JPS643197A - Antiviral compound and antiviral agent containing same - Google Patents

Antiviral compound and antiviral agent containing same

Info

Publication number
JPS643197A
JPS643197A JP63073062A JP7306288A JPS643197A JP S643197 A JPS643197 A JP S643197A JP 63073062 A JP63073062 A JP 63073062A JP 7306288 A JP7306288 A JP 7306288A JP S643197 A JPS643197 A JP S643197A
Authority
JP
Japan
Prior art keywords
antiviral
desoxyazidothymidine
agent containing
phosphate
containing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP63073062A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0546358B2 (enExample
JPH013197A (ja
Inventor
Phillip Frost
Jack Fishman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Research Holdings Inc
Original Assignee
Ivax Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Laboratories Inc filed Critical Ivax Laboratories Inc
Publication of JPH013197A publication Critical patent/JPH013197A/ja
Publication of JPS643197A publication Critical patent/JPS643197A/ja
Publication of JPH0546358B2 publication Critical patent/JPH0546358B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP63073062A 1987-03-27 1988-03-26 Antiviral compound and antiviral agent containing same Granted JPS643197A (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US3051987A 1987-03-27 1987-03-27
US30519 1987-03-27
US7556387A 1987-07-20 1987-07-20
US7590287A 1987-07-20 1987-07-20
US75902 1987-07-20
US75563 1987-07-20
US12273687A 1987-11-19 1987-11-19
US12273587A 1987-11-19 1987-11-19
US122736 1987-11-19
US122735 1987-11-19
US12699687A 1987-11-25 1987-11-25
US126996 1987-11-25

Publications (3)

Publication Number Publication Date
JPH013197A JPH013197A (ja) 1989-01-06
JPS643197A true JPS643197A (en) 1989-01-06
JPH0546358B2 JPH0546358B2 (enExample) 1993-07-13

Family

ID=27556167

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63073062A Granted JPS643197A (en) 1987-03-27 1988-03-26 Antiviral compound and antiviral agent containing same

Country Status (4)

Country Link
EP (1) EP0284405A3 (enExample)
JP (1) JPS643197A (enExample)
AU (1) AU604105B2 (enExample)
CA (1) CA1330794C (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CS264222B1 (en) * 1986-07-18 1989-06-13 Holy Antonin N-phosphonylmethoxyalkylderivatives of bases of pytimidine and purine and method of use them
US4837311A (en) * 1987-06-22 1989-06-06 Hoffman-La Roche Inc. Anti-retroviral compounds
US5179084A (en) * 1989-04-10 1993-01-12 Nippon Kayaku Kabushiki Kaisha Antiviral phosphoric acid esters of oxetanocins
US5585364A (en) * 1989-04-13 1996-12-17 British Technology Group Limited Antiviral compounds
NZ233197A (en) * 1989-04-13 1991-11-26 Richard Thomas Walker Aromatically substituted nucleotide derivatives, intermediates therefor and pharmaceutical compositions
WO1992017185A1 (en) * 1991-03-29 1992-10-15 University Of Florida Targeted drug delivery via mixed phosphate derivatives
FR2685331A1 (fr) * 1991-12-12 1993-06-25 Centre Nat Rech Scient Phosphotriesters de la ddu, leur preparation et leur application en therapeutique.
FR2684996A1 (fr) * 1991-12-12 1993-06-18 Centre Nat Rech Scient Derives de 2',3'-didesoxy-3'-aminothymidine, leur preparation et leur application en therapeutique.
DE69508255T2 (de) * 1994-07-15 1999-10-14 Biosearch Italia S.P.A. Dinukleosid-5',5'- pyrophosphate
WO2001012644A1 (en) * 1999-08-17 2001-02-22 Adani, Alexander Dinucleoside 5',5'-tetraphosphates as inhibitors of viral reverse transcriptases and viruses
AU2003247646A1 (en) * 2002-06-27 2004-01-19 Glaxo Group Limited Antiviral regimens
CN1304408C (zh) * 2004-03-04 2007-03-14 清华大学 一种胸腺嘧啶核苷衍生物及其制备方法与应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5785373A (en) * 1980-09-16 1982-05-28 Ensu Baio Rojikarusu Inc Ring cleavage nucleoside analogue

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015584A3 (de) * 1979-03-12 1980-12-10 Kailash Kumar Dr. Prof. Gauri Neue Nukleotide, Verfahren zu ihrer Herstellung und Arzneimittel
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
ES8507550A1 (es) * 1982-09-30 1985-09-16 Syntex Inc Procedimiento para la preparacion de 1-esteres monofosfato, 1,3-bis-esteres fosfato y esteres fosfato ciclico de 9-(1,3-dihidroxi-2-propoximetil)-guanina
EP0273169A3 (en) * 1983-05-24 1990-08-29 Sri International Novel antiviral agents
HU196607B (en) * 1985-05-15 1988-12-28 Wellcome Found Process for producing dideoxy-nucleosides and pharmaceutics comprising such compounds
ATE190064T1 (de) * 1985-09-17 2000-03-15 Wellcome Found Kombination therapeutische nukleoside mit weiteren therapeutisch wirksamen komponenten.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5785373A (en) * 1980-09-16 1982-05-28 Ensu Baio Rojikarusu Inc Ring cleavage nucleoside analogue

Also Published As

Publication number Publication date
CA1330794C (en) 1994-07-19
JPH0546358B2 (enExample) 1993-07-13
EP0284405A2 (en) 1988-09-28
AU1375888A (en) 1988-09-29
AU604105B2 (en) 1990-12-06
EP0284405A3 (en) 1991-01-16

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Legal Events

Date Code Title Description
LAPS Cancellation because of no payment of annual fees