IT1255007B - Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono. - Google Patents

Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.

Info

Publication number
IT1255007B
IT1255007B ITMI911804A ITMI911804A IT1255007B IT 1255007 B IT1255007 B IT 1255007B IT MI911804 A ITMI911804 A IT MI911804A IT MI911804 A ITMI911804 A IT MI911804A IT 1255007 B IT1255007 B IT 1255007B
Authority
IT
Italy
Prior art keywords
hydroxyethyl
pharmaceutical compositions
pyrolidine
ibuprofen
compositions containing
Prior art date
Application number
ITMI911804A
Other languages
English (en)
Inventor
Elisabetta Donati
Irina Rapaport
Paolo Lualdi
Original Assignee
Altergon Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altergon Sa filed Critical Altergon Sa
Publication of ITMI911804A0 publication Critical patent/ITMI911804A0/it
Priority to ITMI911804A priority Critical patent/IT1255007B/it
Priority to AT92110203T priority patent/ATE151739T1/de
Priority to EP92110203A priority patent/EP0521344B1/en
Priority to ES92110203T priority patent/ES2103325T3/es
Priority to DE69219020T priority patent/DE69219020T2/de
Priority to US07/902,824 priority patent/US5206262A/en
Priority to CA002072407A priority patent/CA2072407A1/en
Publication of ITMI911804A1 publication Critical patent/ITMI911804A1/it
Application granted granted Critical
Publication of IT1255007B publication Critical patent/IT1255007B/it
Priority to GR970401478T priority patent/GR3023840T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Vengono preparati i sali in forma cristallina dell'iboprofen e del naproxen con N-(2-idrossietil) pirrolidina sciogliendo rispettivamente 1) iboprofen ed il naproxen in adatto solvente organico, addizionando N-(2-idrossietil) pirrolidina, facendo reagire i composti, rimuovendo il solvente e cristallizzando il sale ottenuto da soluzione in solvente apolare ed aprotico.Detti sali hanno elevata solubilità in acqua e sono impiegati per preparare composizioni farmaceutiche per somministrazione orale ed altre.
ITMI911804A 1991-07-01 1991-07-01 Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono. IT1255007B (it)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITMI911804A IT1255007B (it) 1991-07-01 1991-07-01 Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.
DE69219020T DE69219020T2 (de) 1991-07-01 1992-06-17 Lösliche Ibuprofen- und Naproxensalze mit N-(2-Hydroxyethyl)-Pyrrolidine und diese enthaltende pharmazeutische Zusammensetzungen
EP92110203A EP0521344B1 (en) 1991-07-01 1992-06-17 Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine and pharmaceutic compositions containing said salts
ES92110203T ES2103325T3 (es) 1991-07-01 1992-06-17 Sales solubles de ibuprofen y naproxen con n-(2-hidroxietil) pirrolidina y composiciones farmaceuticas que contienen dichas sales.
AT92110203T ATE151739T1 (de) 1991-07-01 1992-06-17 Lösliche ibuprofen- und naproxensalze mit n-(2- hydroxyethyl)-pyrrolidine und diese enthaltende pharmazeutische zusammensetzungen
US07/902,824 US5206262A (en) 1991-07-01 1992-06-23 Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine and pharmaceutic compositions containing said salts
CA002072407A CA2072407A1 (en) 1991-07-01 1992-06-25 Soluble salts of ibuprofen and naproxen with n-(2-hydroxyethyl) pyrrolidine and pharmaceutic compositions containing said salts
GR970401478T GR3023840T3 (en) 1991-07-01 1997-06-19 Soluble salts of ibuprofen and naproxen with N-(2-hydroxyethyl) pyrrolidine and pharmaceutic compositions containing said salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911804A IT1255007B (it) 1991-07-01 1991-07-01 Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.

Publications (3)

Publication Number Publication Date
ITMI911804A0 ITMI911804A0 (it) 1991-07-01
ITMI911804A1 ITMI911804A1 (it) 1993-01-01
IT1255007B true IT1255007B (it) 1995-10-11

Family

ID=11360243

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI911804A IT1255007B (it) 1991-07-01 1991-07-01 Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.

Country Status (8)

Country Link
US (1) US5206262A (it)
EP (1) EP0521344B1 (it)
AT (1) ATE151739T1 (it)
CA (1) CA2072407A1 (it)
DE (1) DE69219020T2 (it)
ES (1) ES2103325T3 (it)
GR (1) GR3023840T3 (it)
IT (1) IT1255007B (it)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0769294B1 (en) * 1995-10-17 2001-12-12 Reckitt Benckiser Healthcare (UK) Limited Taste-masked aqueous solutions comprising ibuprofen and menthol
IT1277741B1 (it) * 1995-12-28 1997-11-12 Dompe Spa Composizioni farmaceutiche parenterali contenenti sali di alchilammonio di acidi 2-arilpropionici
US20020144770A1 (en) * 2001-04-06 2002-10-10 Stephane Mabit Carrier-less patch protection including cassette and separation process
CA2479893A1 (en) * 2002-03-22 2003-10-02 Kwan-Hyung Cho Maleic acid salt of (2s)-n-{5-¬amino(imino)methyl|-2-thienyl}methyl-1-{(2r)-2-¬(carboxymethyl)amino|3,3-diphenylpropanoyl}-2-pyrrolidine carboxamide and a process for preparing the same
EP2381937A2 (en) 2008-12-31 2011-11-02 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
US20110052679A1 (en) 2009-08-25 2011-03-03 Pharmaceutics International, Inc. Solid naproxen concentrates and related dosage forms
US9023390B2 (en) 2009-09-17 2015-05-05 Upsher-Smith Laboratories, Inc. Sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti-inflammatory drug
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
JP2014507429A (ja) * 2011-02-04 2014-03-27 バイオコピア リミテッド 心血管疾患の治療のための組成物および方法
KR101784296B1 (ko) * 2016-03-22 2017-10-13 고려대학교 세종산학협력단 온도감응형 복합체 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3910M (it) * 1964-12-31 1966-03-11
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US3637767A (en) * 1968-07-30 1972-01-25 Syntex Corp 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
IT1228242B (it) * 1986-11-13 1991-06-05 Ricerfarma Srl Milano Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
US5028625A (en) * 1989-06-20 1991-07-02 American Home Products Corporation Acid addition salt of ibuprofen and meglumine
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate

Also Published As

Publication number Publication date
EP0521344B1 (en) 1997-04-16
US5206262A (en) 1993-04-27
DE69219020D1 (de) 1997-05-22
GR3023840T3 (en) 1997-09-30
EP0521344A3 (en) 1993-04-07
DE69219020T2 (de) 1997-08-07
CA2072407A1 (en) 1993-01-02
ITMI911804A0 (it) 1991-07-01
ITMI911804A1 (it) 1993-01-01
ES2103325T3 (es) 1997-09-16
ATE151739T1 (de) 1997-05-15
EP0521344A2 (en) 1993-01-07

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0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970730