CN110997662B - 作为腺苷受体拮抗剂的苯并咪唑衍生物 - Google Patents

作为腺苷受体拮抗剂的苯并咪唑衍生物 Download PDF

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CN110997662B
CN110997662B CN201880054520.7A CN201880054520A CN110997662B CN 110997662 B CN110997662 B CN 110997662B CN 201880054520 A CN201880054520 A CN 201880054520A CN 110997662 B CN110997662 B CN 110997662B
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cancer
compounds
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adenosine
receptor
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CN110997662A (zh
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E-M.坦策
K.席曼
M.克莱因
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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CN201880054520.7A 2017-08-21 2018-08-20 作为腺苷受体拮抗剂的苯并咪唑衍生物 Active CN110997662B (zh)

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EP17187101 2017-08-21
EP17187101.5 2017-08-21
PCT/EP2018/072398 WO2019038215A1 (en) 2017-08-21 2018-08-20 BENZIMIDAZOLE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS

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CN110997662B true CN110997662B (zh) 2023-10-31

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