JPWO2020071365A5 - - Google Patents
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- Publication number
- JPWO2020071365A5 JPWO2020071365A5 JP2021518202A JP2021518202A JPWO2020071365A5 JP WO2020071365 A5 JPWO2020071365 A5 JP WO2020071365A5 JP 2021518202 A JP2021518202 A JP 2021518202A JP 2021518202 A JP2021518202 A JP 2021518202A JP WO2020071365 A5 JPWO2020071365 A5 JP WO2020071365A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- cdr
- binding agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 37
- 239000011230 binding agent Substances 0.000 claims 22
- 239000000126 substance Substances 0.000 claims 11
- 125000005647 linker group Chemical group 0.000 claims 10
- 239000000427 antigen Substances 0.000 claims 7
- 102000036639 antigens Human genes 0.000 claims 7
- 108091007433 antigens Proteins 0.000 claims 7
- 125000006239 protecting group Chemical group 0.000 claims 6
- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical compound C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 5
- 239000003053 toxin Substances 0.000 claims 5
- 231100000765 toxin Toxicity 0.000 claims 5
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
- 229940034982 antineoplastic agent Drugs 0.000 claims 4
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 3
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 3
- 102000003705 Syndecan-1 Human genes 0.000 claims 3
- 108090000058 Syndecan-1 Proteins 0.000 claims 3
- 102000001708 Protein Isoforms Human genes 0.000 claims 2
- 108010029485 Protein Isoforms Proteins 0.000 claims 2
- 102100035721 Syndecan-1 Human genes 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 101000917148 Homo sapiens Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 102000055709 human FGFR3 Human genes 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004193 piperazinyl group Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862740337P | 2018-10-02 | 2018-10-02 | |
| US62/740,337 | 2018-10-02 | ||
| PCT/JP2019/038750 WO2020071365A1 (en) | 2018-10-02 | 2019-10-01 | Bi-specific binding agents targeting syndecan-1 and fibroblast growth factor receptor |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022514148A JP2022514148A (ja) | 2022-02-10 |
| JPWO2020071365A5 true JPWO2020071365A5 (https=) | 2022-07-28 |
| JP2022514148A5 JP2022514148A5 (https=) | 2022-07-28 |
Family
ID=70055592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021518202A Withdrawn JP2022514148A (ja) | 2018-10-02 | 2019-10-01 | シンデカン－１および線維芽細胞増殖因子受容体を標的とする二重特異性結合物質 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20220249679A1 (https=) |
| EP (1) | EP3861117A4 (https=) |
| JP (1) | JP2022514148A (https=) |
| KR (1) | KR20210070307A (https=) |
| CN (1) | CN113039271A (https=) |
| AR (1) | AR116563A1 (https=) |
| AU (1) | AU2019353367A1 (https=) |
| BR (1) | BR112021005465A2 (https=) |
| CA (1) | CA3107423A1 (https=) |
| IL (1) | IL281929A (https=) |
| MX (1) | MX2021003861A (https=) |
| PH (1) | PH12021500023A1 (https=) |
| SG (1) | SG11202103143UA (https=) |
| TW (1) | TW202028459A (https=) |
| WO (1) | WO2020071365A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4110404A1 (en) * | 2020-02-28 | 2023-01-04 | Genzyme Corporation | Modified binding polypeptides for optimized drug conjugation |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006048877A2 (en) * | 2004-11-04 | 2006-05-11 | Fibron Limited | Treatment of b-cell malignancies with fgfr3 inhibitors |
| ES2526433T3 (es) * | 2007-12-26 | 2015-01-12 | Biotest Ag | Inmunoconjugados dirigidos a CD138 y usos de los mismos |
| WO2012158818A2 (en) * | 2011-05-16 | 2012-11-22 | Fabion Pharmaceuticals, Inc. | Multi-specific fab fusion proteins and methods of use |
| WO2013082254A1 (en) * | 2011-12-02 | 2013-06-06 | Ibc Pharmaceuticals, Inc. | Multivalent antibody complexes targeting igf-1r show potent toxicity against solid tumors |
| MX358680B (es) * | 2011-12-08 | 2018-08-31 | Biotest Ag | Usos de inmunoconjugados dirigidos a cd138. |
| CA2861031C (en) * | 2012-02-03 | 2022-10-25 | Carole BOURQUIN | Bispecific antibody molecules with antigen-transfected t-cells and their use in medicine |
| HK1211208A1 (zh) * | 2012-08-22 | 2016-05-20 | Immunogen, Inc. | 細胞毒性苯並二氮呯衍生物 |
| US9803021B2 (en) * | 2012-12-07 | 2017-10-31 | The Regents Of The University Of California | CD138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| US10323095B2 (en) * | 2014-03-17 | 2019-06-18 | Mitsubishi Tanabe Pharma Corporation | Antibody-fynomer conjugates |
| RU2611685C2 (ru) * | 2015-07-20 | 2017-02-28 | Илья Владимирович Духовлинов | Гуманизированное моноклональное антитело, специфичное к синдекану-1 |
| EP3577133A1 (en) * | 2017-02-06 | 2019-12-11 | Orionis Biosciences NV | Targeted chimeric proteins and uses thereof |
| US10722589B2 (en) * | 2017-04-03 | 2020-07-28 | Covagen Ag | FGFR3 binding molecules |
| CN110691793A (zh) * | 2017-04-26 | 2020-01-14 | 田边三菱制药株式会社 | 黏结蛋白聚糖-1（cd138）结合剂及其用 |
| JP2021165268A (ja) * | 2020-04-07 | 2021-10-14 | 田辺三菱製薬株式会社 | シンデカン−１および線維芽細胞増殖因子受容体を標的とする二重特異性結合物質を含む医薬組成物 |
-
2019
- 2019-10-01 AU AU2019353367A patent/AU2019353367A1/en not_active Abandoned
- 2019-10-01 US US17/282,368 patent/US20220249679A1/en not_active Abandoned
- 2019-10-01 BR BR112021005465-0A patent/BR112021005465A2/pt not_active IP Right Cessation
- 2019-10-01 AR ARP190102778A patent/AR116563A1/es not_active Application Discontinuation
- 2019-10-01 MX MX2021003861A patent/MX2021003861A/es unknown
- 2019-10-01 WO PCT/JP2019/038750 patent/WO2020071365A1/en not_active Ceased
- 2019-10-01 JP JP2021518202A patent/JP2022514148A/ja not_active Withdrawn
- 2019-10-01 KR KR1020217011453A patent/KR20210070307A/ko not_active Withdrawn
- 2019-10-01 SG SG11202103143UA patent/SG11202103143UA/en unknown
- 2019-10-01 PH PH1/2021/500023A patent/PH12021500023A1/en unknown
- 2019-10-01 CA CA3107423A patent/CA3107423A1/en active Pending
- 2019-10-01 CN CN201980064967.7A patent/CN113039271A/zh active Pending
- 2019-10-01 EP EP19869146.1A patent/EP3861117A4/en not_active Withdrawn
- 2019-10-01 TW TW108135510A patent/TW202028459A/zh unknown
-
2021
- 2021-03-31 IL IL281929A patent/IL281929A/en unknown