JPWO2021030657A5 - - Google Patents
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- Publication number
- JPWO2021030657A5 JPWO2021030657A5 JP2022507875A JP2022507875A JPWO2021030657A5 JP WO2021030657 A5 JPWO2021030657 A5 JP WO2021030657A5 JP 2022507875 A JP2022507875 A JP 2022507875A JP 2022507875 A JP2022507875 A JP 2022507875A JP WO2021030657 A5 JPWO2021030657 A5 JP WO2021030657A5
- Authority
- JP
- Japan
- Prior art keywords
- cys
- scfv
- seq
- exposed
- disulfide bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (21)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962887524P | 2019-08-15 | 2019-08-15 | |
US201962887514P | 2019-08-15 | 2019-08-15 | |
US201962887529P | 2019-08-15 | 2019-08-15 | |
US201962887519P | 2019-08-15 | 2019-08-15 | |
US201962887527P | 2019-08-15 | 2019-08-15 | |
US62/887,519 | 2019-08-15 | ||
US62/887,514 | 2019-08-15 | ||
US62/887,529 | 2019-08-15 | ||
US62/887,527 | 2019-08-15 | ||
US62/887,524 | 2019-08-15 | ||
US201962946877P | 2019-12-11 | 2019-12-11 | |
US201962946882P | 2019-12-11 | 2019-12-11 | |
US201962946897P | 2019-12-11 | 2019-12-11 | |
US201962946886P | 2019-12-11 | 2019-12-11 | |
US201962946865P | 2019-12-11 | 2019-12-11 | |
US62/946,877 | 2019-12-11 | ||
US62/946,865 | 2019-12-11 | ||
US62/946,897 | 2019-12-11 | ||
US62/946,886 | 2019-12-11 | ||
US62/946,882 | 2019-12-11 | ||
PCT/US2020/046303 WO2021030657A1 (en) | 2019-08-15 | 2020-08-14 | Materials and methods for improved single chain variable fragments |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2022544760A JP2022544760A (ja) | 2022-10-21 |
JPWO2021030657A5 true JPWO2021030657A5 (zh) | 2023-08-15 |
Family
ID=72243247
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2022507875A Pending JP2022544760A (ja) | 2019-08-15 | 2020-08-14 | 改善された単鎖可変断片のための材料及び方法 |
Country Status (18)
Country | Link |
---|---|
US (2) | US11787875B2 (zh) |
EP (1) | EP4013783A1 (zh) |
JP (1) | JP2022544760A (zh) |
KR (1) | KR20220062494A (zh) |
CN (1) | CN114258400A (zh) |
AU (1) | AU2020328049A1 (zh) |
BR (1) | BR112022002540A2 (zh) |
CA (1) | CA3148121A1 (zh) |
CO (1) | CO2022001222A2 (zh) |
CR (1) | CR20220054A (zh) |
DO (1) | DOP2022000032A (zh) |
EC (1) | ECSP22011199A (zh) |
IL (1) | IL290436A (zh) |
JO (1) | JOP20220035A1 (zh) |
MX (1) | MX2022001799A (zh) |
PE (1) | PE20220299A1 (zh) |
TW (1) | TW202120537A (zh) |
WO (1) | WO2021030657A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2023506750A (ja) * | 2019-12-11 | 2023-02-20 | シラグ・ゲーエムベーハー・インターナショナル | Ltbr及びedb結合ドメインを含む多重特異性結合分子並びにその使用 |
WO2023089587A1 (en) * | 2021-11-22 | 2023-05-25 | Janssen Biotech, Inc. | Compositions comprising enhanced multispecific binding agents for an immune response |
WO2023152581A1 (en) | 2022-02-09 | 2023-08-17 | Janssen Biotech, Inc. | Method of treating cancer with psmaxcd3 antibody |
WO2023164510A1 (en) | 2022-02-23 | 2023-08-31 | Xencor, Inc. | Anti-cd28 x anti-psma antibodies |
WO2024028731A1 (en) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Transferrin receptor binding proteins for treating brain tumors |
WO2024028732A1 (en) | 2022-08-05 | 2024-02-08 | Janssen Biotech, Inc. | Cd98 binding constructs for treating brain tumors |
Family Cites Families (41)
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US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
GB9610967D0 (en) | 1996-05-24 | 1996-07-31 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7041870B2 (en) | 2000-11-30 | 2006-05-09 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
US6884869B2 (en) | 2001-04-30 | 2005-04-26 | Seattle Genetics, Inc. | Pentapeptide compounds and uses related thereto |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
EP3623473A1 (en) | 2005-03-31 | 2020-03-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
PT1999154E (pt) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Domínios proteicos heterodiméricos modificados |
WO2007147901A1 (en) | 2006-06-22 | 2007-12-27 | Novo Nordisk A/S | Production of bispecific antibodies |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
MX2009010639A (es) | 2007-04-02 | 2009-10-23 | Philogen Spa | Nuevo antigeno asociado con la neovasculatura de metastasis tumoral. |
JP2011507519A (ja) | 2007-12-19 | 2011-03-10 | セントコア・オーソ・バイオテツク・インコーポレーテツド | pIX又はpVIIへの融合を介したヒトデノボpIXファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法 |
US9029508B2 (en) | 2008-04-29 | 2015-05-12 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
CN102089431A (zh) * | 2008-06-30 | 2011-06-08 | 艾斯巴技术,爱尔康生物医药研究装置有限责任公司 | 官能化的多肽 |
CN102459346B (zh) | 2009-04-27 | 2016-10-26 | 昂考梅德药品有限公司 | 制造异源多聚体分子的方法 |
EP2445936A1 (en) | 2009-06-26 | 2012-05-02 | Regeneron Pharmaceuticals, Inc. | Readily isolated bispecific antibodies with native immunoglobulin format |
CA2769619C (en) | 2009-08-17 | 2019-04-30 | Roche Glycart Ag | Targeted immunoconjugates |
ES2667258T3 (es) * | 2009-09-10 | 2018-05-10 | Ucb Biopharma Sprl | Anticuerpos multivalentes |
AU2010336029B2 (en) * | 2009-12-23 | 2011-10-13 | Avipep Pty Ltd | Immuno-conjugates and methods for producing them 2 |
US9150663B2 (en) | 2010-04-20 | 2015-10-06 | Genmab A/S | Heterodimeric antibody Fc-containing proteins and methods for production thereof |
EP2569337A1 (en) | 2010-05-14 | 2013-03-20 | Rinat Neuroscience Corp. | Heterodimeric proteins and methods for producing and purifying them |
EP2420253A1 (en) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Engineering multifunctional and multivalent molecules with collagen XV trimerization domain |
CN103068846B9 (zh) * | 2010-08-24 | 2016-09-28 | 弗·哈夫曼-拉罗切有限公司 | 包含二硫键稳定性Fv片段的双特异性抗体 |
RS59589B1 (sr) | 2010-11-05 | 2019-12-31 | Zymeworks Inc | Dizajniranje stabilnog heterodimernog antitela sa mutacijama u fc domenu |
TWI588156B (zh) * | 2011-03-28 | 2017-06-21 | 賽諾菲公司 | 具有交叉結合區定向之雙重可變區類抗體結合蛋白 |
EP2771364B1 (en) | 2011-10-27 | 2019-05-22 | Genmab A/S | Production of heterodimeric proteins |
CN104080811B (zh) | 2011-11-04 | 2019-09-27 | 酵活有限公司 | 在Fc结构域中具有突变的稳定异源二聚的抗体设计 |
DK2794905T3 (da) | 2011-12-20 | 2020-07-06 | Medimmune Llc | Modificerede polypeptider til bispecifikke antistofgrundstrukturer |
NZ772318A (en) | 2012-04-20 | 2023-06-30 | Merus Nv | Methods and means for the production of ig-like molecules |
WO2013175678A1 (ja) * | 2012-05-24 | 2013-11-28 | パナソニック株式会社 | ヒト心筋由来トロポニンiに特異的にかつ速やかに結合できる変異体タンパク質 |
SG11201507577RA (en) | 2013-03-15 | 2015-10-29 | Janssen Biotech Inc | Manufacturing methods to control c-terminal lysine, galactose and sialic acid content in recombinant proteins |
JP7022123B2 (ja) | 2016-09-30 | 2022-02-17 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Cd3に対する二重特異性抗体 |
EP3684816B1 (en) | 2017-09-22 | 2024-05-29 | Kite Pharma, Inc. | Chimeric polypeptides and uses thereof |
-
2020
- 2020-08-14 WO PCT/US2020/046303 patent/WO2021030657A1/en active Application Filing
- 2020-08-14 TW TW109127754A patent/TW202120537A/zh unknown
- 2020-08-14 CA CA3148121A patent/CA3148121A1/en active Pending
- 2020-08-14 US US16/994,065 patent/US11787875B2/en active Active
- 2020-08-14 JP JP2022507875A patent/JP2022544760A/ja active Pending
- 2020-08-14 CN CN202080057404.8A patent/CN114258400A/zh active Pending
- 2020-08-14 PE PE2022000220A patent/PE20220299A1/es unknown
- 2020-08-14 JO JOP/2022/0035A patent/JOP20220035A1/ar unknown
- 2020-08-14 MX MX2022001799A patent/MX2022001799A/es unknown
- 2020-08-14 BR BR112022002540A patent/BR112022002540A2/pt unknown
- 2020-08-14 AU AU2020328049A patent/AU2020328049A1/en active Pending
- 2020-08-14 KR KR1020227004708A patent/KR20220062494A/ko unknown
- 2020-08-14 CR CR20220054A patent/CR20220054A/es unknown
- 2020-08-14 EP EP20761987.5A patent/EP4013783A1/en active Pending
-
2022
- 2022-02-07 CO CONC2022/0001222A patent/CO2022001222A2/es unknown
- 2022-02-08 DO DO2022000032A patent/DOP2022000032A/es unknown
- 2022-02-08 IL IL290436A patent/IL290436A/en unknown
- 2022-02-11 EC ECSENADI202211199A patent/ECSP22011199A/es unknown
-
2023
- 2023-09-05 US US18/461,191 patent/US20240067754A1/en active Pending
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