JPS6330450A - 重水素化安息香酸類の製造方法 - Google Patents
重水素化安息香酸類の製造方法Info
- Publication number
- JPS6330450A JPS6330450A JP61176450A JP17645086A JPS6330450A JP S6330450 A JPS6330450 A JP S6330450A JP 61176450 A JP61176450 A JP 61176450A JP 17645086 A JP17645086 A JP 17645086A JP S6330450 A JPS6330450 A JP S6330450A
- Authority
- JP
- Japan
- Prior art keywords
- cobalt alloy
- raney cobalt
- deuterium
- corrosion agent
- alkali corrosion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 150000001558 benzoic acid derivatives Chemical class 0.000 title description 2
- IKCLCGXPQILATA-UHFFFAOYSA-N 2-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC=C1Cl IKCLCGXPQILATA-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229910000531 Co alloy Inorganic materials 0.000 claims abstract description 13
- 229910052805 deuterium Inorganic materials 0.000 claims abstract description 13
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims abstract description 12
- 125000001309 chloro group Chemical group Cl* 0.000 claims abstract description 12
- XLYOFNOQVPJJNP-ZSJDYOACSA-N Heavy water Chemical compound [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 claims abstract description 8
- 150000001559 benzoic acids Chemical class 0.000 claims description 14
- 239000003518 caustics Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 abstract description 11
- 238000006243 chemical reaction Methods 0.000 abstract description 9
- 150000001875 compounds Chemical class 0.000 abstract description 8
- 235000010233 benzoic acid Nutrition 0.000 abstract description 6
- 238000002372 labelling Methods 0.000 abstract description 6
- 239000002184 metal Substances 0.000 abstract description 6
- 229910052751 metal Inorganic materials 0.000 abstract description 6
- 239000002994 raw material Substances 0.000 abstract description 5
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract description 4
- 230000007246 mechanism Effects 0.000 abstract description 4
- 239000003905 agrochemical Substances 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 239000012299 nitrogen atmosphere Substances 0.000 abstract description 3
- 239000005711 Benzoic acid Substances 0.000 abstract description 2
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000003513 alkali Substances 0.000 abstract 4
- 230000007797 corrosion Effects 0.000 abstract 4
- 238000005260 corrosion Methods 0.000 abstract 4
- HEMHJVSKTPXQMS-DYCDLGHISA-M Sodium hydroxide-d Chemical compound [Na+].[2H][O-] HEMHJVSKTPXQMS-DYCDLGHISA-M 0.000 abstract 1
- 238000006555 catalytic reaction Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 230000003628 erosive effect Effects 0.000 description 5
- 229910045601 alloy Inorganic materials 0.000 description 4
- 239000000956 alloy Substances 0.000 description 4
- 230000000155 isotopic effect Effects 0.000 description 4
- 238000001816 cooling Methods 0.000 description 3
- 230000008558 metabolic pathway by substance Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- LULAYUGMBFYYEX-UHFFFAOYSA-N 3-chlorobenzoic acid Chemical compound OC(=O)C1=CC=CC(Cl)=C1 LULAYUGMBFYYEX-UHFFFAOYSA-N 0.000 description 2
- 229910000881 Cu alloy Inorganic materials 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 150000002739 metals Chemical class 0.000 description 2
- WPYMKLBDIGXBTP-QYKNYGDISA-N 2-deuteriobenzoic acid Chemical compound [2H]C1=CC=CC=C1C(O)=O WPYMKLBDIGXBTP-QYKNYGDISA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 1
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical class [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000001246 bromo group Chemical group Br* 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000005660 chlorination reaction Methods 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 150000001975 deuterium Chemical class 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61176450A JPS6330450A (ja) | 1986-07-24 | 1986-07-24 | 重水素化安息香酸類の製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP61176450A JPS6330450A (ja) | 1986-07-24 | 1986-07-24 | 重水素化安息香酸類の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS6330450A true JPS6330450A (ja) | 1988-02-09 |
| JPH0575734B2 JPH0575734B2 (enrdf_load_stackoverflow) | 1993-10-21 |
Family
ID=16013918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61176450A Granted JPS6330450A (ja) | 1986-07-24 | 1986-07-24 | 重水素化安息香酸類の製造方法 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6330450A (enrdf_load_stackoverflow) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0274020U (enrdf_load_stackoverflow) * | 1988-11-25 | 1990-06-06 | ||
| WO2004011400A1 (ja) * | 2002-07-26 | 2004-02-05 | Wako Pure Chemical Industries, Ltd. | 芳香環の重水素化方法 |
| US9255070B2 (en) | 2004-01-23 | 2016-02-09 | Wako Pure Chemical Industries, Ltd. | Method of deuteration using mixed catalyst |
-
1986
- 1986-07-24 JP JP61176450A patent/JPS6330450A/ja active Granted
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0274020U (enrdf_load_stackoverflow) * | 1988-11-25 | 1990-06-06 | ||
| WO2004011400A1 (ja) * | 2002-07-26 | 2004-02-05 | Wako Pure Chemical Industries, Ltd. | 芳香環の重水素化方法 |
| CN1296331C (zh) * | 2002-07-26 | 2007-01-24 | 和光纯药工业株式会社 | 芳环的重氢化方法 |
| US8093422B2 (en) | 2002-07-26 | 2012-01-10 | Wako Pure Chemical Industries, Ltd. | Method for deuteration of an aromatic ring |
| US9255070B2 (en) | 2004-01-23 | 2016-02-09 | Wako Pure Chemical Industries, Ltd. | Method of deuteration using mixed catalyst |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0575734B2 (enrdf_load_stackoverflow) | 1993-10-21 |
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