|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
GB9925459D0
(en)
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
|
DE10100586C1
(de)
*
|
2001-01-09 |
2002-04-11 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines Ziegens
|
|
US7829693B2
(en)
*
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
EP1272630A2
(en)
|
2000-03-16 |
2003-01-08 |
Genetica, Inc. |
Methods and compositions for rna interference
|
|
US20030084471A1
(en)
*
|
2000-03-16 |
2003-05-01 |
David Beach |
Methods and compositions for RNA interference
|
|
US8202846B2
(en)
|
2000-03-16 |
2012-06-19 |
Cold Spring Harbor Laboratory |
Methods and compositions for RNA interference
|
|
US7767802B2
(en)
*
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
US7423142B2
(en)
*
|
2001-01-09 |
2008-09-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
US8546143B2
(en)
|
2001-01-09 |
2013-10-01 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
IL159756A0
(en)
|
2001-07-12 |
2004-06-20 |
Univ Massachusetts |
IN VIVO PRODUCTION OF SMALL INTERFERING RNAs THAT MEDIATE GENE SILENCING
|
|
EP1281767A3
(en)
|
2001-07-31 |
2003-05-28 |
Aladar A. Szalay |
Light emitting microorganisms and cells for diagnosis and therapy of tumors
|
|
US7745418B2
(en)
|
2001-10-12 |
2010-06-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting viral replication
|
|
DE10163098B4
(de)
*
|
2001-10-12 |
2005-06-02 |
Alnylam Europe Ag |
Verfahren zur Hemmung der Replikation von Viren
|
|
US20040121348A1
(en)
*
|
2001-10-26 |
2004-06-24 |
Ribopharma Ag |
Compositions and methods for treating pancreatic cancer
|
|
DE10230997A1
(de)
*
|
2001-10-26 |
2003-07-17 |
Ribopharma Ag |
Medikament zur Erhöhung der Wirksamkeit eines Rezeptor-vermittelt Apoptose in Tumorzellen auslösenden Arzneimittels
|
|
CA2468955A1
(en)
*
|
2001-11-28 |
2003-06-05 |
Toudai Tlo, Ltd. |
Sirna expression system and process for producing functional gene knockdown cell or the like using the same
|
|
GB0130955D0
(en)
*
|
2001-12-24 |
2002-02-13 |
Cancer Res Ventures |
Expression system
|
|
DE10202419A1
(de)
|
2002-01-22 |
2003-08-07 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines durch eine Chromosomen-Aberration entstandenen Zielgens
|
|
US7820632B2
(en)
|
2002-02-14 |
2010-10-26 |
City Of Hope |
Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules
|
|
US8137910B2
(en)
|
2002-05-03 |
2012-03-20 |
Duke University |
Method of regulating gene expression
|
|
WO2003095652A2
(de)
*
|
2002-05-08 |
2003-11-20 |
Xantos Biomedicine Ag |
EXPRESSIONSKONSTRUKTE ZUR HERSTELLUNG VON DOPPELSTRANG (ds) RNA UND DEREN ANWENDUNG
|
|
US20030228261A1
(en)
*
|
2002-06-05 |
2003-12-11 |
Aladar Szalay |
Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
|
|
EP1369491A1
(en)
|
2002-06-05 |
2003-12-10 |
Aladar A. Szalay |
Light emitting microorganisms and cells for diagnosis and therapy of diseases associated with wounded or inflamed tissue
|
|
EP1546408A4
(en)
*
|
2002-09-20 |
2007-10-10 |
Pharmacia & Upjohn Co Llc |
A METHOD FOR PRODUCING RANDOM RNAI LIBRARY, AND ITS APPLICATION TO CELLS BASED ON CELLS
|
|
US7892793B2
(en)
|
2002-11-04 |
2011-02-22 |
University Of Massachusetts |
Allele-specific RNA interference
|
|
EP1592412A1
(en)
*
|
2003-01-31 |
2005-11-09 |
Novartis AG |
Down-regulation of target-gene with pei/single-stranded oligoribonucleotide complexes
|
|
WO2004094636A1
(en)
*
|
2003-04-24 |
2004-11-04 |
Galapagos Genomics N.V. |
Effective sirna knock-down constructs
|
|
CA2523785A1
(en)
*
|
2003-05-09 |
2004-11-25 |
University Of Pittsburgh Of The Commonwealth System Of Higher Education |
Small interfering rna libraries and methods of synthesis and use
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
EP1633890B2
(en)
|
2003-06-02 |
2020-11-18 |
University of Massachusetts |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
|
|
PT1633767T
(pt)
|
2003-06-02 |
2019-02-27 |
Univ Massachusetts |
Métodos e composições para controlar a eficácia do silenciamento de arn
|
|
ATE420160T1
(de)
|
2003-06-18 |
2009-01-15 |
Genelux Corp |
Modifizierte rekombinante vacciniaviren, verwendungen davon
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
US20060134787A1
(en)
|
2004-12-22 |
2006-06-22 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
|
|
WO2005063983A1
(en)
*
|
2003-12-29 |
2005-07-14 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
|
ES2425749T3
(es)
|
2004-03-31 |
2013-10-17 |
The General Hospital Corporation |
Método para determinar la respuesta del cáncer a tratamientos dirigidos al receptor del factor de crecimiento epidérmico
|
|
EP2270513A3
(en)
|
2004-04-20 |
2011-04-06 |
Galapagos N.V. |
Methods, compositions and compound assays for inhibiting amyloid-beta protein production
|
|
WO2005103716A2
(en)
|
2004-04-27 |
2005-11-03 |
Galapagos N.V. |
Methods, agents, and compound screening assays for inducing differentiation of undifferentiated mammalian cells into osteoblasts
|
|
EP2290073A3
(en)
|
2004-05-28 |
2011-08-31 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
|
WO2005121778A2
(en)
|
2004-06-14 |
2005-12-22 |
Galapagos N.V. |
Methods for identification, and compounds useful for the treatment of degenerative & inflammatory diseases
|
|
JP2008503712A
(ja)
|
2004-06-21 |
2008-02-07 |
ガラパゴス・ナムローゼ・フェンノートシャップ |
骨関節炎治療の方法及び手段
|
|
JPWO2006006520A1
(ja)
*
|
2004-07-09 |
2008-04-24 |
株式会社ジェノファンクション |
新規創薬標的の探索方法
|
|
US8673268B2
(en)
|
2004-10-15 |
2014-03-18 |
Galapagos N.V. |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
|
|
US7485468B2
(en)
|
2004-10-15 |
2009-02-03 |
Galapagos Bv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
|
|
EP2302055B1
(en)
|
2004-11-12 |
2014-08-27 |
Asuragen, Inc. |
Methods and compositions involving miRNA and miRNA inhibitor molecules
|
|
CA2609142C
(en)
|
2005-05-27 |
2016-02-09 |
Fondazione Centro San Raffaele Del Monte Tabor |
Therapeutic gene vectors comprising mirna target sequences
|
|
US7919583B2
(en)
|
2005-08-08 |
2011-04-05 |
Discovery Genomics, Inc. |
Integration-site directed vector systems
|
|
EP1937066A4
(en)
|
2005-08-18 |
2008-12-24 |
Alnylam Pharmaceuticals Inc |
METHOD AND COMPOSITIONS FOR THE TREATMENT OF NERVOUS DISEASES
|
|
AU2014202015B2
(en)
*
|
2006-03-07 |
2016-06-02 |
The Trustees Of The University Of Pennsylvania |
Random RNAi libraries, methods of generating same, and screening methods utilizing same
|
|
JP5463039B2
(ja)
*
|
2006-03-07 |
2014-04-09 |
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア |
ランダムRNAiライブラリ、その生成方法、及びそれを使用したスクリーニング方法
|
|
FR2898908A1
(fr)
|
2006-03-24 |
2007-09-28 |
Agronomique Inst Nat Rech |
Procede de preparation de cellules aviaires differenciees et genes impliques dans le maintien de la pluripotence
|
|
WO2007137220A2
(en)
*
|
2006-05-22 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of ikk-b gene
|
|
WO2007147067A2
(en)
*
|
2006-06-14 |
2007-12-21 |
Rosetta Inpharmatics Llc |
Methods and compositions for regulating cell cycle progression
|
|
TW200819540A
(en)
|
2006-07-11 |
2008-05-01 |
Genelux Corp |
Methods and compositions for detection of microorganisms and cells and treatment of diseases and disorders
|
|
JP2008086201A
(ja)
*
|
2006-09-29 |
2008-04-17 |
Gifu Prefecture Kenkyu Kaihatsu Zaidan |
マイクロrna生成の検出方法と癌の診断・治療およびマイクロrna生成調整剤
|
|
EP2097517B1
(en)
|
2006-10-16 |
2014-06-04 |
Genelux Corporation |
Recombinant Lister strain vaccinia virus encoding an anti-VEGF single chain antibody
|
|
US8114982B2
(en)
*
|
2006-12-06 |
2012-02-14 |
Albert Einstein College Of Medicine Of Yeshiva University |
Multi-microRNA methods and compositions
|
|
CA2690627C
(en)
*
|
2007-06-15 |
2014-12-02 |
Genelux Corporation |
Microorganisms for imaging and/or treatment of tumors
|
|
WO2008155397A2
(en)
|
2007-06-20 |
2008-12-24 |
Galapagos N.V. |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
|
|
US8841437B2
(en)
*
|
2008-06-20 |
2014-09-23 |
The Board Of Trustees Of The Leland Stanford Junior University |
Precursor miRNA loop-modulated target regulation
|
|
JP4517096B2
(ja)
*
|
2007-07-17 |
2010-08-04 |
愛知県 |
癌の遺伝子治療ベクター及び癌治療用医薬組成物
|
|
WO2009036332A1
(en)
|
2007-09-14 |
2009-03-19 |
Asuragen, Inc. |
Micrornas differentially expressed in cervical cancer and uses thereof
|
|
WO2009054996A2
(en)
*
|
2007-10-25 |
2009-04-30 |
Genelux Corporation |
Systems and methods for viral therapy
|
|
WO2009137807A2
(en)
|
2008-05-08 |
2009-11-12 |
Asuragen, Inc. |
Compositions and methods related to mirna modulation of neovascularization or angiogenesis
|
|
WO2009151591A2
(en)
*
|
2008-06-10 |
2009-12-17 |
Sangamo Biosciences, Inc. |
Methods and compositions for generation of bax- and bak-deficient cell lines
|
|
WO2010008562A2
(en)
|
2008-07-16 |
2010-01-21 |
Recombinetics |
Methods and materials for producing transgenic animals
|
|
EP2816113A3
(en)
|
2008-09-11 |
2015-03-25 |
Galapagos N.V. |
Method for identifying compounds useful for increasing the functional activity and cell surface expression of cf-associated mutant cystic fibrosis transmembrane conductance regulator
|
|
US20120004160A1
(en)
|
2009-02-19 |
2012-01-05 |
Glaxo Group Ltd. |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
|
US20110306655A1
(en)
|
2009-02-19 |
2011-12-15 |
Richard Antonius Jozef Janssen |
Methods for identifying and compounds useful for the diagnosis and treatment of diseases involving inflammation
|
|
JP2012518181A
(ja)
|
2009-02-19 |
2012-08-09 |
ガラパゴス・ナムローゼ・フェンノートシャップ |
炎症を包含する疾患の診断及び治療に有用な同定方法及び化合物
|
|
WO2010112569A1
(en)
|
2009-03-31 |
2010-10-07 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
EP2414830A2
(en)
|
2009-03-31 |
2012-02-08 |
Robert Zimmermann |
Modulation of adipose triglyceride lipase for prevention and treatment of cachexia, loss of weight and muscle atrophy and methods of screening therefor
|
|
US8663930B2
(en)
|
2009-04-01 |
2014-03-04 |
Galapagos Nv |
Methods and means for treatment of osteoarthritis
|
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
TW201120043A
(en)
|
2009-11-05 |
2011-06-16 |
Galapagos Nv |
Fused pyrazine compounds as their salts, useful for the treatment of degenerative and inflammatory diseases
|
|
CA2780875A1
(en)
|
2009-11-13 |
2011-05-19 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
US20130183326A9
(en)
|
2009-11-20 |
2013-07-18 |
St. Jude Children's Research Hospital |
Methods and compositions for modulating the activity of the interleukin-35 receptor complex
|
|
US20110196016A1
(en)
*
|
2010-02-05 |
2011-08-11 |
Anke Geick |
Compositions and Methods for Inhibiting Expression of IKK2 Genes
|
|
JP5794558B2
(ja)
*
|
2010-03-24 |
2015-10-14 |
国立研究開発法人産業技術総合研究所 |
改変された致死遺伝子及び該遺伝子を含むベクター
|
|
US8383793B2
(en)
|
2010-04-15 |
2013-02-26 |
St. Jude Children's Research Hospital |
Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (ALK) kinase inhibitors
|
|
US8993532B2
(en)
|
2010-04-23 |
2015-03-31 |
Cold Spring Harbor Laboratory |
Structurally designed shRNAs
|
|
EP3434772A3
(en)
|
2010-10-18 |
2019-03-20 |
Arrowhead Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of rrm2 genes
|
|
EP2468883A1
(en)
|
2010-12-22 |
2012-06-27 |
Pangaea Biotech S.L. |
Molecular biomarkers for predicting response to tyrosine kinase inhibitors in lung cancer
|
|
EP2492688A1
(en)
|
2011-02-23 |
2012-08-29 |
Pangaea Biotech, S.A. |
Molecular biomarkers for predicting response to antitumor treatment in lung cancer
|
|
US20140157443A1
(en)
|
2011-04-14 |
2014-06-05 |
St. Jude Children's Research Hospital |
Methods and compositions for detecting and modulating a novel mtor complex
|
|
ES2733211T3
(es)
|
2011-04-15 |
2019-11-28 |
Genelux Corp |
Cepas clonales de virus vaccinia atenuados y métodos de uso de las mismas
|
|
EA024762B9
(ru)
|
2011-06-30 |
2017-04-28 |
Эрроухэд Рисерч Корпорейшн |
Композиции и способы ингибирования экспрессии генов вируса гепатита в
|
|
WO2013040251A2
(en)
|
2011-09-13 |
2013-03-21 |
Asurgen, Inc. |
Methods and compositions involving mir-135b for distinguishing pancreatic cancer from benign pancreatic disease
|
|
US20140087362A1
(en)
|
2012-03-16 |
2014-03-27 |
Aladar A. Szalay |
Methods for assessing effectiveness and monitoring oncolytic virus treatment
|
|
WO2013158265A1
(en)
|
2012-04-20 |
2013-10-24 |
Genelux Corporation |
Imaging methods for oncolytic virus therapy
|
|
WO2013190089A1
(en)
|
2012-06-21 |
2013-12-27 |
Pangaea Biotech, S.L. |
Molecular biomarkers for predicting outcome in lung cancer
|
|
US20140140959A1
(en)
|
2012-10-05 |
2014-05-22 |
Aladar A. Szalay |
Energy Absorbing-Based Diagnostic and Therapeutic Methods Employing Nucleic Acid Molecules Encoding Chromophore-Producing Enzymes
|
|
ES2670590T3
(es)
|
2012-11-20 |
2018-05-31 |
Centro De Investigacíon Biomédica En Red De Enfermedades Neurodegenerativas Ciberned |
Neuronas motoras superiores corticoespinales, métodos y composiciones para diferenciar células madre neurales modulando la señalización del receptor de cannabinoides CB1 y usos de los mismos
|
|
WO2014139883A1
(en)
|
2013-03-14 |
2014-09-18 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases
|
|
EP2972381A2
(en)
|
2013-03-14 |
2016-01-20 |
Galapagos NV |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of diseases associated with epithelial mesenchymal transition
|
|
WO2014139884A2
(en)
|
2013-03-14 |
2014-09-18 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrosis
|
|
CN112301024A
(zh)
|
2013-03-15 |
2021-02-02 |
通用医疗公司 |
使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
|
|
US11332719B2
(en)
*
|
2013-03-15 |
2022-05-17 |
The Broad Institute, Inc. |
Recombinant virus and preparations thereof
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
EP2813571A1
(en)
|
2013-06-13 |
2014-12-17 |
Institut d'Investigació Biomèdica de Bellvitge (IDIBELL) |
Method for the treatment of lung cancer
|
|
EP3052464B1
(en)
|
2013-10-04 |
2020-04-15 |
Novartis AG |
3'end caps for rna-interferring agents for use in rna interference
|
|
WO2015051366A2
(en)
|
2013-10-04 |
2015-04-09 |
Novartis Ag |
Novel formats for organic compounds for use in rna interference
|
|
HK1221912A1
(zh)
|
2013-10-04 |
2017-06-16 |
Novartis Ag |
用於治疗乙肝病毒的有机化合物
|
|
CA2935032C
(en)
*
|
2013-12-26 |
2024-01-23 |
The General Hospital Corporation |
Multiplex guide rnas
|
|
WO2015134528A1
(en)
*
|
2014-03-04 |
2015-09-11 |
Donald Danforth Plant Science Center |
New generation of artificial micrornas
|
|
CN107206088A
(zh)
|
2014-12-05 |
2017-09-26 |
豪夫迈·罗氏有限公司 |
使用pd‑1轴拮抗剂和hpk1拮抗剂用于治疗癌症的方法和组合物
|
|
AU2016306275A1
(en)
|
2015-08-07 |
2018-02-08 |
Arrowhead Pharmaceuticals, Inc. |
RNAi therapy for Hepatitis B virus infection
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
JOP20190015A1
(ar)
|
2016-08-04 |
2019-02-04 |
Arrowhead Pharmaceuticals Inc |
عوامل (ار ان ايه آي) لعدوى فيروس الالتهاب الكبدي الوبائي ب
|
|
CN109456995A
(zh)
*
|
2018-11-08 |
2019-03-12 |
杜以军 |
基因敲除质粒、细胞系及制备方法和应用
|
|
JP2022541197A
(ja)
|
2019-07-16 |
2022-09-22 |
ユニヴェルシテ・コート・ダジュール |
腫瘍溶解性ウイルスに対する対象の感受性又は抵抗性を評価する方法、組換えウイルス、その調製、及び使用
|