JP2012519703A5 - - Google Patents
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- Publication number
- JP2012519703A5 JP2012519703A5 JP2011553135A JP2011553135A JP2012519703A5 JP 2012519703 A5 JP2012519703 A5 JP 2012519703A5 JP 2011553135 A JP2011553135 A JP 2011553135A JP 2011553135 A JP2011553135 A JP 2011553135A JP 2012519703 A5 JP2012519703 A5 JP 2012519703A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally
- group
- optionally substituted
- hydrogen atom
- substituted alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 42
- 125000000547 substituted alkyl group Chemical group 0.000 claims 38
- 150000001875 compounds Chemical class 0.000 claims 30
- 125000001424 substituent group Chemical group 0.000 claims 29
- 125000004429 atom Chemical group 0.000 claims 19
- 229910052760 oxygen Inorganic materials 0.000 claims 16
- 150000002148 esters Chemical class 0.000 claims 15
- 229940002612 prodrug Drugs 0.000 claims 15
- 239000000651 prodrug Substances 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 239000012453 solvate Substances 0.000 claims 15
- 229910052717 sulfur Inorganic materials 0.000 claims 15
- 125000002837 carbocyclic group Chemical group 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- 239000000126 substance Substances 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- -1 2-morpholinoethyl Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- YNMUTYLWSRFTPX-GHMZBOCLSA-N (2r,3r)-2-amino-3-methyl-n-(2-morpholin-4-ylethyl)pentanamide Chemical compound CC[C@@H](C)[C@@H](N)C(=O)NCCN1CCOCC1 YNMUTYLWSRFTPX-GHMZBOCLSA-N 0.000 claims 4
- YNMUTYLWSRFTPX-QWRGUYRKSA-N (2s,3s)-2-amino-3-methyl-n-(2-morpholin-4-ylethyl)pentanamide Chemical compound CC[C@H](C)[C@H](N)C(=O)NCCN1CCOCC1 YNMUTYLWSRFTPX-QWRGUYRKSA-N 0.000 claims 4
- 125000003107 substituted aryl group Chemical group 0.000 claims 4
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 4
- 102100036220 PC4 and SFRS1-interacting protein Human genes 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- YNMUTYLWSRFTPX-WDEREUQCSA-N (2r,3s)-2-amino-3-methyl-n-(2-morpholin-4-ylethyl)pentanamide Chemical compound CC[C@H](C)[C@@H](N)C(=O)NCCN1CCOCC1 YNMUTYLWSRFTPX-WDEREUQCSA-N 0.000 claims 2
- YNMUTYLWSRFTPX-MNOVXSKESA-N (2s,3r)-2-amino-3-methyl-n-(2-morpholin-4-ylethyl)pentanamide Chemical compound CC[C@@H](C)[C@H](N)C(=O)NCCN1CCOCC1 YNMUTYLWSRFTPX-MNOVXSKESA-N 0.000 claims 2
- YNMUTYLWSRFTPX-UHFFFAOYSA-N 2-amino-3-methyl-n-(2-morpholin-4-ylethyl)pentanamide Chemical compound CCC(C)C(N)C(=O)NCCN1CCOCC1 YNMUTYLWSRFTPX-UHFFFAOYSA-N 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- IPWFJLQDVFKJDU-UHFFFAOYSA-N pentanamide Chemical compound CCCCC(N)=O IPWFJLQDVFKJDU-UHFFFAOYSA-N 0.000 claims 2
- NUOGPFINGLHYKP-UHFFFAOYSA-N 2-amino-3-methyl-n-(2-morpholin-4-ylethyl)butanamide Chemical compound CC(C)C(N)C(=O)NCCN1CCOCC1 NUOGPFINGLHYKP-UHFFFAOYSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 0 CC(C)(C(*)(*)C(C)(C)N1CCOCC1)N(C=O)C(C(*)N(C)*)=O Chemical compound CC(C)(C(*)(*)C(C)(C)N1CCOCC1)N(C=O)C(C(*)N(C)*)=O 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15830609P | 2009-03-06 | 2009-03-06 | |
| US61/158,306 | 2009-03-06 | ||
| US16428209P | 2009-03-27 | 2009-03-27 | |
| US61/164,282 | 2009-03-27 | ||
| PCT/US2010/026372 WO2010102212A2 (en) | 2009-03-06 | 2010-03-05 | Neurotrophin mimetics and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015145503A Division JP2016026142A (ja) | 2009-03-06 | 2015-07-23 | ニューロトロフィン・ミメティック及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012519703A JP2012519703A (ja) | 2012-08-30 |
| JP2012519703A5 true JP2012519703A5 (https=) | 2013-04-18 |
Family
ID=42710232
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011553135A Pending JP2012519703A (ja) | 2009-03-06 | 2010-03-05 | ニューロトロフィン・ミメティック及びその使用 |
| JP2015145503A Withdrawn JP2016026142A (ja) | 2009-03-06 | 2015-07-23 | ニューロトロフィン・ミメティック及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015145503A Withdrawn JP2016026142A (ja) | 2009-03-06 | 2015-07-23 | ニューロトロフィン・ミメティック及びその使用 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP2403839A4 (https=) |
| JP (2) | JP2012519703A (https=) |
| CA (1) | CA2754570A1 (https=) |
| WO (1) | WO2010102212A2 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1871420A4 (en) | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| US10273219B2 (en) | 2009-11-12 | 2019-04-30 | Pharmatrophix, Inc. | Crystalline forms of neurotrophin mimetic compounds and their salts |
| ES2712752T3 (es) * | 2009-11-12 | 2019-05-14 | Pharmatrophix Inc | Formas cristalinas de compuestos miméticos de neurotrofina y sus sales |
| US9296691B2 (en) | 2010-10-13 | 2016-03-29 | Horacio Uri Saragovi | Inhibitors of p75 receptor and their uses |
| EP2900646A4 (en) | 2012-09-27 | 2016-09-21 | Pharmatrophix Inc | CRYSTALLINE FORMS OF NEUROTROPHINMIMETIC COMPOUNDS AND THEIR SALTS |
| WO2018039641A1 (en) * | 2016-08-25 | 2018-03-01 | Pharmatrophix, Inc. | Methods and compounds for treating alcohol use disorders and associated diseases |
| WO2022265723A1 (en) * | 2021-06-17 | 2022-12-22 | Pharmatrophix, Inc. | Methods and compositions for treating and managing alzheimer's disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2762315B1 (fr) * | 1997-04-22 | 1999-05-28 | Logeais Labor Jacques | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
| US6492380B1 (en) * | 1999-05-17 | 2002-12-10 | Queen's University At Kingston | Method of inhibiting neurotrophin-receptor binding |
| WO2003006423A1 (en) * | 2001-07-11 | 2003-01-23 | Elan Pharmaceuticals, Inc. | N-(3-amino-2-hydroxy-propyl) substituted alkylamide compounds |
| NZ533107A (en) * | 2001-11-08 | 2007-04-27 | Upjohn Co | N, N'-substituted-1,3-diamino-2-hydroxypropane derivatives |
| EP1871420A4 (en) * | 2005-04-15 | 2010-09-22 | Univ North Carolina | PROCESS FOR ENABLING CELL SURVIVAL VIA NEUROTROPHINE MIMETICS |
| WO2008107365A1 (en) * | 2007-03-02 | 2008-09-12 | Medivir Ab | New compounds |
-
2010
- 2010-03-05 EP EP10749395.9A patent/EP2403839A4/en not_active Withdrawn
- 2010-03-05 CA CA2754570A patent/CA2754570A1/en not_active Abandoned
- 2010-03-05 JP JP2011553135A patent/JP2012519703A/ja active Pending
- 2010-03-05 WO PCT/US2010/026372 patent/WO2010102212A2/en not_active Ceased
-
2015
- 2015-07-23 JP JP2015145503A patent/JP2016026142A/ja not_active Withdrawn