JPWO2021047622A5 - - Google Patents
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- Publication number
- JPWO2021047622A5 JPWO2021047622A5 JP2022516434A JP2022516434A JPWO2021047622A5 JP WO2021047622 A5 JPWO2021047622 A5 JP WO2021047622A5 JP 2022516434 A JP2022516434 A JP 2022516434A JP 2022516434 A JP2022516434 A JP 2022516434A JP WO2021047622 A5 JPWO2021047622 A5 JP WO2021047622A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- cycloalkyl
- membered heterocycloalkyl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910863718 | 2019-09-12 | ||
| CN201910863718.6 | 2019-09-12 | ||
| CN201911094782 | 2019-11-11 | ||
| CN201911094782.9 | 2019-11-11 | ||
| CN202010531381.1 | 2020-06-11 | ||
| CN202010531381 | 2020-06-11 | ||
| CN202010923311.0 | 2020-09-04 | ||
| CN202010923311 | 2020-09-04 | ||
| PCT/CN2020/114700 WO2021047622A1 (zh) | 2019-09-12 | 2020-09-11 | 吡啶氮氧化合物及其制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022548104A JP2022548104A (ja) | 2022-11-16 |
| JPWO2021047622A5 true JPWO2021047622A5 (pt) | 2023-09-27 |
Family
ID=74866555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022516434A Pending JP2022548104A (ja) | 2019-09-12 | 2020-09-11 | ピリジン窒素酸化物及びその製造方法と使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230303495A9 (pt) |
| EP (1) | EP4043437A4 (pt) |
| JP (1) | JP2022548104A (pt) |
| KR (1) | KR20220101606A (pt) |
| CN (3) | CN112479996B (pt) |
| AU (1) | AU2020346951A1 (pt) |
| BR (1) | BR112022004495A8 (pt) |
| CA (1) | CA3150400A1 (pt) |
| CL (1) | CL2022000619A1 (pt) |
| CO (1) | CO2022004594A2 (pt) |
| MX (1) | MX2022003032A (pt) |
| PE (1) | PE20221515A1 (pt) |
| TW (1) | TWI770607B (pt) |
| WO (1) | WO2021047622A1 (pt) |
| ZA (1) | ZA202204100B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2022233221A1 (en) * | 2021-03-11 | 2023-10-26 | Jiangxi Jemincare Group Co., Ltd | Crystal form of pyridine nitrogen oxide compound and use thereof |
| JP2024520649A (ja) | 2021-06-04 | 2024-05-24 | バーテックス ファーマシューティカルズ インコーポレイテッド | （２ｒ，３ｓ，４ｓ，５ｒ）－４－［［３－（３，４－ジフルオロ－２－メトキシ－フェニル）－４，５－ジメチル－５－（トリフルオロメチル）テトラヒドロフラン－２－カルボニル］アミノ］ピリジン－２－カルボキサミドを含む固体剤形及び投与レジメン |
| CA3221939A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels |
| AU2022286511A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels |
| CA3221788A1 (en) | 2021-06-04 | 2022-12-08 | Vertex Pharmaceuticals Incorporated | Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels |
| CN117794918A (zh) | 2021-06-04 | 2024-03-29 | 沃泰克斯药物股份有限公司 | 经取代的四氢呋喃类似物作为钠通道调节剂 |
| IL308953A (en) | 2021-06-04 | 2024-01-01 | Vertex Pharma | N-Hydroalkyl(Hetero)Aryl)Tetrahydrofuran Carboxamides as Natrene Channel Modulators |
| EP4370506A1 (en) | 2021-12-30 | 2024-05-22 | Biomea Fusion, Inc. | Pyrazine compounds as inhibitors of flt3 |
| CN116891432A (zh) * | 2022-04-02 | 2023-10-17 | 武汉人福创新药物研发中心有限公司 | Nav1.8抑制剂及其用途 |
| WO2023205465A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023205463A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| TW202408501A (zh) | 2022-04-22 | 2024-03-01 | 美商維泰克斯製藥公司 | 用於治療疼痛之雜芳基化合物 |
| WO2023205468A1 (en) | 2022-04-22 | 2023-10-26 | Vertex Pharmaceuticals Incorporated | Heteroaryl compounds for the treatment of pain |
| WO2023232117A1 (zh) * | 2022-06-02 | 2023-12-07 | 上海济煜医药科技有限公司 | 吡啶氮氧化合物的制备方法 |
| WO2023246867A1 (zh) * | 2022-06-22 | 2023-12-28 | 武汉人福创新药物研发中心有限公司 | Nav1.8抑制剂 |
| WO2024123815A1 (en) | 2022-12-06 | 2024-06-13 | Vertex Pharmaceuticals Incorporated | Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0752421B1 (en) * | 1995-07-07 | 2005-10-12 | AstraZeneca AB | Ortho-substituted aromatic compounds, containing three (het)aryl moieties, their preparation and their use as prostaglandin E2-(PGE2)-antagonists |
| WO2006137376A1 (ja) * | 2005-06-21 | 2006-12-28 | Mitsui Chemicals, Inc. | アミド誘導体ならびに該化合物を含有する殺虫剤 |
| NZ596413A (en) * | 2006-04-11 | 2013-03-28 | Vertex Pharma | Phenyl-sulfinyl-sulfamoylphenyl-benzamide derivatives that inhibit voltage-gated sodium channels |
| JP2010047480A (ja) * | 2006-12-19 | 2010-03-04 | Mitsui Chemicals Inc | 虫害の予防方法 |
| US8779197B2 (en) * | 2007-10-11 | 2014-07-15 | Vertex Pharmaceuticals Incorporated | Aryl amides useful as inhibitors of voltage-gated sodium channels |
| US8389734B2 (en) * | 2007-10-11 | 2013-03-05 | Vertex Pharmaceuticals Incorporated | Amides useful as inhibitors of voltage-gated sodium channels |
| AU2011346751A1 (en) * | 2010-12-22 | 2013-05-02 | Purdue Pharma L.P. | Substituted pyridines as sodium channel blockers |
| KR102226588B1 (ko) * | 2013-01-31 | 2021-03-11 | 버텍스 파마슈티칼스 인코포레이티드 | 나트륨 채널의 조절제로서의 아미드 |
| MX368833B (es) * | 2013-01-31 | 2019-10-18 | Vertex Pharma | Derivados de quinolina y quinazolina amidas como inhibidores de canales de sodio nav1.8 y el uso de los mismos en el tratamiento del dolor. |
| SG11201505953TA (en) * | 2013-01-31 | 2015-08-28 | Vertex Pharma | Pyridone amides as modulators of sodium channels |
| DK3080134T3 (en) * | 2013-12-13 | 2018-10-22 | Vertex Pharma | PRODRUGS OF PYRIDONAMIDS USED AS MODULATORS OF SODIUM CHANNELS |
| JOP20200001A1 (ar) * | 2017-07-11 | 2022-10-30 | Vertex Pharma | كاربوكسأميدات بوصفها معدلات لقنوات الصوديوم |
| SG11202100130QA (en) * | 2018-07-09 | 2021-02-25 | Lieber Institute Inc | Pyridine carboxamide compounds for inhibiting nav1.8 |
-
2020
- 2020-09-11 BR BR112022004495A patent/BR112022004495A8/pt unknown
- 2020-09-11 PE PE2022000407A patent/PE20221515A1/es unknown
- 2020-09-11 EP EP20863934.4A patent/EP4043437A4/en active Pending
- 2020-09-11 CN CN202010957957.0A patent/CN112479996B/zh active Active
- 2020-09-11 WO PCT/CN2020/114700 patent/WO2021047622A1/zh unknown
- 2020-09-11 AU AU2020346951A patent/AU2020346951A1/en active Pending
- 2020-09-11 KR KR1020227012157A patent/KR20220101606A/ko unknown
- 2020-09-11 JP JP2022516434A patent/JP2022548104A/ja active Pending
- 2020-09-11 MX MX2022003032A patent/MX2022003032A/es unknown
- 2020-09-11 CA CA3150400A patent/CA3150400A1/en active Pending
- 2020-09-11 US US17/642,020 patent/US20230303495A9/en active Pending
- 2020-09-11 TW TW109131318A patent/TWI770607B/zh active
- 2020-09-11 CN CN202410255352.5A patent/CN118146148A/zh active Pending
- 2020-09-11 CN CN202080037787.2A patent/CN113906013B/zh active Active
-
2022
- 2022-03-11 CL CL2022000619A patent/CL2022000619A1/es unknown
- 2022-04-11 CO CONC2022/0004594A patent/CO2022004594A2/es unknown
- 2022-04-11 ZA ZA2022/04100A patent/ZA202204100B/en unknown
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