EP3986866A4 - Ionizable lipids for nucleic acid delivery - Google Patents

Ionizable lipids for nucleic acid delivery Download PDF

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Publication number
EP3986866A4
EP3986866A4 EP20826513.2A EP20826513A EP3986866A4 EP 3986866 A4 EP3986866 A4 EP 3986866A4 EP 20826513 A EP20826513 A EP 20826513A EP 3986866 A4 EP3986866 A4 EP 3986866A4
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EP
European Patent Office
Prior art keywords
nucleic acid
acid delivery
ionizable lipids
ionizable
lipids
Prior art date
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EP20826513.2A
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German (de)
French (fr)
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EP3986866A1 (en
EP3986866B1 (en
Inventor
Nikita Jain
Anitha THOMAS
Andrew William BROWN
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Precision Nanosystems ULC
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Precision Nanosystems ULC
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    • C07—ORGANIC CHEMISTRY
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    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/63—Esters of sulfonic acids
    • C07C309/64—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms
    • C07C309/69—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to acyclic carbon atoms of a carbon skeleton substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
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MX2023006056A (en) 2020-11-25 2023-06-06 Akagera Medicines Inc Lipid nanoparticles for delivery of nucleic acids, and related methods of use.
CN114149337B (en) * 2021-07-07 2022-04-29 天津键凯科技有限公司 Novel ionizable lipid for nucleic acid delivery and LNP composition thereof
KR20230017730A (en) 2021-07-27 2023-02-06 에스케이바이오사이언스(주) mRNA and its template for protein expression
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US11510975B1 (en) 2021-11-29 2022-11-29 Replicate Bioscience, Inc. Compositions and methods for inducing ESR1, PI3K, HER2, and HER3 immune responses
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