DK3986866T3 - Ioniserbare lipider til nukleinsyrelevering - Google Patents
Ioniserbare lipider til nukleinsyrelevering Download PDFInfo
- Publication number
- DK3986866T3 DK3986866T3 DK20826513.2T DK20826513T DK3986866T3 DK 3986866 T3 DK3986866 T3 DK 3986866T3 DK 20826513 T DK20826513 T DK 20826513T DK 3986866 T3 DK3986866 T3 DK 3986866T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- acid delivery
- ionizable lipids
- ionizable
- lipids
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
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- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/69—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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- C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
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- C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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US201962864064P | 2019-06-20 | 2019-06-20 | |
US201962877536P | 2019-07-23 | 2019-07-23 | |
US202063009104P | 2020-04-13 | 2020-04-13 | |
PCT/CA2020/050854 WO2020252589A1 (en) | 2019-06-20 | 2020-06-19 | Ionizable lipids for nucleic acid delivery |
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DK20826513.2T DK3986866T3 (da) | 2019-06-20 | 2020-06-19 | Ioniserbare lipider til nukleinsyrelevering |
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EP (1) | EP3986866B1 (da) |
JP (1) | JP7416096B2 (da) |
KR (1) | KR102568997B1 (da) |
CN (1) | CN114746401B (da) |
CA (1) | CA3143577C (da) |
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CA3114699A1 (en) | 2018-10-09 | 2020-04-16 | The University Of British Columbia | Compositions and systems comprising transfection-competent vesicles free of organic-solvents and detergents and methods related thereto |
AU2021385572A1 (en) | 2020-11-25 | 2023-06-22 | Akagera Medicines, Inc. | Lipid nanoparticles for delivery of nucleic acids, and related methods of use |
CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
EP4379055A1 (en) | 2021-07-27 | 2024-06-05 | SK Bioscience Co., Ltd. | Mrna for protein expression and template therefor |
CN115772089A (zh) * | 2021-09-07 | 2023-03-10 | 广州谷森制药有限公司 | 新型阳离子脂质化合物 |
US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
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GB1539268A (en) * | 1976-12-23 | 1979-01-31 | Ici Ltd | Prostane derivatives |
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JP2743198B2 (ja) * | 1989-09-26 | 1998-04-22 | 長谷川香料株式会社 | シクロペンタン類 |
WO2008109238A1 (en) | 2007-03-02 | 2008-09-12 | Janssen Pharmaceutica N.V. | Substituted cyclopentyl piperidine ccr2 antagonists |
US20110117125A1 (en) * | 2008-01-02 | 2011-05-19 | Tekmira Pharmaceuticals Corporation | Compositions and methods for the delivery of nucleic acids |
EP3207944B1 (en) * | 2008-11-10 | 2020-01-15 | Arbutus Biopharma Corporation | Novel lipids and compositions for the delivery of therapeutics |
JP2014001142A (ja) | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
WO2018232502A1 (en) * | 2017-06-20 | 2018-12-27 | Rjh Biosciences Inc. | TRANSFECTION REAGENTS FOR NUCLEIC ACID ADMINISTRATION |
WO2019182527A1 (en) | 2018-03-21 | 2019-09-26 | T.C. Istanbul Medipol Universitesi | Methyl jasmonate derivatives as possible drug candidates for use in treatment of cancer |
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KR102568997B1 (ko) | 2023-08-22 |
EP3986866A1 (en) | 2022-04-27 |
JP7416096B2 (ja) | 2024-01-17 |
CN114746401A (zh) | 2022-07-12 |
CA3143577A1 (en) | 2020-12-24 |
CA3143577C (en) | 2024-02-20 |
JP2022537305A (ja) | 2022-08-25 |
EP3986866B1 (en) | 2023-12-20 |
KR20220042119A (ko) | 2022-04-04 |
CN114746401B (zh) | 2023-12-08 |
EP3986866A4 (en) | 2022-08-31 |
WO2020252589A1 (en) | 2020-12-24 |
US20220396548A1 (en) | 2022-12-15 |
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