JP2018048209A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018048209A5 JP2018048209A5 JP2017253312A JP2017253312A JP2018048209A5 JP 2018048209 A5 JP2018048209 A5 JP 2018048209A5 JP 2017253312 A JP2017253312 A JP 2017253312A JP 2017253312 A JP2017253312 A JP 2017253312A JP 2018048209 A5 JP2018048209 A5 JP 2018048209A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- membered
- aralkyl
- cycloalkyl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 125000003710 aryl alkyl group Chemical group 0.000 claims 21
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 19
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 19
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 239000001257 hydrogen Substances 0.000 claims 17
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 16
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 16
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 16
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 15
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 13
- 210000002027 skeletal muscle Anatomy 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 150000002367 halogens Chemical class 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 229940125913 troponin activator Drugs 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052731 fluorine Inorganic materials 0.000 claims 3
- 239000011737 fluorine Substances 0.000 claims 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 2
- 125000000753 cycloalkyl group Chemical group 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims 2
- AKWIAIDKXNKXDI-UHFFFAOYSA-N 1h-pyrrole-3-carboxamide Chemical compound NC(=O)C=1C=CNC=1 AKWIAIDKXNKXDI-UHFFFAOYSA-N 0.000 claims 1
- -1 2-((3-fluoro-1- (3-fluoropyridin-2-yl) cyclobutyl) methylamino) pyrimidin-5-yl Chemical group 0.000 claims 1
- DGXUBNJTSDKMNH-UHFFFAOYSA-N 3-[2-[[3-fluoro-1-(3-fluoropyridin-2-yl)cyclobutyl]methylamino]pyrimidin-5-yl]benzamide Chemical group NC(=O)C1=CC=CC(C=2C=NC(NCC3(CC(F)C3)C=3C(=CC=CN=3)F)=NC=2)=C1 DGXUBNJTSDKMNH-UHFFFAOYSA-N 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010049565 Muscle fatigue Diseases 0.000 claims 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 208000007502 anemia Diseases 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- KXDAEFPNCMNJSK-UHFFFAOYSA-N benzene carboxamide Natural products NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 150000003857 carboxamides Chemical class 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 125000001786 isothiazolyl group Chemical group 0.000 claims 1
- 125000000842 isoxazolyl group Chemical group 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261623003P | 2012-04-11 | 2012-04-11 | |
| US61/623,003 | 2012-04-11 | ||
| US201261646842P | 2012-05-14 | 2012-05-14 | |
| US61/646,842 | 2012-05-14 | ||
| US201261693061P | 2012-08-24 | 2012-08-24 | |
| US61/693,061 | 2012-08-24 | ||
| US201261735809P | 2012-12-11 | 2012-12-11 | |
| US61/735,809 | 2012-12-11 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505896A Division JP6352244B2 (ja) | 2012-04-11 | 2013-04-11 | 骨格筋疲労に対する耐性を向上させるための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018048209A JP2018048209A (ja) | 2018-03-29 |
| JP2018048209A5 true JP2018048209A5 (https=) | 2018-07-26 |
| JP6535727B2 JP6535727B2 (ja) | 2019-06-26 |
Family
ID=49328282
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505896A Expired - Fee Related JP6352244B2 (ja) | 2012-04-11 | 2013-04-11 | 骨格筋疲労に対する耐性を向上させるための方法 |
| JP2017253312A Expired - Fee Related JP6535727B2 (ja) | 2012-04-11 | 2017-12-28 | 骨格筋疲労に対する耐性を向上させるための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015505896A Expired - Fee Related JP6352244B2 (ja) | 2012-04-11 | 2013-04-11 | 骨格筋疲労に対する耐性を向上させるための方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US20150250784A1 (https=) |
| EP (1) | EP2836590A4 (https=) |
| JP (2) | JP6352244B2 (https=) |
| KR (1) | KR102163931B1 (https=) |
| CN (2) | CN111840294A (https=) |
| AU (3) | AU2013245917A1 (https=) |
| BR (1) | BR112014025251B1 (https=) |
| CA (1) | CA2869675C (https=) |
| EA (1) | EA032480B1 (https=) |
| HK (1) | HK1206389A1 (https=) |
| IL (2) | IL234886A (https=) |
| MX (1) | MX2014012179A (https=) |
| PH (1) | PH12014502286B1 (https=) |
| SG (2) | SG11201406359TA (https=) |
| WO (1) | WO2013155262A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8299248B2 (en) | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
| AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
| KR101951220B1 (ko) | 2011-07-13 | 2019-02-22 | 싸이토키네틱스, 인코포레이티드 | 조합 als 치료법 |
| EP2970240B1 (en) | 2013-03-14 | 2018-01-10 | Novartis AG | 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh |
| HUE057533T2 (hu) * | 2014-04-29 | 2022-05-28 | Cytokinetics Inc | Eljárások vitálkapacitás csökkenésének gátlására |
| KR102431436B1 (ko) | 2014-08-29 | 2022-08-10 | 테스 파마 에스.알.엘. | α-아미노-β-카복시뮤콘산 세미알데히드 데카복실라제의 억제제 |
| JP6573618B2 (ja) * | 2014-09-09 | 2019-09-11 | アステラス製薬株式会社 | 尿失禁予防用及び／又は治療用新規医薬組成物 |
| BR112018016475A2 (en) | 2016-02-12 | 2018-12-26 | Cytokinetics, Incorporated | tetrahydroisoquinoline derivatives |
| EP3484876A1 (en) | 2016-07-14 | 2019-05-22 | Pfizer Inc | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| KR20220038056A (ko) | 2019-07-23 | 2022-03-25 | 아모피컬 리미티드 | 운동 수행능력을 개선시키기 위한 비정질 탄산칼슘 |
| AU2020321955A1 (en) | 2019-07-30 | 2022-03-17 | Eikonizo Therapapeutics, Inc. | HDAC6 inhibitors and uses thereof |
| WO2022099011A1 (en) | 2020-11-06 | 2022-05-12 | Cytokinetics, Inc. | Bicyclic 1,4-diazepanones and therapeutic uses thereof |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| IL316201A (en) | 2022-04-08 | 2024-12-01 | Eikonizo Therapeutics Inc | Oxadiazole HDAC6 inhibitors and their uses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005139081A (ja) * | 2003-11-04 | 2005-06-02 | Takada Seiyaku Kk | ビントペロール含有製剤 |
| US8227603B2 (en) * | 2006-08-01 | 2012-07-24 | Cytokinetics, Inc. | Modulating skeletal muscle |
| US8299248B2 (en) * | 2006-08-02 | 2012-10-30 | Cytokinetics, Incorporated | Certain 1H-imidazo[4,5-b]pyrazin-2(3H)-ones and 1H-imidazo[4,5-b]pyrazin-2-ols and methods for their use |
| CN101522681B (zh) * | 2006-08-02 | 2012-10-03 | 赛特凯恩蒂克公司 | 特定的化学个体、组合物和方法 |
| EP2244711A4 (en) * | 2008-02-04 | 2011-08-24 | Cytokinetics Inc | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS |
| AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
| SG10201701101YA (en) * | 2012-04-02 | 2017-04-27 | Cytokinetics Inc | Methods for improving diaphragm function |
-
2013
- 2013-04-11 CN CN202010369880.5A patent/CN111840294A/zh active Pending
- 2013-04-11 MX MX2014012179A patent/MX2014012179A/es unknown
- 2013-04-11 US US14/391,087 patent/US20150250784A1/en not_active Abandoned
- 2013-04-11 KR KR1020147028128A patent/KR102163931B1/ko not_active Expired - Fee Related
- 2013-04-11 WO PCT/US2013/036114 patent/WO2013155262A2/en not_active Ceased
- 2013-04-11 SG SG11201406359TA patent/SG11201406359TA/en unknown
- 2013-04-11 SG SG10201704166RA patent/SG10201704166RA/en unknown
- 2013-04-11 CN CN201380019567.7A patent/CN104395458A/zh active Pending
- 2013-04-11 HK HK15106995.5A patent/HK1206389A1/xx unknown
- 2013-04-11 JP JP2015505896A patent/JP6352244B2/ja not_active Expired - Fee Related
- 2013-04-11 EP EP13775275.4A patent/EP2836590A4/en not_active Ceased
- 2013-04-11 EA EA201491666A patent/EA032480B1/ru not_active IP Right Cessation
- 2013-04-11 CA CA2869675A patent/CA2869675C/en active Active
- 2013-04-11 BR BR112014025251-3A patent/BR112014025251B1/pt not_active IP Right Cessation
- 2013-04-11 AU AU2013245917A patent/AU2013245917A1/en not_active Abandoned
-
2014
- 2014-09-29 IL IL234886A patent/IL234886A/en active IP Right Grant
- 2014-10-10 PH PH12014502286A patent/PH12014502286B1/en unknown
-
2017
- 2017-02-06 IL IL250473A patent/IL250473A0/en unknown
- 2017-12-28 JP JP2017253312A patent/JP6535727B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-08 AU AU2018200930A patent/AU2018200930A1/en not_active Abandoned
- 2018-11-30 US US16/206,747 patent/US20190167676A1/en not_active Abandoned
-
2019
- 2019-11-22 AU AU2019268177A patent/AU2019268177A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018048209A5 (https=) | ||
| JP2010511721A5 (https=) | ||
| JP2018516904A5 (https=) | ||
| JP2011522789A5 (https=) | ||
| NZ603594A (en) | Certain amino-pyrimidines, compositions thereof, and methods for their use | |
| JP2009529540A5 (https=) | ||
| JP2018538248A5 (https=) | ||
| JP2014520767A5 (https=) | ||
| JP2018502912A5 (https=) | ||
| JP2015509110A5 (https=) | ||
| JP2018024682A5 (https=) | ||
| JP2013543845A5 (https=) | ||
| JP2012515776A5 (https=) | ||
| JP2005523310A5 (https=) | ||
| JP2014506907A5 (https=) | ||
| JP2018537413A5 (ja) | 化合物、医薬的に許容される塩又はその立体異性体及び医薬組成物 | |
| JP2011037841A5 (https=) | ||
| JP2016505614A5 (https=) | ||
| JP2012092103A5 (https=) | ||
| PE20212253A1 (es) | Compuestos de piperidina urea 4-metilsulfonil-sustituidos para el tratamiento de miocardiopatia dilatada (mcd) | |
| JP2019510794A5 (https=) | ||
| JP2019513745A5 (https=) | ||
| MX2009008509A (es) | Compuesto de anillo puenteado-aza. | |
| JP2013060411A5 (ja) | カルバゾール化合物 | |
| JP2020504434A5 (https=) |