JP2016502503A5 - - Google Patents
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- Publication number
- JP2016502503A5 JP2016502503A5 JP2015536018A JP2015536018A JP2016502503A5 JP 2016502503 A5 JP2016502503 A5 JP 2016502503A5 JP 2015536018 A JP2015536018 A JP 2015536018A JP 2015536018 A JP2015536018 A JP 2015536018A JP 2016502503 A5 JP2016502503 A5 JP 2016502503A5
- Authority
- JP
- Japan
- Prior art keywords
- aliphatic
- residue
- unsubstituted
- residues
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001931 aliphatic group Chemical group 0.000 description 433
- 125000001424 substituent group Chemical group 0.000 description 159
- 229910052799 carbon Inorganic materials 0.000 description 110
- 125000001072 heteroaryl group Chemical group 0.000 description 43
- 125000002723 alicyclic group Chemical group 0.000 description 40
- 125000003118 aryl group Chemical group 0.000 description 38
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 36
- 125000004076 pyridyl group Chemical group 0.000 description 35
- 229910052757 nitrogen Inorganic materials 0.000 description 34
- 125000004433 nitrogen atom Chemical group N* 0.000 description 34
- 125000004432 carbon atom Chemical group C* 0.000 description 23
- 125000001544 thienyl group Chemical group 0.000 description 22
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 18
- 125000002541 furyl group Chemical group 0.000 description 12
- 125000002971 oxazolyl group Chemical group 0.000 description 12
- 125000000335 thiazolyl group Chemical group 0.000 description 12
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 10
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 10
- 125000002393 azetidinyl group Chemical group 0.000 description 8
- 125000002757 morpholinyl group Chemical group 0.000 description 8
- 125000003386 piperidinyl group Chemical group 0.000 description 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 6
- -1 racemates Chemical class 0.000 description 6
- 125000004122 cyclic group Chemical group 0.000 description 5
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 5
- 125000004193 piperazinyl group Chemical group 0.000 description 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 4
- 125000005961 oxazepanyl group Chemical group 0.000 description 4
- SEPPVOUBHWNCAW-FNORWQNLSA-N (E)-4-oxonon-2-enal Chemical compound CCCCCC(=O)\C=C\C=O SEPPVOUBHWNCAW-FNORWQNLSA-N 0.000 description 3
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 description 3
- 125000003566 oxetanyl group Chemical group 0.000 description 3
- 125000000466 oxiranyl group Chemical group 0.000 description 3
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 2
- 229920006395 saturated elastomer Polymers 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 125000003725 azepanyl group Chemical group 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 125000004611 dihydroisoindolyl group Chemical group C1(NCC2=CC=CC=C12)* 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000003039 tetrahydroisoquinolinyl group Chemical group C1(NCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000004568 thiomorpholinyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12007118 | 2012-10-11 | ||
| EP12007118.8 | 2012-10-11 | ||
| PCT/EP2013/003064 WO2014056620A1 (en) | 2012-10-11 | 2013-10-11 | Treatment and/or prophylaxis of tspo mediated diseases and/or disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016502503A JP2016502503A (ja) | 2016-01-28 |
| JP2016502503A5 true JP2016502503A5 (https=) | 2017-06-15 |
Family
ID=47073259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015536018A Pending JP2016502503A (ja) | 2012-10-11 | 2013-10-11 | Ｔｓｐｏ媒介性疾患および／または障害の治療および／または予防 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9775843B2 (https=) |
| EP (1) | EP2906217A1 (https=) |
| JP (1) | JP2016502503A (https=) |
| CN (1) | CN104994857A (https=) |
| AU (1) | AU2013329832A1 (https=) |
| HK (1) | HK1213175A1 (https=) |
| MX (1) | MX2015004511A (https=) |
| WO (1) | WO2014056620A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3319968A1 (en) | 2015-07-06 | 2018-05-16 | Rodin Therapeutics, Inc. | Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase |
| WO2017007756A1 (en) | 2015-07-06 | 2017-01-12 | Rodin Therapeutics, Inc | Hetero-halo inhibitors of histone deacetylase |
| HUE057849T2 (hu) | 2017-01-11 | 2022-06-28 | Alkermes Inc | Hiszton deacetiláz biciklusos gátlói |
| LT3664802T (lt) | 2017-08-07 | 2022-06-27 | Alkermes, Inc. | Bicikliniai histonų deacetilazės inhibitoriai |
| CN111840267A (zh) * | 2020-08-05 | 2020-10-30 | 牡丹江医学院 | 一种治疗小儿口腔黏膜疾病的药物及其制备方法 |
| AU2024282841A1 (en) * | 2023-06-02 | 2025-12-11 | The Johns Hopkins University | Uses of psma-targeting and tspo-targeting compounds for evaluation of injuries in the peripheral nervous system |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704544D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| US6756382B2 (en) * | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
| DE10239303B4 (de) | 2002-08-27 | 2006-08-03 | Siemens Ag | Energieautark modulierter Backscatter-Transponder |
| US20050197350A1 (en) * | 2003-03-31 | 2005-09-08 | Taisho Pharmaceutical Co., Ltd. | Novel quinoline, tetrahydroquinazoline, and pyrimidine derivatives and methods of treatment related to the use thereof |
| SE0302323D0 (sv) * | 2003-08-28 | 2003-08-28 | Astrazeneca Ab | Novel compounds |
| DE602004026095D1 (de) | 2003-11-24 | 2010-04-29 | Pfizer | Chinoloncarbonsäureverbindungen mit 5-ht4-rezeptoragonistischer wirkung |
| EP1912946B1 (en) * | 2005-07-20 | 2009-05-27 | Eli Lilly And Company | Pyridine derivatives as dipeptedyl peptidase inhibitors |
| DE102007044277A1 (de) * | 2007-09-17 | 2009-03-19 | Grünenthal GmbH | Substituierte Nicotinamid-Verbindungen und deren Verwendung in Arzneimitteln |
| CN101392001A (zh) * | 2007-09-21 | 2009-03-25 | 上海恒瑞医药有限公司 | 氨甲酰类衍生物、其制备方法及其在医药上的用途 |
| TWI461197B (zh) | 2009-03-12 | 2014-11-21 | 2-mercaptoquinoline-3-carboxamide as a KCNQ2 / 3 modifier | |
| TWI475020B (zh) | 2009-03-12 | 2015-03-01 | The substituted nicotine amide as a KCNQ2 / 3 modifier | |
| JP6023926B2 (ja) * | 2010-02-12 | 2016-11-09 | 株式会社ＡｓｋＡｔ | 認知症治療のための５−ｈｔ４受容体アゴニスト |
| CA2805932A1 (en) | 2010-08-27 | 2012-03-01 | Gruenenthal Gmbh | Substituted 2-amino-quinoline-3-carboxamides as kcnq2/3 modulators |
| CA2804824A1 (en) * | 2010-08-27 | 2012-03-01 | Gruenenthal Gmbh | Substituted quinoline-3-carboxamides as kcnq2/3 modulators |
| RU2595894C2 (ru) * | 2010-08-27 | 2016-08-27 | Грюненталь Гмбх | Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3 |
| MX342459B (es) * | 2010-08-27 | 2016-09-29 | Grünenthal Gmbh * | 2-oxo- y 2-tioxo-dihidroquinolin-3-carboxamidas sustituidas, como moduladores de kcnq2/3. |
| US9168259B2 (en) * | 2010-10-20 | 2015-10-27 | Grünenthal GmbH | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators |
| JP5947307B2 (ja) * | 2010-10-20 | 2016-07-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Ｋｃｎｑ２／３調節因子としての置換６−アミノ−ニコチンアミド |
-
2013
- 2013-10-11 CN CN201380064616.9A patent/CN104994857A/zh active Pending
- 2013-10-11 AU AU2013329832A patent/AU2013329832A1/en not_active Abandoned
- 2013-10-11 HK HK16101006.2A patent/HK1213175A1/zh unknown
- 2013-10-11 JP JP2015536018A patent/JP2016502503A/ja active Pending
- 2013-10-11 WO PCT/EP2013/003064 patent/WO2014056620A1/en not_active Ceased
- 2013-10-11 EP EP13776727.3A patent/EP2906217A1/en not_active Ceased
- 2013-10-11 US US14/434,943 patent/US9775843B2/en not_active Expired - Fee Related
- 2013-10-11 MX MX2015004511A patent/MX2015004511A/es unknown
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