CL2021001451A1 - Compuesto macrociclico y su uso - Google Patents
Compuesto macrociclico y su usoInfo
- Publication number
- CL2021001451A1 CL2021001451A1 CL2021001451A CL2021001451A CL2021001451A1 CL 2021001451 A1 CL2021001451 A1 CL 2021001451A1 CL 2021001451 A CL2021001451 A CL 2021001451A CL 2021001451 A CL2021001451 A CL 2021001451A CL 2021001451 A1 CL2021001451 A1 CL 2021001451A1
- Authority
- CL
- Chile
- Prior art keywords
- diseases
- disease
- kidney
- mitochondrial
- inflammatory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto representado por la fórmula (I): donde cada símbolo es como se lo define en la presente, o una sal de éste, que presenta actividad de activación sobre NRF2, del cual se espera que sea útil como agente preventivo o terapéutico para enfermedades asociadas al estrés oxidativo, particularmente, enfermedades hepáticas (por ejemplo, esteatohepatitis no alcohólica (ENA)), enfermedades cardiovasculares (por ejemplo, insuficiencia cardíaca o hipertensión arterial pulmonar), enfermedades pulmonares (por ejemplo, enfermedad pulmonar obstructiva crónica (EPOC)), enfermedades renales (por ejemplo, enfermedad renal crónica (ERC) o lesión renal aguda (LRA)), enfermedades en el sistema nervioso central (por ejemplo, enfermedad de Parkinson), enfermedades mitocondriales (por ejemplo, ataxia motora de Friedreich o miopatía mitocondrial), enfermedades inflamatorias (por ejemplo, 11 esclerosis múltiple (EM) o enfermedad inflamatoria intestinal (EII)), enfermedades en las células falciformes, cánceres o similares.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018228234 | 2018-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2021001451A1 true CL2021001451A1 (es) | 2021-12-24 |
Family
ID=70975488
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2021001451A CL2021001451A1 (es) | 2018-12-05 | 2021-06-02 | Compuesto macrociclico y su uso |
Country Status (17)
Country | Link |
---|---|
US (1) | US11518763B2 (es) |
EP (1) | EP3890738A4 (es) |
JP (1) | JP2022510736A (es) |
KR (1) | KR20210099622A (es) |
CN (1) | CN113164468A (es) |
AR (1) | AR117251A1 (es) |
AU (1) | AU2019391942B2 (es) |
BR (1) | BR112021010704A2 (es) |
CA (1) | CA3121952A1 (es) |
CL (1) | CL2021001451A1 (es) |
CO (1) | CO2021007304A2 (es) |
MX (1) | MX2021006527A (es) |
PH (1) | PH12021551262A1 (es) |
SG (1) | SG11202105125XA (es) |
TW (1) | TWI820266B (es) |
UA (1) | UA127872C2 (es) |
WO (1) | WO2020116660A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3108534A1 (en) | 2018-08-20 | 2020-02-27 | Janssen Pharmaceutica Nv | Inhibitors of keap1-nrf2 protein-protein interaction |
WO2022056448A1 (en) * | 2020-09-14 | 2022-03-17 | Sanofi | Tetrahydroisoquinoline derivatives for the treatment of red blood disorders and inflammatory diseases |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5946454B2 (ja) | 2010-08-31 | 2016-07-06 | バイオニュア ファーマ, エセ.エレ. | ニューロトロフィン受容体のアゴニストおよび医薬としてのその使用 |
RS58581B1 (sr) | 2013-06-21 | 2019-05-31 | Karyopharm Therapeutics Inc | 1,2,4-triazoli kao modulatori jedarnog transporta i njihova primena |
MX370410B (es) * | 2013-12-18 | 2019-12-11 | Glaxosmithkline Ip Dev Ltd | Reguladores de nrf2. |
PL3307739T3 (pl) | 2015-06-15 | 2021-05-31 | Glaxosmithkline Intellectual Property Development Limited | Regulatory nrf2 |
EP3307719A1 (en) | 2015-06-15 | 2018-04-18 | GlaxoSmithKline Intellectual Property Development Limited | Nrf2 regulators |
MA52032A (fr) | 2015-06-15 | 2021-01-20 | Astex Therapeutics Ltd | Régulateurs de nrf2 |
WO2017026516A1 (ja) | 2015-08-12 | 2017-02-16 | 持田製薬株式会社 | イソチアゾール誘導体 |
WO2017060855A1 (en) | 2015-10-06 | 2017-04-13 | Glaxosmithkline Intellectual Property Development Limited | Arylcyclohexyl pyrazoles as nrf2 regulators |
EP3359532A1 (en) | 2015-10-06 | 2018-08-15 | GlaxoSmithKline Intellectual Property Development Limited | Biaryl pyrazoles as nrf2 regulators |
JP2020500919A (ja) | 2016-12-12 | 2020-01-16 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited | Nrf2レギュレーターとしての3−カルボン酸ピロール |
EP3551621A1 (en) | 2016-12-12 | 2019-10-16 | GlaxoSmithKline Intellectual Property Development Limited | N-aryl pyrazoles as nrf2 regulators |
WO2018109643A1 (en) | 2016-12-14 | 2018-06-21 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl heterocycles as nrf2 acti |
US11078216B2 (en) | 2016-12-14 | 2021-08-03 | Glaxosmithkline Intellectual Property Development Limited | Bisaryl amides as NRF2 activators |
ES2848699T3 (es) | 2016-12-14 | 2021-08-11 | Glaxosmithkline Ip Dev Ltd | Compuestos de 3-oxo-1,4-diazepinilo como activadores de NRF2 |
EP3555082B1 (en) | 2016-12-15 | 2022-01-26 | GlaxoSmithKline Intellectual Property Development Limited | Ether linked triazoles as nrf2 regulators |
CN110114361B (zh) | 2016-12-15 | 2022-04-12 | 葛兰素史密斯克莱知识产权发展有限公司 | Nrf2化合物 |
AR110590A1 (es) | 2016-12-27 | 2019-04-10 | Biogen Ma Inc | Activador de nrf2 |
WO2018140876A1 (en) | 2017-01-30 | 2018-08-02 | Biogen Ma Inc. | Nrf2 activator |
EP3573963B1 (en) | 2017-01-30 | 2021-09-01 | Biogen MA Inc. | Nrf2 activator |
JP2020097526A (ja) * | 2017-03-28 | 2020-06-25 | 武田薬品工業株式会社 | 複素環化合物 |
-
2019
- 2019-12-04 WO PCT/JP2019/048593 patent/WO2020116660A1/en unknown
- 2019-12-04 AU AU2019391942A patent/AU2019391942B2/en active Active
- 2019-12-04 MX MX2021006527A patent/MX2021006527A/es unknown
- 2019-12-04 KR KR1020217020790A patent/KR20210099622A/ko active Search and Examination
- 2019-12-04 UA UAA202102856A patent/UA127872C2/uk unknown
- 2019-12-04 US US17/299,659 patent/US11518763B2/en active Active
- 2019-12-04 SG SG11202105125XA patent/SG11202105125XA/en unknown
- 2019-12-04 JP JP2021554804A patent/JP2022510736A/ja active Pending
- 2019-12-04 TW TW108144324A patent/TWI820266B/zh active
- 2019-12-04 BR BR112021010704-5A patent/BR112021010704A2/pt unknown
- 2019-12-04 CA CA3121952A patent/CA3121952A1/en active Pending
- 2019-12-04 AR ARP190103549A patent/AR117251A1/es unknown
- 2019-12-04 EP EP19892751.9A patent/EP3890738A4/en active Pending
- 2019-12-04 CN CN201980080214.5A patent/CN113164468A/zh active Pending
-
2021
- 2021-05-31 PH PH12021551262A patent/PH12021551262A1/en unknown
- 2021-06-02 CL CL2021001451A patent/CL2021001451A1/es unknown
- 2021-06-03 CO CONC2021/0007304A patent/CO2021007304A2/es unknown
Also Published As
Publication number | Publication date |
---|---|
MX2021006527A (es) | 2021-07-21 |
PH12021551262A1 (en) | 2021-10-25 |
AU2019391942A1 (en) | 2021-06-03 |
TWI820266B (zh) | 2023-11-01 |
BR112021010704A2 (pt) | 2021-08-24 |
EP3890738A4 (en) | 2022-08-17 |
AR117251A1 (es) | 2021-07-21 |
CA3121952A1 (en) | 2020-06-11 |
WO2020116660A1 (en) | 2020-06-11 |
EP3890738A1 (en) | 2021-10-13 |
US11518763B2 (en) | 2022-12-06 |
AU2019391942B2 (en) | 2024-03-21 |
KR20210099622A (ko) | 2021-08-12 |
CN113164468A (zh) | 2021-07-23 |
US20220119391A1 (en) | 2022-04-21 |
JP2022510736A (ja) | 2022-01-27 |
CO2021007304A2 (es) | 2021-06-21 |
UA127872C2 (uk) | 2024-01-31 |
SG11202105125XA (en) | 2021-06-29 |
TW202039494A (zh) | 2020-11-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2021001451A1 (es) | Compuesto macrociclico y su uso | |
CO6280490A2 (es) | 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso | |
BR112016023808A2 (pt) | ?veículo? | |
CR20130524A (es) | Derivados de ácido 3-fenilpropiónico ramificados y su uso | |
ECSP088628A (es) | Moduladores de receptores cannabinoides | |
CR20130259A (es) | Ácidos 1-bencilcicloalquilcarboxílicos sustituidos y su uso | |
BR112014003587A2 (pt) | derivados de 5-flúor-4-imino-3-(substituído)-3,4-di-hidropirimidin-2(1h)ona | |
UY31310A1 (es) | Ácidos 6-fenilnicotínicos sustituidos y su uso | |
BR112013002112A2 (pt) | composto, composição farmacêutica, e, uso de um composto, ou de um respectivo sal farmaceuticamente aceitável ou n-óxido, ou um solvato ou hidrato do mesmo, ou de uma composição | |
CR20210085A (es) | Compuestos de 2,6-diaminopiridina | |
BR112015017251A8 (pt) | composições farmacêuticas compreendendo doadores de nitroxil, misturas e usos das referidas composições farmacêuticas | |
AR085616A1 (es) | Composicion farmaceutica inhalable que comprende glicopirrolato, uso | |
AR090806A1 (es) | Glucosidos de pirazol y su utilizacion en el tratamiento de la diabetes tipo i y ii | |
AR103415A1 (es) | Tratamiento de pacientes pediátricos con diabetes mellitus de tipo 2 | |
AR091888A1 (es) | Compuestos de urea y su uso como inhibidores de enzimas | |
BR112014012892A2 (pt) | agentes de reversão anticoagulantes | |
CO6400226A2 (es) | Micrólido anti-inflamatorio | |
CL2013000021A1 (es) | Forma cristalina delta de la sal de arginina de perindoprilo; procedimiento de preparacion; composiciones farmaceuticas que la contienen; y su uso par el tratamiento de las enfermedades cardiovasculares, tales como hipertension arterial, insuficiencia cardiaca o enfermedad coronaria estable. | |
AR084209A1 (es) | Metodo para la sintesis de derivados de aminociclohexanona sustituidos | |
WO2014176510A3 (en) | N-(4-(bis(4-(dimethylamino)phenyl)methylene)-8-(dimethylamino) naphthalen-1(4h)-ylidene)-n-methylmethanaminium, derivatives, and their use in treating cancer | |
Schumacher | Arthritis and other Musculoskeletal Features in SLE | |
Johnson | Cardiotoxicity: 2 case reports | |
ES2446215R2 (es) | Aplicación terapéutica de agentes inhibidores de cd44 frente a la leucemia linfoblástica aguda (all) humana. | |
TH160030A (th) | ไตรเทอร์พีนอยด์สังเคราะห์และวิธีการของการใช้ในการบำบัดของโรค | |
MOHAMMED | CHRONIC OBSTRUCTIVE PULMONARY DISEASE AMONG WOMEN USING BIOMAS FUELS IN SOME RURAL AREAS OF FAYOUM GOVERNORATE |