JPWO2019038215A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2019038215A5 JPWO2019038215A5 JP2020511371A JP2020511371A JPWO2019038215A5 JP WO2019038215 A5 JPWO2019038215 A5 JP WO2019038215A5 JP 2020511371 A JP2020511371 A JP 2020511371A JP 2020511371 A JP2020511371 A JP 2020511371A JP WO2019038215 A5 JPWO2019038215 A5 JP WO2019038215A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- alkyl
- nch
- groups
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000002950 monocyclic group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- -1 SO2CH3 Chemical group 0.000 claims description 3
- 229910006074 SO2NH2 Inorganic materials 0.000 claims description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 3
- 125000000565 sulfonamide group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187101 | 2017-08-21 | ||
| EP17187101.5 | 2017-08-21 | ||
| PCT/EP2018/072398 WO2019038215A1 (en) | 2017-08-21 | 2018-08-20 | BENZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020531531A JP2020531531A (ja) | 2020-11-05 |
| JP2020531531A5 JP2020531531A5 (https=) | 2023-02-02 |
| JPWO2019038215A5 true JPWO2019038215A5 (https=) | 2023-02-02 |
| JP7287952B2 JP7287952B2 (ja) | 2023-06-06 |
Family
ID=59677148
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511371A Active JP7287952B2 (ja) | 2017-08-21 | 2018-08-20 | アデノシン受容体アンタゴニストとしてのベンズイミダゾール誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11453647B2 (https=) |
| EP (1) | EP3672952B1 (https=) |
| JP (1) | JP7287952B2 (https=) |
| KR (1) | KR20200043433A (https=) |
| CN (1) | CN110997662B (https=) |
| AU (1) | AU2018320673B2 (https=) |
| BR (1) | BR112020003594A2 (https=) |
| CA (1) | CA3073333A1 (https=) |
| ES (1) | ES2940408T3 (https=) |
| IL (1) | IL272637B2 (https=) |
| SG (1) | SG11202001337XA (https=) |
| TW (1) | TWI791593B (https=) |
| WO (1) | WO2019038215A1 (https=) |
| ZA (1) | ZA202001780B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019152437A1 (en) | 2018-01-30 | 2019-08-08 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| WO2020160100A1 (en) | 2019-01-29 | 2020-08-06 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US20230121497A1 (en) * | 2020-01-29 | 2023-04-20 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| CA3167275A1 (en) | 2020-01-29 | 2021-08-05 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| AU2022214582C1 (en) * | 2021-01-29 | 2025-02-27 | Korea Research Institute Of Chemical Technology | Benzothiazole and benzimidazole derivatives, pharmaceutically acceptable salt thereof, preparation method therefor, and pharmaceutical composition comprising same as active ingredient |
| JP2024509268A (ja) | 2021-03-09 | 2024-02-29 | フォグホーン セラピューティクス インコーポレイテッド | 結晶形、それらを含有する組成物、及びそれらの使用方法 |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| WO2022258622A1 (en) | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| EP4714938A1 (en) * | 2023-05-15 | 2026-03-25 | Wigen Biomedicine Technology (Shanghai) Co., Ltd. | Hdac1/2 selective inhibitor and use thereof |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207554A (en) | 1972-08-04 | 1980-06-10 | Med-El Inc. | Method and apparatus for automated classification and analysis of cells |
| US4125828A (en) | 1972-08-04 | 1978-11-14 | Med-El Inc. | Method and apparatus for automated classification and analysis of cells |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| AU1688599A (en) | 1998-01-05 | 1999-07-26 | Eisai Co. Ltd. | Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| US6841549B1 (en) | 1999-07-02 | 2005-01-11 | Eisai Co., Ltd. | Condensed imidazole compounds and a therapeutic agent for diabetes mellitus |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| WO2004089942A2 (en) | 2001-10-02 | 2004-10-21 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| EP1465634B1 (en) | 2001-12-12 | 2014-10-22 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Methods for using adenosine receptor inhibitors to enhance immune response and inflammation |
| EP1618108A2 (en) | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines useful as a2a adenosine receptor antagonists |
| AU2004238508B2 (en) | 2003-05-13 | 2009-11-19 | F. Hoffmann-La Roche Ag | Imidazo-benzothiazoles |
| JP4444290B2 (ja) | 2003-05-19 | 2010-03-31 | エフ．ホフマン−ラ ロシュ アーゲー | アデノシン受容体リガンドとしてのベンゾチアゾール誘導体 |
| PL1628662T3 (pl) | 2003-05-21 | 2007-07-31 | Hoffmann La Roche | Pochodne benzotiazolu i ich zastosowanie w leczeniu chorób związanych z receptorem adenozynowym A2A |
| BRPI0414266A (pt) | 2003-09-19 | 2006-11-07 | Hoffmann La Roche | derivados de tiazolopiridina como ligandos receptores da adenosina |
| CN1956983B (zh) | 2004-05-24 | 2010-05-26 | 弗·哈夫曼-拉罗切有限公司 | 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺 |
| CN1989139B (zh) | 2004-07-22 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 苯并噻唑衍生物 |
| ES2400287T3 (es) | 2005-03-14 | 2013-04-08 | High Point Pharmaceuticals, Llc | Derivados de benzazol, composiciones y procedimientos de uso como inhibidores de beta-secretasa |
| CN102731488A (zh) * | 2011-04-02 | 2012-10-17 | 中国医学科学院药物研究所 | 苯并咪唑类衍生物、及其制法和药物组合物与用途 |
-
2018
- 2018-08-20 AU AU2018320673A patent/AU2018320673B2/en not_active Ceased
- 2018-08-20 KR KR1020207007994A patent/KR20200043433A/ko not_active Ceased
- 2018-08-20 EP EP18753209.8A patent/EP3672952B1/en active Active
- 2018-08-20 TW TW107128915A patent/TWI791593B/zh not_active IP Right Cessation
- 2018-08-20 CA CA3073333A patent/CA3073333A1/en active Pending
- 2018-08-20 BR BR112020003594-7A patent/BR112020003594A2/pt not_active Application Discontinuation
- 2018-08-20 JP JP2020511371A patent/JP7287952B2/ja active Active
- 2018-08-20 CN CN201880054520.7A patent/CN110997662B/zh active Active
- 2018-08-20 WO PCT/EP2018/072398 patent/WO2019038215A1/en not_active Ceased
- 2018-08-20 IL IL272637A patent/IL272637B2/en unknown
- 2018-08-20 ES ES18753209T patent/ES2940408T3/es active Active
- 2018-08-20 SG SG11202001337XA patent/SG11202001337XA/en unknown
- 2018-08-20 US US16/640,490 patent/US11453647B2/en active Active
-
2020
- 2020-03-20 ZA ZA2020/01780A patent/ZA202001780B/en unknown
-
2022
- 2022-03-14 US US17/693,527 patent/US20220306588A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPWO2019038215A5 (https=) | ||
| JP2021514001A5 (https=) | ||
| JP2004525117A5 (https=) | ||
| JP2018048209A5 (https=) | ||
| JPWO2019038214A5 (https=) | ||
| JP2005523922A5 (https=) | ||
| JP2021535177A5 (https=) | ||
| CA2457054A1 (en) | Activator of peroxisome proliferator-activated receptor .delta. | |
| JP2009536221A5 (https=) | ||
| RU2009102252A (ru) | Хиноксалинилмакроциклические ингибиторы серинпротеазы вируса гепатита с | |
| JP2010532768A5 (https=) | ||
| JPWO2023060253A5 (https=) | ||
| JP2021535174A5 (https=) | ||
| JP2009541225A5 (https=) | ||
| JP2020528922A5 (https=) | ||
| JP2011517697A5 (https=) | ||
| JP2005503435A5 (https=) | ||
| JP2008543781A5 (https=) | ||
| JPWO2022256434A5 (https=) | ||
| JPH10316662A5 (https=) | ||
| JP2006513222A5 (https=) | ||
| JPWO2019025099A5 (https=) | ||
| JP2012519703A5 (https=) | ||
| JPH1081664A5 (https=) | ||
| RU2007112501A (ru) | Бензимидазольные производные, содержащие их композиции, их получение и применение |