JPWO2020086665A5 - - Google Patents
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- Publication number
- JPWO2020086665A5 JPWO2020086665A5 JP2021523230A JP2021523230A JPWO2020086665A5 JP WO2020086665 A5 JPWO2020086665 A5 JP WO2020086665A5 JP 2021523230 A JP2021523230 A JP 2021523230A JP 2021523230 A JP2021523230 A JP 2021523230A JP WO2020086665 A5 JPWO2020086665 A5 JP WO2020086665A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- sequence
- epcam
- antibody fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000004965 antibodies Human genes 0.000 claims 180
- 108090001123 antibodies Proteins 0.000 claims 180
- 102000018651 Epithelial Cell Adhesion Molecule Human genes 0.000 claims 70
- 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 claims 70
- 108010027440 Immunoconjugates Proteins 0.000 claims 21
- 102000018748 Immunoconjugates Human genes 0.000 claims 21
- 210000004027 cells Anatomy 0.000 claims 21
- 230000000873 masking Effects 0.000 claims 20
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 201000011510 cancer Diseases 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 9
- 239000011780 sodium chloride Substances 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 108010047814 Antigen-Antibody Complex Proteins 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 6
- 102000038129 antigens Human genes 0.000 claims 6
- 108091007172 antigens Proteins 0.000 claims 6
- 206010017758 Gastric cancer Diseases 0.000 claims 5
- 229920000023 polynucleotide Polymers 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 201000011549 stomach cancer Diseases 0.000 claims 5
- 201000011231 colorectal cancer Diseases 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- 102000033147 ERVK-25 Human genes 0.000 claims 3
- 108091005771 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 206010046766 Uterine cancer Diseases 0.000 claims 3
- -1 Val-Cit Proteins 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 239000000758 substrate Substances 0.000 claims 3
- PVGATNRYUYNBHO-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O PVGATNRYUYNBHO-UHFFFAOYSA-N 0.000 claims 2
- LCZVQHWMSQLWSC-UHFFFAOYSA-N 1-[4-(2,5-dioxopyrrol-1-yl)butanoyloxy]-2,5-dioxopyrrolidine-3-sulfonic acid Chemical compound O=C1C(S(=O)(=O)O)CC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O LCZVQHWMSQLWSC-UHFFFAOYSA-N 0.000 claims 2
- LIWMQSWFLXEGMA-WDSKDSINSA-N Ala-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](C)N LIWMQSWFLXEGMA-WDSKDSINSA-N 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- DEFJQIDDEAULHB-QWWZWVQMSA-N D-alanyl-D-alanine zwitterion Chemical compound C[C@@H]([NH3+])C(=O)N[C@H](C)C([O-])=O DEFJQIDDEAULHB-QWWZWVQMSA-N 0.000 claims 2
- 230000035693 Fab Effects 0.000 claims 2
- DEFJQIDDEAULHB-IMJSIDKUSA-N L-alanyl-L-alanine Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(O)=O DEFJQIDDEAULHB-IMJSIDKUSA-N 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010027476 Metastasis Diseases 0.000 claims 2
- 208000002154 Non-Small-Cell Lung Carcinoma Diseases 0.000 claims 2
- 108009000071 Non-small cell lung cancer Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 208000008443 Pancreatic Carcinoma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 206010038038 Rectal cancer Diseases 0.000 claims 2
- 108010056243 alanylalanine Proteins 0.000 claims 2
- 108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- FAQVCWVVIYYWRR-WHFBIAKZSA-N (2S)-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CCC(N)=O FAQVCWVVIYYWRR-WHFBIAKZSA-N 0.000 claims 1
- QXRNAOYBCYVZCD-BQBZGAKWSA-N (2S)-6-amino-2-[[(2S)-2-aminopropanoyl]amino]hexanoic acid Chemical compound C[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN QXRNAOYBCYVZCD-BQBZGAKWSA-N 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- NCPQROHLJFARLL-UHFFFAOYSA-N 4-(2,5-dioxopyrrol-1-yl)butanoic acid Chemical compound OC(=O)CCCN1C(=O)C=CC1=O NCPQROHLJFARLL-UHFFFAOYSA-N 0.000 claims 1
- FSHURBQASBLAPO-WDSKDSINSA-N Ala-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@H](C)N FSHURBQASBLAPO-WDSKDSINSA-N 0.000 claims 1
- OMLWNBVRVJYMBQ-YUMQZZPRSA-N Arg-Arg Chemical compound NC(N)=NCCC[C@H](N)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O OMLWNBVRVJYMBQ-YUMQZZPRSA-N 0.000 claims 1
- DAQIJMOLTMGJLO-YUMQZZPRSA-N Arg-Val Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCNC(N)=N DAQIJMOLTMGJLO-YUMQZZPRSA-N 0.000 claims 1
- SJUXYGVRSGTPMC-UHFFFAOYSA-N Asparaginyl-Alanine Chemical compound OC(=O)C(C)NC(=O)C(N)CC(N)=O SJUXYGVRSGTPMC-UHFFFAOYSA-N 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 101700038562 CCND1 Proteins 0.000 claims 1
- HHNFORCFJOVQNF-UHFFFAOYSA-N Cyl-1 Chemical compound N1C(=O)C(CCCCCC(=O)C2OC2)NC(=O)C2CCCN2C(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(OC)C=C1 HHNFORCFJOVQNF-UHFFFAOYSA-N 0.000 claims 1
- QNAYBMKLOCPYGJ-UWTATZPHSA-N D-alanine Chemical compound C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims 1
- VHLZDSUANXBJHW-UHFFFAOYSA-N Glutaminyl-Phenylalanine Chemical compound NC(=O)CCC(N)C(=O)NC(C(O)=O)CC1=CC=CC=C1 VHLZDSUANXBJHW-UHFFFAOYSA-N 0.000 claims 1
- MRVYVEQPNDSWLH-UHFFFAOYSA-N Glutaminyl-Valine Chemical compound CC(C)C(C(O)=O)NC(=O)C(N)CCC(N)=O MRVYVEQPNDSWLH-UHFFFAOYSA-N 0.000 claims 1
- 108010009504 Gly-Phe-Leu-Gly Proteins 0.000 claims 1
- 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 claims 1
- NVGBPTNZLWRQSY-UWVGGRQHSA-N Lys-Lys Chemical compound NCCCC[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN NVGBPTNZLWRQSY-UWVGGRQHSA-N 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- JHKXZYLNVJRAAJ-WDSKDSINSA-N Met-Ala Chemical compound CSCC[C@H](N)C(=O)N[C@@H](C)C(O)=O JHKXZYLNVJRAAJ-WDSKDSINSA-N 0.000 claims 1
- 210000000441 Neoplastic Stem Cells Anatomy 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- MIDZLCFIAINOQN-WPRPVWTQSA-N Phe-Ala Chemical compound OC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=CC=C1 MIDZLCFIAINOQN-WPRPVWTQSA-N 0.000 claims 1
- FADYJNXDPBKVCA-UHFFFAOYSA-N Phenylalanyl-Lysine Chemical compound NCCCCC(C(O)=O)NC(=O)C(N)CC1=CC=CC=C1 FADYJNXDPBKVCA-UHFFFAOYSA-N 0.000 claims 1
- 102000005632 Single-Chain Antibodies Human genes 0.000 claims 1
- 108010070144 Single-Chain Antibodies Proteins 0.000 claims 1
- 206010054184 Small intestine carcinoma Diseases 0.000 claims 1
- 206010044285 Tracheal cancer Diseases 0.000 claims 1
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 1
- HSRXSKHRSXRCFC-WDSKDSINSA-N Val-Ala Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C)C(O)=O HSRXSKHRSXRCFC-WDSKDSINSA-N 0.000 claims 1
- IBIDRSSEHFLGSD-YUMQZZPRSA-N Val-Arg Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCN=C(N)N IBIDRSSEHFLGSD-YUMQZZPRSA-N 0.000 claims 1
- JKHXYJKMNSSFFL-IUCAKERBSA-N Val-Lys Chemical compound CC(C)[C@H](N)C(=O)N[C@H](C(O)=O)CCCCN JKHXYJKMNSSFFL-IUCAKERBSA-N 0.000 claims 1
- 108010054982 alanyl-leucyl-alanyl-leucine Proteins 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 108010068380 arginylarginine Proteins 0.000 claims 1
- 108010036533 arginylvaline Proteins 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000004113 cell culture Methods 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000000032 diagnostic agent Substances 0.000 claims 1
- 150000002019 disulfides Chemical class 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 108010054155 lysyllysine Proteins 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 108010024607 phenylalanylalanine Proteins 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
- 108010073969 valyllysine Proteins 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862751530P | 2018-10-26 | 2018-10-26 | |
| US62/751,530 | 2018-10-26 | ||
| US201962824539P | 2019-03-27 | 2019-03-27 | |
| US62/824,539 | 2019-03-27 | ||
| US201962846297P | 2019-05-10 | 2019-05-10 | |
| US62/846,297 | 2019-05-10 | ||
| PCT/US2019/057569 WO2020086665A1 (en) | 2018-10-26 | 2019-10-23 | Epcam antibodies, activatable antibodies, and immunoconjugates, and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022506072A JP2022506072A (ja) | 2022-01-17 |
| JPWO2020086665A5 true JPWO2020086665A5 (ko) | 2022-10-31 |
Family
ID=70331831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021523230A Pending JP2022506072A (ja) | 2018-10-26 | 2019-10-23 | ＥｐＣＡＭ抗体、活性化可能抗体、および免疫複合体、ならびにそれらの使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20210403594A1 (ko) |
| EP (1) | EP3873512A4 (ko) |
| JP (1) | JP2022506072A (ko) |
| KR (1) | KR20210095874A (ko) |
| CN (1) | CN113194985A (ko) |
| AU (1) | AU2019364400A1 (ko) |
| BR (1) | BR112021007918A2 (ko) |
| CA (1) | CA3117548A1 (ko) |
| IL (1) | IL282496A (ko) |
| MX (1) | MX2021004808A (ko) |
| SG (1) | SG11202103949SA (ko) |
| TW (1) | TW202029980A (ko) |
| WO (1) | WO2020086665A1 (ko) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4359438A1 (en) * | 2021-06-21 | 2024-05-01 | Bristol-Myers Squibb Company | Use of sucrose, mannitol and glycine to reduce reconstitution time of high concentration lyophilized biologics drug products |
| WO2023183888A1 (en) | 2022-03-23 | 2023-09-28 | Cytomx Therapeutics, Inc. | Activatable antigen-binding protein constructs and uses of the same |
| WO2023183923A1 (en) | 2022-03-25 | 2023-09-28 | Cytomx Therapeutics, Inc. | Activatable dual-anchored masked molecules and methods of use thereof |
| WO2023192606A2 (en) | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Cd3-binding proteins and methods of use thereof |
| WO2023192973A1 (en) | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Activatable multispecific molecules and methods of use thereof |
| WO2024015830A1 (en) | 2022-07-12 | 2024-01-18 | Cytomx Therapeutics, Inc. | Epcam immunoconjugates and uses thereof |
| WO2024030845A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
| WO2024030850A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable substrates and methods of use thereof |
| WO2024030843A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
| WO2024030858A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable substrates and methods of use thereof |
| WO2024030847A1 (en) | 2022-08-01 | 2024-02-08 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
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| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
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| ATE336514T1 (de) | 2000-02-11 | 2006-09-15 | Merck Patent Gmbh | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
| ES2727425T3 (es) | 2000-12-12 | 2019-10-16 | Medimmune Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
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| SG11201710734UA (en) * | 2015-06-24 | 2018-01-30 | Japan Chem Res | Anti-human transferrin receptor antibody permeating blood-brain barrier |
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| EP3328894B1 (en) * | 2015-08-06 | 2018-11-14 | Agency For Science, Technology And Research | Il2rbeta/common gamma chain antibodies |
-
2019
- 2019-10-22 TW TW108138004A patent/TW202029980A/zh unknown
- 2019-10-23 EP EP19876033.2A patent/EP3873512A4/en active Pending
- 2019-10-23 WO PCT/US2019/057569 patent/WO2020086665A1/en unknown
- 2019-10-23 MX MX2021004808A patent/MX2021004808A/es unknown
- 2019-10-23 SG SG11202103949SA patent/SG11202103949SA/en unknown
- 2019-10-23 CN CN201980084482.4A patent/CN113194985A/zh active Pending
- 2019-10-23 BR BR112021007918-1A patent/BR112021007918A2/pt unknown
- 2019-10-23 KR KR1020217015710A patent/KR20210095874A/ko active Search and Examination
- 2019-10-23 AU AU2019364400A patent/AU2019364400A1/en active Pending
- 2019-10-23 JP JP2021523230A patent/JP2022506072A/ja active Pending
- 2019-10-23 CA CA3117548A patent/CA3117548A1/en active Pending
- 2019-10-23 US US17/288,469 patent/US20210403594A1/en active Pending
-
2021
- 2021-04-20 IL IL282496A patent/IL282496A/en unknown
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