MX2011005425A - Derivados de carboxiamida lantibiotica con actividad antibacteriana mejorada. - Google Patents

Derivados de carboxiamida lantibiotica con actividad antibacteriana mejorada.

Info

Publication number
MX2011005425A
MX2011005425A MX2011005425A MX2011005425A MX2011005425A MX 2011005425 A MX2011005425 A MX 2011005425A MX 2011005425 A MX2011005425 A MX 2011005425A MX 2011005425 A MX2011005425 A MX 2011005425A MX 2011005425 A MX2011005425 A MX 2011005425A
Authority
MX
Mexico
Prior art keywords
lantibiotic
antibacterial activity
enhanced antibacterial
carboxyamide derivatives
derivatives
Prior art date
Application number
MX2011005425A
Other languages
English (en)
Inventor
Sonia Ilaria Maffioli
Cristina Brunati
Donatella Potenza
Francesca Vasile
Stefano Donadio
Original Assignee
Sentinella Pharmaceuticals Inc Sentinella
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sentinella Pharmaceuticals Inc Sentinella filed Critical Sentinella Pharmaceuticals Inc Sentinella
Publication of MX2011005425A publication Critical patent/MX2011005425A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La presente invención concierne a nuevos derivados amida del lantibiótico 97518 y a sus usos. En particular, la presente invención describe nuevos compuestos que tienen la Fórmula General (II) y sus usos como antibiótico.
MX2011005425A 2008-11-24 2008-11-24 Derivados de carboxiamida lantibiotica con actividad antibacteriana mejorada. MX2011005425A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2008/003184 WO2010058238A1 (en) 2008-11-24 2008-11-24 Lantibiotic carboxyamide derivatives with enhanced antibacterial activity

Publications (1)

Publication Number Publication Date
MX2011005425A true MX2011005425A (es) 2011-09-27

Family

ID=40668282

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011005425A MX2011005425A (es) 2008-11-24 2008-11-24 Derivados de carboxiamida lantibiotica con actividad antibacteriana mejorada.

Country Status (15)

Country Link
US (1) US20120053115A1 (es)
EP (1) EP2367845A1 (es)
JP (1) JP2012509866A (es)
KR (1) KR20110086582A (es)
CN (1) CN102224164A (es)
AR (1) AR074222A1 (es)
AU (1) AU2008364202A1 (es)
BR (1) BRPI0822946A2 (es)
CA (1) CA2742753A1 (es)
CL (1) CL2009002129A1 (es)
IL (1) IL213043A0 (es)
MX (1) MX2011005425A (es)
RU (1) RU2506272C2 (es)
TW (1) TW201023876A (es)
WO (1) WO2010058238A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0600928D0 (en) 2006-01-17 2006-02-22 Novacta Biosystems Ltd Improvements relating to lantibiotics
GB0714030D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd The use of type-B lantibiotic-based compounds having antimicrobial activity
GB0714029D0 (en) 2007-07-18 2007-08-29 Novacta Biosystems Ltd Lantibiotic-based compounds having antimicrobial activity
DK2387580T3 (da) 2009-01-14 2014-10-13 Novacta Biosystems Ltd Deoxyactagardinderivater
CN102388060B (zh) 2009-02-04 2014-09-10 诺瓦克塔生物系统有限公司 阿肽加定衍生物
GB201001688D0 (en) 2010-02-02 2010-03-17 Novacta Biosystems Ltd Compounds
GB201013513D0 (en) 2010-08-11 2010-09-22 Novacta Biosystems Ltd Formulations
EP2701718A4 (en) * 2011-03-30 2014-11-19 Sentinella Pharmaceuticals Inc LANTIBIOTIC NAI-802, PHARMACEUTICALLY ACCEPTABLE SALTS, ITS COMPOSITIONS, AND USES THEREOF
WO2014009763A1 (en) * 2012-07-12 2014-01-16 Naicons S.C.A.R.L. Novel lantipeptide
JP2016501232A (ja) 2012-11-30 2016-01-18 ナイコンス，エセエッレエレＮａｉｃｏｎｓ，Ｓｒｌ 新規ランチビオティック誘導体およびその調製プロセス
CA2972836A1 (en) * 2015-01-19 2016-07-28 Universiteit Utrecht Holding B.V. Nisin-based compounds and use thereof in the treatment of bacterial infections
WO2017085257A1 (en) * 2015-11-18 2017-05-26 Helmholtz-Zentrum für Infektionsforschung GmbH Labyrinthopeptins as anti-viral agents
CN106188253B (zh) * 2016-08-26 2020-08-18 上海交通大学 抗菌肽Lexapeptide及其制备方法和用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4882313A (en) * 1987-07-31 1989-11-21 Smithkline Beckman Corporation Carboxamide derivatives of glycopeptides
DE69433357T2 (de) * 1994-09-12 2004-09-09 Aventis Pharma Deutschland Gmbh Rekombinantes Mersacidin und Verfahren zu seiner Herstellung
NZ311535A (en) * 1995-06-23 2001-05-25 Ambi Inc A method for the control of antibiotic-resistant gram positive bacteria and treatment of infection
DE19745583A1 (de) * 1997-10-15 1999-04-22 Hoechst Marion Roussel De Gmbh Neues Lantibiotikum verwandt mit Actagardine, Verfahren zur Herstellung und Verwendung derselben
US6861236B2 (en) * 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
EP1481986A1 (en) * 2003-05-30 2004-12-01 Vicuron Pharmaceuticals, Inc. Antibiotic 97518, pharmaceutically acceptable salts and compositions, and use thereof
RS52513B (en) * 2005-01-12 2013-04-30 Sentinella Pharmaceuticals Inc. ("Sentinella") ANTIBIOTIC 107891, ITS FACTORS, PHARMACEUTICALALLY ACCEPTABLE SALTS AND MIXTURES, AND THEIR USE

Also Published As

Publication number Publication date
BRPI0822946A2 (pt) 2015-06-23
CN102224164A (zh) 2011-10-19
RU2011125941A (ru) 2012-12-27
IL213043A0 (en) 2011-07-31
CL2009002129A1 (es) 2010-09-10
EP2367845A1 (en) 2011-09-28
KR20110086582A (ko) 2011-07-28
TW201023876A (en) 2010-07-01
US20120053115A1 (en) 2012-03-01
JP2012509866A (ja) 2012-04-26
AR074222A1 (es) 2010-12-29
CA2742753A1 (en) 2010-05-27
AU2008364202A1 (en) 2011-07-07
RU2506272C2 (ru) 2014-02-10
WO2010058238A1 (en) 2010-05-27

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Legal Events

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