JPWO2006115190A1 - 皮膚化粧料及びシワ改善剤 - Google Patents
皮膚化粧料及びシワ改善剤 Download PDFInfo
- Publication number
- JPWO2006115190A1 JPWO2006115190A1 JP2007514663A JP2007514663A JPWO2006115190A1 JP WO2006115190 A1 JPWO2006115190 A1 JP WO2006115190A1 JP 2007514663 A JP2007514663 A JP 2007514663A JP 2007514663 A JP2007514663 A JP 2007514663A JP WO2006115190 A1 JPWO2006115190 A1 JP WO2006115190A1
- Authority
- JP
- Japan
- Prior art keywords
- skin
- wrinkle
- wrinkles
- general formula
- improving agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC(C)(C)OC(CO)C(C(C1O*(C)(C)OC1)O)O Chemical compound CC(C)(C)OC(CO)C(C(C1O*(C)(C)OC1)O)O 0.000 description 1
- ODYBCPSCYHAGHA-UHFFFAOYSA-N CC(C)(OC1)OC1C(C(C1OC(C)(C)OC1)O)O Chemical compound CC(C)(OC1)OC1C(C(C1OC(C)(C)OC1)O)O ODYBCPSCYHAGHA-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Cosmetics (AREA)
- Saccharide Compounds (AREA)
Abstract
Description
一般式(1)中、nは1〜5であることが好ましく、さらに好ましくはn=2である。
試験開始時10週齢のヘアレスマウス1群10匹を用いた。
2−1.光老化条件および測定方法
光老化は、UVAとUVBを1日1回、週5回、8週間照射することで誘発させた。照射量はUVAが20J/cm2、25J/cm2、30J/cm2、UVBを20mJ/cm2、30mJ/cm2、40mJ/cm2と一週ごとに増量し、3週目以降は最大量を照射した。
シワ改善効果はシワスコアにより評価した。シワスコアは、Bissettらの方法(Photochem Photobiol 46:367−378、1987)に従って採点した。すなわち、シワの大きさおよび深さを肉眼で総合的に評価し、最高点を3点として、「大きく深いシワが確認できる」を3、「シワが確認できる」を2、「シワが確認できない」を1、「正常なキメが観察される」を0とした。
50vol%エタノール水溶液(基剤)に、化合物1を1%配合した試料を調製した(実施例1)。また基剤のみの試料を比較例1とした。
まず、これらの試料0.1mLをヘアレスマウスの背部皮膚(直径約2.5cm)に1日1回、一週間に5回の頻度で、UV照射開始後5週目から照射終了後4週目まで塗布した。そして、塗布終了後にシワスコアを採点した。シワスコアは基剤塗布群を対照として比較した。
本実施例および比較例では、下記組成のスキンクリームを後述の調製法にしたがって調製し、それを試料として次の操作によってシワ改善効果を評価した。
C成分の化合物1をB成分に添加して、A,B成分を各々80℃に加熱溶解した後、混合して撹拌しつつ、30℃まで冷却して各スキンクリームを調製した。
下記組成のスキンローションを常法にしたがって調製し、事前アンケートで目尻のシワを肌悩みとして挙げた20名の健常人(女性、42〜58歳)に2週間以上使用してもらいアンケート調査を行った。
Claims (6)
- 一般式(2)で表される化合物がジイソプロピリデン−D−マンニトールであることを特徴とする請求項3記載の皮膚化粧料。
- 一般式(2)で表される化合物がジイソプロピリデン−D−マンニトールであることを特徴とする請求項4記載のシワ改善剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005124309 | 2005-04-21 | ||
JP2005124309 | 2005-04-21 | ||
PCT/JP2006/308394 WO2006115190A1 (ja) | 2005-04-21 | 2006-04-21 | 皮膚化粧料及びシワ改善剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2006115190A1 true JPWO2006115190A1 (ja) | 2008-12-18 |
JP4567732B2 JP4567732B2 (ja) | 2010-10-20 |
Family
ID=37214806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007514663A Expired - Fee Related JP4567732B2 (ja) | 2005-04-21 | 2006-04-21 | 皮膚化粧料及びシワ改善剤 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7956087B2 (ja) |
EP (1) | EP1872764B1 (ja) |
JP (1) | JP4567732B2 (ja) |
KR (1) | KR100942861B1 (ja) |
CN (1) | CN101163462B (ja) |
TW (1) | TWI311914B (ja) |
WO (1) | WO2006115190A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4667335B2 (ja) * | 2006-09-28 | 2011-04-13 | 花王株式会社 | 皮膚外用剤 |
JP4667336B2 (ja) * | 2006-09-28 | 2011-04-13 | 花王株式会社 | 皮膚外用剤 |
FR2936421B1 (fr) * | 2008-09-29 | 2011-02-11 | Bouill Mariya Le | Produit de beaute et de soin pour faire disparaitre les rides du visage, empecher leur apparition et maintenir la tonicite de la peau |
JP5623901B2 (ja) * | 2010-12-22 | 2014-11-12 | 花王株式会社 | 抗酸化剤 |
JP5580191B2 (ja) * | 2010-12-27 | 2014-08-27 | 花王株式会社 | 抗酸化剤 |
JP6616941B2 (ja) * | 2013-11-29 | 2019-12-04 | 花王株式会社 | 抗炎症剤及びメラニン生成抑制剤 |
DE102016223412A1 (de) * | 2016-11-25 | 2018-05-30 | Henkel Ag & Co. Kgaa | Cyclische Ketale als Duftstoffvorläuferverbindungen |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5927844A (ja) * | 1982-08-09 | 1984-02-14 | Kao Corp | D−マンニト−ルアルキルエ−テル及びこれを含有する化粧料 |
JPS6028944A (ja) * | 1983-07-25 | 1985-02-14 | Kao Corp | 新規なポリオ−ルエ−テル化合物およびその製造方法ならびにこれを含有する化粧料 |
JPS60174796A (ja) * | 1984-02-20 | 1985-09-09 | Kao Corp | 1―o―アルキルマンノフラノシド |
JPH06157507A (ja) * | 1992-11-20 | 1994-06-03 | Kao Corp | アミド誘導体及びそれを含有する皮膚外用剤 |
US5565439A (en) * | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
JPH09278732A (ja) * | 1995-09-07 | 1997-10-28 | Kao Corp | アミド誘導体及びこれを含有する外用剤組成物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3342680A (en) | 1964-12-21 | 1967-09-19 | Atlas Chem Ind | Isosorbide as an oral osmotic diuretic |
US4169152A (en) | 1977-10-31 | 1979-09-25 | Ici Americas Inc. | Isohexide and tetrahydrofuran ethers and their carbamates in method of bringing about relaxation of skeletal musculature |
JPS57197235A (en) * | 1981-05-28 | 1982-12-03 | Kao Corp | Preparation of 2-hydroxy-3-alkoxypropyl glyceryl ether |
JPS61200921A (ja) | 1985-03-04 | 1986-09-05 | Kao Corp | 皮脂腺機能抑制剤 |
EP0623124B1 (en) | 1992-11-20 | 1998-02-18 | Kao Corporation | Amide derivatives and dermatologic preparations containing the same |
EP0761644A3 (en) | 1995-09-07 | 1999-04-07 | Kao Corporation | Amide derivatives and their use in cosmetic composition |
ATE496054T1 (de) * | 2002-08-06 | 2011-02-15 | Pharmasset Inc | Verfahren zur herstellung von 1,3-dioxolan- nucleosiden |
-
2006
- 2006-04-12 US US11/918,657 patent/US7956087B2/en not_active Expired - Fee Related
- 2006-04-20 TW TW095114060A patent/TWI311914B/zh not_active IP Right Cessation
- 2006-04-21 EP EP06732202.4A patent/EP1872764B1/en not_active Expired - Fee Related
- 2006-04-21 CN CN2006800133774A patent/CN101163462B/zh not_active Expired - Fee Related
- 2006-04-21 KR KR1020077027028A patent/KR100942861B1/ko active IP Right Grant
- 2006-04-21 WO PCT/JP2006/308394 patent/WO2006115190A1/ja active Application Filing
- 2006-04-21 JP JP2007514663A patent/JP4567732B2/ja not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5927844A (ja) * | 1982-08-09 | 1984-02-14 | Kao Corp | D−マンニト−ルアルキルエ−テル及びこれを含有する化粧料 |
JPS6028944A (ja) * | 1983-07-25 | 1985-02-14 | Kao Corp | 新規なポリオ−ルエ−テル化合物およびその製造方法ならびにこれを含有する化粧料 |
JPS60174796A (ja) * | 1984-02-20 | 1985-09-09 | Kao Corp | 1―o―アルキルマンノフラノシド |
JPH06157507A (ja) * | 1992-11-20 | 1994-06-03 | Kao Corp | アミド誘導体及びそれを含有する皮膚外用剤 |
US5565439A (en) * | 1992-11-24 | 1996-10-15 | The Procter & Gamble Company | Methods of using lysophosphatidic acid for treating hyperproliferative conditions |
JPH09278732A (ja) * | 1995-09-07 | 1997-10-28 | Kao Corp | アミド誘導体及びこれを含有する外用剤組成物 |
Also Published As
Publication number | Publication date |
---|---|
CN101163462B (zh) | 2012-09-26 |
KR20080003910A (ko) | 2008-01-08 |
TWI311914B (en) | 2009-07-11 |
JP4567732B2 (ja) | 2010-10-20 |
US7956087B2 (en) | 2011-06-07 |
TW200719923A (en) | 2007-06-01 |
EP1872764A1 (en) | 2008-01-02 |
EP1872764B1 (en) | 2018-09-26 |
KR100942861B1 (ko) | 2010-02-17 |
WO2006115190A1 (ja) | 2006-11-02 |
US20090069416A1 (en) | 2009-03-12 |
CN101163462A (zh) | 2008-04-16 |
EP1872764A4 (en) | 2015-05-27 |
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