JPS6362520B2 - - Google Patents
Info
- Publication number
- JPS6362520B2 JPS6362520B2 JP55053691A JP5369180A JPS6362520B2 JP S6362520 B2 JPS6362520 B2 JP S6362520B2 JP 55053691 A JP55053691 A JP 55053691A JP 5369180 A JP5369180 A JP 5369180A JP S6362520 B2 JPS6362520 B2 JP S6362520B2
- Authority
- JP
- Japan
- Prior art keywords
- cells
- lymphoblastic leukemia
- mouse
- cell
- normal human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 210000004027 cell Anatomy 0.000 claims abstract description 117
- 241000282414 Homo sapiens Species 0.000 claims abstract description 77
- 206010035226 Plasma cell myeloma Diseases 0.000 claims abstract description 28
- 201000000050 myeloid neoplasm Diseases 0.000 claims abstract description 28
- 206010025323 Lymphomas Diseases 0.000 claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 85
- 210000004408 hybridoma Anatomy 0.000 claims description 60
- 238000000034 method Methods 0.000 claims description 30
- 210000004698 lymphocyte Anatomy 0.000 claims description 26
- 210000004988 splenocyte Anatomy 0.000 claims description 19
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 16
- 230000002093 peripheral effect Effects 0.000 claims description 15
- 208000032839 leukemia Diseases 0.000 claims description 14
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims description 13
- 230000004927 fusion Effects 0.000 claims description 11
- 238000006243 chemical reaction Methods 0.000 claims description 9
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- 208000029052 T-cell acute lymphoblastic leukemia Diseases 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
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- 241000282412 Homo Species 0.000 claims 8
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 5
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 5
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 5
- 238000010367 cloning Methods 0.000 claims 2
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- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 8
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- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 6
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 4
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- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical group CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 description 4
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- 241000701044 Human gammaherpesvirus 4 Species 0.000 description 3
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 3
- 241000283973 Oryctolagus cuniculus Species 0.000 description 3
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- 239000002202 Polyethylene glycol Substances 0.000 description 3
- 201000011176 T-cell adult acute lymphocytic leukemia Diseases 0.000 description 3
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- 239000007924 injection Substances 0.000 description 3
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- LPXQRXLUHJKZIE-UHFFFAOYSA-N 8-azaguanine Chemical compound NC1=NC(O)=C2NN=NC2=N1 LPXQRXLUHJKZIE-UHFFFAOYSA-N 0.000 description 2
- 229960005508 8-azaguanine Drugs 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
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- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
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- 230000007910 cell fusion Effects 0.000 description 2
- 239000006285 cell suspension Substances 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 230000001605 fetal effect Effects 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000010166 immunofluorescence Methods 0.000 description 2
- 229940027941 immunoglobulin g Drugs 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 230000021633 leukocyte mediated immunity Effects 0.000 description 2
- 230000036210 malignancy Effects 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 210000005087 mononuclear cell Anatomy 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
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- 238000010561 standard procedure Methods 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- 239000003981 vehicle Substances 0.000 description 2
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- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- TVZGACDUOSZQKY-LBPRGKRZSA-N 4-aminofolic acid Chemical compound C1=NC2=NC(N)=NC(N)=C2N=C1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 TVZGACDUOSZQKY-LBPRGKRZSA-N 0.000 description 1
- 238000013296 A/J mouse Methods 0.000 description 1
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- 210000003771 C cell Anatomy 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- 229920001917 Ficoll Polymers 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- OWXMKDGYPWMGEB-UHFFFAOYSA-N HEPPS Chemical compound OCCN1CCN(CCCS(O)(=O)=O)CC1 OWXMKDGYPWMGEB-UHFFFAOYSA-N 0.000 description 1
- 208000003456 Juvenile Arthritis Diseases 0.000 description 1
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- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 101710160107 Outer membrane protein A Proteins 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 210000000662 T-lymphocyte subset Anatomy 0.000 description 1
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- 229960003896 aminopterin Drugs 0.000 description 1
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- 210000002751 lymph Anatomy 0.000 description 1
- MIKKOBKEXMRYFQ-WZTVWXICSA-N meglumine amidotrizoate Chemical compound C[NH2+]C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CC(=O)NC1=C(I)C(NC(C)=O)=C(I)C(C([O-])=O)=C1I MIKKOBKEXMRYFQ-WZTVWXICSA-N 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
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- 210000001616 monocyte Anatomy 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 210000004287 null lymphocyte Anatomy 0.000 description 1
- 229940043515 other immunoglobulins in atc Drugs 0.000 description 1
- 238000007500 overflow downdraw method Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
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- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
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- 238000002360 preparation method Methods 0.000 description 1
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- 102000004196 processed proteins & peptides Human genes 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57426—Specifically defined cancers leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/948—Microorganisms using viruses or cell lines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/806—Antigenic peptides or proteins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Food Science & Technology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hybrid Cells (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/033,669 US4361549A (en) | 1979-04-26 | 1979-04-26 | Complement-fixing monoclonal antibody to human T cells, and methods of preparing same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63101498A Division JPH0198478A (ja) | 1979-04-26 | 1988-04-26 | ＩｇＧモノクローナル抗体−生産性ハイブリドマ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55145617A JPS55145617A (en) | 1980-11-13 |
| JPS6362520B2 true JPS6362520B2 (US08063081-20111122-C00044.png) | 1988-12-02 |
Family
ID=21871750
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5369180A Granted JPS55145617A (en) | 1979-04-26 | 1980-04-24 | Hybrid cell line* antibody and method for manufacturing complementtfixing monoclonal antibody against human t cell |
| JP63101498A Granted JPH0198478A (ja) | 1979-04-26 | 1988-04-26 | ＩｇＧモノクローナル抗体−生産性ハイブリドマ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63101498A Granted JPH0198478A (ja) | 1979-04-26 | 1988-04-26 | ＩｇＧモノクローナル抗体−生産性ハイブリドマ |
Country Status (22)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0277212U (US08063081-20111122-C00044.png) * | 1989-01-25 | 1990-06-13 | ||
| JPH0291833U (US08063081-20111122-C00044.png) * | 1988-12-29 | 1990-07-20 | ||
| JPH0420550U (US08063081-20111122-C00044.png) * | 1990-06-11 | 1992-02-20 |
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| FR956062A (US08063081-20111122-C00044.png) * | 1950-01-24 | |||
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| US4172124A (en) * | 1978-04-28 | 1979-10-23 | The Wistar Institute | Method of producing tumor antibodies |
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-
1979
- 1979-04-26 US US06/033,669 patent/US4361549A/en not_active Expired - Lifetime
-
1980
- 1980-04-01 CA CA000348978A patent/CA1182406A/en not_active Expired
- 1980-04-17 NZ NZ193469A patent/NZ193469A/en unknown
- 1980-04-24 JP JP5369180A patent/JPS55145617A/ja active Granted
- 1980-04-24 AU AU57757/80A patent/AU544791B2/en not_active Expired
- 1980-04-24 IL IL59917A patent/IL59917A/xx unknown
- 1980-04-24 PT PT71147A patent/PT71147B/pt active IP Right Revival
- 1980-04-25 FI FI801342A patent/FI75183C/fi not_active IP Right Cessation
- 1980-04-25 AT AT80301357T patent/ATE14023T1/de not_active IP Right Cessation
- 1980-04-25 IE IE840/80A patent/IE50422B1/en not_active IP Right Cessation
- 1980-04-25 EP EP80301357A patent/EP0018795B2/en not_active Expired - Lifetime
- 1980-04-25 NO NO801214A patent/NO159221C/no unknown
- 1980-04-25 DE DE198080301357T patent/DE18795T1/de active Pending
- 1980-04-25 DE DE8080301357T patent/DE3070803D1/de not_active Expired
- 1980-04-25 PH PH23955A patent/PH16642A/en unknown
- 1980-04-25 ZA ZA00802525A patent/ZA802525B/xx unknown
- 1980-04-25 DK DK180380A patent/DK154769C/da not_active IP Right Cessation
- 1980-04-25 YU YU114680A patent/YU48442B/sh unknown
- 1980-04-25 ES ES490944A patent/ES490944A0/es active Granted
-
1986
- 1986-01-21 SG SG66/86A patent/SG6686G/en unknown
- 1986-04-03 HK HK238/86A patent/HK23886A/xx not_active IP Right Cessation
- 1986-12-30 MY MY514/86A patent/MY8600514A/xx unknown
-
1988
- 1988-04-26 JP JP63101498A patent/JPH0198478A/ja active Granted
-
1993
- 1993-07-02 NL NL930131C patent/NL930131I2/nl unknown
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0291833U (US08063081-20111122-C00044.png) * | 1988-12-29 | 1990-07-20 | ||
| JPH0277212U (US08063081-20111122-C00044.png) * | 1989-01-25 | 1990-06-13 | ||
| JPH0420550U (US08063081-20111122-C00044.png) * | 1990-06-11 | 1992-02-20 |
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