Cell-free method of producing synthetic circular nucleic acid |
| ES3062031T3 (https=) * | 2023-02-01 | 2026-04-08 | 4Basebio Uk Ltd | |
| EP4410995A1 (en) * | 2023-02-01 | 2024-08-07 | 4basebio, S.L.U. | Linear dna with enhanced resistance against exonucleases and methods for the production thereof |
| WO2025034978A1 (en) * | 2023-08-09 | 2025-02-13 | Code Biotherapeutics, Inc. | Enhanced dna dendrimers and methods of use thereof |
| WO2025064396A1 (en) * | 2023-09-18 | 2025-03-27 | Intellia Therapeutics, Inc. | Nuclease resistant double stranded dna product for non-viral delivery to a cell and methods of production thereof |
| WO2025096807A2 (en) * | 2023-10-31 | 2025-05-08 | Flagship Pioneering Innovations Vii, Llc | Novel therapeutic dna forms |
| WO2025202929A1 (en) * | 2024-03-29 | 2025-10-02 | Pfizer Inc. | Methods for producing nucleic acids |
| EP4663200A1 (en) * | 2024-06-10 | 2025-12-17 | CPTx GmbH | Compositions and methods |
| WO2026012450A1 (zh) * | 2024-07-11 | 2026-01-15 | 石药集团中奇制药技术（石家庄）有限公司 | 一种非病毒载体介导的大片段dna定点敲入系统 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| JP4517061B2 (ja) * | 2003-08-08 | 2010-08-04 | 独立行政法人産業技術総合研究所 | ダンベル型ｄｎａの効率的な製造方法 |
| CN1918293A (zh) * | 2004-02-20 | 2007-02-21 | 莫洛根股份公司 | 用于对人及高等动物进行治疗性和预防性免疫刺激的取代的非编码核酸分子 |
| WO2006085664A1 (ja) | 2005-02-10 | 2006-08-17 | The University Of Tokyo | ポリカチオン荷電性ポリマー及び核酸のキャリヤーとしての使用 |
| ES2359058B1 (es) | 2009-07-02 | 2012-03-27 | Consejo Superior De Investigaciones Cient�?Ficas (Csic) | Quimera de adn polimerasa del fago ph1 29. |
| GB2523187A (en) * | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
| US20170067097A1 (en) * | 2014-04-11 | 2017-03-09 | Redvault Biosciences, Lp | Systems and methods for clonal replication and amplification of nucleic acid molecules for genomic and therapeutic applications |
| GB201418159D0 (en) * | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| DK3500682T3 (da) * | 2016-08-16 | 2020-08-24 | Touchlight Ip Ltd | Fremstilling af lukket, lineært dna |
| US11473090B2 (en) * | 2017-05-16 | 2022-10-18 | Helix Nanotechnologies, Inc. | Linear covalently closed vectors and related compositions and methods thereof |
| EP3714064B8 (en) * | 2017-11-21 | 2024-10-30 | 4basebio UK Ltd | Methods and kits for amplification of double stranded dna |
-
2021
- 2021-01-29 CA CA3164390A patent/CA3164390A1/en active Pending
- 2021-01-29 US US17/796,532 patent/US20230323343A1/en active Pending
- 2021-01-29 CN CN202180011940.9A patent/CN115003829A/zh active Pending
- 2021-01-29 AU AU2021213927A patent/AU2021213927A1/en active Pending
- 2021-01-29 WO PCT/EP2021/052204 patent/WO2021152147A1/en not_active Ceased
- 2021-01-29 EP EP21703640.9A patent/EP4097253A1/en active Pending
- 2021-01-29 KR KR1020227030065A patent/KR20220133999A/ko active Pending
- 2021-01-29 JP JP2022545423A patent/JP2023511992A/ja active Pending
-
2025
- 2025-08-21 JP JP2025137441A patent/JP2025186257A/ja active Pending
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