ATE151739T1 - Lösliche ibuprofen- und naproxensalze mit n-(2- hydroxyethyl)-pyrrolidine und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Lösliche ibuprofen- und naproxensalze mit n-(2- hydroxyethyl)-pyrrolidine und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
ATE151739T1
ATE151739T1 AT92110203T AT92110203T ATE151739T1 AT E151739 T1 ATE151739 T1 AT E151739T1 AT 92110203 T AT92110203 T AT 92110203T AT 92110203 T AT92110203 T AT 92110203T AT E151739 T1 ATE151739 T1 AT E151739T1
Authority
AT
Austria
Prior art keywords
pyrrolidine
hydroxyethyl
pharmaceutical compositions
compositions containing
naproxen
Prior art date
Application number
AT92110203T
Other languages
English (en)
Inventor
Elisabetta Donati
Irina Rapaport
Paolo Lualdi
Original Assignee
Altergon Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altergon Sa filed Critical Altergon Sa
Application granted granted Critical
Publication of ATE151739T1 publication Critical patent/ATE151739T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Medicinal Preparation (AREA)
AT92110203T 1991-07-01 1992-06-17 Lösliche ibuprofen- und naproxensalze mit n-(2- hydroxyethyl)-pyrrolidine und diese enthaltende pharmazeutische zusammensetzungen ATE151739T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI911804A IT1255007B (it) 1991-07-01 1991-07-01 Sale solubile dell'ibuprofen c0n n-(2-idrossietil) pirrolidina e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number Publication Date
ATE151739T1 true ATE151739T1 (de) 1997-05-15

Family

ID=11360243

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92110203T ATE151739T1 (de) 1991-07-01 1992-06-17 Lösliche ibuprofen- und naproxensalze mit n-(2- hydroxyethyl)-pyrrolidine und diese enthaltende pharmazeutische zusammensetzungen

Country Status (8)

Country Link
US (1) US5206262A (de)
EP (1) EP0521344B1 (de)
AT (1) ATE151739T1 (de)
CA (1) CA2072407A1 (de)
DE (1) DE69219020T2 (de)
ES (1) ES2103325T3 (de)
GR (1) GR3023840T3 (de)
IT (1) IT1255007B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164849T3 (es) * 1995-10-17 2002-03-01 Reckitt Benckiser Healthcare Soluciones acuosas con sabor enmascarado que contienen ibuprofeno y mentol.
IT1277741B1 (it) * 1995-12-28 1997-11-12 Dompe Spa Composizioni farmaceutiche parenterali contenenti sali di alchilammonio di acidi 2-arilpropionici
US20020144770A1 (en) * 2001-04-06 2002-10-10 Stephane Mabit Carrier-less patch protection including cassette and separation process
MXPA04009101A (es) * 2002-03-22 2004-12-06 Lg Life Sciences Ltd Sal de acido maleico de (2s) -n-{5- [amino(imino) metil]-2 -tienil} metil-1 -{(2r)- 2-[(carboximetil) amino]-3, 3- difenilpropanoil} -2-pirrolidin carboxamida y un proceso para preparacion de la misma.
US8362029B2 (en) 2008-12-31 2013-01-29 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
US20110052679A1 (en) 2009-08-25 2011-03-03 Pharmaceutics International, Inc. Solid naproxen concentrates and related dosage forms
EP2477610A1 (de) 2009-09-17 2012-07-25 Upsher-Smith Laboratories, Inc. Verzögert freigesetztes produkt mit einer kombination aus einem nichtopioiden amin und einem nichtsteroiden entzündungshemmenden mittel
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US8895536B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating chronic inflammation and inflammatory diseases
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
ES2981782T3 (es) * 2011-02-04 2024-10-10 Infirst Healthcare Ltd Composiciones y métodos para tratar la inflamación crónica y enfermedades inflamatorias
KR101784296B1 (ko) * 2016-03-22 2017-10-13 고려대학교 세종산학협력단 온도감응형 복합체 및 이의 제조방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3910M (de) * 1964-12-31 1966-03-11
US3558690A (en) * 1965-04-08 1971-01-26 Gelgy Chemical Corp Substituted derivatives of 2-anilinophenylacetic acids and a process of preparation
US3637767A (en) * 1968-07-30 1972-01-25 Syntex Corp 2-(6'-methoxynaphth-2'-yl)propylene oxide and 5'-halo derivatives
IT1228242B (it) * 1986-11-13 1991-06-05 Ricerfarma Srl Milano Sale del diclofenac con idrossietilpirrolidina e composizioni farmaceutiche che lo contengono
GB8813682D0 (en) * 1988-06-09 1988-07-13 Reckitt & Colmann Prod Ltd Pharmaceutical compositions
US5028625A (en) * 1989-06-20 1991-07-02 American Home Products Corporation Acid addition salt of ibuprofen and meglumine
US4994604A (en) * 1990-01-10 1991-02-19 Merck & Co., Inc. Formation and resolution of ibuprofen lysinate

Also Published As

Publication number Publication date
DE69219020T2 (de) 1997-08-07
EP0521344A2 (de) 1993-01-07
US5206262A (en) 1993-04-27
ITMI911804A1 (it) 1993-01-01
CA2072407A1 (en) 1993-01-02
IT1255007B (it) 1995-10-11
EP0521344B1 (de) 1997-04-16
GR3023840T3 (en) 1997-09-30
ITMI911804A0 (it) 1991-07-01
ES2103325T3 (es) 1997-09-16
EP0521344A3 (en) 1993-04-07
DE69219020D1 (de) 1997-05-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee