JPS6351126B2 - - Google Patents
Info
- Publication number
- JPS6351126B2 JPS6351126B2 JP55129760A JP12976080A JPS6351126B2 JP S6351126 B2 JPS6351126 B2 JP S6351126B2 JP 55129760 A JP55129760 A JP 55129760A JP 12976080 A JP12976080 A JP 12976080A JP S6351126 B2 JPS6351126 B2 JP S6351126B2
- Authority
- JP
- Japan
- Prior art keywords
- extract
- perilla
- thermal
- alcoholic
- pain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 235000004347 Perilla Nutrition 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 15
- 239000000843 powder Substances 0.000 claims description 11
- 239000000419 plant extract Substances 0.000 claims description 9
- 229940007061 capsicum extract Drugs 0.000 claims description 8
- 239000001943 capsicum frutescens fruit extract Substances 0.000 claims description 8
- 230000001476 alcoholic effect Effects 0.000 claims description 6
- 229940002508 ginger extract Drugs 0.000 claims description 5
- 235000020708 ginger extract Nutrition 0.000 claims description 5
- 239000008738 huangbai Substances 0.000 claims description 5
- 239000006286 aqueous extract Substances 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 3
- 125000004432 carbon atom Chemical group C* 0.000 claims description 3
- 235000002566 Capsicum Nutrition 0.000 claims description 2
- 239000001390 capsicum minimum Substances 0.000 claims description 2
- 240000008574 Capsicum frutescens Species 0.000 claims 1
- 244000124853 Perilla frutescens Species 0.000 claims 1
- RGOVYLWUIBMPGK-UHFFFAOYSA-N nonivamide Chemical compound CCCCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1 RGOVYLWUIBMPGK-UHFFFAOYSA-N 0.000 description 21
- 241000229722 Perilla <angiosperm> Species 0.000 description 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 208000002193 Pain Diseases 0.000 description 14
- 239000011505 plaster Substances 0.000 description 14
- 239000012675 alcoholic extract Substances 0.000 description 13
- 238000010792 warming Methods 0.000 description 12
- 241000234314 Zingiber Species 0.000 description 10
- 235000006886 Zingiber officinale Nutrition 0.000 description 9
- 235000008397 ginger Nutrition 0.000 description 9
- 239000000203 mixture Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 230000035807 sensation Effects 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 235000002568 Capsicum frutescens Nutrition 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 241001247145 Sebastes goodei Species 0.000 description 5
- 230000000638 stimulation Effects 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 229940116257 pepper extract Drugs 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- 239000000021 stimulant Substances 0.000 description 4
- 241000228212 Aspergillus Species 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 235000017663 capsaicin Nutrition 0.000 description 3
- 239000000865 liniment Substances 0.000 description 3
- 241001061264 Astragalus Species 0.000 description 2
- 206010016334 Feeling hot Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AKDLSISGGARWFP-UHFFFAOYSA-N Homodihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCCCC(C)C)=CC=C1O AKDLSISGGARWFP-UHFFFAOYSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- VQEONGKQWIFHMN-UHFFFAOYSA-N Nordihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCC(C)C)=CC=C1O VQEONGKQWIFHMN-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 235000006533 astragalus Nutrition 0.000 description 2
- 229960002504 capsaicin Drugs 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- 229940040145 liniment Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
- 210000004233 talus Anatomy 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 2
- RUMOYJJNUMEFDD-SNVBAGLBSA-N (R)-(+)-Perillaldehyde Natural products CC(=C)[C@H]1CCC(C=O)=CC1 RUMOYJJNUMEFDD-SNVBAGLBSA-N 0.000 description 1
- TZZAKSLHHIJRLL-UHFFFAOYSA-N 4-hydroxy-3-methoxybenzamide Chemical compound COC1=CC(C(N)=O)=CC=C1O TZZAKSLHHIJRLL-UHFFFAOYSA-N 0.000 description 1
- ZPSOISAMGWYNQX-ONEGZZNKSA-N 6E-nonenoic acid Chemical compound CC\C=C\CCCCC(O)=O ZPSOISAMGWYNQX-ONEGZZNKSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000208293 Capsicum Species 0.000 description 1
- 241001487832 Cupressus duclouxiana Species 0.000 description 1
- 206010064503 Excessive skin Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 208000008930 Low Back Pain Diseases 0.000 description 1
- PTPHDVKWAYIFRX-UHFFFAOYSA-N Palmatine Natural products C1C2=C(OC)C(OC)=CC=C2C=C2N1CCC1=C2C=C(OC)C(OC)=C1 PTPHDVKWAYIFRX-UHFFFAOYSA-N 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 241000920652 Quercus lusitanica Species 0.000 description 1
- 244000131415 Zanthoxylum piperitum Species 0.000 description 1
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 description 1
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 1
- 241000963384 Zingiber mioga Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- XJQPQKLURWNAAH-UHFFFAOYSA-N dihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCCC(C)C)=CC=C1O XJQPQKLURWNAAH-UHFFFAOYSA-N 0.000 description 1
- RBCYRZPENADQGZ-UHFFFAOYSA-N dihydrocapsaicin Natural products COC1=CC(COC(=O)CCCCCCC(C)C)=CC=C1O RBCYRZPENADQGZ-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- GOBFKCLUUUDTQE-UHFFFAOYSA-N homodihydrocapsaicin-II Natural products CCC(C)CCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1 GOBFKCLUUUDTQE-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- -1 methanol and ethanol Chemical class 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 229920003052 natural elastomer Polymers 0.000 description 1
- 229920001194 natural rubber Polymers 0.000 description 1
- 208000004296 neuralgia Diseases 0.000 description 1
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- QUCQEUCGKKTEBI-UHFFFAOYSA-N palmatine Chemical compound COC1=CC=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C1OC QUCQEUCGKKTEBI-UHFFFAOYSA-N 0.000 description 1
- RUMOYJJNUMEFDD-UHFFFAOYSA-N perillyl aldehyde Chemical compound CC(=C)C1CCC(C=O)=CC1 RUMOYJJNUMEFDD-UHFFFAOYSA-N 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55129760A JPS5753404A (en) | 1980-09-17 | 1980-09-17 | External preparation for skin obtained by blending plant extract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55129760A JPS5753404A (en) | 1980-09-17 | 1980-09-17 | External preparation for skin obtained by blending plant extract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5753404A JPS5753404A (en) | 1982-03-30 |
| JPS6351126B2 true JPS6351126B2 (enrdf_load_stackoverflow) | 1988-10-13 |
Family
ID=15017512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP55129760A Granted JPS5753404A (en) | 1980-09-17 | 1980-09-17 | External preparation for skin obtained by blending plant extract |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5753404A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0237157A (ja) * | 1988-07-26 | 1990-02-07 | Kubota Ltd | エンジンのクランクケースカバー素材 |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5953407A (ja) * | 1982-09-21 | 1984-03-28 | Tsumura Juntendo Inc | 化粧料 |
| JPS6013710A (ja) * | 1983-07-05 | 1985-01-24 | Lion Corp | 低刺激性温熱パツプ剤 |
| JP2901629B2 (ja) * | 1989-01-06 | 1999-06-07 | エーザイ株式会社 | 生薬エキスからなる経皮吸収促進剤 |
| CN1037242C (zh) * | 1994-04-22 | 1998-02-04 | 天津轻工业学院 | 以干红辣椒为原料制备辣椒碱的方法 |
| JP4677063B2 (ja) * | 1997-07-18 | 2011-04-27 | 帝國製薬株式会社 | オランダカラシエキス配合外用製剤 |
| WO2004039372A1 (en) * | 2002-10-29 | 2004-05-13 | Sungkyunkwan University | Medicament component of berberine for the use of prevention and treatment of psycological dependence on and analgesic tolerance to morphine |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| ES2429443T3 (es) | 2004-04-19 | 2013-11-14 | Strategic Science & Technologies, Llc | Suministro transdérmico de sustancias beneficiosas efectuado mediante un entorno de fuerza iónica elevada |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| ES2607476T3 (es) | 2009-06-24 | 2017-03-31 | Strategic Science & Technologies, Llc | Composición tópica que contiene ibuprofeno |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| EP2445493A1 (en) | 2009-06-24 | 2012-05-02 | Strategic Science & Technologies, LLC | Topical composition containing naproxen |
| JP2014504592A (ja) | 2010-12-29 | 2014-02-24 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | 勃起不全および他の適応症の処置 |
| JP2014501283A (ja) | 2010-12-29 | 2014-01-20 | ストラテジック サイエンス アンド テクノロジーズ， エルエルシー | アレルギーおよび他の適応症の処置のためのシステムおよび方法 |
| SG11201806281UA (en) * | 2016-02-25 | 2018-09-27 | Hisamitsu Pharmaceutical Co | Adhesive patch |
| CN110934737A (zh) * | 2019-12-06 | 2020-03-31 | 湖南富兴飞鸽药业有限公司 | 一种代灸中药贴膏及其制备方法 |
-
1980
- 1980-09-17 JP JP55129760A patent/JPS5753404A/ja active Granted
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0237157A (ja) * | 1988-07-26 | 1990-02-07 | Kubota Ltd | エンジンのクランクケースカバー素材 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5753404A (en) | 1982-03-30 |
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