JPWO2019243159A5 - - Google Patents

Info

Publication number

JPWO2019243159A5

JPWO2019243159A5 JP2020568439A JP2020568439A JPWO2019243159A5 JP WO2019243159 A5 JPWO2019243159 A5 JP WO2019243159A5 JP 2020568439 A JP2020568439 A JP 2020568439A JP 2020568439 A JP2020568439 A JP 2020568439A JP WO2019243159 A5 JPWO2019243159 A5 JP WO2019243159A5

Authority

JP

Japan

Prior art keywords

seq

salt

solvate

indicated

variable

Prior art date

2022-06-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 150000003839 salts Chemical class 0.000 claims 64
• 239000012453 solvate Substances 0.000 claims 62
• 239000000427 antigen Substances 0.000 claims 33
• 102000036639 antigens Human genes 0.000 claims 33
• 108091007433 antigens Proteins 0.000 claims 33
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 28
• 239000012634 fragment Substances 0.000 claims 26
• 125000004042 4-aminobutyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])N([H])[H] 0.000 claims 13
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 13
• 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 12
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 12
• 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 12
• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 12
• 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 12
• AYEKOFBPNLCAJY-UHFFFAOYSA-O thiamine pyrophosphate Chemical compound CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N AYEKOFBPNLCAJY-UHFFFAOYSA-O 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 6
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
• 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 6
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 6
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
• 229910052739 hydrogen Inorganic materials 0.000 claims 6
• 239000001257 hydrogen Substances 0.000 claims 6
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 6
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 5
• 201000011510 cancer Diseases 0.000 claims 5
• 238000004519 manufacturing process Methods 0.000 claims 5
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 238000002619 cancer immunotherapy Methods 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 3
• 230000002491 angiogenic effect Effects 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 150000001875 compounds Chemical class 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 230000003463 hyperproliferative effect Effects 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 239000013543 active substance Substances 0.000 claims 1
• 231100000252 nontoxic Toxicity 0.000 claims 1
• 230000003000 nontoxic effect Effects 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 229940124597 therapeutic agent Drugs 0.000 claims 1