JPS62228048A - アミド誘導体及びそれを含有する皮膚外用剤 - Google Patents
アミド誘導体及びそれを含有する皮膚外用剤Info
- Publication number
- JPS62228048A JPS62228048A JP61251485A JP25148586A JPS62228048A JP S62228048 A JPS62228048 A JP S62228048A JP 61251485 A JP61251485 A JP 61251485A JP 25148586 A JP25148586 A JP 25148586A JP S62228048 A JPS62228048 A JP S62228048A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- skin
- amide derivative
- hydrocarbon group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001408 amides Chemical class 0.000 title claims description 16
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 claims abstract description 19
- 239000004094 surface-active agent Substances 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 9
- 229920006395 saturated elastomer Polymers 0.000 claims description 8
- 229930195735 unsaturated hydrocarbon Natural products 0.000 claims description 7
- 239000000126 substance Substances 0.000 claims description 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 5
- 229930195734 saturated hydrocarbon Natural products 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 10
- 239000000203 mixture Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 7
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract description 4
- 150000002430 hydrocarbons Chemical group 0.000 abstract description 3
- 125000004185 ester group Chemical group 0.000 abstract description 2
- 229930195733 hydrocarbon Natural products 0.000 abstract description 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 206010040849 Skin fissures Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 32
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 10
- 239000002537 cosmetic Substances 0.000 description 8
- -1 0.1 to 20% by weight Substances 0.000 description 7
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 7
- 238000000921 elemental analysis Methods 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000003921 oil Substances 0.000 description 7
- 235000019198 oils Nutrition 0.000 description 7
- 210000000434 stratum corneum Anatomy 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000000843 powder Substances 0.000 description 5
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- YRHYCMZPEVDGFQ-UHFFFAOYSA-N methyl decanoate Chemical compound CCCCCCCCCC(=O)OC YRHYCMZPEVDGFQ-UHFFFAOYSA-N 0.000 description 4
- 206010013786 Dry skin Diseases 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000012043 crude product Substances 0.000 description 3
- GYZLOYUZLJXAJU-UHFFFAOYSA-N diglycidyl ether Chemical compound C1OC1COCC1CO1 GYZLOYUZLJXAJU-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 239000005640 Methyl decanoate Substances 0.000 description 2
- FLIACVVOZYBSBS-UHFFFAOYSA-N Methyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC FLIACVVOZYBSBS-UHFFFAOYSA-N 0.000 description 2
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 238000003818 flash chromatography Methods 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- AOJFQRQNPXYVLM-UHFFFAOYSA-N pyridin-1-ium;chloride Chemical compound [Cl-].C1=CC=[NH+]C=C1 AOJFQRQNPXYVLM-UHFFFAOYSA-N 0.000 description 2
- 235000015961 tonic Nutrition 0.000 description 2
- 230000001256 tonic effect Effects 0.000 description 2
- 229960000716 tonics Drugs 0.000 description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 1
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- ZXJBWUAALADCRI-UHFFFAOYSA-N 2-(octadecoxymethyl)oxirane Chemical compound CCCCCCCCCCCCCCCCCCOCC1CO1 ZXJBWUAALADCRI-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- XHFWUECSNJWBJU-UHFFFAOYSA-N N-(docosanoyl)ethanolamine Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)NCCO XHFWUECSNJWBJU-UHFFFAOYSA-N 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000005037 alkyl phenyl group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Substances 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000000730 antalgic agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000003212 astringent agent Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 210000000736 corneocyte Anatomy 0.000 description 1
- 239000008271 cosmetic emulsion Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 1
- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000019387 fatty acid methyl ester Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- HSEMFIZWXHQJAE-UHFFFAOYSA-N hexadecanamide Chemical compound CCCCCCCCCCCCCCCC(N)=O HSEMFIZWXHQJAE-UHFFFAOYSA-N 0.000 description 1
- 229940081141 hexadecanamide Drugs 0.000 description 1
- 229940125697 hormonal agent Drugs 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- 239000012046 mixed solvent Substances 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- LYRFLYHAGKPMFH-UHFFFAOYSA-N octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(N)=O LYRFLYHAGKPMFH-UHFFFAOYSA-N 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 102220051077 rs145247495 Human genes 0.000 description 1
- 102200001405 rs377584435 Human genes 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940031439 squalene Drugs 0.000 description 1
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K31/00—Actuating devices; Operating means; Releasing devices
- F16K31/12—Actuating devices; Operating means; Releasing devices actuated by fluid
- F16K31/18—Actuating devices; Operating means; Releasing devices actuated by fluid actuated by a float
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S516/00—Colloid systems and wetting agents; subcombinations thereof; processes of
- Y10S516/01—Wetting, emulsifying, dispersing, or stabilizing agents
- Y10S516/07—Organic amine, amide, or n-base containing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Mechanical Engineering (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| MYPI86000167A MY100343A (en) | 1985-12-20 | 1986-12-04 | Amide derivative and external medicament comprising same |
| KR1019860010438A KR940011454B1 (ko) | 1985-12-20 | 1986-12-06 | 아미드유도체 및 이를 함유하는 외용약제 |
| US06/938,954 US4778823A (en) | 1985-12-20 | 1986-12-08 | Amide derivative and external medicament comprising same |
| AT86117200T ATE46323T1 (de) | 1985-12-20 | 1986-12-10 | Amid-derivate und diese enthaltende aeusserlich anwendbares arzneimittel. |
| EP86117200A EP0227994B1 (en) | 1985-12-20 | 1986-12-10 | Amide derivative and external medicament comprising same |
| ES86117200T ES2012045B3 (es) | 1985-12-20 | 1986-12-10 | Derivados amidicos y medicamentos de uso externo que los contienen. |
| DE8686117200T DE3665580D1 (en) | 1985-12-20 | 1986-12-10 | Amide derivative and external medicament comprising same |
| PH24630A PH22844A (en) | 1985-12-20 | 1986-12-19 | Amide derivative and external medicament comprising same |
| HK335/91A HK33591A (en) | 1985-12-20 | 1991-05-02 | Amide derivative and external medicament comprising same |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP60-286999 | 1985-12-20 | ||
| JP28699985 | 1985-12-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62228048A true JPS62228048A (ja) | 1987-10-06 |
| JPH0142934B2 JPH0142934B2 (ko) | 1989-09-18 |
Family
ID=17711709
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP61251485A Granted JPS62228048A (ja) | 1985-12-20 | 1986-10-22 | アミド誘導体及びそれを含有する皮膚外用剤 |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JPS62228048A (ko) |
| KR (1) | KR940011454B1 (ko) |
| ES (1) | ES2012045B3 (ko) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02306949A (ja) * | 1989-05-19 | 1990-12-20 | Kao Corp | アミド誘導体及びそれを含有する皮膚外用剤 |
| JPH04217610A (ja) * | 1990-12-18 | 1992-08-07 | Kao Corp | 皮膚外用剤 |
| EP1803439A2 (en) | 2001-03-06 | 2007-07-04 | Kao Corporation | Composition for external application containing a diamide derivative |
| JP2011178677A (ja) * | 2010-02-26 | 2011-09-15 | Kao Corp | 皮膚外用剤 |
| WO2014046300A2 (en) | 2012-09-20 | 2014-03-27 | Kao Corporation | Cleansing composition for skin or hair |
| WO2014142116A1 (ja) | 2013-03-12 | 2014-09-18 | 花王株式会社 | セラミド様機能付与剤 |
| JP2014189542A (ja) * | 2013-03-28 | 2014-10-06 | Kao Corp | アミド誘導体の製造方法 |
| WO2018221603A1 (ja) | 2017-05-30 | 2018-12-06 | 花王株式会社 | 油中水型乳化組成物 |
| WO2018221602A1 (ja) | 2017-05-30 | 2018-12-06 | 花王株式会社 | 油中水型乳化組成物 |
| WO2019131987A1 (ja) | 2017-12-28 | 2019-07-04 | 花王株式会社 | 脂質微粒子分散物 |
| WO2021157688A1 (ja) | 2020-02-07 | 2021-08-12 | 花王株式会社 | 皮膚外用組成物 |
| WO2023095810A1 (ja) | 2021-11-26 | 2023-06-01 | 花王株式会社 | 乳化組成物 |
-
1986
- 1986-10-22 JP JP61251485A patent/JPS62228048A/ja active Granted
- 1986-12-06 KR KR1019860010438A patent/KR940011454B1/ko not_active IP Right Cessation
- 1986-12-10 ES ES86117200T patent/ES2012045B3/es not_active Expired - Lifetime
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02306949A (ja) * | 1989-05-19 | 1990-12-20 | Kao Corp | アミド誘導体及びそれを含有する皮膚外用剤 |
| JPH04217610A (ja) * | 1990-12-18 | 1992-08-07 | Kao Corp | 皮膚外用剤 |
| EP1803439A2 (en) | 2001-03-06 | 2007-07-04 | Kao Corporation | Composition for external application containing a diamide derivative |
| JP2011178677A (ja) * | 2010-02-26 | 2011-09-15 | Kao Corp | 皮膚外用剤 |
| WO2014046300A2 (en) | 2012-09-20 | 2014-03-27 | Kao Corporation | Cleansing composition for skin or hair |
| US10143667B2 (en) | 2013-03-12 | 2018-12-04 | Kao Corporation | Ceramide-like function imparting agent |
| WO2014142116A1 (ja) | 2013-03-12 | 2014-09-18 | 花王株式会社 | セラミド様機能付与剤 |
| JP2014189542A (ja) * | 2013-03-28 | 2014-10-06 | Kao Corp | アミド誘導体の製造方法 |
| WO2018221603A1 (ja) | 2017-05-30 | 2018-12-06 | 花王株式会社 | 油中水型乳化組成物 |
| WO2018221602A1 (ja) | 2017-05-30 | 2018-12-06 | 花王株式会社 | 油中水型乳化組成物 |
| WO2019131987A1 (ja) | 2017-12-28 | 2019-07-04 | 花王株式会社 | 脂質微粒子分散物 |
| WO2021157688A1 (ja) | 2020-02-07 | 2021-08-12 | 花王株式会社 | 皮膚外用組成物 |
| WO2023095810A1 (ja) | 2021-11-26 | 2023-06-01 | 花王株式会社 | 乳化組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0142934B2 (ko) | 1989-09-18 |
| ES2012045B3 (es) | 1990-03-01 |
| KR870005968A (ko) | 1987-07-08 |
| KR940011454B1 (ko) | 1994-12-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0227994B1 (en) | Amide derivative and external medicament comprising same | |
| JP4358996B2 (ja) | 外用剤組成物 | |
| JPS63192703A (ja) | 皮膚外用剤 | |
| JPS62228048A (ja) | アミド誘導体及びそれを含有する皮膚外用剤 | |
| CA1315803C (en) | N-alkoxyalkylamides of hydroxyacids and skin treating compositions therewith | |
| JPH0517399A (ja) | エステル誘導体及びこれを含有する化粧料 | |
| JP2016199479A (ja) | 脂肪酸アルカノールアミド誘導体及びそれを含有する化粧料 | |
| JP5445070B2 (ja) | 毛髪用コシ及び／又は滑沢性付与剤、並びに毛髪用化粧料 | |
| JPH0676358B2 (ja) | アミド誘導体及びこれを含有する皮膚外用剤 | |
| JPH06145123A (ja) | アミド誘導体及びその製造中間体、並びに該アミド誘導体を含有する皮膚外用剤 | |
| JPS63216812A (ja) | 皮膚外用剤 | |
| JP2002179518A (ja) | 化粧料 | |
| JPS63227513A (ja) | 皮膚外用剤 | |
| JP4112741B2 (ja) | 保湿剤 | |
| JPH078844B2 (ja) | アミド誘導体及びそれを含有する皮膚外用剤 | |
| JPS63227514A (ja) | 皮膚外用剤 | |
| JP3833724B2 (ja) | しわ改善剤 | |
| JP4220625B2 (ja) | 外用剤組成物 | |
| JPH0763613B2 (ja) | 油中水型乳化組成物 | |
| JPH0565485B2 (ko) | ||
| JPH04217610A (ja) | 皮膚外用剤 | |
| JP3712676B2 (ja) | 外用剤組成物 | |
| JPS63218609A (ja) | 皮膚外用剤 | |
| JP4150738B2 (ja) | 外用剤組成物 | |
| JPH0710731A (ja) | 油中水型乳化化粧料 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |