JPS63122680A - 結晶性２―（１―ペンチル―３―グアニジノ）―４―（２―メチル―４―イミダゾリル）チアゾール・二塩酸塩・三水和物 - Google Patents

結晶性２―（１―ペンチル―３―グアニジノ）―４―（２―メチル―４―イミダゾリル）チアゾール・二塩酸塩・三水和物

Info

Publication number
JPS63122680A
JPS63122680A JP62274631A JP27463187A JPS63122680A JP S63122680 A JPS63122680 A JP S63122680A JP 62274631 A JP62274631 A JP 62274631A JP 27463187 A JP27463187 A JP 27463187A JP S63122680 A JPS63122680 A JP S63122680A
Authority
JP
Japan
Prior art keywords
formula
pentyl
acid
methyl
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62274631A
Other languages
English (en)
Japanese (ja)
Other versions
JPH0513952B2 (https=
Inventor
ダグラス・ジョン・メルドラム・アレン
バークレイ・ウェンデル・キュー・ジュニア
ポール・デーヴィッド・ヒル
ウイリアム・マイケル・スナイダー
スタンレー・ウォルター・ウォリンスキー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of JPS63122680A publication Critical patent/JPS63122680A/ja
Publication of JPH0513952B2 publication Critical patent/JPH0513952B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/24—Derivatives of thiourea containing any of the groups, X being a hetero atom, Y being any atom
    • C07C335/28—Y being a hetero atom, e.g. thiobiuret

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP62274631A 1986-10-29 1987-10-29 結晶性２―（１―ペンチル―３―グアニジノ）―４―（２―メチル―４―イミダゾリル）チアゾール・二塩酸塩・三水和物 Granted JPS63122680A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/US1986/002307 WO1988003140A1 (en) 1986-10-29 1986-10-29 Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride trihydrate
WO86/02307 1986-10-29
WO86/02308 1986-10-29

Publications (2)

Publication Number Publication Date
JPS63122680A true JPS63122680A (ja) 1988-05-26
JPH0513952B2 JPH0513952B2 (https=) 1993-02-23

Family

ID=22195693

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62274631A Granted JPS63122680A (ja) 1986-10-29 1987-10-29 結晶性２―（１―ペンチル―３―グアニジノ）―４―（２―メチル―４―イミダゾリル）チアゾール・二塩酸塩・三水和物

Country Status (11)

Country Link
US (1) US4997949A (https=)
JP (1) JPS63122680A (https=)
AU (1) AU579775B2 (https=)
CA (1) CA1313378C (https=)
DD (2) DD272851A5 (https=)
FI (1) FI89918C (https=)
NO (1) NO170417C (https=)
PH (1) PH23922A (https=)
RU (1) RU1779252C (https=)
WO (1) WO1988003140A1 (https=)
ZA (1) ZA878083B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387597A (en) * 1991-02-25 1995-02-07 Pfizer Inc. Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole
NO329085B1 (no) * 2008-01-31 2010-08-16 Sorbwater Technology As Fremgangsmate og apparat for separasjon av fluidfaser, samt anvendelser derav

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795972A (en) * 1980-10-14 1982-06-15 Pfizer 2-guanidino-4-heteroarylthiazole compound
JPS6191122A (ja) * 1984-10-11 1986-05-09 フアイザー・インコーポレーテツド ２―グアニジノ―４―（２―メチル―４―イミダゾリル）チアゾール類からなる慢性関節リウマチ治療用組成物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5795972A (en) * 1980-10-14 1982-06-15 Pfizer 2-guanidino-4-heteroarylthiazole compound
JPS6191122A (ja) * 1984-10-11 1986-05-09 フアイザー・インコーポレーテツド ２―グアニジノ―４―（２―メチル―４―イミダゾリル）チアゾール類からなる慢性関節リウマチ治療用組成物

Also Published As

Publication number Publication date
AU579775B2 (en) 1988-12-08
FI89918C (fi) 1993-12-10
JPH0513952B2 (https=) 1993-02-23
NO882861L (no) 1988-06-28
AU8042887A (en) 1988-05-05
ZA878083B (en) 1989-06-28
DD272851A5 (de) 1989-10-25
US4997949A (en) 1991-03-05
DD262659A5 (de) 1988-12-07
CA1313378C (en) 1993-02-02
NO170417B (no) 1992-07-06
FI892034L (fi) 1989-04-28
NO882861D0 (no) 1988-06-28
RU1779252C (ru) 1992-11-30
NO170417C (no) 1992-10-14
FI892034A0 (fi) 1989-04-28
FI89918B (fi) 1993-08-31
PH23922A (en) 1990-01-23
WO1988003140A1 (en) 1988-05-05

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