JPS643197A - Antiviral compound and antiviral agent containing same - Google Patents
Antiviral compound and antiviral agent containing sameInfo
- Publication number
- JPS643197A JPS643197A JP63073062A JP7306288A JPS643197A JP S643197 A JPS643197 A JP S643197A JP 63073062 A JP63073062 A JP 63073062A JP 7306288 A JP7306288 A JP 7306288A JP S643197 A JPS643197 A JP S643197A
- Authority
- JP
- Japan
- Prior art keywords
- antiviral
- desoxyazidothymidine
- agent containing
- phosphate
- containing same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003443 antiviral agent Substances 0.000 title abstract 2
- 230000000840 anti-viral effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- QWZNMUPRNVZTEK-XVKPBYJWSA-N 1-[(2R,5S)-2-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@]1(N=[N+]=[N-])O[C@H](CO)CC1 QWZNMUPRNVZTEK-XVKPBYJWSA-N 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- NJDPBWLDVFCXNP-UHFFFAOYSA-L 2-cyanoethyl phosphate Chemical compound [O-]P([O-])(=O)OCCC#N NJDPBWLDVFCXNP-UHFFFAOYSA-L 0.000 abstract 1
- -1 3'-desoxyazidothymidine-5'-phosphate Chemical compound 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3051987A | 1987-03-27 | 1987-03-27 | |
| US30519 | 1987-03-27 | ||
| US7556387A | 1987-07-20 | 1987-07-20 | |
| US7590287A | 1987-07-20 | 1987-07-20 | |
| US75563 | 1987-07-20 | ||
| US75902 | 1987-07-20 | ||
| US12273587A | 1987-11-19 | 1987-11-19 | |
| US12273687A | 1987-11-19 | 1987-11-19 | |
| US122736 | 1987-11-19 | ||
| US122735 | 1987-11-19 | ||
| US12699687A | 1987-11-25 | 1987-11-25 | |
| US126996 | 1987-11-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPS643197A true JPS643197A (en) | 1989-01-06 |
| JPH013197A JPH013197A (ja) | 1989-01-06 |
| JPH0546358B2 JPH0546358B2 (ja) | 1993-07-13 |
Family
ID=
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5785373A (en) * | 1980-09-16 | 1982-05-28 | Ensu Baio Rojikarusu Inc | Ring cleavage nucleoside analogue |
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5785373A (en) * | 1980-09-16 | 1982-05-28 | Ensu Baio Rojikarusu Inc | Ring cleavage nucleoside analogue |
Also Published As
| Publication number | Publication date |
|---|---|
| EP0284405A3 (en) | 1991-01-16 |
| AU1375888A (en) | 1988-09-29 |
| EP0284405A2 (en) | 1988-09-28 |
| JPH0546358B2 (ja) | 1993-07-13 |
| CA1330794C (en) | 1994-07-19 |
| AU604105B2 (en) | 1990-12-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Cancellation because of no payment of annual fees |