JPWO2019038214A5 - - Google Patents
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- Publication number
- JPWO2019038214A5 JPWO2019038214A5 JP2020511322A JP2020511322A JPWO2019038214A5 JP WO2019038214 A5 JPWO2019038214 A5 JP WO2019038214A5 JP 2020511322 A JP2020511322 A JP 2020511322A JP 2020511322 A JP2020511322 A JP 2020511322A JP WO2019038214 A5 JPWO2019038214 A5 JP WO2019038214A5
- Authority
- JP
- Japan
- Prior art keywords
- atoms
- nch
- replaced
- alkyl
- unsubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims description 39
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 15
- 125000002950 monocyclic group Chemical group 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 125000005842 heteroatom Chemical group 0.000 claims description 6
- 125000000623 heterocyclic group Chemical group 0.000 claims description 6
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 4
- -1 SO2CH3 Chemical group 0.000 claims description 3
- 229910006074 SO2NH2 Inorganic materials 0.000 claims description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 3
- 125000000565 sulfonamide group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 2
- 229940002612 prodrug Drugs 0.000 claims 2
- 239000000651 prodrug Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17187100 | 2017-08-21 | ||
| EP17187100.7 | 2017-08-21 | ||
| PCT/EP2018/072397 WO2019038214A1 (en) | 2017-08-21 | 2018-08-20 | QUINOXALINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2020531526A JP2020531526A (ja) | 2020-11-05 |
| JP2020531526A5 JP2020531526A5 (https=) | 2023-02-02 |
| JPWO2019038214A5 true JPWO2019038214A5 (https=) | 2023-02-02 |
| JP7287951B2 JP7287951B2 (ja) | 2023-06-06 |
Family
ID=59677147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020511322A Active JP7287951B2 (ja) | 2017-08-21 | 2018-08-20 | アデノシン受容体アンタゴニストとしてのキノキサリン誘導体 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US11192899B2 (https=) |
| EP (1) | EP3672951B1 (https=) |
| JP (1) | JP7287951B2 (https=) |
| KR (1) | KR20200043434A (https=) |
| CN (1) | CN110944994B (https=) |
| AU (1) | AU2018320672B2 (https=) |
| BR (1) | BR112020003283A2 (https=) |
| CA (1) | CA3073343A1 (https=) |
| DK (1) | DK3672951T3 (https=) |
| ES (1) | ES2964026T3 (https=) |
| IL (1) | IL272638B2 (https=) |
| SG (1) | SG11202001340VA (https=) |
| TW (1) | TW201920123A (https=) |
| WO (1) | WO2019038214A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020182929A1 (en) | 2019-03-13 | 2020-09-17 | Bayer Aktiengesellschaft | Substituted ureas and derivatives as new antifungal agents |
| US12583869B2 (en) | 2019-03-28 | 2026-03-24 | Cstone Pharmaceutical (Suzhou) Co., Ltd. | Salt form and crystal form of A2A receptor antagonist and preparation method therefor |
| JP7584623B2 (ja) * | 2020-07-23 | 2024-11-15 | シトシンラボ セラピューティクス カンパニー， リミテッド | キナーゼ阻害活性を有する化合物 |
| WO2022058327A1 (en) | 2020-09-15 | 2022-03-24 | Bayer Aktiengesellschaft | Substituted ureas and derivatives as new antifungal agents |
| US20220127231A1 (en) * | 2020-10-27 | 2022-04-28 | Shilpa Medicare Ltd | Process for the prepartion of amifampridine phosphate |
| EP4059498A1 (en) * | 2021-03-16 | 2022-09-21 | Centre Hospitalier Universitaire Vaudois (CHUV) | Methods and compositions for treating conditions associated with hypermineralization |
| WO2022258622A1 (en) | 2021-06-07 | 2022-12-15 | Ares Trading S.A. | Combination treatment of cancer |
| CN116514803A (zh) * | 2022-01-21 | 2023-08-01 | 上海赛岚生物科技有限公司 | 一种激酶抑制剂的盐晶型和自由碱晶型 |
| CN121270522B (zh) * | 2025-12-10 | 2026-03-17 | 四川大学华西医院 | 吲唑-苯并三唑-吡唑结构衍生物及其制备方法和应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4207554A (en) | 1972-08-04 | 1980-06-10 | Med-El Inc. | Method and apparatus for automated classification and analysis of cells |
| US4125828A (en) | 1972-08-04 | 1978-11-14 | Med-El Inc. | Method and apparatus for automated classification and analysis of cells |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| BR9707495A (pt) | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
| US6291455B1 (en) | 1996-03-05 | 2001-09-18 | Zeneca Limited | 4-anilinoquinazoline derivatives |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| AU1688599A (en) | 1998-01-05 | 1999-07-26 | Eisai Co. Ltd. | Purine derivatives and adenosine a2 receptor antagonists serving as preventives/remedies for diabetes |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| US6841549B1 (en) | 1999-07-02 | 2005-01-11 | Eisai Co., Ltd. | Condensed imidazole compounds and a therapeutic agent for diabetes mellitus |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| CN1255392C (zh) | 2000-07-07 | 2006-05-10 | 安吉奥金尼药品有限公司 | 作为血管生成抑制剂的秋水仙醇衍生物 |
| IL153484A0 (en) | 2000-07-07 | 2003-07-06 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors |
| WO2004089942A2 (en) | 2001-10-02 | 2004-10-21 | Acadia Pharmaceuticals Inc. | Benzimidazolidinone derivatives as muscarinic agents |
| EP1465634B1 (en) | 2001-12-12 | 2014-10-22 | The Government of the United States of America, as represented by the Secretary Department of Health and Human Services | Methods for using adenosine receptor inhibitors to enhance immune response and inflammation |
| EP1618108A2 (en) | 2003-04-09 | 2006-01-25 | Biogen Idec MA Inc. | Triazolo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines useful as a2a adenosine receptor antagonists |
| JP4444290B2 (ja) | 2003-05-19 | 2010-03-31 | エフ．ホフマン−ラ ロシュ アーゲー | アデノシン受容体リガンドとしてのベンゾチアゾール誘導体 |
| BRPI0414266A (pt) | 2003-09-19 | 2006-11-07 | Hoffmann La Roche | derivados de tiazolopiridina como ligandos receptores da adenosina |
| JP2005154434A (ja) | 2003-11-05 | 2005-06-16 | Kyowa Hakko Kogyo Co Ltd | ２−アミノキナゾリン誘導体 |
| CN1956983B (zh) | 2004-05-24 | 2010-05-26 | 弗·哈夫曼-拉罗切有限公司 | 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺 |
| CN1989139B (zh) | 2004-07-22 | 2010-05-12 | 弗·哈夫曼-拉罗切有限公司 | 苯并噻唑衍生物 |
| CA2717171A1 (en) | 2008-03-04 | 2009-09-11 | Schering Corporation | Amino-quinoxaline and amino-quinoline compounds for use as adenosine a2a receptor antagonists |
-
2018
- 2018-08-20 ES ES18753208T patent/ES2964026T3/es active Active
- 2018-08-20 US US16/640,526 patent/US11192899B2/en active Active
- 2018-08-20 WO PCT/EP2018/072397 patent/WO2019038214A1/en not_active Ceased
- 2018-08-20 KR KR1020207008007A patent/KR20200043434A/ko not_active Abandoned
- 2018-08-20 IL IL272638A patent/IL272638B2/en unknown
- 2018-08-20 CA CA3073343A patent/CA3073343A1/en active Pending
- 2018-08-20 DK DK18753208.0T patent/DK3672951T3/da active
- 2018-08-20 CN CN201880054521.1A patent/CN110944994B/zh active Active
- 2018-08-20 BR BR112020003283-2A patent/BR112020003283A2/pt not_active Application Discontinuation
- 2018-08-20 AU AU2018320672A patent/AU2018320672B2/en not_active Ceased
- 2018-08-20 TW TW107128914A patent/TW201920123A/zh unknown
- 2018-08-20 JP JP2020511322A patent/JP7287951B2/ja active Active
- 2018-08-20 EP EP18753208.0A patent/EP3672951B1/en active Active
- 2018-08-20 SG SG11202001340VA patent/SG11202001340VA/en unknown
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