JPWO2008126367A1 - 精神安定剤および機能性食品 - Google Patents
精神安定剤および機能性食品 Download PDFInfo
- Publication number
- JPWO2008126367A1 JPWO2008126367A1 JP2009508890A JP2009508890A JPWO2008126367A1 JP WO2008126367 A1 JPWO2008126367 A1 JP WO2008126367A1 JP 2009508890 A JP2009508890 A JP 2009508890A JP 2009508890 A JP2009508890 A JP 2009508890A JP WO2008126367 A1 JPWO2008126367 A1 JP WO2008126367A1
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- JP
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- Prior art keywords
- vitamin
- tranquilizer
- menaquinone
- present
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Abstract
Description
抗ストレス食品の開発と展望 横越英彦監修 シーエムシー出版(2006年)
〔実施例1〕
外界の刺激は、感覚器を通して脳に入り、扁桃体および海馬-外側中隔系に送られ、ここで有益か有害かが判断される(これを生物学的価値評価という)。評価された情報は、扁桃体および海馬に記憶されると同時に、生体反応が起こり、情動表出として観察者により視認される。ヒトや動物は、経験により得られた生物学的価値評価の情報を学習(獲得)し、再び同じ刺激を受けたときに扁桃体および海馬-外側中隔系において比較され、このときの反応を条件付け情動反応という。例えば、ラットやマウスを限定した箱に入れて、これらが嫌悪する電気刺激を負荷し、6日後に再度同じ箱に入れると電気刺激されていないにもかかわらず、ある期間すくみ行動(無動)を起こす。この無動を恐怖条件付け誘発無動という。現在、無動の時間の短縮を指標として、抗不安および抗うつ作用を評価する動物モデルが広く用いられている。例えば、市販抗うつ薬である塩酸ミルナシプラン30mg/kgの7日間の経口投与で改善されることが確認されている。
媒体として使用するメチルセルロース(製品名:メトローズ(登録商標)SM-400、以下MCという)を、信越化学工業株式会社より購入し、0.5w/v%となるよう注射用水(株式会社大塚製薬工場製)に溶解した。
一般状態および死亡の有無を、1日1回投与前に観察した。体重測定は、1日1回、投与前に測定した。電気刺激および無動時間の測定は、フェアードコンディション計測装置(Acti Metrics社)を用いた。群分けしたマウスをフェアードコンディション計測装置の中に入れ、恐怖条件付けの電気刺激を行い、同時に無動時間を測定した。電気刺激は、15秒毎に1秒の0.3mAの刺激を240秒間行った。電気刺激終了直後に、マウスに試料を投与した。投与7日後、コントロール(0.5%MC)群およびビタミンK投与群は、最終投与から2時間〜2時間1分後に再度、フェアードコンディション計測装置の中に入れ、電気刺激無しの条件で4分間の無動時間を測定した。なお、無動時間は、60秒毎の% of freezingとして表した。なお、マウスの呼吸に関する骨格筋とひげの動き以外が観察されない状態を無動とし、観察される状態を活動と判定した。
体重値は、群毎の平均値、標準偏差を算出した。無動時間は、0〜240秒の% of freezingを算出し、群毎の60秒毎および0〜240秒の% of freezingの平均値、標準偏差を算出した。有意差検定は、コントロール群とビタミンK群との間でそれぞれ2群間比較検定を行った。60秒毎の% of freezingの有意差検定は、二元配置分散分析を行い、0〜240秒の% of freezingの有意差検定は、コントロール群と被験物質群との間でそれぞれF検定による等分散性の検定を行い、等分散の場合はStudentのt検定を、不等分散の場合はWelch検定を行った。有意確率(p値)は、すべての組み合わせについて表示した。また、いずれの検定も危険率5%未満を有意とし、5%未満(p<0.05)と1%未満(p<0.01)とに分けて表示した。なお、上記の有意差検定に使用するソフトウエアは、市販の統計プログラム(SAS software ReL.8.2 TS 020. SAS前臨床パッケージVersion 5.0; SAS Institute Japan株式会社)とした。得た成績でヒストグラムおよび正規分布を確認し、検定法を確認した。ヒストグラムおよび正規分布の確認は、市販の統計プログラム(JMP、SASリリース5.1.1; SAS Institute Japan株式会社)を用いた。
コントロール群とビタミンK群において、死亡はみられず、一般状態に異常はみられなかった。図1に示すように、体重は、コントロール群とメナキノン-4群、メナキノン-7群のいずれも、投与期間を通して、ほぼ同じ値を推移し、群間に差は認められなかった。
2. ビタミンKの含有量が0.0001〜100重量%である、上記1項に記載の精神安定剤。
3. 前記ビタミンKがビタミンK2である、上記1項に記載の精神安定剤。
4. 前記ビタミンKがメナキノン−4および/またはメナキノン−7である、上記1項に記載の精神安定剤。
5. 上記いずれか一項の精神安定剤を含むサプリメント、健康食品または機能性食品。
6. ヒト用である、上記1項に記載の精神安定剤。
7. ヒト用である、上記5項に記載のサプリメント、健康食品または機能性食品。
8. ビタミンKを有効成分として含有する、精神安定剤を投与することからなる、不安症、うつ病および/ストレスの治療方法。
9. ビタミンKを有効成分として含有する、精神安定剤を投与することからなる、不安症、うつ病および/ストレスの予防方法。
10. 精神安定剤を製造するためのビタミンKの使用。
Claims (4)
- ビタミンKを有効成分として含有する精神安定剤。
- 前記ビタミンKがビタミンK2である、請求項1に記載の精神安定剤。
- 前記ビタミンKがメナキノン−4および/またはメナキノン−7である、請求項1に記載の精神安定剤。
- 請求項1〜3のいずれか一項の精神安定剤を含有するサプリメント、健康食品または機能性食品。
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CN102799246A (zh) * | 2012-08-27 | 2012-11-28 | 无锡市福曼科技有限公司 | Cpu的三流道水冷模块 |
CN102854955A (zh) * | 2012-08-27 | 2013-01-02 | 无锡市福曼科技有限公司 | 电脑cpu的双流道水冷风冷混合装置结构 |
US10280202B2 (en) | 2015-03-02 | 2019-05-07 | Kyoto University | Peptide |
CN106858608B (zh) * | 2017-02-14 | 2021-07-06 | 深圳奥萨制药有限公司 | 一种有益于抑郁症患者健康的营养组合物 |
CN109864985A (zh) * | 2018-11-28 | 2019-06-11 | 北京大学第三医院 | 治疗孕产妇产后抑郁的药物组合物 |
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JP2943031B2 (ja) | 1991-11-30 | 1999-08-30 | 株式会社ホーネンコーポレーション | 天然ビタミンk濃縮物の製造方法 |
JP2900238B2 (ja) | 1994-07-07 | 1999-06-02 | 株式会社ホーネンコーポレーション | 天然メナキノン−7高含量脂質 |
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JPH10295393A (ja) | 1997-04-30 | 1998-11-10 | New Food Kurieeshiyon Gijutsu Kenkyu Kumiai | ビタミンkの製造法 |
JP3876395B2 (ja) | 1997-09-25 | 2007-01-31 | 株式会社J−オイルミルズ | ビタミンk2濃縮物の製造法 |
JP2001136959A (ja) | 1999-11-17 | 2001-05-22 | Hiroyuki Sumi | 枯草菌菌体および/またはその産生物を含む培養物、これに由来する水溶性ビタミンk誘導体、これらを含む医薬、食品および飼料ならびにこれらの製造方法 |
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US20040127409A1 (en) * | 2002-11-07 | 2004-07-01 | Milkhaus Laboratory, Inc. | Method of treatment of psychological conditions by administration of nerve growth factor |
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US7951844B2 (en) | 2011-05-31 |
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KR20090127260A (ko) | 2009-12-10 |
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