JPS6479188A - 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof - Google Patents

3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof

Info

Publication number
JPS6479188A
JPS6479188A JP63196258A JP19625888A JPS6479188A JP S6479188 A JPS6479188 A JP S6479188A JP 63196258 A JP63196258 A JP 63196258A JP 19625888 A JP19625888 A JP 19625888A JP S6479188 A JPS6479188 A JP S6479188A
Authority
JP
Japan
Prior art keywords
cephem
formula
salts
carboxylic acid
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63196258A
Other languages
English (en)
Other versions
JPH0369354B2 (ja
Inventor
Ikuo Ueda
Masakazu Kobayashi
Choji Yamada
Hiroki Ono
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS6479188A publication Critical patent/JPS6479188A/ja
Publication of JPH0369354B2 publication Critical patent/JPH0369354B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP63196258A 1978-10-24 1988-08-05 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof Granted JPS6479188A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7841754 1978-10-24

Publications (2)

Publication Number Publication Date
JPS6479188A true JPS6479188A (en) 1989-03-24
JPH0369354B2 JPH0369354B2 (ja) 1991-10-31

Family

ID=10500550

Family Applications (2)

Application Number Title Priority Date Filing Date
JP13682479A Granted JPS5559195A (en) 1978-10-24 1979-10-22 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compound or its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
JP63196258A Granted JPS6479188A (en) 1978-10-24 1988-08-05 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP13682479A Granted JPS5559195A (en) 1978-10-24 1979-10-22 3,7-disubstituted-2 or 3-cephem-4-carboxylic acid compound or its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents

Country Status (5)

Country Link
US (2) US4327093A (ja)
EP (1) EP0010313B1 (ja)
JP (2) JPS5559195A (ja)
AT (1) ATE2330T1 (ja)
DE (1) DE2964634D1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692969A (ja) * 1990-11-09 1994-04-05 Eisai Co Ltd ７−アシル−３−置換カルバモイルオキシセフェム化合物及びその製造法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds
US4652651A (en) * 1983-05-31 1987-03-24 Hoffmann-La Roche Inc. Process for the manufacture of 1-sulpho-2-oxoazetidine carboxylic acid intermediates via catalytic ester cleavage
JPH05230068A (ja) * 1992-02-07 1993-09-07 Kyoto Yakuhin Kogyo Kk ３−ジ置換カルバモイルオキシメチルセファロスポリン化合物、その製造法および中間体化合物
MX352760B (es) 2011-09-09 2017-12-07 Merck Sharp & Dohme Corp Star Metodos para tratar infecciones intrapulmonares.
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
MX2020004205A (es) 2013-03-15 2021-11-16 Merck Sharp & Dohme Llc Composiciones antibioticas de ceftolozano.
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
WO2015035376A2 (en) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL36281A (en) 1970-03-13 1977-04-29 Merck & Co Inc History of cephalosporins, antibiotic mixtures that include them and the process for their preparation
SE376250B (ja) 1970-05-05 1975-05-12 Basf Ag
US3966717A (en) * 1971-05-14 1976-06-29 Glaxo Laboratories Limited 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
SE7503274L (sv) * 1974-04-11 1975-10-13 Ciba Geigy Ag Cefalosporin
US4011215A (en) * 1974-08-15 1977-03-08 Glaxo Laboratories Limited 3-Chloroalkylcarbamoyloxymethyl-7-[2-(fur-2-yl)-2-methoxyiminoacetamido]ceph-3-em-4-carboxylic acids and physiologically acceptable salts or oxides thereof
DK154939C (da) * 1974-12-19 1989-06-12 Takeda Chemical Industries Ltd Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
DE2619243C2 (de) * 1975-05-06 1985-07-04 Takeda Chemical Industries, Ltd., Osaka Verfahren zur Herstellung von 3-Acyloxymethyl-cephem-Verbindungen
JPS5278891A (en) * 1975-12-24 1977-07-02 Asahi Chem Ind Co Ltd Synthesis of cephalosporin antibiotics
US4061630A (en) * 1976-02-20 1977-12-06 Eli Lilly And Company 7-Substituted-ureido-3-carbamoyloxymethyl cephalosporin antibiotics
JPS52125188A (en) * 1976-04-14 1977-10-20 Takeda Chem Ind Ltd Cephalosporin derivatives and their preparation
US4292427A (en) * 1976-11-17 1981-09-29 Merck & Co., Inc. Cephalosporin compounds
CA1128930A (en) * 1978-04-07 1982-08-03 Stuart B. Laing Cephalosporin compounds
US4327093A (en) * 1978-10-24 1982-04-27 Fujisawa Pharmaceutical Co., Ltd. 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0692969A (ja) * 1990-11-09 1994-04-05 Eisai Co Ltd ７−アシル−３−置換カルバモイルオキシセフェム化合物及びその製造法

Also Published As

Publication number Publication date
JPS5559195A (en) 1980-05-02
EP0010313B1 (en) 1983-01-26
US4399278A (en) 1983-08-16
US4327093A (en) 1982-04-27
EP0010313A1 (en) 1980-04-30
JPH0369354B2 (ja) 1991-10-31
ATE2330T1 (de) 1983-02-15
DE2964634D1 (en) 1983-03-03
JPH0144714B2 (ja) 1989-09-29

Similar Documents

Publication Publication Date Title
JPS5520800A (en) Cephem compounds, their salts, their preparation, and preventive or remedy for microbism containing the same as the effective component
JPS6479188A (en) 3,7-disubstituted-2-or 3-cephem-4-carboxylic acid compound or intermediate for salts thereof
JPS5686187A (en) 7-acylamino-3-vinylcephalosporanic acid derivative and its preparation
JPS55105689A (en) Novel cephem and cepham compounds, their preparation and preventive and remedy for microbism
JPS5798288A (en) Novel cephem compound or its salt, their preparation, and preventive and remedy for bacteriosis containing said compound as active component
JPS565487A (en) Cephalosporin compound, its preparation, and antimicrobial comprising it
JPS5547688A (en) Novel cephem compound and its preparation
ES8207548A1 (es) Un procedimiento para preparar nuevos compuestos de cefem
IE811811L (en) Cephalosporins
JPS5799592A (en) Novel cephalosporins
IE802552L (en) Cephalosporins.
ES8100299A1 (es) Un procedimiento para preparar un semi-acido-sal cristalino de un derivado de cefalosporina
JPS5515454A (en) Novel cephalosporin derivative
JPS55124790A (en) Cephem compound, its preparation and antimicrobials consisting the same mainly
JPS5649389A (en) Novel cephem compound, its preparation, and preventive and remedy for microbism
JPS5547690A (en) Cephem compound, its salt, their preparation, and preventives and remedies for microbism comprising them as active constituents
SE8008610L (sv) Anordning for utmatning av lost pulver- eller kornformigt material, flis eller liknande ur en forradsbehallare
JPS6425784A (en) Thiadiazolylacetamidocephem derivative
JPS56152491A (en) Cephalosporin derivative having triazine ring
JPS55149295A (en) Novel cephalosporin compound and its preparation
JPS5649387A (en) Novel cephem compound, its preparation, and remedy and preventive for microbism
JPS5585594A (en) Cephem compound and their preparation
JPS6431787A (en) Oxyiminoalkenamide cephalosporin derivative
JPS56131591A (en) 3,7-disubstituted-3-cephem-4-carboxylic acid compound, its salt, preparation thereof and preventing agent and remedy for microbism containing the same as active consitutent
JPS5538350A (en) Preparation of 3-cephem compound