DK3986866T3 - Ioniserbare lipider til nukleinsyrelevering - Google Patents
Ioniserbare lipider til nukleinsyrelevering Download PDFInfo
- Publication number
- DK3986866T3 DK3986866T3 DK20826513.2T DK20826513T DK3986866T3 DK 3986866 T3 DK3986866 T3 DK 3986866T3 DK 20826513 T DK20826513 T DK 20826513T DK 3986866 T3 DK3986866 T3 DK 3986866T3
- Authority
- DK
- Denmark
- Prior art keywords
- nucleic acid
- acid delivery
- ionizable lipids
- ionizable
- lipids
- Prior art date
Links
- 150000002632 lipids Chemical class 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
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- C07C309/63—Esters of sulfonic acids
- C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
- C07C309/69—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by nitrogen atoms, not being part of nitro or nitroso groups
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- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/20—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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- C07C217/12—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a ring other than a six-membered aromatic ring
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US201962864064P | 2019-06-20 | 2019-06-20 | |
US201962877536P | 2019-07-23 | 2019-07-23 | |
US202063009104P | 2020-04-13 | 2020-04-13 | |
PCT/CA2020/050854 WO2020252589A1 (en) | 2019-06-20 | 2020-06-19 | Ionizable lipids for nucleic acid delivery |
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EP (1) | EP3986866B1 (da) |
JP (1) | JP7416096B2 (da) |
KR (1) | KR102568997B1 (da) |
CN (1) | CN114746401B (da) |
CA (1) | CA3143577C (da) |
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FI3864163T3 (fi) | 2018-10-09 | 2024-05-03 | Univ British Columbia | Koostumukset ja järjestelmät, joihin sisältyvät transfektiokompetentit vesikkelit, joissa ei ole orgaanisia liuottimia eikä pesuaineita, sekä niihin liittyvät menetelmät |
CN117098541A (zh) | 2020-11-25 | 2023-11-21 | 阿卡格拉医药公司 | 用于递送核酸的脂质纳米粒及相关使用方法 |
CN114149337B (zh) * | 2021-07-07 | 2022-04-29 | 天津键凯科技有限公司 | 一种用于核酸递送的新型可电离脂质及其lnp组合物 |
WO2023008793A1 (ko) | 2021-07-27 | 2023-02-02 | 에스케이바이오사이언스(주) | 단백질 발현을 위한 mrna와 이를 위한 주형 |
CN115772089A (zh) * | 2021-09-07 | 2023-03-10 | 广州谷森制药有限公司 | 新型阳离子脂质化合物 |
US11510975B1 (en) | 2021-11-29 | 2022-11-29 | Replicate Bioscience, Inc. | Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses |
WO2024006863A1 (en) | 2022-06-30 | 2024-01-04 | Precision NanoSystems ULC | Lipid nanoparticle formulations for vaccines |
WO2024126423A1 (en) | 2022-12-12 | 2024-06-20 | Precision NanoSystems ULC | Lipid nanoparticles lyophilization methods and compositions |
WO2024133635A1 (en) | 2022-12-23 | 2024-06-27 | Biontech Delivery Technologies Gmbh | Composition |
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GB1539268A (en) * | 1976-12-23 | 1979-01-31 | Ici Ltd | Prostane derivatives |
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JP2743198B2 (ja) * | 1989-09-26 | 1998-04-22 | 長谷川香料株式会社 | シクロペンタン類 |
WO2008109238A1 (en) | 2007-03-02 | 2008-09-12 | Janssen Pharmaceutica N.V. | Substituted cyclopentyl piperidine ccr2 antagonists |
CA3044134A1 (en) * | 2008-01-02 | 2009-07-09 | Arbutus Biopharma Corporation | Improved compositions and methods for the delivery of nucleic acids |
KR102344392B1 (ko) * | 2008-11-10 | 2021-12-28 | 알닐람 파마슈티칼스 인코포레이티드 | 치료제 운반용 신규 지질 및 조성물 |
JP2014001142A (ja) | 2010-10-05 | 2014-01-09 | Astellas Pharma Inc | シクロアルカン化合物 |
US11964057B2 (en) * | 2017-06-20 | 2024-04-23 | Rjh Biosciences Inc. | Transfection reagents for delivery of nucleic acids |
WO2019182527A1 (en) | 2018-03-21 | 2019-09-26 | T.C. Istanbul Medipol Universitesi | Methyl jasmonate derivatives as possible drug candidates for use in treatment of cancer |
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KR102568997B1 (ko) | 2023-08-22 |
ES2973521T3 (es) | 2024-06-20 |
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EP3986866A1 (en) | 2022-04-27 |
JP2022537305A (ja) | 2022-08-25 |
CN114746401A (zh) | 2022-07-12 |
CA3143577C (en) | 2024-02-20 |
CA3143577A1 (en) | 2020-12-24 |
US20220396548A1 (en) | 2022-12-15 |
EP3986866B1 (en) | 2023-12-20 |
JP7416096B2 (ja) | 2024-01-17 |
EP3986866A4 (en) | 2022-08-31 |
CN114746401B (zh) | 2023-12-08 |
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