JPWO2020116660A5 - - Google Patents
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- Publication number
- JPWO2020116660A5 JPWO2020116660A5 JP2021554804A JP2021554804A JPWO2020116660A5 JP WO2020116660 A5 JPWO2020116660 A5 JP WO2020116660A5 JP 2021554804 A JP2021554804 A JP 2021554804A JP 2021554804 A JP2021554804 A JP 2021554804A JP WO2020116660 A5 JPWO2020116660 A5 JP WO2020116660A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- ring
- optionally substituted
- different
- atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 12
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 4
- 229910052801 chlorine Inorganic materials 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 2
- 208000019693 Lung disease Diseases 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 208000015114 central nervous system disease Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 208000017169 kidney disease Diseases 0.000 claims 2
- 208000012268 mitochondrial disease Diseases 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 208000007056 sickle cell anemia Diseases 0.000 claims 2
- 101000588302 Homo sapiens Nuclear factor erythroid 2-related factor 2 Proteins 0.000 claims 1
- 102100031701 Nuclear factor erythroid 2-related factor 2 Human genes 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000002440 hepatic effect Effects 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 125000005750 substituted cyclic group Chemical group 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024102161A JP2024123202A (ja) | 2018-12-05 | 2024-06-25 | 大環状化合物とその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018228234 | 2018-12-05 | ||
| JP2018228234 | 2018-12-05 | ||
| PCT/JP2019/048593 WO2020116660A1 (en) | 2018-12-05 | 2019-12-04 | Macrocyclic compound and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024102161A Division JP2024123202A (ja) | 2018-12-05 | 2024-06-25 | 大環状化合物とその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022510736A JP2022510736A (ja) | 2022-01-27 |
| JP2022510736A5 JP2022510736A5 (https=) | 2022-11-30 |
| JPWO2020116660A5 true JPWO2020116660A5 (https=) | 2022-11-30 |
Family
ID=70975488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021554804A Pending JP2022510736A (ja) | 2018-12-05 | 2019-12-04 | 大環状化合物とその使用 |
| JP2024102161A Pending JP2024123202A (ja) | 2018-12-05 | 2024-06-25 | 大環状化合物とその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024102161A Pending JP2024123202A (ja) | 2018-12-05 | 2024-06-25 | 大環状化合物とその使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US11518763B2 (https=) |
| EP (1) | EP3890738A4 (https=) |
| JP (2) | JP2022510736A (https=) |
| KR (1) | KR102919982B1 (https=) |
| CN (1) | CN113164468A (https=) |
| AR (1) | AR117251A1 (https=) |
| AU (1) | AU2019391942B2 (https=) |
| BR (1) | BR112021010704A2 (https=) |
| CA (1) | CA3121952C (https=) |
| CL (1) | CL2021001451A1 (https=) |
| CO (1) | CO2021007304A2 (https=) |
| MX (1) | MX2021006527A (https=) |
| NZ (1) | NZ776102A (https=) |
| PH (1) | PH12021551262A1 (https=) |
| SG (1) | SG11202105125XA (https=) |
| TW (1) | TWI820266B (https=) |
| UA (1) | UA127872C2 (https=) |
| WO (1) | WO2020116660A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3833662B1 (en) | 2018-08-20 | 2024-01-17 | Janssen Pharmaceutica NV | Inhibitors of keap1-nrf2 protein-protein interaction |
| AU2020283361B2 (en) | 2019-05-31 | 2025-11-27 | Ube Corporation | Benzotriazole derivative |
| CN116406364A (zh) * | 2020-09-14 | 2023-07-07 | 赛诺菲公司 | 用于治疗红细胞障碍和炎性疾病的四氢异喹啉衍生物 |
| KR20260005897A (ko) * | 2023-04-03 | 2026-01-12 | 에이스링크 테라퓨틱스, 인코포레이티드 | 신규 화합물 및 이의 용도 |
| CN119707895B (zh) * | 2023-12-18 | 2026-03-31 | 江苏苏中药业研究院有限公司 | 一种7-甲酰基-2,3-二氢苯并呋喃-4-碳腈的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012028959A1 (en) | 2010-08-31 | 2012-03-08 | Pablo Villoslada | Agonists of neurotrophin receptors and their use as medicaments |
| DK3492455T3 (da) | 2013-06-21 | 2023-08-14 | Karyopharm Therapeutics Inc | 1,2,4-triazoler som nukleare transportmodulatorer og anvendelse til behandling af specifikke former for cancer |
| SG11201604611SA (en) * | 2013-12-18 | 2016-07-28 | Glaxosmithkline Ip Dev Ltd | Nrf2 regulators |
| LT3307739T (lt) | 2015-06-15 | 2021-03-10 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 reguliatoriai |
| WO2016203401A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| CA2988373A1 (en) | 2015-06-15 | 2016-12-22 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 regulators |
| US10201531B2 (en) | 2015-08-12 | 2019-02-12 | Mochida Pharmaceutical Co., Ltd. | Indazolyl-oxo-isothiazole compounds |
| US10364256B2 (en) | 2015-10-06 | 2019-07-30 | Glaxosmithkline Intellectual Property Development Limited | Biaryl pyrazoles as NRF2 regulators |
| US10351530B2 (en) | 2015-10-06 | 2019-07-16 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as NRF2 regulators |
| JP2020500919A (ja) | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしての３−カルボン酸ピロール |
| JP2020500918A (ja) | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２レギュレーターとしてのｎ−アリールピラゾール |
| EP3555068B1 (en) | 2016-12-14 | 2020-12-02 | GlaxoSmithKline Intellectual Property Development Limited | 3-oxo-1,4-diazepinyle compounds as nrf2 activators |
| ES2901617T3 (es) | 2016-12-14 | 2022-03-23 | Glaxosmithkline Ip Dev Ltd | Bisarilamidas como reguladores de NRF2 |
| US11117905B2 (en) | 2016-12-14 | 2021-09-14 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as NRF2 activators |
| CA3044773A1 (en) | 2016-12-15 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Nrf2 activators |
| JP2020502152A (ja) | 2016-12-15 | 2020-01-23 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | Ｎｒｆ２アクチベーターとしてのエーテル結合トリアゾール |
| UY37551A (es) | 2016-12-27 | 2018-07-31 | Biogen Ma Inc | Activador de nrf2 |
| WO2018140876A1 (en) * | 2017-01-30 | 2018-08-02 | Biogen Ma Inc. | Nrf2 activator |
| US20190389830A1 (en) | 2017-01-30 | 2019-12-26 | Biogen Ma Inc. | Nrf2 activator |
| JP2020097526A (ja) * | 2017-03-28 | 2020-06-25 | 武田薬品工業株式会社 | 複素環化合物 |
-
2019
- 2019-12-04 MX MX2021006527A patent/MX2021006527A/es unknown
- 2019-12-04 AU AU2019391942A patent/AU2019391942B2/en active Active
- 2019-12-04 UA UAA202102856A patent/UA127872C2/uk unknown
- 2019-12-04 NZ NZ776102A patent/NZ776102A/en unknown
- 2019-12-04 BR BR112021010704-5A patent/BR112021010704A2/pt unknown
- 2019-12-04 EP EP19892751.9A patent/EP3890738A4/en active Pending
- 2019-12-04 SG SG11202105125XA patent/SG11202105125XA/en unknown
- 2019-12-04 JP JP2021554804A patent/JP2022510736A/ja active Pending
- 2019-12-04 CN CN201980080214.5A patent/CN113164468A/zh active Pending
- 2019-12-04 US US17/299,659 patent/US11518763B2/en active Active
- 2019-12-04 TW TW108144324A patent/TWI820266B/zh active
- 2019-12-04 AR ARP190103549A patent/AR117251A1/es unknown
- 2019-12-04 CA CA3121952A patent/CA3121952C/en active Active
- 2019-12-04 WO PCT/JP2019/048593 patent/WO2020116660A1/en not_active Ceased
- 2019-12-04 KR KR1020217020790A patent/KR102919982B1/ko active Active
-
2021
- 2021-05-31 PH PH12021551262A patent/PH12021551262A1/en unknown
- 2021-06-02 CL CL2021001451A patent/CL2021001451A1/es unknown
- 2021-06-03 CO CONC2021/0007304A patent/CO2021007304A2/es unknown
-
2024
- 2024-06-25 JP JP2024102161A patent/JP2024123202A/ja active Pending
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