JPWO2020122093A5 - - Google Patents
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- Publication number
- JPWO2020122093A5 JPWO2020122093A5 JP2020559268A JP2020559268A JPWO2020122093A5 JP WO2020122093 A5 JPWO2020122093 A5 JP WO2020122093A5 JP 2020559268 A JP2020559268 A JP 2020559268A JP 2020559268 A JP2020559268 A JP 2020559268A JP WO2020122093 A5 JPWO2020122093 A5 JP WO2020122093A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- ring
- alkyl
- groups
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 7
- 125000005915 C6-C14 aryl group Chemical group 0.000 claims 5
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 125000005115 alkyl carbamoyl group Chemical group 0.000 claims 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 3
- -1 formylcarbonyl group Chemical group 0.000 claims 3
- 201000003631 narcolepsy Diseases 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000003226 pyrazolyl group Chemical group 0.000 claims 2
- 125000004076 pyridyl group Chemical group 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- QPDFCVIMRQHVFW-UHFFFAOYSA-N N-[2-ethyl-7-[[1-(5-fluoropyrimidin-2-yl)piperidin-4-yl]oxymethyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-6-yl]methanesulfonamide Chemical compound C(C)C1=NN2C(CCC(C2COC2CCN(CC2)C2=NC=C(C=N2)F)NS(=O)(=O)C)=C1 QPDFCVIMRQHVFW-UHFFFAOYSA-N 0.000 claims 1
- SUTARHSQDHRJKK-UHFFFAOYSA-N N-[2-propan-2-yl-7-[(1-pyrimidin-2-ylpiperidin-4-yl)oxymethyl]-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-6-yl]methanesulfonamide Chemical compound CC(C)C1=NN2C(CCC(C2COC2CCN(CC2)C2=NC=CC=N2)NS(=O)(=O)C)=C1 SUTARHSQDHRJKK-UHFFFAOYSA-N 0.000 claims 1
- LQXDOQOAYTVLIZ-UHFFFAOYSA-N N-[7-[[1-(5-fluoropyrimidin-2-yl)piperidin-4-yl]oxymethyl]-2-propan-2-yl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-6-yl]methanesulfonamide Chemical compound FC=1C=NC(=NC1)N1CCC(CC1)OCC1C(CCC=2N1N=C(C2)C(C)C)NS(=O)(=O)C LQXDOQOAYTVLIZ-UHFFFAOYSA-N 0.000 claims 1
- 102000002512 Orexin Human genes 0.000 claims 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- 108060005714 orexin Proteins 0.000 claims 1
- 125000003431 oxalo group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
- 239000000018 receptor agonist Substances 0.000 claims 1
- 229940044601 receptor agonist Drugs 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018232993 | 2018-12-12 | ||
| JP2018232993 | 2018-12-12 | ||
| PCT/JP2019/048385 WO2020122093A1 (ja) | 2018-12-12 | 2019-12-11 | 複素環化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2020122093A1 JPWO2020122093A1 (ja) | 2021-10-21 |
| JPWO2020122093A5 true JPWO2020122093A5 (enExample) | 2022-12-19 |
| JP7408569B2 JP7408569B2 (ja) | 2024-01-05 |
Family
ID=71077291
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020559268A Active JP7408569B2 (ja) | 2018-12-12 | 2019-12-11 | 複素環化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US12091410B2 (enExample) |
| EP (1) | EP3896060B1 (enExample) |
| JP (1) | JP7408569B2 (enExample) |
| WO (1) | WO2020122093A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3896060B1 (en) | 2018-12-12 | 2023-08-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| US12071434B2 (en) | 2018-12-12 | 2024-08-27 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| CN118420600A (zh) | 2019-01-31 | 2024-08-02 | 武田药品工业株式会社 | 杂环化合物及其用途 |
| EP4065585B1 (en) | 2019-11-25 | 2025-08-20 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| JP7665527B2 (ja) | 2019-11-27 | 2025-04-21 | 武田薬品工業株式会社 | 複素環化合物 |
| PE20231384A1 (es) | 2020-08-18 | 2023-09-12 | Merck Sharp And Dohme Llc | Agonistas de bicicloheptano pirrolidina de los receptores de orexina |
| US12006330B2 (en) | 2020-12-21 | 2024-06-11 | Alkermes, Inc. | Substituted macrocyclic compounds and related methods of treatment |
| US11760747B2 (en) | 2020-12-21 | 2023-09-19 | Alkermes, Inc. | Substituted piperidino compounds and related methods of treatment |
| US20240165092A1 (en) | 2021-04-02 | 2024-05-23 | Takeda Pharmaceutical Limited Company | Use of an orexin 2 receptor agonist for post operation recovery |
| JP7591592B2 (ja) * | 2022-01-14 | 2024-11-28 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物を含有する医薬 |
| WO2023136279A1 (ja) * | 2022-01-14 | 2023-07-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 置換ピペリジン化合物の結晶並びに置換ピペリジン化合物の塩及びそれらの結晶 |
| WO2023199091A1 (en) | 2022-04-12 | 2023-10-19 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| JP7592226B1 (ja) | 2022-10-31 | 2024-11-29 | 武田薬品工業株式会社 | 複素環化合物 |
| AU2023403030A1 (en) | 2022-11-30 | 2025-06-05 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| IL322817A (en) | 2023-03-16 | 2025-10-01 | Takeda Pharmaceuticals Co | Macrocyclic heterocyclic compounds and their uses |
| WO2025124698A1 (en) | 2023-12-12 | 2025-06-19 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| WO2025132542A1 (en) | 2023-12-19 | 2025-06-26 | Idorsia Pharmaceuticals Ltd | Macrocyclic orexin agonists |
| WO2025224168A1 (en) | 2024-04-24 | 2025-10-30 | Idorsia Pharmaceuticals Ltd | Aryl sulfone and sulfanone derivatives as orexin receptor modulators |
| WO2025229494A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2025229495A1 (en) | 2024-04-29 | 2025-11-06 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6166193A (en) | 1997-07-25 | 2000-12-26 | Board Of Regents, University Of Texas System | Polynucleotides encoding MY1 receptor |
| DE60045005D1 (de) | 1999-06-28 | 2010-11-04 | Oklahoma Med Res Found | Inhibitoren des memapsin 2 und ihre verwendung |
| AU6615300A (en) | 1999-07-30 | 2001-02-19 | Board Of Trustees Of The Leland Stanford Junior University | Hypocretin and hypocretin receptors in regulation of sleep and related disorders |
| AU2001251306A1 (en) | 2000-04-04 | 2001-10-15 | Siegel, Jerome M. | Treatment of sleep disorders with hypocretin-1 |
| CA2498264A1 (en) | 2002-09-09 | 2004-05-13 | Nura, Inc. | G protein coupled receptors and uses thereof |
| DE60320302T2 (de) | 2002-12-13 | 2009-05-20 | Janssen Pharmaceutica N.V. | Verfahren zur identifikation von modulatoren des humanen orexin-2-rezeptors |
| US20110053859A1 (en) | 2007-10-10 | 2011-03-03 | The U. S. Government Respresented by the Department of Veterans Affairs | Methods to reduce the effects of sleep deprivation |
| US8258163B2 (en) | 2008-06-04 | 2012-09-04 | Board Of Regents, The University Of Texas System | Small-molecule agonists for type-2 orexin receptor |
| JP2013509166A (ja) | 2009-11-02 | 2013-03-14 | ビーエーエスエフ ソシエタス・ヨーロピア | ポリアミン類の製造方法 |
| JP5976011B2 (ja) * | 2011-04-05 | 2016-08-23 | 武田薬品工業株式会社 | スルホンアミド誘導体およびその用途 |
| WO2014170343A1 (en) | 2013-04-15 | 2014-10-23 | Icm (Institut Du Cerveau Et De La Moelle Épinière) | Depolarizing agents and nicotinic acetylcholine receptor modulators for treating dopaminergic-related disorders |
| WO2014198880A1 (en) | 2013-06-14 | 2014-12-18 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
| ITBO20130077U1 (it) | 2013-07-04 | 2015-01-05 | Cefla Coop | Piano a spessore ribassato per scaffalature metalliche per l'esposizione delle merci |
| US20160250224A1 (en) | 2013-09-24 | 2016-09-01 | The Board Of Regents Of The University Of Texas System | Orexin-control of bone formation and loss |
| US10172916B2 (en) | 2013-11-15 | 2019-01-08 | The Board Of Trustees Of The Leland Stanford Junior University | Methods of treating heart failure with agonists of hypocretin receptor 2 |
| JP6552117B2 (ja) | 2014-03-28 | 2019-07-31 | 国立大学法人 筑波大学 | 敗血症の予防治療剤 |
| UY36272A (es) | 2014-08-13 | 2016-02-29 | Eolas Therapeutics Inc | Difluoropirrolidinas como moduladores de los receptores de orexinas |
| EP3029024A1 (en) | 2014-12-02 | 2016-06-08 | Ferrer Internacional, S.A. | 2-(2-aminophenoxy)-3-chloronaphthalene-1,4-dione compounds having orexin 2 receptor agonist activity |
| EP3309146A4 (en) | 2015-06-12 | 2019-02-27 | University of Tsukuba | SULPHONAMID DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITIVE SALT THEREOF |
| PT3984994T (pt) * | 2016-02-04 | 2024-10-10 | Takeda Pharmaceuticals Co | Composto de piperidina substituída como agonista de orexina tipo 2 para o tratamento da narcolepsia |
| JP6957598B2 (ja) | 2017-03-08 | 2021-11-02 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| JP7012703B2 (ja) | 2017-03-08 | 2022-02-14 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
| EP3663281B1 (en) | 2017-08-03 | 2022-12-28 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| UA125597C2 (uk) | 2017-08-03 | 2022-04-27 | Такеда Фармасьютікал Компані Лімітед | Гетероциклічна сполука та її застосування |
| JPWO2019112007A1 (ja) | 2017-12-07 | 2020-12-24 | 国立大学法人 筑波大学 | 鎮痛薬による眠気の予防または治療薬 |
| EP3816154B1 (en) | 2018-06-29 | 2025-04-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and application thereof |
| US11655241B2 (en) | 2018-06-29 | 2023-05-23 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| EP3896060B1 (en) | 2018-12-12 | 2023-08-16 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
| WO2020167701A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | Pyrrolidine orexin receptor agonists |
| WO2020167706A1 (en) | 2019-02-13 | 2020-08-20 | Merck Sharp & Dohme Corp. | 5-alkyl pyrrolidine orexin receptor agonists |
-
2019
- 2019-12-11 EP EP19895161.8A patent/EP3896060B1/en active Active
- 2019-12-11 WO PCT/JP2019/048385 patent/WO2020122093A1/ja not_active Ceased
- 2019-12-11 US US17/413,473 patent/US12091410B2/en active Active
- 2019-12-11 JP JP2020559268A patent/JP7408569B2/ja active Active
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