JPS63152372A - ジクロフェナックと環状有機塩基との塩，およびそれを含有する薬剤組成物 - Google Patents
ジクロフェナックと環状有機塩基との塩，およびそれを含有する薬剤組成物Info
- Publication number
- JPS63152372A JPS63152372A JP62285664A JP28566487A JPS63152372A JP S63152372 A JPS63152372 A JP S63152372A JP 62285664 A JP62285664 A JP 62285664A JP 28566487 A JP28566487 A JP 28566487A JP S63152372 A JPS63152372 A JP S63152372A
- Authority
- JP
- Japan
- Prior art keywords
- diclofenac
- formula
- salt
- cyclic organic
- organic base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title claims description 23
- -1 cyclic organic base Chemical class 0.000 title claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 5
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims description 32
- 229960001259 diclofenac Drugs 0.000 claims description 30
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical group CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- 239000008187 granular material Substances 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000004480 active ingredient Substances 0.000 claims description 4
- 150000001875 compounds Chemical class 0.000 claims description 4
- 239000003960 organic solvent Substances 0.000 claims description 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 229910052760 oxygen Inorganic materials 0.000 claims description 3
- 239000001301 oxygen Substances 0.000 claims description 3
- 239000003208 petroleum Substances 0.000 claims description 3
- 229910052717 sulfur Inorganic materials 0.000 claims description 3
- 239000011593 sulfur Substances 0.000 claims description 3
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000000126 substance Substances 0.000 claims 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- KZTWONRVIPPDKH-UHFFFAOYSA-N 2-(piperidin-1-yl)ethanol Chemical compound OCCN1CCCCC1 KZTWONRVIPPDKH-UHFFFAOYSA-N 0.000 description 7
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- XBRDBODLCHKXHI-UHFFFAOYSA-N epolamine Chemical compound OCCN1CCCC1 XBRDBODLCHKXHI-UHFFFAOYSA-N 0.000 description 6
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000013355 food flavoring agent Nutrition 0.000 description 3
- 238000002844 melting Methods 0.000 description 3
- 230000008018 melting Effects 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 229960003424 phenylacetic acid Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 229940127271 compound 49 Drugs 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 150000001923 cyclic compounds Chemical class 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- JYGFTBXVXVMTGB-UHFFFAOYSA-N indolin-2-one Chemical class C1=CC=C2NC(=O)CC2=C1 JYGFTBXVXVMTGB-UHFFFAOYSA-N 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 239000002357 osmotic agent Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 239000006104 solid solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT22320A/86 | 1986-11-13 | ||
| IT8622320A IT1228242B (it) | 1986-11-13 | 1986-11-13 | Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63152372A true JPS63152372A (ja) | 1988-06-24 |
| JPH0344062B2 JPH0344062B2 (da) | 1991-07-04 |
Family
ID=11194630
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62285664A Granted JPS63152372A (ja) | 1986-11-13 | 1987-11-13 | ジクロフェナックと環状有機塩基との塩，およびそれを含有する薬剤組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4948805A (da) |
| EP (1) | EP0271709B1 (da) |
| JP (1) | JPS63152372A (da) |
| KR (1) | KR960003327B1 (da) |
| AT (1) | ATE63304T1 (da) |
| AU (1) | AU8117587A (da) |
| CA (1) | CA1303050C (da) |
| DE (1) | DE3769943D1 (da) |
| DK (1) | DK592987A (da) |
| ES (1) | ES2029254T3 (da) |
| FI (1) | FI875023A (da) |
| GR (1) | GR3002386T3 (da) |
| IE (1) | IE873006L (da) |
| IT (1) | IT1228242B (da) |
| NO (1) | NO874733L (da) |
| PT (1) | PT86121B (da) |
| ZA (1) | ZA878405B (da) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0621263A3 (en) * | 1993-04-23 | 1995-02-15 | Teikoku Seiyaku Kk | Anti-inflammatory and analgesic external plaster preparation. |
| WO2011083787A1 (ja) | 2010-01-07 | 2011-07-14 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1229489B (it) * | 1988-12-09 | 1991-09-03 | Altergon Sa | Composizioni farmaceutiche lipidiche per uso topico atte a veicolare un principio attivo antiinfiammatorio idrosolubile |
| WO1992008686A1 (en) * | 1990-11-19 | 1992-05-29 | Ethyl Corporation | Process for improving flow characteristics of crystalline ibuprofen |
| IT1255007B (it) * | 1991-07-01 | 1995-10-11 | Altergon Sa | Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono. |
| US5474985A (en) * | 1993-12-22 | 1995-12-12 | The Regents Of The University Of California | Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors |
| DE4403943A1 (de) * | 1994-02-08 | 1995-08-10 | Hexal Pharma Gmbh | Orale Azrneimittelzubereitung mit Diclofenac-Natrium |
| US5708024A (en) * | 1994-06-29 | 1998-01-13 | Novartis Corporation | Salts of 2- (2,6-dichlorophenyl)amine!phenylacetoxyacetic acid with organic basic cations |
| US5599535A (en) * | 1995-06-07 | 1997-02-04 | Regents Of The University Of California | Methods for the cyto-protection of the trabecular meshwork |
| US5674888A (en) * | 1995-06-07 | 1997-10-07 | University Of California | Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division |
| ITMI20030269A1 (it) * | 2003-02-14 | 2004-08-15 | Advance Holdings Ltd | Sale di cetilpiridino di un agente antiinfiammatorio |
| US7943668B2 (en) * | 2008-03-03 | 2011-05-17 | Altergon S.A. | Process for preparing a pharmaceutical composition with anti-inflammatory and analgesic activity for administration via a patch for external use, and composition thus obtained |
| WO2010069397A1 (en) * | 2008-12-19 | 2010-06-24 | Cosma S.P.A. | Process for the preparation of diclofenac epolamine |
| ITMI20121205A1 (it) | 2012-07-11 | 2014-01-12 | Glycores 2000 Srl | Composizione con attivita' antinfiammatoria ed analgesica da somministrare per uso esterno mediante vaporizzazione |
| WO2021048748A1 (en) | 2019-09-09 | 2021-03-18 | Ftf Pharma Private Limited | Pharmaceutical formulations comprising diclofenac |
| IT202100016751A1 (it) | 2021-06-25 | 2022-12-25 | Altergon Sa | Formulazione topica di diclofenac ad elevato tasso di assorbimento |
| WO2023180792A1 (en) | 2022-03-25 | 2023-09-28 | Glycores 2000 Srl | Topical pharmaceutical composition with anti-inflammatory and analgesic activity and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558690A (en) * | 1965-04-08 | 1971-01-26 | Gelgy Chemical Corp | Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation |
| LU83138A1 (de) * | 1981-02-16 | 1981-09-11 | T Eckert | Topische pharmazeutische praeparate,enthaltend salze von alkancarbonsaeuren sowie neue carbonsaeuresalze und verfahren zu ihrer herstellung |
-
1986
- 1986-11-13 IT IT8622320A patent/IT1228242B/it active
-
1987
- 1987-11-09 ZA ZA878405A patent/ZA878405B/xx unknown
- 1987-11-09 EP EP87116513A patent/EP0271709B1/en not_active Expired - Lifetime
- 1987-11-09 IE IE873006A patent/IE873006L/xx unknown
- 1987-11-09 DE DE8787116513T patent/DE3769943D1/de not_active Expired - Fee Related
- 1987-11-09 US US07/117,823 patent/US4948805A/en not_active Expired - Lifetime
- 1987-11-09 ES ES198787116513T patent/ES2029254T3/es not_active Expired - Lifetime
- 1987-11-09 AT AT87116513T patent/ATE63304T1/de not_active IP Right Cessation
- 1987-11-12 AU AU81175/87A patent/AU8117587A/en not_active Abandoned
- 1987-11-12 KR KR1019870012712A patent/KR960003327B1/ko not_active IP Right Cessation
- 1987-11-12 NO NO874733A patent/NO874733L/no unknown
- 1987-11-12 PT PT86121A patent/PT86121B/pt not_active IP Right Cessation
- 1987-11-12 CA CA000551717A patent/CA1303050C/en not_active Expired - Fee Related
- 1987-11-12 DK DK592987A patent/DK592987A/da not_active Application Discontinuation
- 1987-11-13 FI FI875023A patent/FI875023A/fi not_active Application Discontinuation
- 1987-11-13 JP JP62285664A patent/JPS63152372A/ja active Granted
-
1991
- 1991-07-25 GR GR91401092T patent/GR3002386T3/el unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0621263A3 (en) * | 1993-04-23 | 1995-02-15 | Teikoku Seiyaku Kk | Anti-inflammatory and analgesic external plaster preparation. |
| US5607690A (en) * | 1993-04-23 | 1997-03-04 | Teikoku Seiyaku Co., Ltd. | External anti-inflammatory and analgesic plaster preparation |
| WO2011083787A1 (ja) | 2010-01-07 | 2011-07-14 | 帝國製薬株式会社 | 消炎鎮痛外用貼付剤 |
| US8657798B2 (en) | 2010-01-07 | 2014-02-25 | Teikoku Seiyaku Co., Ltd. | Anti-inflammatory analgesic adhesive patch for external use |
Also Published As
| Publication number | Publication date |
|---|---|
| FI875023A (fi) | 1988-05-14 |
| DK592987A (da) | 1988-05-14 |
| IT8622320A0 (it) | 1986-11-13 |
| KR880006218A (ko) | 1988-07-22 |
| CA1303050C (en) | 1992-06-09 |
| NO874733L (no) | 1988-05-16 |
| ATE63304T1 (de) | 1991-05-15 |
| GR3002386T3 (en) | 1992-12-30 |
| AU8117587A (en) | 1988-05-19 |
| IE873006L (en) | 1988-05-13 |
| DE3769943D1 (de) | 1991-06-13 |
| JPH0344062B2 (da) | 1991-07-04 |
| PT86121B (pt) | 1990-08-31 |
| NO874733D0 (no) | 1987-11-12 |
| PT86121A (en) | 1987-12-01 |
| FI875023A0 (fi) | 1987-11-13 |
| DK592987D0 (da) | 1987-11-12 |
| US4948805A (en) | 1990-08-14 |
| EP0271709A1 (en) | 1988-06-22 |
| ZA878405B (en) | 1988-05-05 |
| EP0271709B1 (en) | 1991-05-08 |
| ES2029254T3 (es) | 1992-08-01 |
| KR960003327B1 (ko) | 1996-03-08 |
| IT1228242B (it) | 1991-06-05 |
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Legal Events
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| R250 | Receipt of annual fees |
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| R250 | Receipt of annual fees |
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| LAPS | Cancellation because of no payment of annual fees |