JPWO2014196592A1 - ダイヤモンド粒子含有口腔用組成物 - Google Patents
ダイヤモンド粒子含有口腔用組成物 Download PDFInfo
- Publication number
- JPWO2014196592A1 JPWO2014196592A1 JP2015521482A JP2015521482A JPWO2014196592A1 JP WO2014196592 A1 JPWO2014196592 A1 JP WO2014196592A1 JP 2015521482 A JP2015521482 A JP 2015521482A JP 2015521482 A JP2015521482 A JP 2015521482A JP WO2014196592 A1 JPWO2014196592 A1 JP WO2014196592A1
- Authority
- JP
- Japan
- Prior art keywords
- composition
- diamond particles
- particles
- rda
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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- 239000000203 mixture Substances 0.000 title claims abstract description 60
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- 229910003460 diamond Inorganic materials 0.000 title claims abstract description 45
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 71
- 210000000214 mouth Anatomy 0.000 claims description 24
- 239000000377 silicon dioxide Substances 0.000 claims description 21
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- 230000001186 cumulative effect Effects 0.000 claims description 12
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- 238000009826 distribution Methods 0.000 claims description 8
- 238000005498 polishing Methods 0.000 abstract description 18
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- 125000000217 alkyl group Chemical group 0.000 description 12
- 239000000551 dentifrice Substances 0.000 description 12
- 210000003298 dental enamel Anatomy 0.000 description 11
- 230000000052 comparative effect Effects 0.000 description 9
- 210000004268 dentin Anatomy 0.000 description 9
- 238000000034 method Methods 0.000 description 9
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- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
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- 159000000000 sodium salts Chemical class 0.000 description 1
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
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- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
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- 229960000790 thymol Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- XJPBRODHZKDRCB-UHFFFAOYSA-N trans-alpha-ocimene Natural products CC(=C)CCC=C(C)C=C XJPBRODHZKDRCB-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
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- 239000000080 wetting agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
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- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
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- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
- 229930007845 β-thujaplicin Natural products 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
Description
項1.
ダイヤモンド粒子及び研磨性シリカ粒子を含有し、
前記ダイヤモンド粒子は、メジアン径(d50)が2.0〜3.5μmであり、
前記研磨性シリカ粒子は、RDAが50以上200以下である、
口腔用組成物。
項2.
前記ダイヤモンド粒子の、粒径の累積分布10%値(d10)とd50との差が2μm以内であり、粒径の累積分布99%値(d99)とd50との差が3μm以内である、
項1に記載の口腔用組成物。
項3.前記研磨性シリカ粒子のメジアン径(d50)が、2.5〜10μmである、項1又は2に記載の口腔用組成物。
項4.
前記ダイヤモンド粒子を0.1〜0.3質量%含有する、項1〜3のいずれかに記載の口腔用組成物。
項5.
前記研磨性シリカ粒子を1〜10質量%含有する、項1〜4のいずれかに記載の口腔用組成物。
項6.
さらにスルホコハク酸系界面活性剤を含有する、項1〜5のいずれかに記載の口腔用組成物。
一般式(1):
一般式(1)で表されるスルホコハク酸モノエステルにおいて、R1は天然由来または合成した炭素数8〜22程度の直鎖または分岐のアルキル基またはアルケニル基である。例えば、ラウリル、ココイル、ミリスチル、ステアリル、C12〜C14合成アルキル、イソノニル、イソドデシル、オクテニル、ドデケニルなどが挙げられる。R1の炭素数が長いほど苦味や刺激は低減されるが、短いほどステイン形成阻害効果が高くなるので、R1の炭素数は10〜16程度が好ましく、12〜14程度がより好ましい。特に、C12〜C14合成アルキルあるいはラウリルとミリスチルを組合せて用いるのが最も好ましい。
下記表1に記載の組成に従い、実施例1〜9及び比較例1〜3の口腔用組成物(ペースト)を調製した。具体的には、ダイヤモンド粒子、研磨性シリカ粒子、発泡剤(スルホコハク酸ナトリウム及びラウリル硫酸ナトリウム)以外の原料を混合し、これにダイヤモンド粒子及び研磨性シリカ粒子を加えて撹拌・均一化し、最後に発泡剤を加え、真空下で撹拌・均一化(脱泡処理も兼ねる)した。なお、ダイヤモンド粒子は、Microdiamant AG, CH-8574 Lingwil,スイス から購入して用いた。また、表1の各成分の数値は、質量%を示す。
(シリカA粒子)d50:2μm、 RDA:120
(シリカB粒子)d50:3μm、 RDA:160
(シリカC粒子)d50:4μm、 RDA:200
(シリカD粒子)d50:8μm、 RDA:150
(シリカE粒子)d50:14μm、 RDA:100
(シリカF粒子)d50:14μm、 RDA:130
また、3種類のダイヤモンド粒子(それぞれダイヤモンド粒子A〜Cとする)を用いた。ダイヤモンド粒子Aは、d50が2.8μm、d10が1.8μm、d99が4.5μmであり、ダイヤモンド粒子Bは、d50が2μm、d10が1μm以上、d99が3.5μm以下であり、ダイヤモンド粒子Cは、d50が3μm、d10が1.8μm以上、d99が4.5μm以下であった。
得られた各口腔用組成物について、Stookyらの方法(J Dent Research, 61: 1236-1239,1982)に従いステイン除去力(PCR;Pellicle cleaning ratio)を測定した。また、ISO11609;2010 Annex Bに記載された方法に従いRDAを評価した。結果は、表1に併せて示した。
Claims (6)
- ダイヤモンド粒子及び研磨性シリカ粒子を含有し、
前記ダイヤモンド粒子は、メジアン径(d50)が2〜3.5μmであり、
前記研磨性シリカ粒子は、RDAが50以上200以下である、
口腔用組成物。 - 前記ダイヤモンド粒子の、粒径の累積分布10%値(d10)とd50との差が2μm以内であり、粒径の累積分布99%値(d99)とd50との差が3μm以内である、
請求項1に記載の口腔用組成物。 - 前記研磨性シリカ粒子のメジアン径(d50)が、2.5〜10μmである、請求項1又は2に記載の口腔用組成物。
- 前記ダイヤモンド粒子を0.1〜0.3質量%含有する、請求項1〜3のいずれかに記載の口腔用組成物。
- 前記研磨性シリカ粒子を1〜10質量%含有する、請求項1〜4のいずれかに記載の口腔用組成物。
- さらにスルホコハク酸系界面活性剤を含有する、請求項1〜5のいずれかに記載の口腔用組成物。
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EP (1) | EP3006013B1 (ja) |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH1017443A (ja) * | 1996-07-05 | 1998-01-20 | Sunstar Inc | スルホコハク酸系界面活性剤含有口腔用組成物 |
US6399111B1 (en) * | 1996-01-19 | 2002-06-04 | Crosfield Limited | Amorphous silicas and oral compositions |
JP2004238321A (ja) * | 2003-02-05 | 2004-08-26 | Kao Corp | 口腔用組成物 |
JP2007091636A (ja) * | 2005-09-29 | 2007-04-12 | Gc Corp | 歯科研磨用組成物 |
US20090092562A1 (en) * | 2007-04-30 | 2009-04-09 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
US20090130031A1 (en) * | 2007-11-16 | 2009-05-21 | Michael Herman | Diamond, precious and semi-precious dust polishing agent for dental veneers and teeth |
WO2010060653A2 (en) * | 2008-11-27 | 2010-06-03 | Amc Abrasives Marketing & Consulting Llp | Dental care products with diamond particles |
US20100254915A1 (en) * | 2009-04-06 | 2010-10-07 | Lisa Marie Kao | Dental cleaning and polishing composition comprising diamond particles |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294155B1 (en) * | 1998-04-08 | 2001-09-25 | W. R. Grace & Co. -Conn. | Abrasive silica compositions and dentifrice compositions prepared therefrom |
ATE525113T1 (de) * | 2001-07-05 | 2011-10-15 | Sunstar Inc | Orales präparat |
JP3803868B2 (ja) | 2001-07-05 | 2006-08-02 | サンスター株式会社 | 口腔用組成物 |
AU2006338180B2 (en) * | 2005-12-21 | 2010-08-26 | Colgate-Palmolive Company | Abrasive system for oral care compositions |
AU2010363052B2 (en) * | 2010-10-27 | 2014-11-20 | Colgate-Palmolive Company | Oral care composition comprising arginine and calcium carbonate |
-
2014
- 2014-06-05 ES ES14808461.9T patent/ES2683128T3/es active Active
- 2014-06-05 JP JP2015521482A patent/JP6382190B2/ja active Active
- 2014-06-05 US US14/895,310 patent/US20160120774A1/en not_active Abandoned
- 2014-06-05 EP EP14808461.9A patent/EP3006013B1/en active Active
- 2014-06-05 CN CN201480032286.XA patent/CN105307623B/zh active Active
- 2014-06-05 CA CA2914216A patent/CA2914216A1/en not_active Abandoned
- 2014-06-05 WO PCT/JP2014/064934 patent/WO2014196592A1/ja active Application Filing
- 2014-06-06 TW TW103119721A patent/TWI638663B/zh active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6399111B1 (en) * | 1996-01-19 | 2002-06-04 | Crosfield Limited | Amorphous silicas and oral compositions |
JPH1017443A (ja) * | 1996-07-05 | 1998-01-20 | Sunstar Inc | スルホコハク酸系界面活性剤含有口腔用組成物 |
JP2004238321A (ja) * | 2003-02-05 | 2004-08-26 | Kao Corp | 口腔用組成物 |
JP2007091636A (ja) * | 2005-09-29 | 2007-04-12 | Gc Corp | 歯科研磨用組成物 |
US20090092562A1 (en) * | 2007-04-30 | 2009-04-09 | Colgate-Palmolive Company | Oral Care Composition To Reduce Or Eliminate Dental Sensitivity |
US20090130031A1 (en) * | 2007-11-16 | 2009-05-21 | Michael Herman | Diamond, precious and semi-precious dust polishing agent for dental veneers and teeth |
WO2010060653A2 (en) * | 2008-11-27 | 2010-06-03 | Amc Abrasives Marketing & Consulting Llp | Dental care products with diamond particles |
JP2012509920A (ja) * | 2008-11-27 | 2012-04-26 | エイエムシー・アブレイシブズ・マーケティング・アンド・コンサルティング・リミテッド・ライアビリティ・パートナーシップ | ダイヤモンド粒子を伴うデンタルケア製品 |
US20100254915A1 (en) * | 2009-04-06 | 2010-10-07 | Lisa Marie Kao | Dental cleaning and polishing composition comprising diamond particles |
Non-Patent Citations (1)
Title |
---|
SIDENT9, JPN7018000979, March 2013 (2013-03-01), ISSN: 0003768672 * |
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CN105307623A (zh) | 2016-02-03 |
EP3006013A1 (en) | 2016-04-13 |
ES2683128T3 (es) | 2018-09-25 |
WO2014196592A1 (ja) | 2014-12-11 |
JP6382190B2 (ja) | 2018-08-29 |
EP3006013A4 (en) | 2017-03-22 |
TW201501725A (zh) | 2015-01-16 |
CA2914216A1 (en) | 2014-12-11 |
US20160120774A1 (en) | 2016-05-05 |
TWI638663B (zh) | 2018-10-21 |
EP3006013B1 (en) | 2018-05-30 |
CN105307623B (zh) | 2018-06-15 |
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