JPWO2020252589A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020252589A5 JPWO2020252589A5 JP2021574974A JP2021574974A JPWO2020252589A5 JP WO2020252589 A5 JPWO2020252589 A5 JP WO2020252589A5 JP 2021574974 A JP2021574974 A JP 2021574974A JP 2021574974 A JP2021574974 A JP 2021574974A JP WO2020252589 A5 JPWO2020252589 A5 JP WO2020252589A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkenyl
- independently
- alkynyl
- bond
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962864064P | 2019-06-20 | 2019-06-20 | |
| US62/864,064 | 2019-06-20 | ||
| US201962877536P | 2019-07-23 | 2019-07-23 | |
| US62/877,536 | 2019-07-23 | ||
| US202063009104P | 2020-04-13 | 2020-04-13 | |
| US63/009,104 | 2020-04-13 | ||
| PCT/CA2020/050854 WO2020252589A1 (en) | 2019-06-20 | 2020-06-19 | Ionizable lipids for nucleic acid delivery |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022537305A JP2022537305A (ja) | 2022-08-25 |
| JPWO2020252589A5 true JPWO2020252589A5 (https=) | 2023-06-26 |
| JP2022537305A5 JP2022537305A5 (https=) | 2023-06-26 |
| JP7416096B2 JP7416096B2 (ja) | 2024-01-17 |
Family
ID=74036881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021574974A Active JP7416096B2 (ja) | 2019-06-20 | 2020-06-19 | 核酸送達のためのイオン化可能な脂質 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12503432B2 (https=) |
| EP (1) | EP3986866B1 (https=) |
| JP (1) | JP7416096B2 (https=) |
| KR (1) | KR102568997B1 (https=) |
| CN (1) | CN114746401B (https=) |
| CA (1) | CA3143577C (https=) |
| DK (1) | DK3986866T3 (https=) |
| ES (1) | ES2973521T3 (https=) |
| WO (1) | WO2020252589A1 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113166783B (zh) | 2018-10-09 | 2024-10-11 | 不列颠哥伦比亚大学 | 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法 |
| CA3112837A1 (en) * | 2018-10-19 | 2020-04-23 | Translate Bio, Inc. | Pumpless encapsulation of messenger rna |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| KR20230017730A (ko) | 2021-07-27 | 2023-02-06 | 에스케이바이오사이언스(주) | 단백질 발현을 위한 mRNA와 이를 위한 주형 |
| CN115772089B (zh) * | 2021-09-07 | 2025-06-10 | 广州谷森制药有限公司 | 阳离子脂质化合物 |
| US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| AU2023393613A1 (en) | 2022-12-12 | 2025-06-19 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticles lyophilization methods and compositions |
| KR102921785B1 (ko) * | 2022-12-19 | 2026-02-03 | 주식회사 녹십자 | 핵산 전달용 사이클로알칸계 지질 화합물 및 이를 포함하는 지질 나노입자 |
| IL321425A (en) | 2022-12-23 | 2025-08-01 | Biontech Delivery Tech Gmbh | compound |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| AU2023457271A1 (en) | 2023-06-28 | 2025-12-18 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations for cell therapy and related methods |
| CN121712495A (zh) | 2023-08-21 | 2026-03-20 | 环球生命科学解决方案加拿大有限公司 | 用于离子流脂质纳米颗粒的制造方法和装置 |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
| WO2025224267A1 (en) | 2024-04-25 | 2025-10-30 | Global Life Sciences Solutions Canada Ulc | Method for producing a liquid composition including a nanoparticle, and formulation thereof |
| WO2026035680A1 (en) | 2024-08-06 | 2026-02-12 | Kernal Biologics, Inc. | Compositions and methods for delivery of agents |
| WO2026052854A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
| WO2026052844A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1539268A (en) | 1976-12-23 | 1979-01-31 | Ici Ltd | Prostane derivatives |
| JPH0822830B2 (ja) | 1988-10-19 | 1996-03-06 | 長谷川香料株式会社 | ２（ｚ）−ペンテニル置換シクロペンタン類およびその新規中間体 |
| JP2743198B2 (ja) | 1989-09-26 | 1998-04-22 | 長谷川香料株式会社 | シクロペンタン類 |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US6734171B1 (en) | 1997-10-10 | 2004-05-11 | Inex Pharmaceuticals Corp. | Methods for encapsulating nucleic acids in lipid bilayers |
| EP1412065A2 (en) | 2001-07-27 | 2004-04-28 | President And Fellows Of Harvard College | Laminar mixing apparatus and methods |
| WO2008109238A1 (en) | 2007-03-02 | 2008-09-12 | Janssen Pharmaceutica N.V. | Substituted cyclopentyl piperidine ccr2 antagonists |
| WO2009086558A1 (en) * | 2008-01-02 | 2009-07-09 | Tekmira Pharmaceuticals Corporation | Improved compositions and methods for the delivery of nucleic acids |
| HUE037082T2 (hu) | 2008-11-10 | 2018-08-28 | Arbutus Biopharma Corp | Új lipidek és készítmények terápiás hatóanyagok szállítására |
| MX342785B (es) | 2009-06-10 | 2016-10-12 | Alnylam Pharmaceuticals Inc | Formulacion mejorada de lipido. |
| CA2816925C (en) | 2009-11-04 | 2023-01-10 | The University Of British Columbia | Nucleic acid-containing lipid particles and related methods |
| JP2014001142A (ja) | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
| CA2824526C (en) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| WO2012108397A1 (ja) | 2011-02-08 | 2012-08-16 | 第一三共株式会社 | 新規脂質 |
| EP3069785A1 (en) | 2011-10-25 | 2016-09-21 | The University Of British Columbia | Limit size lipid nanoparticles and related methods |
| CA2906732C (en) | 2013-03-15 | 2023-08-08 | The University Of British Columbia | Lipid nanoparticles for transfection and related methods |
| AU2016385135B2 (en) | 2016-01-06 | 2022-02-17 | The University Of British Columbia | Bifurcating mixers and methods of their use and manufacture |
| EP3481539A4 (en) | 2016-07-06 | 2020-02-26 | Precision Nanosystems Inc | INTELLIGENT MICROFLUIDIC MIXING INSTRUMENT AND CARTRIDGES |
| WO2018232502A1 (en) * | 2017-06-20 | 2018-12-27 | Rjh Biosciences Inc. | Transfection reagents for delivery of nucleic acids |
| WO2019182527A1 (en) | 2018-03-21 | 2019-09-26 | T.C. Istanbul Medipol Universitesi | Methyl jasmonate derivatives as possible drug candidates for use in treatment of cancer |
-
2020
- 2020-06-19 US US17/620,575 patent/US12503432B2/en active Active
- 2020-06-19 CN CN202080045008.3A patent/CN114746401B/zh active Active
- 2020-06-19 WO PCT/CA2020/050854 patent/WO2020252589A1/en not_active Ceased
- 2020-06-19 EP EP20826513.2A patent/EP3986866B1/en active Active
- 2020-06-19 ES ES20826513T patent/ES2973521T3/es active Active
- 2020-06-19 CA CA3143577A patent/CA3143577C/en active Active
- 2020-06-19 JP JP2021574974A patent/JP7416096B2/ja active Active
- 2020-06-19 KR KR1020227002023A patent/KR102568997B1/ko active Active
- 2020-06-19 DK DK20826513.2T patent/DK3986866T3/da active
-
2025
- 2025-09-24 US US19/338,244 patent/US20260078085A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2020252589A5 (https=) | ||
| JPWO2021000041A5 (https=) | ||
| MX2024007720A (es) | Lipidos para la administracion de agentes activos en nanoparticulas lipidicas. | |
| JP2017522376A5 (https=) | ||
| JPWO2020081938A5 (https=) | ||
| MX2025002671A (es) | Lipidos para uso en formulaciones de nanoparticulas de lipidos | |
| JP6270848B2 (ja) | ベータ−クロロシクロペンタンの親水性エステルプロドラッグの使用による角膜中央部肥厚の低下 | |
| JP2018524339A5 (https=) | ||
| JP2009523841A5 (https=) | ||
| RU93058253A (ru) | Соединения-антибиотики, способы их получения, промежуточные соединения, фармкомпозиция, способ лечения | |
| KR920009796A (ko) | 3-아미도인돌릴 유도체 | |
| RU2003133448A (ru) | 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс- хемокинового рецептора | |
| KR950700265A (ko) | 고지혈증 치료에 유용한 벤조티아제핀 화합물(hypolipidaemic ben zothiazepine compounds) | |
| JP2012507522A5 (https=) | ||
| JPWO2023099592A5 (https=) | ||
| JP2004517099A5 (https=) | ||
| JP2004517843A5 (https=) | ||
| JPWO2023114943A5 (https=) | ||
| MX2025013218A (es) | Lipidos para usarse en formulaciones de nanoparticulas de lipido | |
| RU99127433A (ru) | Эрголиновые производные и их применение в качестве антагонистов рецепторов соматостатина | |
| JPWO2022152821A5 (https=) | ||
| JPWO2023114944A5 (https=) | ||
| JPH02255652A (ja) | ベンゼンスルホンアミド類およびその製造方法 | |
| JP3131693B2 (ja) | 眼疾患を処置するための５―メチル―イソオキサゾール―４―カルボン酸アニリド類または２―ヒドロキシエチリデン―シアノ酢酸アニリド類含有医薬組成物 | |
| JPWO2023091787A5 (https=) |