|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5608039A
(en)
|
1990-10-12 |
1997-03-04 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Single chain B3 antibody fusion proteins and their uses
|
|
US6099842A
(en)
|
1990-12-03 |
2000-08-08 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant immunotoxin composed of a single chain antibody reacting with the human transferrin receptor and diptheria toxin
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
ES2136092T3
(es)
|
1991-09-23 |
1999-11-16 |
Medical Res Council |
Procedimientos para la produccion de anticuerpos humanizados.
|
|
US6066718A
(en)
|
1992-09-25 |
2000-05-23 |
Novartis Corporation |
Reshaped monoclonal antibodies against an immunoglobulin isotype
|
|
US5702946A
(en)
|
1994-03-03 |
1997-12-30 |
Genentech, Inc. |
Anti-IL-8 monoclonal antibodies for treatment of inflammatory disorders
|
|
CA2194907A1
(en)
|
1994-07-13 |
1996-02-01 |
Kouji Matsushima |
Reshaped human antibody against human interleukin-8
|
|
GB0321295D0
(en)
|
2003-09-11 |
2003-10-15 |
Spirogen Ltd |
Synthesis of protected pyrrolobenzodiazepines
|
|
US7511032B2
(en)
|
2003-10-22 |
2009-03-31 |
The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
|
|
PL1879901T3
(pl)
|
2005-04-21 |
2010-06-30 |
Medimmune Ltd |
Pirolobenzodiazepiny
|
|
CA2638889C
(en)
*
|
2006-02-06 |
2015-06-02 |
Metheresis Translational Research S.A. |
Anti-met monoclonal antibody, fragments and vectors thereof, for the treatment of tumors and corresponding products
|
|
US7910702B2
(en)
*
|
2006-07-28 |
2011-03-22 |
The Governors Of The University Of Alberta |
Recombinant antibodies to sclerotinia antigens
|
|
RU2601892C2
(ru)
|
2008-03-06 |
2016-11-10 |
Дженентек, Инк. |
Комбинированная терапия антагонистами с-мет и egfr
|
|
KR20200058590A
(ko)
|
2008-04-30 |
2020-05-27 |
이뮤노젠 아이엔씨 |
가교제 및 그 용도
|
|
GB0819095D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
GB0819097D0
(en)
|
2008-10-17 |
2008-11-26 |
Spirogen Ltd |
Pyrrolobenzodiazepines
|
|
BRPI1010620B8
(pt)
|
2009-06-03 |
2021-05-25 |
Immunogen Inc |
métodos de conjugação
|
|
DK2528625T3
(da)
|
2010-04-15 |
2013-10-14 |
Spirogen Sarl |
Pyrrolobenzodiazepiner og konjugater deraf
|
|
GB201006340D0
(en)
|
2010-04-15 |
2010-06-02 |
Spirogen Ltd |
Synthesis method and intermediates
|
|
US8697688B2
(en)
|
2010-04-15 |
2014-04-15 |
Seattle Genetics Inc. |
Pyrrolobenzodiazepines used to treat proliferative diseases
|
|
MX391454B
(es)
|
2010-04-15 |
2025-03-05 |
Seagen Inc |
Compuesto de engarce-fármaco para conjugación a una unidad de ligando.
|
|
JP6049642B2
(ja)
|
2011-02-15 |
2016-12-21 |
イミュノジェン・インコーポレーテッド |
複合体の調製方法
|
|
UA118950C2
(uk)
*
|
2011-04-22 |
2019-04-10 |
Аптево Рісьорч Енд Девелопмент Ллс |
Поліпептид, який зв'язує специфічний мембранний антиген простати та комплекс т-клітинного рецептора
|
|
HUE045348T2
(hu)
|
2011-05-08 |
2019-12-30 |
Legochem Biosciences Inc |
Fehérje-hatóanyag konjugátumok és eljárás elõállításukra
|
|
JP6170494B2
(ja)
|
2011-09-20 |
2017-07-26 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ピロロベンゾジアゼピン
|
|
WO2013055993A1
(en)
|
2011-10-14 |
2013-04-18 |
Seattle Genetics, Inc. |
Pyrrolobenzodiazepines and targeted conjugates
|
|
CA2850096C
(en)
|
2011-10-14 |
2018-07-03 |
Spirogen Sarl |
Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
|
|
CA2850103C
(en)
|
2011-10-14 |
2019-09-10 |
Spirogen Sarl |
Pyrrolobenzodiazepines
|
|
CN103998449A
(zh)
|
2011-10-14 |
2014-08-20 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓
|
|
JP6104257B2
(ja)
|
2011-10-14 |
2017-03-29 |
メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ |
ピロロベンゾジアゼピンおよびそのコンジュゲート
|
|
ES2945932T3
(es)
|
2011-10-14 |
2023-07-10 |
Seagen Inc |
Pirrolobenzodiazepinas y conjugados dirigidos
|
|
KR101463098B1
(ko)
|
2011-11-28 |
2014-11-27 |
한국생명공학연구원 |
ｃ-Ｍｅｔ에 대한 인간항체에 약물이 접합된 약물 복합체 및 이의 용도
|
|
EP2650335B1
(en)
|
2012-04-13 |
2018-05-30 |
Tata Consultancy Services Ltd. |
A process for synthesis of doped titania nanoparticles having photocatalytic activity in sunlight
|
|
CA2871172C
(en)
|
2012-04-30 |
2020-08-25 |
Spirogen Sarl |
Pyrrolobenzodiazepines
|
|
WO2013177481A1
(en)
|
2012-05-25 |
2013-11-28 |
Immunogen, Inc. |
Benzodiazepines and conjugates thereof
|
|
CN104837502B
(zh)
|
2012-10-12 |
2018-08-10 |
麦迪穆有限责任公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
SI2906252T1
(sl)
|
2012-10-12 |
2017-10-30 |
Adc Therapeutics Sa |
Pirolobenzodiazepin-anti-HER2 protitelesni konjugati
|
|
AU2013328674B2
(en)
|
2012-10-12 |
2017-06-22 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof
|
|
EP2906295A4
(en)
*
|
2012-10-15 |
2016-06-01 |
Oncomed Pharm Inc |
METHOD FOR THE TREATMENT OF EYE DISEASES
|
|
US10131682B2
(en)
|
2012-11-24 |
2018-11-20 |
Hangzhou Dac Biotech Co., Ltd. |
Hydrophilic linkers and their uses for conjugation of drugs to a cell binding molecules
|
|
CN105246894A
(zh)
|
2012-12-21 |
2016-01-13 |
斯皮罗根有限公司 |
用于治疗增殖性和自身免疫疾病的非对称吡咯并苯并二氮杂卓二聚物
|
|
CN105189507A
(zh)
|
2012-12-21 |
2015-12-23 |
斯皮罗根有限公司 |
吡咯并苯并二氮杂卓及其结合物
|
|
BR112015019909A2
(pt)
|
2013-02-22 |
2017-08-29 |
Abbvie Stemcentrx Llc |
Conjugados anticorpo-fármaco, composição farmacêutica, usos dos mesmos, e kit
|
|
CA2905181C
(en)
|
2013-03-13 |
2020-06-02 |
Medimmune Limited |
Pyrrolobenzodiazepines and conjugates thereof for providing targeted therapy
|
|
SG11201507214SA
(en)
|
2013-03-13 |
2015-10-29 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
NZ710746A
(en)
|
2013-03-13 |
2018-11-30 |
Medimmune Ltd |
Pyrrolobenzodiazepines and conjugates thereof
|
|
US20160106861A1
(en)
|
2013-04-26 |
2016-04-21 |
Spirogen Sarl |
Axl antibody-drug conjugate and its use for the treatment of cancer
|
|
JP6744212B2
(ja)
|
2013-06-21 |
2020-08-19 |
イナート・ファルマ・ソシエテ・アノニムＩｎｎａｔｅ Ｐｈａｒｍａ Ｐｈａｒｍａ Ｓ．Ａ． |
ポリペプチドの酵素的結合
|
|
AU2014299561B2
(en)
|
2013-06-24 |
2017-06-08 |
Ablbio |
Antibody-drug conjugate having improved stability and use thereof
|
|
KR102150616B1
(ko)
|
2013-09-12 |
2020-09-03 |
삼성전자주식회사 |
c-Met 표적 화합물-생체활성 물질 접합체 및 그 용도
|
|
CA2927022C
(en)
|
2013-10-11 |
2018-08-21 |
Asana Biosciences, Llc |
Protein-polymer-drug conjugates
|
|
GB201317982D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
GB201317981D0
(en)
|
2013-10-11 |
2013-11-27 |
Spirogen Sarl |
Pyrrolobenzodiazepines and conjugates thereof
|
|
CA2938919C
(en)
|
2014-02-28 |
2020-12-29 |
Hangzhou Dac Biotech Co., Ltd |
Charged linkers and their uses for conjugation
|
|
BR112016024214B8
(pt)
*
|
2014-04-18 |
2023-12-26 |
Univ New York State Res Found |
Anticorpo monoclonal parcialmente humanizado, composição farmacêutica e uso de um anticorpo monoclonal
|
|
ES2895623T3
(es)
|
2014-05-22 |
2022-02-22 |
Byondis Bv |
Conjugación de sitio específico de fármacos enlazadores con anticuerpos y ADC resultantes
|
|
US10450376B2
(en)
|
2014-09-16 |
2019-10-22 |
Symphogen A/S |
Anti-MET antibodies and compositions
|
|
EA201791203A1
(ru)
*
|
2014-12-08 |
2018-04-30 |
Сорренто Терапьютикс, Инк. |
ЛЕКАРСТВЕННЫЙ КОНЪЮГАТ АНТИТЕЛА ПРОТИВ с-МЕТ
|
|
CN107613974B
(zh)
|
2015-03-16 |
2021-01-15 |
塞尔德克斯医疗公司 |
抗-met抗体及其使用方法
|
|
CA2996902C
(en)
|
2015-10-02 |
2020-06-02 |
Genentech, Inc. |
Pyrrolobenzodiazepine antibody drug conjugates and methods of use
|
|
GB201602356D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201602359D0
(en)
|
2016-02-10 |
2016-03-23 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
GB201607478D0
(en)
|
2016-04-29 |
2016-06-15 |
Medimmune Ltd |
Pyrrolobenzodiazepine Conjugates
|
|
RS61659B1
(sr)
*
|
2016-05-17 |
2021-04-29 |
Abbvie Biotherapeutics Inc |
Konjugati antitelo lek anti-cmet i metode za njihovu upotrebu
|
|
HUE054571T2
(hu)
|
2016-09-14 |
2021-09-28 |
Merck Patent Gmbh |
Hatékony tumorgátlásra szolgáló C-MET elleni ellenanyagok és ellenanyag-drog konjugátumaik
|
|
JP6942179B2
(ja)
|
2016-09-29 |
2021-09-29 |
田辺三菱製薬株式会社 |
ｃＭＥＴモノクローナル結合剤、その薬物複合体およびその使用
|