CN114746401B - 用于核酸递送的可离子化脂质 - Google Patents
用于核酸递送的可离子化脂质 Download PDFInfo
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- CN114746401B CN114746401B CN202080045008.3A CN202080045008A CN114746401B CN 114746401 B CN114746401 B CN 114746401B CN 202080045008 A CN202080045008 A CN 202080045008A CN 114746401 B CN114746401 B CN 114746401B
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| PCT/CA2020/050854 WO2020252589A1 (en) | 2019-06-20 | 2020-06-19 | Ionizable lipids for nucleic acid delivery |
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| CA3112837A1 (en) * | 2018-10-19 | 2020-04-23 | Translate Bio, Inc. | Pumpless encapsulation of messenger rna |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| IL303195A (en) | 2020-11-25 | 2023-07-01 | Akagera Medicines Inc | Lipid nanoparticles for delivery of nucleic acids and related methods of use |
| CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| KR20230017730A (ko) | 2021-07-27 | 2023-02-06 | 에스케이바이오사이언스(주) | 단백질 발현을 위한 mRNA와 이를 위한 주형 |
| CN115772089B (zh) * | 2021-09-07 | 2025-06-10 | 广州谷森制药有限公司 | 阳离子脂质化合物 |
| US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
| EP4531819A2 (en) | 2022-05-25 | 2025-04-09 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids and methods of use thereof |
| WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
| AU2023393613A1 (en) | 2022-12-12 | 2025-06-19 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticles lyophilization methods and compositions |
| KR102921785B1 (ko) * | 2022-12-19 | 2026-02-03 | 주식회사 녹십자 | 핵산 전달용 사이클로알칸계 지질 화합물 및 이를 포함하는 지질 나노입자 |
| IL321425A (en) | 2022-12-23 | 2025-08-01 | Biontech Delivery Tech Gmbh | compound |
| US12311033B2 (en) | 2023-05-31 | 2025-05-27 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| AU2023457271A1 (en) | 2023-06-28 | 2025-12-18 | Global Life Sciences Solutions Canada Ulc | Lipid nanoparticle formulations for cell therapy and related methods |
| CN121712495A (zh) | 2023-08-21 | 2026-03-20 | 环球生命科学解决方案加拿大有限公司 | 用于离子流脂质纳米颗粒的制造方法和装置 |
| WO2025049579A1 (en) | 2023-08-31 | 2025-03-06 | Global Life Sciences Solutions Canada Ulc | Intranasal formulation for pulmonary delivery of nanoparticles, compositions, uses, and manufacturing methods thereof |
| WO2025219528A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Non-destructive plasmid delivery to immune cells |
| WO2025219491A1 (en) | 2024-04-17 | 2025-10-23 | Global Life Sciences Solutions Canada Ulc | Method and composition for hdr template dna delivery |
| WO2025224267A1 (en) | 2024-04-25 | 2025-10-30 | Global Life Sciences Solutions Canada Ulc | Method for producing a liquid composition including a nanoparticle, and formulation thereof |
| WO2026035680A1 (en) | 2024-08-06 | 2026-02-12 | Kernal Biologics, Inc. | Compositions and methods for delivery of agents |
| WO2026052854A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
| WO2026052844A1 (en) | 2024-09-09 | 2026-03-12 | Global Life Sciences Solutions Canada Ulc | 3-component lipid nanoparticle compositions, uses, and manufacturing methods thereof |
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| ES2973521T3 (es) | 2024-06-20 |
| KR20220042119A (ko) | 2022-04-04 |
| JP7416096B2 (ja) | 2024-01-17 |
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| US12503432B2 (en) | 2025-12-23 |
| EP3986866A1 (en) | 2022-04-27 |
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| CN114746401A (zh) | 2022-07-12 |
| KR102568997B1 (ko) | 2023-08-22 |
| US20260078085A1 (en) | 2026-03-19 |
| US20220396548A1 (en) | 2022-12-15 |
| JP2022537305A (ja) | 2022-08-25 |
| CA3143577A1 (en) | 2020-12-24 |
| CA3143577C (en) | 2024-02-20 |
| DK3986866T3 (da) | 2024-03-04 |
| EP3986866B1 (en) | 2023-12-20 |
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