JPWO2020022272A5 - - Google Patents

Info

Publication number

JPWO2020022272A5

JPWO2020022272A5 JP2020501584A JP2020501584A JPWO2020022272A5 JP WO2020022272 A5 JPWO2020022272 A5 JP WO2020022272A5 JP 2020501584 A JP2020501584 A JP 2020501584A JP 2020501584 A JP2020501584 A JP 2020501584A JP WO2020022272 A5 JPWO2020022272 A5 JP WO2020022272A5

Authority

JP

Japan

Prior art keywords

vaccine

influenza

amino

enhances

antigen

Prior art date

2019-07-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000427 antigen Substances 0.000 claims 32
• 102000036639 antigens Human genes 0.000 claims 32
• 108091007433 antigens Proteins 0.000 claims 32
• 206010022000 influenza Diseases 0.000 claims 26
• 229960005486 vaccine Drugs 0.000 claims 26
• 239000000203 mixture Substances 0.000 claims 25
• 239000012646 vaccine adjuvant Substances 0.000 claims 23
• 229940124931 vaccine adjuvant Drugs 0.000 claims 23
• 230000001766 physiological effect Effects 0.000 claims 17
• 229960003971 influenza vaccine Drugs 0.000 claims 16
• 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 14
• 102100039390 Toll-like receptor 7 Human genes 0.000 claims 14
• 150000001875 compounds Chemical class 0.000 claims 13
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 12
• 238000010306 acid treatment Methods 0.000 claims 9
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 9
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 8
• 150000003384 small molecules Chemical group 0.000 claims 8
• 125000004432 carbon atom Chemical group C* 0.000 claims 7
• 238000004519 manufacturing process Methods 0.000 claims 7
• 150000003839 salts Chemical class 0.000 claims 6
• 239000000126 substance Substances 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 5
• 150000002632 lipids Chemical class 0.000 claims 5
• -1 2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methyl Pyrimidin-5-yl Chemical group 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 3
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 3
• GFFGJBXGBJISGV-UHFFFAOYSA-N adenyl group Chemical group N1=CN=C2N=CNC2=C1N GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims 3
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
• JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims 3
• 230000002265 prevention Effects 0.000 claims 3
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 3
• 125000006850 spacer group Chemical group 0.000 claims 3
• 229940032094 squalane Drugs 0.000 claims 3
• 229940031439 squalene Drugs 0.000 claims 3
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• SSPCAEAQHPGDQR-AKFKWKOHSA-N 4-[[2-amino-4-[[(2S)-1-hydroxypentan-2-yl]amino]-6-methylpyrimidin-5-yl]methyl]-N-[2-[[(4E,8E,12E,16E,20E)-4,8,12,17,21,25-hexamethylhexacosa-4,8,12,16,20,24-hexaenoyl]amino]ethyl]-3-methoxybenzamide Chemical compound C1(C(=O)NCCNC(=O)CC/C(=C/CC/C(=C/CC/C(=C/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)/C)/C)/C)=CC(OC)=C(CC2=C(C)N=C(N=C2N[C@@H](CCC)CO)N)C=C1 SSPCAEAQHPGDQR-AKFKWKOHSA-N 0.000 claims 2
• 101000800483 Homo sapiens Toll-like receptor 8 Proteins 0.000 claims 2
• 102000008235 Toll-Like Receptor 9 Human genes 0.000 claims 2
• 108010060818 Toll-Like Receptor 9 Proteins 0.000 claims 2
• 102000002689 Toll-like receptor Human genes 0.000 claims 2
• 108020000411 Toll-like receptor Proteins 0.000 claims 2
• 102100033110 Toll-like receptor 8 Human genes 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
• RHKWIGHJGOEUSM-UHFFFAOYSA-N 3h-imidazo[4,5-h]quinoline Chemical group C1=CN=C2C(N=CN3)=C3C=CC2=C1 RHKWIGHJGOEUSM-UHFFFAOYSA-N 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• SQQXRXKYTKFFSM-UHFFFAOYSA-N chembl1992147 Chemical compound OC1=C(OC)C(OC)=CC=C1C1=C(C)C(C(O)=O)=NC(C=2N=C3C4=NC(C)(C)N=C4C(OC)=C(O)C3=CC=2)=C1N SQQXRXKYTKFFSM-UHFFFAOYSA-N 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 125000004857 imidazopyridinyl group Chemical group N1C(=NC2=C1C=CC=N2)* 0.000 claims 1
• 229940124669 imidazoquinoline Drugs 0.000 claims 1
• 238000011321 prophylaxis Methods 0.000 claims 1
• 125000002294 quinazolinyl group Chemical group N1=C(N=CC2=CC=CC=C12)* 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1