JPWO2020086881A5 - - Google Patents
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- JPWO2020086881A5 JPWO2020086881A5 JP2021516750A JP2021516750A JPWO2020086881A5 JP WO2020086881 A5 JPWO2020086881 A5 JP WO2020086881A5 JP 2021516750 A JP2021516750 A JP 2021516750A JP 2021516750 A JP2021516750 A JP 2021516750A JP WO2020086881 A5 JPWO2020086881 A5 JP WO2020086881A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- plasmid
- sequence
- seq
- downstream
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024161633A JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862750603P | 2018-10-25 | 2018-10-25 | |
| US62/750,603 | 2018-10-25 | ||
| PCT/US2019/057916 WO2020086881A1 (en) | 2018-10-25 | 2019-10-24 | Aav triple-plasmid system |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024161633A Division JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022511348A JP2022511348A (ja) | 2022-01-31 |
| JP2022511348A5 JP2022511348A5 (https=) | 2022-10-19 |
| JPWO2020086881A5 true JPWO2020086881A5 (https=) | 2022-10-19 |
| JP7560447B2 JP7560447B2 (ja) | 2024-10-02 |
Family
ID=70331899
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021516750A Active JP7560447B2 (ja) | 2018-10-25 | 2019-10-24 | Ａａｖトリプルプラスミドシステム |
| JP2024161633A Pending JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024161633A Pending JP2025000711A (ja) | 2018-10-25 | 2024-09-19 | Ａａｖトリプルプラスミドシステム |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12383587B2 (https=) |
| EP (1) | EP3870148A4 (https=) |
| JP (2) | JP7560447B2 (https=) |
| KR (1) | KR20210086645A (https=) |
| CN (1) | CN112888426A (https=) |
| AU (1) | AU2019363593A1 (https=) |
| CA (1) | CA3112883A1 (https=) |
| IL (1) | IL281909A (https=) |
| TW (1) | TW202029957A (https=) |
| WO (1) | WO2020086881A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019144061A1 (en) | 2018-01-19 | 2019-07-25 | Duke University | Genome engineering with crispr-cas systems in eukaryotes |
| US10557149B1 (en) * | 2019-07-15 | 2020-02-11 | Vigene Biosciences, Inc. | Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus |
| EP4189077A1 (en) | 2020-07-30 | 2023-06-07 | Shape Therapeutics Inc. | Stable cell lines for inducible production of raav virions |
| WO2022087321A1 (en) * | 2020-10-21 | 2022-04-28 | Duke University | Dual aav vector-mediated deletion of large mutational hotspot for treatment of duchenne muscular dystrophy |
| IL302578A (en) * | 2020-11-04 | 2023-07-01 | Synplogen Co Ltd | Production of a virus vector plasmid in Bacillus Subtilis |
| US11926842B2 (en) * | 2021-02-02 | 2024-03-12 | University Of Massachusetts | Use of inverted terminal repeats (ITRS) from adeno-associated virus serotypes 8 and RH.39 in gene therapy vectors |
| US20240360422A1 (en) * | 2021-04-21 | 2024-10-31 | Michael T. Leonard | Stable production systems for adeno-associated virus production |
| US12305188B2 (en) | 2021-05-27 | 2025-05-20 | Neuracle Genetics Inc. | Dual helper plasmid |
| KR102685652B1 (ko) * | 2021-05-27 | 2024-07-19 | 주식회사 뉴라클제네틱스 | 신규한 듀얼 헬퍼 플라스미드 |
| EP4377471A4 (en) * | 2021-07-28 | 2025-10-15 | Atsena Therapeutics Inc | AAV TRANSFER PLASMIDS |
| CN114196705B (zh) * | 2021-12-07 | 2024-09-06 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒包装质粒、重组腺相关病毒及其应用 |
| WO2023102736A1 (zh) * | 2021-12-07 | 2023-06-15 | 中国科学院深圳先进技术研究院 | 一种重组腺相关病毒包装质粒、重组腺相关病毒及其应用 |
| KR20250009975A (ko) * | 2022-05-12 | 2025-01-20 | 아브너진 인코포레이티드 | 재조합 파르보바이러스 생산을 위한 조성물 및 방법 |
| CN119866377A (zh) * | 2022-08-31 | 2025-04-22 | 镇江蓬勃生物科技有限公司 | 能够提高腺相关病毒滴度的腺相关病毒结构质粒 |
| CN116064672B (zh) * | 2022-09-15 | 2025-02-14 | 思鹏生物科技(苏州)有限公司 | 利用ires基因提升aav包装效率的方法及其功能基因 |
| WO2024098035A2 (en) * | 2022-11-04 | 2024-05-10 | National Resilience, Inc. | Methods and compositions for preparing recombinant adeno associated viruses and uses thereof |
| WO2024160232A1 (zh) * | 2023-02-01 | 2024-08-08 | 纽福斯(苏州)生物科技有限公司 | 质粒包装系统及其应用 |
| CN116411024A (zh) * | 2023-03-10 | 2023-07-11 | 上海泰昶生物技术有限公司 | 用于生产重组腺相关病毒的质粒系统 |
| US20240352483A1 (en) * | 2023-04-03 | 2024-10-24 | Decibel Therapeutics, Inc. | Modified rep-cap plasmids and uses thereof |
| WO2024238742A2 (en) * | 2023-05-16 | 2024-11-21 | Oxford Biomedica (Us) Llc | Compositions and methods for increasing aav productivity |
| WO2025050347A1 (en) * | 2023-09-07 | 2025-03-13 | Chigenovo Co., Ltd. | Aav vector backbone optimization and use thereof |
| CN117683797B (zh) * | 2023-12-04 | 2024-07-05 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN117925663A (zh) * | 2023-12-04 | 2024-04-26 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN117778431B (zh) * | 2023-12-04 | 2024-10-25 | 广州派真生物技术有限公司 | 一种用于重组腺相关病毒包装的质粒系统及其应用 |
| CN121780618A (zh) * | 2023-12-13 | 2026-04-03 | 广州派真生物技术有限公司 | 一种高产重组腺相关病毒的辅助质粒及应用 |
| CN117660534B (zh) * | 2023-12-13 | 2024-05-07 | 广州派真生物技术有限公司 | 一种降低重组腺相关病毒中宿主细胞dna残留的辅助质粒及应用 |
| US20250276095A1 (en) | 2024-03-04 | 2025-09-04 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of duchenne muscular dystrophy |
| WO2025217308A1 (en) * | 2024-04-10 | 2025-10-16 | Solid Biosciences Inc. | Method of aav production |
| WO2025226842A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Expression control by drg-expressed mirnas |
| WO2025226841A1 (en) | 2024-04-24 | 2025-10-30 | Kate Therapeutics, Inc. | Gene therapy approach for treating disorders associated with tnnt2 |
| WO2026011008A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Expression control by skeletal muscle-expressed mirnas |
| WO2026011009A1 (en) | 2024-07-02 | 2026-01-08 | Kate Therapeutics, Inc. | Compositions and methods for muscle disorders |
| WO2026030242A1 (en) | 2024-07-29 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of facioscapulohumeral muscular dystrophy |
| WO2026030244A1 (en) | 2024-07-30 | 2026-02-05 | Kate Therapeutics, Inc. | Adeno-associated virus compositions for the treatment of limb girdle muscular dystrophy 2a |
| WO2026050402A1 (en) | 2024-08-29 | 2026-03-05 | Kate Therapeutics, Inc. | Liver de-targeted muscle tropic capsids |
| CN119662733B (zh) * | 2024-12-09 | 2025-10-28 | 广州派真生物技术有限公司 | 一种高产rAAV的质粒系统及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6004797A (en) | 1995-11-09 | 1999-12-21 | Avigen, Inc. | Adenovirus helper-free recombinant AAV Virion production |
| CA2369985A1 (en) | 2002-01-18 | 2003-07-18 | Duke University | Generation of recombinant adeno-associated viral vectors by a complete adenovirus-mediated approach |
| US9249425B2 (en) | 2011-05-16 | 2016-02-02 | The Trustees Of The University Of Pennslyvania | Proviral plasmids and production of recombinant adeno-associated virus |
| US9163259B2 (en) * | 2012-05-04 | 2015-10-20 | Novartis Ag | Viral vectors for the treatment of retinal dystrophy |
| MX384795B (es) * | 2013-03-15 | 2025-03-14 | Childrens Hospital Philadelphia | Vectores que comprenden secuencias de polinucleotidos rellenadoras/de relleno y metodos de uso. |
| KR20240090694A (ko) | 2013-07-22 | 2024-06-21 | 더 칠드런스 호스피탈 오브 필라델피아 | 변종 ａａｖ 및 조성물, 세포, 기관 및 조직으로의 유전자 전이를 위한 방법 및 용도 |
| EP3039129B1 (en) | 2013-08-30 | 2018-06-27 | Amgen Inc. | High titer recombinant aav vector production in adherent and suspension cells |
| CN105765066B (zh) | 2013-11-29 | 2018-12-14 | 宝生物工程株式会社 | 用于定量腺伴随病毒的方法 |
| AU2015229464B2 (en) * | 2014-03-11 | 2021-07-22 | Wayne State University | A modified mGluR6 promoter and methods of use |
| WO2016074016A1 (en) | 2014-11-10 | 2016-05-19 | Murdoch Childrens Research Institute | Vectors and methods for targeted integration in loci comprising constitutively expressed genes |
| RS63416B1 (sr) | 2015-03-03 | 2022-08-31 | Fond Telethon | Sistem višestrukih vektora i njegove primene |
| WO2016183422A1 (en) | 2015-05-14 | 2016-11-17 | St. Jude Children's Research Hospital, Inc. | Nucleic acid molecules containing spacers and methods of use thereof |
| US11027024B2 (en) | 2015-05-29 | 2021-06-08 | University Of Iowa Research Foundation | Methods of delivery of transgenes for treating brain diseases |
| KR102445192B1 (ko) | 2016-10-31 | 2022-09-20 | 코오롱생명과학 주식회사 | 통증 완화 또는 치료용 조성물 |
| JP2021520232A (ja) | 2018-04-05 | 2021-08-19 | オックスフォード ユニバーシティ イノベーション リミテッドＯｘｆｏｒｄ Ｕｎｉｖｅｒｓｉｔｙ Ｉｎｎｏｖａｔｉｏｎ Ｌｉｍｉｔｅｄ | 黄斑ジストロフィーを処置するための組成物及び方法 |
-
2019
- 2019-10-24 EP EP19876857.4A patent/EP3870148A4/en active Pending
- 2019-10-24 KR KR1020217014276A patent/KR20210086645A/ko active Pending
- 2019-10-24 CN CN201980069110.4A patent/CN112888426A/zh active Pending
- 2019-10-24 WO PCT/US2019/057916 patent/WO2020086881A1/en not_active Ceased
- 2019-10-24 US US17/288,141 patent/US12383587B2/en active Active
- 2019-10-24 CA CA3112883A patent/CA3112883A1/en active Pending
- 2019-10-24 AU AU2019363593A patent/AU2019363593A1/en active Pending
- 2019-10-24 JP JP2021516750A patent/JP7560447B2/ja active Active
- 2019-10-25 TW TW108138732A patent/TW202029957A/zh unknown
-
2021
- 2021-03-30 IL IL281909A patent/IL281909A/en unknown
-
2024
- 2024-09-19 JP JP2024161633A patent/JP2025000711A/ja active Pending
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