MX2012001524A - Derivados de oxoadenina lipidada. - Google Patents
Derivados de oxoadenina lipidada.Info
- Publication number
- MX2012001524A MX2012001524A MX2012001524A MX2012001524A MX2012001524A MX 2012001524 A MX2012001524 A MX 2012001524A MX 2012001524 A MX2012001524 A MX 2012001524A MX 2012001524 A MX2012001524 A MX 2012001524A MX 2012001524 A MX2012001524 A MX 2012001524A
- Authority
- MX
- Mexico
- Prior art keywords
- lipidated
- oxoadenine
- derivatives
- oxoadenine derivatives
- oxoadenines
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Botany (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Se describen nuevas oxoadeninas lipidadas que comprenden una molécula de oxoadenina sustituida con heterociclilo de nitrógeno covalentemente ligada a un fosfo o fosfonolípido se muestran para inducirse del interferón-a y otras citocinas inmunoestimuladoras. Los compuestos son útiles como inmunoestimuladores y adyuvantes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23213209P | 2009-08-07 | 2009-08-07 | |
PCT/US2010/044703 WO2011017611A1 (en) | 2009-08-07 | 2010-08-06 | Lipidated oxoadenine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012001524A true MX2012001524A (es) | 2012-02-29 |
Family
ID=43544685
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012001524A MX2012001524A (es) | 2009-08-07 | 2010-08-06 | Derivados de oxoadenina lipidada. |
Country Status (15)
Country | Link |
---|---|
US (1) | US9044481B2 (es) |
EP (2) | EP2461690A4 (es) |
JP (1) | JP5759992B2 (es) |
KR (1) | KR20120055623A (es) |
CN (1) | CN102469790B (es) |
AU (1) | AU2010279299B2 (es) |
BR (1) | BR112012002349A2 (es) |
CA (1) | CA2768195A1 (es) |
EA (1) | EA023536B1 (es) |
ES (1) | ES2732999T3 (es) |
MX (1) | MX2012001524A (es) |
SG (1) | SG178237A1 (es) |
TR (1) | TR201909600T4 (es) |
WO (1) | WO2011017611A1 (es) |
ZA (1) | ZA201200646B (es) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8802684B2 (en) | 2008-08-11 | 2014-08-12 | Glaxosmithkline Llc | Adenine derivatives |
SG193149A1 (en) * | 2008-08-11 | 2013-09-30 | Glaxosmithkline Llc | Novel adenine derivatives |
EP2324025A1 (en) * | 2008-08-11 | 2011-05-25 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
WO2010088924A1 (en) | 2009-02-06 | 2010-08-12 | Telormedix Sa | Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration |
NO2491035T3 (es) | 2009-10-22 | 2018-01-27 | ||
JP2013519644A (ja) | 2010-02-10 | 2013-05-30 | グラクソスミスクライン エルエルシー | プリン誘導体およびそれらの薬学的使用 |
AU2011247358B2 (en) | 2010-04-30 | 2014-10-30 | Urogen Pharma Ltd. | Phospholipid drug analogs |
US9050319B2 (en) | 2010-04-30 | 2015-06-09 | Telormedix, Sa | Phospholipid drug analogs |
AU2011247359A1 (en) * | 2010-04-30 | 2012-11-15 | Telormedix Sa | Methods for inducing an immune response |
US10112946B2 (en) | 2011-07-22 | 2018-10-30 | Glaxosmithkline Llc | Composition |
EP2674170B1 (en) | 2012-06-15 | 2014-11-19 | Invivogen | Novel compositions of TLR7 and/or TLR8 agonists conjugated to lipids |
US9555036B2 (en) | 2012-08-24 | 2017-01-31 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
PT2922549T (pt) * | 2012-11-20 | 2017-09-01 | Glaxosmithkline Llc | Novos compostos |
WO2014081644A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
ES2625023T3 (es) | 2012-11-20 | 2017-07-18 | Glaxosmithkline Llc | Compuestos novedosos |
US9295732B2 (en) | 2013-02-22 | 2016-03-29 | Invivogen | Conjugated TLR7 and/or TLR8 and TLR2 polycationic agonists |
WO2015036044A1 (en) * | 2013-09-13 | 2015-03-19 | Telormedix Sa | Cationic lipid vehicles for delivery of tlr7 agonists for specific targeting of human cd14+ monocytes in whole blood |
AR100137A1 (es) | 2014-04-22 | 2016-09-14 | Hoffmann La Roche | Compuestos 4-amino-imidazoquinolina |
CA2967248A1 (en) | 2014-11-13 | 2016-05-19 | Glaxosmithkline Biologicals Sa | Adenine derivatives which are useful in the treatment of allergic diseases or other inflammatory conditions |
LT3265458T (lt) | 2015-03-06 | 2019-03-12 | F. Hoffmann-La Roche Ag | Benzazepino dikarboksamido junginiai |
WO2016142880A1 (en) * | 2015-03-10 | 2016-09-15 | Glaxosmithkline Biologicals Sa | Compositions and uses |
EP3350168B1 (en) | 2015-09-17 | 2019-12-18 | H. Hoffnabb-La Roche Ag | Sulfinylphenyl or sulfonimidoylphenyl benzazepines |
EP3355933B1 (en) | 2015-09-29 | 2020-05-06 | Sumitomo Dainippon Pharma Co., Ltd. | Adenine conjugate compounds and their use as vaccine adjuvants |
US10632192B2 (en) | 2015-10-07 | 2020-04-28 | Sumitomo Dainippon Pharma Co., Ltd. | Pyrimidine compounds and their use as vaccine adjuvants |
US10774099B2 (en) | 2015-12-14 | 2020-09-15 | Glaxosmithkline Biologicals Sa | Phospholipidation of imidazoquinolines and oxoadenines |
JP6918838B2 (ja) | 2016-05-23 | 2021-08-11 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 第三級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
JP7022702B2 (ja) | 2016-05-23 | 2022-02-18 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | 第二級アミド基を有するベンズアゼピンジカルボキサミド化合物 |
JP7012668B2 (ja) | 2016-06-12 | 2022-02-14 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | ジヒドロピリミジニルベンズアゼピンジカルボキサミド化合物 |
EP3774806A1 (en) | 2018-04-13 | 2021-02-17 | GlaxoSmithKline Biologicals SA | Tlr7 and / or tlr8 agonists |
BR112020026890A2 (pt) | 2018-07-03 | 2021-03-30 | Jiangsu Hengrui Medicine Co., Ltd. | Derivado de piridopirimidina, método de preparação do mesmo e uso médico do mesmo |
US20210353737A1 (en) | 2018-07-23 | 2021-11-18 | Japan As Represented By Director General Of National Institute Of Infectious Diseases | Composition containing influenza vaccine |
KR20220018503A (ko) * | 2019-05-23 | 2022-02-15 | 더 유니버시티 오브 몬타나 | Tlr 수용체 리간드에 기반한 백신 애주번트 |
US20220305115A1 (en) | 2019-06-18 | 2022-09-29 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
AU2020416484A1 (en) | 2020-01-02 | 2022-08-25 | Jiangsu Hengrui Medicine Co., Ltd. | Crystal form of pyridopyrimidine derivative and preparation method thereof |
KR102549083B1 (ko) | 2021-02-01 | 2023-06-29 | 주식회사 에이티솔루션 | 레이다 전자 표적 발생 장치에서 발생되는 표적의 거리를 최소화하는 전파 지연 장치 및 방법 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3042540B2 (ja) * | 1990-08-20 | 2000-05-15 | ミヨシ油脂株式会社 | 8―ヒドロキシアデノシン―5′―リン酸を含むアデノシンモノホスフェート系三量体、その製造方法及びその化合物からなる蛋白質合成阻害剤 |
JPH093091A (ja) * | 1995-06-21 | 1997-01-07 | Rikagaku Kenkyusho | ヌクレオシド誘導体物質、その製造法及び抗腫瘍剤 |
ES2232871T3 (es) * | 1996-07-03 | 2005-06-01 | Sumitomo Pharmaceuticals Company, Limited | Nuevos derivados de purina. |
WO2003066649A1 (en) * | 2002-02-04 | 2003-08-14 | Biomira Inc. | Immunostimulatory, covalently lipidated oligonucleotides |
US20090192153A1 (en) | 2005-09-22 | 2009-07-30 | Dainippon Sumitomo Pharma Co., Ltd. a corporation of Japan | Novel adenine compound |
ES2437871T3 (es) * | 2006-07-07 | 2014-01-14 | Gilead Sciences, Inc. | Moduladores del receptor tipo toll 7 |
DK2132209T3 (da) * | 2007-03-19 | 2014-04-14 | Astrazeneca Ab | 9-substituerede 8-oxo-adeninforbindelser som modulatorer af tlr7 (toll-like receptor 7) |
JP5519670B2 (ja) * | 2008-08-11 | 2014-06-11 | グラクソスミスクライン エルエルシー | アレルギー性、炎症性及び感染性疾患治療用のプリン誘導体 |
EP2324025A1 (en) * | 2008-08-11 | 2011-05-25 | Smithkline Beecham Corporation | Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases |
-
2010
- 2010-08-06 EA EA201290036A patent/EA023536B1/ru not_active IP Right Cessation
- 2010-08-06 ES ES16190246T patent/ES2732999T3/es active Active
- 2010-08-06 CN CN201080034927.7A patent/CN102469790B/zh not_active Expired - Fee Related
- 2010-08-06 US US13/389,307 patent/US9044481B2/en active Active
- 2010-08-06 MX MX2012001524A patent/MX2012001524A/es active IP Right Grant
- 2010-08-06 EP EP20100807229 patent/EP2461690A4/en not_active Withdrawn
- 2010-08-06 JP JP2012523976A patent/JP5759992B2/ja not_active Expired - Fee Related
- 2010-08-06 SG SG2012007522A patent/SG178237A1/en unknown
- 2010-08-06 WO PCT/US2010/044703 patent/WO2011017611A1/en active Application Filing
- 2010-08-06 EP EP16190246.5A patent/EP3199159B1/en active Active
- 2010-08-06 AU AU2010279299A patent/AU2010279299B2/en not_active Ceased
- 2010-08-06 CA CA2768195A patent/CA2768195A1/en not_active Abandoned
- 2010-08-06 BR BR112012002349A patent/BR112012002349A2/pt not_active Application Discontinuation
- 2010-08-06 KR KR1020127005993A patent/KR20120055623A/ko not_active Application Discontinuation
- 2010-08-06 TR TR2019/09600T patent/TR201909600T4/tr unknown
-
2012
- 2012-01-25 ZA ZA2012/00646A patent/ZA201200646B/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112012002349A2 (pt) | 2015-10-13 |
EP2461690A4 (en) | 2013-03-27 |
KR20120055623A (ko) | 2012-05-31 |
EA023536B1 (ru) | 2016-06-30 |
AU2010279299A1 (en) | 2012-03-29 |
EP3199159B1 (en) | 2019-04-10 |
CN102469790A (zh) | 2012-05-23 |
AU2010279299B2 (en) | 2015-10-01 |
EA201290036A1 (ru) | 2012-12-28 |
WO2011017611A1 (en) | 2011-02-10 |
TR201909600T4 (tr) | 2019-07-22 |
JP2013501730A (ja) | 2013-01-17 |
EP3199159A1 (en) | 2017-08-02 |
SG178237A1 (en) | 2012-03-29 |
JP5759992B2 (ja) | 2015-08-05 |
US9044481B2 (en) | 2015-06-02 |
ZA201200646B (en) | 2013-06-26 |
ES2732999T3 (es) | 2019-11-27 |
US20120135963A1 (en) | 2012-05-31 |
CA2768195A1 (en) | 2011-02-10 |
CN102469790B (zh) | 2014-12-03 |
EP2461690A1 (en) | 2012-06-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2012001524A (es) | Derivados de oxoadenina lipidada. | |
MY153880A (en) | Proline derivatives as cathepsin inhibitors | |
PH12016501375A1 (en) | Pyridin-2-amides useful as cb2 agonists | |
SG10201407927UA (en) | Imidazopyridine derivatives as jak inhibitors | |
NZ588884A (en) | Cross-linkers and their uses | |
PH12015501083A1 (en) | Novel pyridine derivatives | |
MX2013001868A (es) | Composiciones, formulaciones y metodos de compuestos lipidicos modificadores de respuestas inmunitaria. | |
MX353308B (es) | Derivados fosforosos como inhibidores de cinasa. | |
EA201491447A1 (ru) | Ендиины, их конъюгаты и способы их получения и применения | |
GEP201706703B (en) | Boronate ester compounds and pharmaceutical compositions thereof | |
AU2012213775A8 (en) | 7-azaindole derivatives | |
MX2013004004A (es) | Pirrolidinonas como inhibidores de metionina aminopeptidasa (metap-2). | |
UA118666C2 (uk) | Похідні піразолу | |
BR112012011328A2 (pt) | inibidores de akt | |
TW200700064A (en) | Novel compounds | |
MX2012006805A (es) | Indolil-piperidinil bencilaminas como inhibidores de beta-triptasa. | |
WO2014089177A3 (en) | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines | |
MX349373B (es) | Nuevos derivados de pirazina. | |
MX360330B (es) | Regimen de administracion para nitrocatecoles. | |
WO2013083975A3 (en) | Novel pyrrole derivatives | |
MX2012007835A (es) | Derivados de oxazolopirimidina sustituida en 2, 5,7. | |
MY149154A (en) | Novel microbiocides | |
MX346090B (es) | Derivados de pirrolidina usados como inhibidores de catepsina. | |
MX2014008918A (es) | Nuevos derivados de pirrolidina. | |
MX2013003498A (es) | Derivados de cromeno. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |